- Shaker O, Alnoury A, Hegazy G, El Haddad H, Sayed S, Hamdy A. Methylene tetrahydrofolate reductase, transforming growth factor-?1 and lymphotoxin-? genes polymorphisms and susceptibility to rheumatoid arthritis. Rev Bras Reumatol Engl Ed. 2016;56:414-420 pubmed publisher..Our findings suggest that there is association between MTHFR C677 T and LT-? A252G genes polymorphisms and increased risk of RA in this sample of Egyptian population. ..