Li H, Wei S, Cheng K, Gounko N, Ericksen R, Xu A, et al
. BIG3 inhibits insulin granule biogenesis and insulin secretion. EMBO Rep. 2014;15:714-22 pubmed publisher
..Collectively, these results demonstrate that BIG3 negatively modulates insulin granule biogenesis and insulin secretion and participates in the regulation of systemic glucose homeostasis. ..
Qiu B, Shi X, Zhou Q, Chen H, Lim J, Han W, et al
. Hypothalamic NUCKS regulates peripheral glucose homoeostasis. Biochem J. 2015;469:391-8 pubmed publisher
..These studies indicate that hypothalamic NUCKS plays an essential role in regulating glucose homoeostasis and insulin signalling in vivo. ..
Ericksen R, Lim S, McDonnell E, Shuen W, Vadiveloo M, White P, et al
. Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. Cell Metab. 2019;: pubmed publisher
..Dietary BCAA intake in humans also correlated with cancer mortality risk. In summary, loss of BCAA catabolism in tumors confers functional advantages, which could be exploited by therapeutic interventions in certain cancers. ..
Chong Y, Lim T, Fu Y, Shin E, Tergaonkar V, Han W. Indian Hedgehog links obesity to development of hepatocellular carcinoma. Oncogene. 2018;: pubmed publisher
..We propose that therapeutic targeting of the Hh pathway offers benefit for patients with dietary / NAFLD-driven steatotic HCC. ..
Peng X, Zhang Q, Liao C, Han W, Xu F. Epigenomic Control of Thermogenic Adipocyte Differentiation and Function. Int J Mol Sci. 2018;19: pubmed publisher
..In this review, we summarize and discuss the recent advance in these studies and highlight the insights gained into the epigenomic regulation of thermogenic program as well as the pathogenesis of human metabolic diseases. ..
Lim C, Hong W, Han W. Adiponectin is released via a unique regulated exocytosis pathway from a pre-formed vesicle pool on insulin stimulation. Biochem J. 2015;471:381-9 pubmed publisher
..Taken together, our results show that adiponectin is stored in a unique vesicular compartment, and released through a regulated exocytosis pathway that is dependent on insulin signalling. ..
Qiu B, Shi X, Wong E, Lim J, Bezzi M, Low D, et al
. NUCKS is a positive transcriptional regulator of insulin signaling. Cell Rep. 2014;7:1876-86 pubmed publisher
..Altogether, NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators. ..
Liu T, Li H, Gounko N, Zhou Z, Xu A, Hong W, et al
. Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice. Am J Physiol Endocrinol Metab. 2014;307:E611-8 pubmed publisher
..Depletion of BIG3 leads to an enlarged releasable pool of insulin granules, which accounts for increased release frequency and consequently increased insulin secretion. ..