Mee Jung Han

Summary

Publications

  1. ncbi request reprint Comparison of the large-scale periplasmic proteomes of the Escherichia coli K-12 and B strains
    Mee Jung Han
    Department of Biomolecular and Chemical Engineering, Dongyang University, 145 Dongyang daero, Punggi eup, Yeongju, Gyeongbuk 750 711, Republic of Korea Electronic address
    J Biosci Bioeng 117:437-42. 2014
  2. pmc Comparative multi-omics systems analysis of Escherichia coli strains B and K-12
    Sung Ho Yoon
    Systems and Synthetic Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305 806, Korea
    Genome Biol 13:R37. 2012
  3. ncbi request reprint Comparative analysis of envelope proteomes in Escherichia coli B and K-12 strains
    Mee Jung Han
    Department of Biomolecular and Chemical Engineering, Dongyang University, Gyeongbuk 750 711, Korea
    J Microbiol Biotechnol 22:470-8. 2012
  4. doi request reprint Biotechnological applications of microbial proteomes
    Mee Jung Han
    Department of Chemical and Biomolecular Engineering, Dongyang University, 1 Gyochon dong, Punggi eup, Yeongju, Gyeongbuk 750 711, Republic of Korea
    J Biotechnol 145:341-9. 2010
  5. doi request reprint Extracellular proteome of Aspergillus terreus grown on different carbon sources
    Mee Jung Han
    Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Institute for the BioCentury, KAIST, Yuseong Gu, Daejeon, Republic of Korea
    Curr Genet 56:369-82. 2010
  6. pmc A systems biology analysis of metastatic melanoma using in-depth three-dimensional protein profiling
    Mee Jung Han
    The Wistar Institute, Philadelphia, PA 19104, USA
    Proteomics 10:4450-62. 2010
  7. doi request reprint Understanding and engineering of microbial cells based on proteomics and its conjunction with other omics studies
    Mee Jung Han
    Department of Biomolecular and Chemical Engineering, Dongyang University, Gyeongbuk, Republic of Korea
    Proteomics 11:721-43. 2011
  8. ncbi request reprint Combined transcriptome and proteome analysis of Escherichia coli during high cell density culture
    Sung Ho Yoon
    Department of Chemical and Biomolecular Engineering, and BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Korea
    Biotechnol Bioeng 81:753-67. 2003
  9. doi request reprint Genome-wide identification of the subcellular localization of the Escherichia coli B proteome using experimental and computational methods
    Mee Jung Han
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, BioProcess Engineering Research Center, and Institute for the BioCentury, KAIST, Yuseong Gu, Daejeon, Republic of Korea
    Proteomics 11:1213-27. 2011
  10. doi request reprint Comparison of the extracellular proteomes of Escherichia coli B and K-12 strains during high cell density cultivation
    Xiao Xia Xia
    Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Institute for the BioCentury, Korea Advanced Institute of Science and Technology KAIST, Yuseong Gu, Daejeon, Republic of Korea
    Proteomics 8:2089-103. 2008

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Comparison of the large-scale periplasmic proteomes of the Escherichia coli K-12 and B strains
    Mee Jung Han
    Department of Biomolecular and Chemical Engineering, Dongyang University, 145 Dongyang daero, Punggi eup, Yeongju, Gyeongbuk 750 711, Republic of Korea Electronic address
    J Biosci Bioeng 117:437-42. 2014
    ..Additionally, these findings are summarized as reference proteome maps that will be useful for studying protein secretion and may provide new strategies for the enhanced secretory production of recombinant proteins...
  2. pmc Comparative multi-omics systems analysis of Escherichia coli strains B and K-12
    Sung Ho Yoon
    Systems and Synthetic Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305 806, Korea
    Genome Biol 13:R37. 2012
    ..Here, we demonstrate that comparative analyses of multi-omics data combined with a computational modeling approach provide a framework for elucidating the phenotypic characteristics of organisms whose genomes are sequenced...
  3. ncbi request reprint Comparative analysis of envelope proteomes in Escherichia coli B and K-12 strains
    Mee Jung Han
    Department of Biomolecular and Chemical Engineering, Dongyang University, Gyeongbuk 750 711, Korea
    J Microbiol Biotechnol 22:470-8. 2012
    ..Thus, these findings suggest that E. coli K-12 and its derivatives will be more favorable strains in certain biotechnological applications, such as cell surface display or membrane engineering studies...
