Fang Han

Summary

Publications

  1. ncbi request reprint [Acute respiratory failure and noninvasive positive pressure ventilation treatment in patients with severe acute respiratory syndrome]
    Fang Han
    Department of Respiratory Medicine, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:593-7. 2004
  2. pmc Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic
    Fang Han
    Department of Pulmonary, Critical Care Medicine, Peking University People s Hospital, Beijing, China
    PLoS Genet 9:e1003880. 2013
  3. doi request reprint Sleepiness that cannot be overcome: narcolepsy and cataplexy
    Fang Han
    Department of Respiratory Medicine, The Peking University People s Hospital, Beijing, China
    Respirology 17:1157-65. 2012
  4. doi request reprint HLA-DQ association and allele competition in Chinese narcolepsy
    F Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Tissue Antigens 80:328-35. 2012
  5. pmc TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy
    Fang Han
    Department of Pulmonary Medicine, Peking University People s Hospital, Beijing, China
    Sleep Med 13:269-72. 2012
  6. doi request reprint Respiratory regulation in narcolepsy
    Fang Han
    Department of Pulmonary Medicine, Peking University People s Hospital, Beijing, China
    Sleep Breath 16:241-5. 2012
  7. pmc Presentations of primary hypersomnia in Chinese children
    Fang Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Sleep 34:627-32. 2011
  8. doi request reprint Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China
    Fang Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Ann Neurol 70:410-7. 2011
  9. ncbi request reprint Influence of UPPP surgery on tolerance to subsequent continuous positive airway pressure in patients with OSAHS
    Fang Han
    Department of Pulmonary Medicine, People s Hospital, Beijing University, 11 Xi Zhi Men Nan Da Jie, Xi Chen Qu, Beijing, 100044, People s Republic of China
    Sleep Breath 10:37-42. 2006
  10. doi request reprint Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status
    F Han
    Dept of Pulmonary Medicine, The People s Hospital, Beijing University, Beijing 100044, China
    Eur Respir J 36:577-83. 2010

