Wei Dong Han

Summary

Publications

  1. pmc LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation
    Zhiqiang Wu
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, China
    PLoS ONE 6:e18157. 2011
  2. pmc Culturing on Wharton's jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways
    Haojie Hao
    Institute of Basic Medicine Science, Chinese PLA General Hospital, Beijing, China
    PLoS ONE 8:e58314. 2013
  3. pmc A microRNA component of the neoplastic microenvironment: microregulators with far-reaching impact
    Xiaolei Li
    Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing 100853, China
    Biomed Res Int 2013:762183. 2013
  4. pmc Characterization of adult α- and β-globin elevated by hydrogen peroxide in cervical cancer cells that play a cytoprotective role against oxidative insults
    Xiaolei Li
    Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, China
    PLoS ONE 8:e54342. 2013
  5. pmc A facile and specific assay for quantifying microRNA by an optimized RT-qPCR approach
    Qian Mei
    Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, People s Republic of China
    PLoS ONE 7:e46890. 2012
  6. pmc Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity
    Yiling Si
    Institute of Basic Medicine, College of Life Science, Chinese PLA General Hospital, Beijing, China
    Diabetes 61:1616-25. 2012
  7. pmc Keratin 18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm
    Yuanguang Meng
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, 100853, China
    BMC Cell Biol 10:96. 2009
  8. pmc Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors
    Yuanguang Meng
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing, 100853, PR China
    BMC Cancer 9:75. 2009
  9. pmc FHL2 interacts with and acts as a functional repressor of Id2 in human neuroblastoma cells
    Weidong Han
    Department of Molecular Biology, Chinese PLA General Hospital, Beijing 100853, China
    Nucleic Acids Res 37:3996-4009. 2009
  10. doi request reprint GC-rich promoter elements maximally confers estrogen-induced transactivation of LRP16 gene through ERalpha/Sp1 interaction in MCF-7 cells
    Wei Dong Han
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China
    J Steroid Biochem Mol Biol 109:47-56. 2008