  4. doi request reprint Biotechnological applications of microbial proteomes
    Mee Jung Han
    Department of Chemical and Biomolecular Engineering, Dongyang University, 1 Gyochon dong, Punggi eup, Yeongju, Gyeongbuk 750 711, Republic of Korea
    J Biotechnol 145:341-9. 2010
    ..Successful applications of proteomic information have proven to have enormous value for both scientific and practical applications...
  5. doi request reprint Extracellular proteome of Aspergillus terreus grown on different carbon sources
    Mee Jung Han
    Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Institute for the BioCentury, KAIST, Yuseong Gu, Daejeon, Republic of Korea
    Curr Genet 56:369-82. 2010
    ..These proteomic data will be useful for studying protein secretion in further detail, and finding fusion partners for the extracellular production of homologous or heterologous proteins in A. terreus...
  6. pmc A systems biology analysis of metastatic melanoma using in-depth three-dimensional protein profiling
    Mee Jung Han
    The Wistar Institute, Philadelphia, PA 19104, USA
    Proteomics 10:4450-62. 2010
    ..These results provide novel insights into cellular pathways implicated in melanoma metastasis...
  7. doi request reprint Understanding and engineering of microbial cells based on proteomics and its conjunction with other omics studies
    Mee Jung Han
    Department of Biomolecular and Chemical Engineering, Dongyang University, Gyeongbuk, Republic of Korea
    Proteomics 11:721-43. 2011
    ....
  8. ncbi request reprint Combined transcriptome and proteome analysis of Escherichia coli during high cell density culture
    Sung Ho Yoon
    Department of Chemical and Biomolecular Engineering, and BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Korea
    Biotechnol Bioeng 81:753-67. 2003
    ..These findings should be invaluable in designing metabolic engineering and fermentation strategies for the production of recombinant proteins and metabolites by HCDC of E. coli...
  9. doi request reprint Genome-wide identification of the subcellular localization of the Escherichia coli B proteome using experimental and computational methods
    Mee Jung Han
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, BioProcess Engineering Research Center, and Institute for the BioCentury, KAIST, Yuseong Gu, Daejeon, Republic of Korea
    Proteomics 11:1213-27. 2011
    ..coli B, and will be useful as a reference for proteome profiling studies under various conditions. The complete proteome data are available online (http://ecolib.kaist.ac.kr)...
  10. doi request reprint Comparison of the extracellular proteomes of Escherichia coli B and K-12 strains during high cell density cultivation
    Xiao Xia Xia
    Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Institute for the BioCentury, Korea Advanced Institute of Science and Technology KAIST, Yuseong Gu, Daejeon, Republic of Korea
    Proteomics 8:2089-103. 2008
    ..These findings summarized as reference proteome maps will be useful for studying protein release in further detail, and provide new strategies for enhanced excretory production of recombinant proteins...
  11. doi request reprint Isolation of a potential anchoring motif based on proteome analysis of Escherichia coli and its use for cell surface display
    Sung Sun Yim
    Department of Chemical and Biomolecular Engineering, KAIST, 335 Gwahagno, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Appl Biochem Biotechnol 170:787-804. 2013
    ..coli cell surface with high activity. These results reveal that the use of OmpX as an anchoring motif is an efficient method to display functional enzymes on the surface of an E. coli host...
  12. pmc Engineering Escherichia coli for increased productivity of serine-rich proteins based on proteome profiling
    Mee Jung Han
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    Appl Environ Microbiol 69:5772-81. 2003
    ..The approach taken in this study should be useful in designing a strategy for improving recombinant protein production...
  13. pmc Enhanced display of lipase on the Escherichia coli cell surface, based on transcriptome analysis
    Jong Hwan Baek
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, BioProcess Engineering Research Center, Dongyang University, Yeongju, Gyeongbuk 750 711, Republic of Korea
    Appl Environ Microbiol 76:971-3. 2010
    ..The fused Pseudomonas fluorescens SIK W1 lipase was successfully displayed on the surface of E. coli cells, and the lipase activity could be enhanced by the coexpression of the gadBC genes identified by transcriptome analysis...