Collaborators

Detail Information

Publications46

  1. ncbi request reprint [Acute respiratory failure and noninvasive positive pressure ventilation treatment in patients with severe acute respiratory syndrome]
    Fang Han
    Department of Respiratory Medicine, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:593-7. 2004
    ....
  2. pmc Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic
    Fang Han
    Department of Pulmonary, Critical Care Medicine, Peking University People s Hospital, Beijing, China
    PLoS Genet 9:e1003880. 2013
    ....
  3. doi request reprint Sleepiness that cannot be overcome: narcolepsy and cataplexy
    Fang Han
    Department of Respiratory Medicine, The Peking University People s Hospital, Beijing, China
    Respirology 17:1157-65. 2012
    ....
  4. doi request reprint HLA-DQ association and allele competition in Chinese narcolepsy
    F Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Tissue Antigens 80:328-35. 2012
    ....
  5. pmc TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy
    Fang Han
    Department of Pulmonary Medicine, Peking University People s Hospital, Beijing, China
    Sleep Med 13:269-72. 2012
    ..Our aim was to study whether these polymorphisms are associated with narcolepsy and its clinical characteristics in Chinese patients with narcolepsy...
  6. doi request reprint Respiratory regulation in narcolepsy
    Fang Han
    Department of Pulmonary Medicine, Peking University People s Hospital, Beijing, China
    Sleep Breath 16:241-5. 2012
    ..This disorder is also associated with the gene marker, HLADQB1*0602. An increased prevalence of sleep apnea in narcolepsy suggested interactions among ventilatory chemosensitivity, narcolepsy-cataplexy, and sleep apnea...
  7. pmc Presentations of primary hypersomnia in Chinese children
    Fang Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Sleep 34:627-32. 2011
    ..To retrospectively describe childhood presentations of primary hypersomnia with an emphasis on narcolepsy-cataplexy in a Chinese population...
  8. doi request reprint Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China
    Fang Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Ann Neurol 70:410-7. 2011
    ..Recently, concern has been raised over reports of narcolepsy in northern Europe following H1N1 vaccination...
  9. ncbi request reprint Influence of UPPP surgery on tolerance to subsequent continuous positive airway pressure in patients with OSAHS
    Fang Han
    Department of Pulmonary Medicine, People s Hospital, Beijing University, 11 Xi Zhi Men Nan Da Jie, Xi Chen Qu, Beijing, 100044, People s Republic of China
    Sleep Breath 10:37-42. 2006
    ..One of the three tested both before and after surgery failed in the CPAP treatment after surgery during REM sleep. UPPP may compromise nasal CPAP therapy in OSAHS, especially in procedures with greater resection of the soft palate...
  10. doi request reprint Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status
    F Han
    Dept of Pulmonary Medicine, The People s Hospital, Beijing University, Beijing 100044, China
    Eur Respir J 36:577-83. 2010
    ..13 ± 0.08 versus 0.20 ± 0.14 L·min(-1) per %S(p,O(2)); p<0.0001). Thus, a lower hypoxic responsiveness in the narcolepsy-cataplexy group is a result of DQB1*0602 status rather than the clinical features of disease...
  11. ncbi request reprint [Influence of different sleep stages on respiratory regulation in normal humans]
    Fang Han
    Department of Pulmonary Medicine, The People s Hospital, Peking University, Beijing 100044, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:237-40. 2004
    ..To understand the influence of different sleep stages on respiratory regulation in normal people...
  12. ncbi request reprint Noninvasive positive pressure ventilation treatment for acute respiratory failure in SARS
    Fang Han
    Department of Pulmonary Medicine, The People s Hospital, Beijing University, Beijing, China
    Sleep Breath 8:97-106. 2004
    ..7% (8/120); it was higher (26.7%) in those needing NPPV. No caregiver contracted SARS. We conclude that NPPV is a feasible and appropriate treatment for ARF occurring as a result of a SARS infection...
  13. ncbi request reprint [Daytime hypercapnia in patients with obstructive sleep apnea hypopnea syndrome]
    Hui Ling Wang
    Department of Respiratory and Critical Care Medicine, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Jie He He Hu Xi Za Zhi 36:490-2. 2013
    ..To evaluate the incidence and factors related to daytime CO2 retention (PaCO2 ≥ 45 mm Hg, 1 mm Hg = 0.133 kPa) in Chinese patients with obstructive sleep apnea hypopnea syndrome...
  14. ncbi request reprint [Effects of short-term continuous positive airway pressure treatment on arterial stiffness in patients with obstructive sleep apnea hypopnea syndrome]
    Yun Hui Lü
    Department of Pulmonary Medicine, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 88:1189-91. 2008
    ..To investigate the effect of short-term continuous positive airway pressure (CPAP) treatment on the arterial stiffness in patients with obstructive sleep apnea hypopnea syndrome (OSAHS)...
  15. ncbi request reprint [Effect of acute hypoxia and hypercapnia on arterial stiffness and blood pressure in patients with obstructive sleep apnea hypopnea syndrome]
    Yun Hui Lü
    Department of Pulmonary Medicine, First People s Hospital of Yunnan Province, Kunming 650032, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:42-5. 2009
    ..To investigate the effect of acute hypoxia and/or hypercapnia on cardio-ankle vascular index (CAVI) and blood pressure (BP) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS)...
  16. ncbi request reprint [Effect of noninvasive ventilation on chemoresponsiveness in patients with sleep apnea and chronic obstructive pulmonary disease]
    Hui Ling Wang
    Department of Pulmonary Medicine, People s Hospital, Peking University, Beijing, China
    Zhonghua Yi Xue Za Zhi 87:2193-7. 2007