Collaborators

Detail Information

Publications38

  1. pmc LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation
    Zhiqiang Wu
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, China
    PLoS ONE 6:e18157. 2011
    ..Here, we investigated the regulatory role of LRP16 on NF-κB activation...
  2. pmc Culturing on Wharton's jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways
    Haojie Hao
    Institute of Basic Medicine Science, Chinese PLA General Hospital, Beijing, China
    PLoS ONE 8:e58314. 2013
    ....
  3. pmc A microRNA component of the neoplastic microenvironment: microregulators with far-reaching impact
    Xiaolei Li
    Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing 100853, China
    Biomed Res Int 2013:762183. 2013
    ....
  4. pmc Characterization of adult α- and β-globin elevated by hydrogen peroxide in cervical cancer cells that play a cytoprotective role against oxidative insults
    Xiaolei Li
    Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, China
    PLoS ONE 8:e54342. 2013
    ..However, Hgb is also expressed in nonerythroid cells. In the present study, the expression of Hgb in human uterine cervix carcinoma cells and its role in cervical cancer were investigated...
  5. pmc A facile and specific assay for quantifying microRNA by an optimized RT-qPCR approach
    Qian Mei
    Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, People s Republic of China
    PLoS ONE 7:e46890. 2012
    ....
  6. pmc Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity
    Yiling Si
    Institute of Basic Medicine, College of Life Science, Chinese PLA General Hospital, Beijing, China
    Diabetes 61:1616-25. 2012
    ..This is the first report of MSC treatment improving insulin sensitivity in T2D. These data indicate that multiple roles and mechanisms are involved in the efficacy of MSCs in ameliorating hyperglycemia in T2D...
  7. pmc Keratin 18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm
    Yuanguang Meng
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, 100853, China
    BMC Cell Biol 10:96. 2009
    ..However, the regulation of the functional availability of this coactivator protein is not yet clear...
  8. pmc Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors
    Yuanguang Meng
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing, 100853, PR China
    BMC Cancer 9:75. 2009
    ..We aimed to reveal the role of Id2 in invasion potential in poorly invasive and estrogen receptor alpha (ERalpha)-positive MCF-7 and SKOV-3 cancer cells...
  9. pmc FHL2 interacts with and acts as a functional repressor of Id2 in human neuroblastoma cells
    Weidong Han
    Department of Molecular Biology, Chinese PLA General Hospital, Beijing 100853, China
    Nucleic Acids Res 37:3996-4009. 2009
    ..Altogether, these results indicate that FHL2 is an important repressor of the oncogenic activity of Id2 in neuroblastoma cells...
  10. doi request reprint GC-rich promoter elements maximally confers estrogen-induced transactivation of LRP16 gene through ERalpha/Sp1 interaction in MCF-7 cells
    Wei Dong Han
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China
    J Steroid Biochem Mol Biol 109:47-56. 2008
    ..We also provide a model for Sp1-dependent regulation of genes by E2 through GC-rich motifs...
  11. doi request reprint The macro domain protein family: structure, functions, and their potential therapeutic implications
    Weidong Han
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing 100853, China
    Mutat Res 727:86-103. 2011
    ..Finally, a series of observations will be highlighted that should be addressed in future efforts to develop macro domains as effective therapeutic targets...
  12. doi request reprint Repeated transfusions of autologous cytokine-induced killer cells for treatment of haematological malignancies in elderly patients: a pilot clinical trial
    Bo Yang
    Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China
    Hematol Oncol 30:115-22. 2012
    ..At the end of follow-up, the mean survival time was 20 months. Transfusion with autologous CIK cells plus rhIL-2 treatment is safe and effective for treating haematological malignancies in elderly patients...
  13. ncbi request reprint Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin
    Yuan Guang Meng
    Department of Obstetrics and Gynecology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
    Cell Res 17:869-80. 2007
    ..These results suggest that the upregulation of LRP16 by estrogen could be involved in invasive growth by downregulating E-cadherin in human ECs...
  14. ncbi request reprint FHL2 inhibits the Id3-promoted proliferation and invasive growth of human MCF-7 breast cancer cells
    Yi Hong Chen
    Medical Logistics Division, Chinese People s Liberation Army General Hospital, Beijing 100853, China
    Chin Med J (Engl) 125:2329-33. 2012
    ..This study aimed to investigate the effects of FHL2 on the transcriptional regulation and oncogenic activities of Id3 in human breast cancer cells...
  15. ncbi request reprint [Promotive effect of LRP16 gene on proliferation of K562 cells]
    Bo Yang
    Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:1154-8. 2009
    ..It is concluded that LRP16 gene overexpression shows a promotive effect on proliferation of K562 cells...
  16. ncbi request reprint [Research progress on immunocyte senescence - review]
    Bo Yang
    Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 20:782-7. 2012
    ..This review summarized the research progress on immunosenescence characteristics in aged phase...
  17. ncbi request reprint [Clinical study of autologous cytokine induced killer cells combined with chemotherapy for elderly patients with acute myeloid leukemia]
    Yang Yang
    Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 22:58-63. 2014
    ..It is concluded that autologous CIK cells combined with chemotherapy is safe and efficacious for the elderly patients with acute myeloid leukemia...
  18. ncbi request reprint [Expression and clinical significance of LRP16 gene in human breast cancer]
    Dai Xiang Liao
    Department of Molecular Biology, Institute of Basic Medicine, PLA General Hospital, Beijing, 100853, P R China
    Ai Zheng 25:866-70. 2006
    ..This study was to detect the mRNA level of LRP16 gene in breast cancer, and investigate its correlation to the clinicopathologic features...
  19. pmc Autologous CIK cell immunotherapy in patients with renal cell carcinoma after radical nephrectomy
    Yajing Zhang
    Biotherapeutic Department, Chinese PLA General Hospital, Beijing 100853, China
    Clin Dev Immunol 2013:195691. 2013
    ..To evaluate the efficacy of autologous cytokine-induced killer (CIK) cells in patients with renal cell carcinoma (RCC)...
  20. ncbi request reprint [Inhibitory effect of antisense human telomerase reverse transcriptase(hTERT) on telomerase activity of human pulmonary giant cell carcinoma cell line(PLA-801D)]
    Xue Bin Ma
    Molecular Biology Laboratory, General Hospital of PLA, Beijing, 100853, PR China
    Ai Zheng 22:932-7. 2003
    ....
  21. doi request reprint MSCs: Biological characteristics, clinical applications and their outstanding concerns
    Yi Ling Si
    Institute of Basic Medicine Science, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
    Ageing Res Rev 10:93-103. 2011
    ..These interventions might help to establish a new clinical paradigm to turn MSC transplantation into a routine therapy for at least some diseases in the near future...