  14. doi request reprint Expression of a lipase on the cell-surface of Escherichia coli using the OmpW anchoring motif and its application to enantioselective reactions
    Hyuk Lee
    Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P O Box 107, 141 Gajeong ro, Yuseong Gu, Daejeon, 305 600, Republic of Korea
    Biotechnol Lett 35:1677-83. 2013
    ....
  15. ncbi request reprint Roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli
    Mee Jung Han
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering and BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
    Biotechnol Bioeng 88:426-36. 2004
    ..This strategy seems to be generally applicable as it was successfully employed for the enhanced cytosolic or secretory production of several other recombinant proteins in E. coli...
  16. doi request reprint Microscale solution IEF combined with 2-D DIGE substantially enhances analysis depth of complex proteomes such as mammalian cell and tissue extracts
    Mee Jung Han
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Yuseong Gu, Daejeon, Republic of Korea
    Electrophoresis 29:695-705. 2008
    ..Thus the 3-D DIGE strategy produces a powerful method for more comprehensive and more reliable quantitative comparisons of protein profiles of very complex proteomes...
  17. ncbi request reprint Display of lipase on the cell surface of Escherichia coli using OprF as an anchor and its application to enantioselective resolution in organic solvent
    Seung Hwan Lee
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, and BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Yuseong Gu, Daejeon, Republic of Korea
    Biotechnol Bioeng 90:223-30. 2005
    ..These results suggest that E. coli cells displaying lipases using OprF as an anchoring motif can be employed for various biotechnological applications both in aqueous and nonaqueous phases...
  18. ncbi request reprint Enhanced proteome profiling by inhibiting proteolysis with small heat shock proteins
    Mee Jung Han
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Daejeon, Republic of Korea
    J Proteome Res 4:2429-34. 2005
    ..Therefore, the use of sHsps during 2-DE significantly improves proteome profiling by generally enabling the detection of many more protein spots that could not be seen previously...
  19. ncbi request reprint Proteome profiling and its use in metabolic and cellular engineering
    Mee Jung Han
    Metabolic and Biomolecular Engineering National Research Laboratory, Korean Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Korea
    Proteomics 3:2317-24. 2003
    ..In this paper, we review the approaches of exploiting the proteome profiling results to the development of the strategies for the metabolic and cellular engineering of microorganisms...
  20. pmc The Escherichia coli proteome: past, present, and future prospects
    Mee Jung Han
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Microbiol Mol Biol Rev 70:362-439. 2006
    ..Here, we review the past development and current status of E. coli proteome research in terms of its biological, biotechnological, and methodological significance and suggest future prospects...
  21. doi request reprint Microbial small heat shock proteins and their use in biotechnology
    Mee Jung Han
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology KAIST, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Biotechnol Adv 26:591-609. 2008
    ..In this review, we discuss the properties and diversity of microbial sHsps, as well as their potential uses in the biotechnology industry...
  22. pmc Transcriptome and proteome analyses of adaptive responses to methyl methanesulfonate in Escherichia coli K-12 and ada mutant strains
    Jong Hwan Baek
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology and Institute for the BioCentury, KAIST, Daejeon, Republic of Korea
    BMC Microbiol 9:186. 2009
    ..Here we present time-dependent global gene and protein expression profiles following treatment with methyl methanesulfonate (MMS) in E. coli W3110 and its ada mutant strains...
  23. ncbi request reprint Proteomic analyses of the phase transition from acidogenesis to solventogenesis using solventogenic and non-solventogenic Clostridium acetobutylicum strains
    Yu Sin Jang
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 plus program, BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, 291 Daehak ro, Yuseong Gu, Daejeon, 305 701, South Korea
    Appl Microbiol Biotechnol 98:5105-15. 2014
    ..The proteomic data from this study will improve our understanding on how cell physiology is affected through protein levels patterns in clostridia. ..
  24. doi request reprint Microscale isoelectric focusing in solution: a method for comprehensive and quantitative proteome analysis using 1-D and 2-D DIGE combined with MicroSol IEF prefractionation
    Mee Jung Han
    The Wistar Institute, Philadelphia, Pennsylvania, USA
    Methods Mol Biol 424:241-56. 2008
    ..The combination of DIGE and MicroSol IEF produces a powerful method for more comprehensive and quantitative comparison of protein profiles of complex proteomes...