    ..To investigate the effect of noninvasive ventilation on respiratory control in patients with chronic obstructive pulmonary disease (COPD) combined with sleep a apnea-hypopnea syndrome (SAHS)-overlap syndrome (OS)...
  17. ncbi request reprint [Respiratory control during sleep and the development of nocturnal hypoxia in patients with obstructive sleep apnea hypopnea syndrome]
    Fang Han
    Department of Respiratory Medicine, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Jie He He Hu Xi Za Zhi 26:522-5. 2003
    ..It is assumed that the reduced ventilatory control during sleep may be related to the nocturnal hypoxia in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and daytime CO(2) retention...
  18. doi request reprint Hypocretin (orexin) neuropeptide precursor gene, HCRT, polymorphisms in early-onset narcolepsy with cataplexy
    Xiao Song Dong
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Sleep Med 14:482-7. 2013
    ..To test if the hypocretin (orexin) neuropeptide precursor (HCRT) gene, HCRT, mutations are implicated in the development of narcolepsy with cataplexy deficiency in young children...
  19. ncbi request reprint [HLA-DRB and -DQB allele contribution to narcolepsy susceptibility in Chinese patients with narcolepsy]
    Fang Han
    Department of Pulmonary Medicine, People s Hospital, Beijing University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 83:644-6. 2003
    ..To study the association of narcolepsy with HLA class II alleles in Chinese narcoleptic patients...
  20. ncbi request reprint [Changes of sleep architecture in patients with narcolepsy]
    Jing Li
    Department of Pulmonary Medicine, People s Hospital, Beijing University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 87:619-21. 2007
    ..To investigate the sleep architectures of patients with narcolepsy...
  21. ncbi request reprint [Effect of continuous positive airway pressure upon 24 h changes of blood glucose level in patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes]
    Cui ying Wei
    Department of Respiritory Medicine, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 89:2686-9. 2009
    ..To assess the effect of short-term continuous positive airway pressure (CPAP) upon 24 h glucose control via a continuous glucose monitoring system (CGMS) in patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes (OWD)...
  22. ncbi request reprint [Clinical features of respiratory failure and heart failure in patients with sleep disordered breathing]
    Ying Hui Gao
    Departments of Respiratory and Critical Care Medicine, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Jie He He Hu Xi Za Zhi 35:429-34. 2012
    ..To assess the clinical characteristics of heart failure and respiratory failure in patients with sleep disordered breathing (SDB)...
  23. ncbi request reprint [Utility of portable monitoring device with airflow, oxygen saturation and respiratory effort in the diagnosis of sleep apnea hypopnea syndrome]
    Han Yan
    Department of Respiratory Medicine, Peking University People s Hospital, Beijing, China
    Zhonghua Yi Xue Za Zhi 93:415-8. 2013
    ..To validate the values of monitoring airflow, oxygen saturation and respiratory effort in the diagnosis of sleep apnea-hypopnea syndrome (SAHS)...
  24. ncbi request reprint [Comparison of tolerance to sequential continuous positive airway pressure therapy between patients after classical and after modified uvulopalatopharyngoplasty]
    Li Hong Zhang
    Department of Otorhinolaryngology, People s Hospital, Beijing University, Beijing 100044, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 38:176-9. 2003
    ..To investigate the effect of uvulopalatopharyngoplasty (UPPP) on postoperation continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea hypopnea syndrome (OSAHS)...
  25. ncbi request reprint [Positivity analysis of human leukocyte histocompatibility antigen-DQB1*0602 allele in Chinese patients with narcolepsy]
    Jing Li
    Department of Respiratory and Critical Care Medicine, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 94:763-5. 2014
    ..To explore the association of narcolepsy with human leukocyte histocompatibility antigen (HLA)-DQB1*0602 allele in Chinese narcoleptic patients and examine its relationship with different phenotypes...
  26. ncbi request reprint [Clinical features of early-onset narcolepsy]
    Xiao Song Dong
    Department of Pulmonary Medicine, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 85:3107-9. 2005
    ..To investigate the clinical features of early onset narcolepsy...
  27. ncbi request reprint [Value of cerebral spinal fluid measurement of hypocretin-1 in the diagnosis of Chinese patients with narcolepsy]
    Xiao Song Dong
    Department of Respiratory Medicine, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 93:2038-42. 2013
    ..To evaluate the diagnostic value of cerebral spinal fluid (CSF) measurement of hypocretin-1 (hcrt-1) in Chinese patients with narcolepsy...
  28. ncbi request reprint [Respiration control dysfunction and the relationship to sleep-disordered breathing in patients with chronic obstructive pulmonary disease]
    Zhong Ming He
    Department of Pulmonary Medicine, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Jie He He Hu Xi Za Zhi 30:673-6. 2007
    ..To analyze the polysomnographic (PSG) features of sleep apnea hypopnea syndrome (SAHS) in patients with chronic obstructive pulmonary disease (COPD), and to define the association between SAHS and respiratory control disorder...
  29. ncbi request reprint [Screening of sleep apnea syndrome by ECG derived respiration of ambulatory electrocardiogram]
    Guang ming Tong
    Department of Cardiology, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 86:1545-8. 2006
    ..To evaluate the feasibility of screening sleep apnea-hypopnea syndrome (SAHS) by from electrocardiogram derived respiration (EDR) of ambulatory electrocardiogram (AECG) monitoring...
  30. ncbi request reprint [Value of transcutaneous monitoring of CO2 pressure in the diagnosis and treatment of sleep and breathing disorders]