  22. ncbi request reprint [Short-term curative efficacy of autologous cytokine induced killer cells combined with low-dose IL-2 regimen containing immune enhancement by thymic peptide in elderly patients with B-cell chronic lymphocytic leukemia]
    Li Li Cai
    Department of Geriatric Laboratory Medicine, Chinese PLA General Hospital, Beijing, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 20:564-70. 2012
    ..It is concluded that the regimen of autologous CIK cells combined with low-dose IL-2 containing immune enhancement of thymic peptide is safety and effective for the treatment of elderly patients with B-CLL...
  23. ncbi request reprint [Application of immune function test to evaluate effect of cytokine-induced autologous killer cell infusion for elderly patients with hematological malignancies]
    Li Li Cai
    Department of Geriatric Laboratory Medicine, Institute of Basic Medical Sciences, Chinese PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1250-5. 2010
    ..It is concluded that the autologous CIK cell infusion can improve immunity in elderly patients of hematological malignancies and displays its effectiveness and safety for elderly patients...
  24. ncbi request reprint [Epidermal growth factor receptor mutation in non-small cell lung cancer and breast cancer]
    Ya Li Zhao
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing 100853, China
    Yi Chuan 29:547-53. 2007
    ..EGFR mutation rate in Chinese NSCLC patients was higher than that in Caucasians. Our data indicated that Chinese adenocarcinoma patients could benefit from TK inhibitor Gefitinib...
  25. ncbi request reprint [Clinical study of autologous cytokine induced killer cell infusion treating for elderly patients with myelodysplastic syndrome]
    Yang Liu
    Department of Geriatric Hematology, Institute of Basic Sciences, Chinese PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:787-92. 2011
    ..It is concluded that the autologous CIK cell infusion is a safe and effective therapy for geriatric myelodysplastic syndrome...
  26. ncbi request reprint [Analysis of LRP16 gene promoter activity]
    Xue Chun Lu
    Department of Gerontological Hematology, General Hospital of PLA, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:146-9. 2006
    ..A known gene promoter sequence can be freely obtained from NCBI database. It is concluded that LRP16 promoter is a standard type II promoter and its activity is strongest in the region from -200 to -600 bp...
  27. doi request reprint CIK cells from recurrent or refractory AML patients can be efficiently expanded in vitro and used for reduction of leukemic blasts in vivo
    Yao Wang
    Department of Immunology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, China
    Exp Hematol 41:241-52.e3. 2013
    ..CIK cells can be efficiently expanded in vitro from patients with recurrent or refractory AML and may be used for reduction of leukemic blasts in vivo...
  28. doi request reprint [Curative effect of decitabine combined with cytokine-induced killer cells in two elderly patients with acute myeloid leukemia]
    Cheng Chang
    Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 21:62-7. 2013
    ..The patients' life quality significantly improved. It is concluded that decitabine combined with CIK for treatment of elderly patients with AML is safe and effective...
  29. ncbi request reprint [Curative efficiency of rituximab combined with autologous cytokine induced killer cells on aged patient with orbital diffuse large B cell lymphoma]
    Su Xia Li
    Department of Geriatric Hematology, PLA General Hospital, Beijng, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 20:1117-21. 2012
    ..It is concluded that CIK cell infusion may prevent recurrence, prolong progression-free survival and improve quality of life after rituximab (alone or with chemotherapy) for aged patients with orbital diffuse large B-cell lymphoma...
  30. pmc Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma
    Hong Qing Xi
    Department of Pathology, Chinese People s Liberation Army General Hospital, Beijing 100853, China
    World J Gastroenterol 16:1644-8. 2010
    ..To explore the expression of leukemia related protein 16 (LRP16) in colorectal carcinoma, and analyze its correlation with clinicopathologic features and prognosis...
  31. doi request reprint Clinical study of autologous cytokine-induced killer cells for the treatment of elderly patients with diffuse large B-cell lymphoma
    Xue Chun Lu
    Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China
    Cell Biochem Biophys 62:257-65. 2012
    ..All patients achieved complete remission at study endpoint. No adverse reactions were reported. Autologous CIK cell immunotherapy is safe and efficacious for the treatment of elderly patients with diffuse large B-cell lymphoma...
  32. pmc Clinicopathological significance of LRP16 protein in 336 gastric carcinoma patients
    Ya zhuo Li
    Department of Pathology, Chinese People s Liberation Army General Hospital, Beijing, China
    World J Gastroenterol 15:4833-7. 2009
    ..To investigate the expression of leukemia related protein 16 (LRP16), and the possible relationship between LRP16 expression and clinicopathological indices in 336 gastric carcinoma patients...
  33. ncbi request reprint [Study on DNA methylation status of WT1 gene promoter in leukemia cell]
    Quan Shun Wang
    Department of Hematology, PLA General Hospital, Beijing 100853, China
    Zhonghua Xue Ye Xue Za Zhi 24:527-9. 2003
    ..To analyse the WT1 expression and its DNA methylation status of its promoter domain...
  34. ncbi request reprint [Cloning of the full length cDNA for a novel leukemia relapse-associated candidate gene LRP15]
    Zhou min Xu
    Department of Hematology, General Hospital of PLA, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 11:22-6. 2003
    ..It is concluded that RACE is an effective method to clone novel genes and LRP15 may be a leukemia relapse-associated candidate gene playing an important role in carcinogenesis...
  35. doi request reprint Microenvironment-evoked cell lineage conversion: Shifting the focus from internal reprogramming to external forcing
    Ji Lin
    Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, PR China
    Ageing Res Rev 12:29-38. 2013
    ..Based on the relatively slight safety and technical issues, we conclude that microenvironment-evoked cell lineage conversion, instead of reprogramming, will be the shifting focus in regenerative medicine...
  36. ncbi request reprint [Lrp16 gene expression in leukemia cell lines and bone marrow cells of leukemia patients and its clinical implication]
    Bo Yang
    Department of Geriatric Hematology, PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:857-60. 2009
    ..001). It is concluded that the lrp16 gene is a leukemic oncogene and closely relates to genesis and progression of leukemia, which may be an indicator for evaluating clinical efficacy of leukemia therapy...
  37. ncbi request reprint [Clinical study of autologous cytokine induced killer cells combined with IL-2 for therapy of elderly patients with B-cell malignant lymphoma]
    Bo Yang
    Department of Geriatric Hematology, Institute of Basic Medical Sciences, Chinese PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1244-9. 2010
    ..In conclusion, regimen of autologous CIK cells combined with IL-2 is safe and effective for the therapy of elderly patients with B-cell malignant lymphoma...