    Yanan Liu
    Department of Respiratory Medicine and Intensive Care Unit, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 94:408-11. 2014
    ..To evaluate the clinical value of transcutaneous carbon dioxide (TcPCO2) measurement during sleep respiratory monitoring...
  31. doi request reprint Expression and immune effect of toll-like receptor 4 in human trophoblast cells
    Feitao Deng
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
    J Huazhong Univ Sci Technolog Med Sci 29:359-62. 2009
    ..05). Our results suggest that TLR4 plays an important role in the immunological mechanism of apoptosis and secretion of TNF-alpha of human term trophoblast cells stimulated by LPS...
  32. ncbi request reprint Chronic intermittent hypoxia from pedo-stage decreases glucose transporter 4 expression in adipose tissue and causes insulin resistance
    Lin Chen
    Department of Pneumology, Peking University People s Hospital, Beijing 100044, China
    Chin Med J (Engl) 123:463-70. 2010
    ..We tested the hypothesis that the changes of GLUTs in adipose tissue may be one of the reasons for persistent SDB among clinical OSA children after T&A surgery...
  33. doi request reprint Epilepsy and narcolepsy-cataplexy in a child
    Zhixian Yang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    J Child Neurol 27:807-10. 2012
    ..The coexistence of both disorders in this single patient indicated that there might be a common mechanism between epilepsy and narcolepsy-cataplexy...
  34. doi request reprint Identification of obstructive sleep apnea syndrome by ambulatory electrocardiography: clinical evaluation of time-domain and frequency-domain analyses of heart rate variability in Chinese patients
    Jianling Sun
    Department of Cardiology, Aviation Industry Central Hospital, An Ding Men Wai Bei Yuan Road 3, Beijing, 100012, China
    Cell Biochem Biophys 59:165-70. 2011
    ..In conclusion, time-domain and frequency-domain HRV analyses are useful methods for OSAS screening, and the frequency-domain analysis is more sensitive...
  35. ncbi request reprint [Retrospective analysis of the studies on sleep apnea-hypopnea syndrome in the past twenty years in our country]
    Quan Ying He
    Respiratory Department, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Jie He He Hu Xi Za Zhi 26:279-81. 2003
    ..To summarize and evaluate the studies on sleep apnea-hypopnea syndrome (SAHA) in our country...
  36. ncbi request reprint [Analysis of eleven cases of severe pneumonia in kidney transplant recipients]
    Tao Xu
    Department of Urology, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Wai Ke Za Zhi 43:672-4. 2005
    ..To analyse retrospectively the diagnosis and treatment of severe pneumonia in kidney transplantation recipients...
  37. ncbi request reprint Periodic breathing in the mouse
    Fang Han
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol (1985) 92:1133-40. 2002
    ..We conclude that differences in expression of PB between these strains indicate that genetic influences strongly affect the stability of ventilation in the mouse...
  38. ncbi request reprint Domperidone and ventilatory behavior: Sprague-Dawley versus Brown Norway rats
    Shyamsunder Subramanian
    Department of Medicine, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 155:22-8. 2007
    ..We speculate that hypoxic ventilatory responses may be differently configured even among strains of the same species...
  39. ncbi request reprint L-NAME differentially alters ventilatory behavior in Sprague-Dawley and Brown Norway rats
    Shyam Subramanian
    Department of Medicine, Case Western Reserve University, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Appl Physiol 93:984-9. 2002
    ..3 vs. 134.4 beats/min at baseline; VE: 66.3 vs. 88.8 ml/min at baseline; P < 0.05). Thus NOS blockade results in a strain-specific alteration in resting ventilation and uncovers the Dejours phenomenon in the SD strain...
  40. ncbi request reprint [Epidemiologic study on sleep apnea-hypopnea syndrome by home investigation in Chengde city]
    Qing Zhang
    Department of Respiratory Disease, Affiliated Hospital of Chengde Medical College, Chengde 067000, China
    Zhonghua Jie He He Hu Xi Za Zhi 26:273-5. 2003
    ..To investigate the prevalence of sleep apnea-hypopnea syndrome (SAHS) among adults aged over 30 yr in Chengde city of Hebei province...
  41. ncbi request reprint 7-nitroindazole and posthypoxic ventilatory behavior in the A/J and C57BL/6J mouse strains
    Edwin R Price
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Appl Physiol 95:1097-104. 2003
    ..Furthermore, neuronal nitric oxide may be an organizing feature in the presence, length, and/or cycle length of apnea in the susceptible strain...
  42. ncbi request reprint Strain differences in murine ventilatory behavior persist after urethane anesthesia
    Iahn Gonsenhauser
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4941, USA
    J Appl Physiol 97:888-94. 2004
    ..The neural substrate for these differences, at least partially, exists within subcortical structures generating the breathing pattern...
  43. ncbi request reprint Ventilatory behavior during sleep among A/J and C57BL/6J mouse strains
    Lee Friedman
    The MIND Institute, Albuquerque, New Mexico 87106, USA
    J Appl Physiol (1985) 97:1787-95. 2004
    ..035) and B6 (P < 0.0001). We conclude that genetic background affects features of breathing during NREM and REM sleep, despite broad changes in state, metabolism, and heart rate...
  44. ncbi request reprint [Sleep apnea and dysfunction of respiratory regulation]
    Fang Han
    Zhonghua Yi Xue Za Zhi 85:3101-2. 2005
  45. ncbi request reprint New approach for new target: adaptive servo-ventilation on Cheyne-Stokes respiration in congestive heart failure
    Fang Han
    Chin Med J (Engl) 119:619-21. 2006
  46. ncbi request reprint Obstructive sleep apnea hypopnea syndrome: a proinflammatory disorder
    Fang Han
    Chin Med J (Engl) 120:1475-6. 2007