Glenda M Halliday

Summary

Publications

  1. doi Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43
    Rachel H Tan
    Neuroscience Research Australia, Barker Street, Randwick, Sydney 2031, Australia
    Acta Neuropathol Commun 1:33. 2013
  2. doi ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies
    Karen E Murphy
    Neuroscience Research Australia, Sydney 2031, Australia
    Acta Neuropathol Commun 1:11. 2013
  3. pmc LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models
    Patrícia Silva Guerreiro
    Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon 04250, Portugal
    J Mol Med (Berl) 91:513-22. 2013
  4. pmc Can we clinically diagnose dementia with Lewy bodies yet?
    Yue Huang
    Neuroscience Research Australia, The University of New South Wales, Sydney, NSW, 2031, Australia
    Transl Neurodegener 2:4. 2013
  5. pmc Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation
    Yue Huang
    Neuroscience Research Australia and the University of New South Wales, Sydney, 2031, Australia
    Transl Neurodegener 1:2. 2012
  6. doi Striatal β-amyloid in dementia with Lewy bodies but not Parkinson's disease
    Glenda M Halliday
    Neuroscience Research Australia, Randwick, Sydney, NSW, Australia
    J Neural Transm 118:713-9. 2011
  7. doi Glia: initiators and progressors of pathology in Parkinson's disease
    Glenda M Halliday
    Neuroscience Research Australia, Sydney, Australia
    Mov Disord 26:6-17. 2011
  8. doi Neuropathology underlying clinical variability in patients with synucleinopathies
    Glenda M Halliday
    Neuroscience Research Australia, University of New South Wales, Randwick, Sydney, Australia
    Acta Neuropathol 122:187-204. 2011
  9. pmc Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9
    Agnes A Luty
    Prince of Wales Medical Research Institute, Sydney, NSW, Australia
    BMC Neurol 8:32. 2008
  10. ncbi Pick bodies in a family with presenilin-1 Alzheimer's disease
    Glenda M Halliday
    Prince of Wales Medical Research Institute and the University of New South Wales, Barker Street, Randwick, Sydney, 2031 NSW, Australia
    Ann Neurol 57:139-43. 2005

Detail Information

Publications87

  1. doi Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43
    Rachel H Tan
    Neuroscience Research Australia, Barker Street, Randwick, Sydney 2031, Australia
    Acta Neuropathol Commun 1:33. 2013
    ..The present study compares the severity of pathological lesions identified with pTDP43 and iTDP43 in a cohort of 14 FTLD-TDP cases, and assesses the accuracy and inter-observer reliability found with either of these antibodies...
  2. doi ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies
    Karen E Murphy
    Neuroscience Research Australia, Sydney 2031, Australia
    Acta Neuropathol Commun 1:11. 2013
    ....
  3. pmc LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models
    Patrícia Silva Guerreiro
    Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon 04250, Portugal
    J Mol Med (Berl) 91:513-22. 2013
    ....
  4. pmc Can we clinically diagnose dementia with Lewy bodies yet?
    Yue Huang
    Neuroscience Research Australia, The University of New South Wales, Sydney, NSW, 2031, Australia
    Transl Neurodegener 2:4. 2013
    ..To achieve the goal of more accurate clinical diagnosis of DLB, breakthroughs are necessary on the pathogenesis of DLB...
  5. pmc Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation
    Yue Huang
    Neuroscience Research Australia and the University of New South Wales, Sydney, 2031, Australia
    Transl Neurodegener 1:2. 2012
    ..abstract:..
  6. doi Striatal β-amyloid in dementia with Lewy bodies but not Parkinson's disease
    Glenda M Halliday
    Neuroscience Research Australia, Randwick, Sydney, NSW, Australia
    J Neural Transm 118:713-9. 2011
    ..These data suggest that striatal Aβ deposition in Lewy body diseases contributes to early dementia and in these cases may impact on the efficacy of treatments targeting the striatum...
  7. doi Glia: initiators and progressors of pathology in Parkinson's disease
    Glenda M Halliday
    Neuroscience Research Australia, Sydney, Australia
    Mov Disord 26:6-17. 2011
    ....
  8. doi Neuropathology underlying clinical variability in patients with synucleinopathies
    Glenda M Halliday
    Neuroscience Research Australia, University of New South Wales, Randwick, Sydney, Australia
    Acta Neuropathol 122:187-204. 2011
    ..The recognition of considerable heterogeneity within the synucleinopathy syndromes is important for the identification of factors involved in changing their pathological phenotype...
  9. pmc Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9
    Agnes A Luty
    Prince of Wales Medical Research Institute, Sydney, NSW, Australia
    BMC Neurol 8:32. 2008
    ..The objective in this study is to identify the genetic locus in a multi-generational Australian family with FTLD-MND...
  10. ncbi Pick bodies in a family with presenilin-1 Alzheimer's disease
    Glenda M Halliday
    Prince of Wales Medical Research Institute and the University of New South Wales, Barker Street, Randwick, Sydney, 2031 NSW, Australia
    Ann Neurol 57:139-43. 2005
    ..M146L mutant PS-1 may predispose to both Pick's disease and AD by affecting multiple intracellular pathways involving tau phosphorylation and amyloid metabolism...
  11. doi Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains
    Janet van Eersel
    Discipline of Pathology, The University of Sydney, Sydney, NSW, 2006, Australia
    J Neural Transm 116:1243-51. 2009
    ..Such differences in solubility and phosphorylation may contribute, at least in part, to the formation of distinct tau deposits, but may also have implications for the clinical differences between AD and PiD...
  12. doi Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease
    Jenny Wong
    Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia
    J Neurochem 123:159-71. 2012
    ..Conversely, Srp20 expression knockdown produced the opposite effects. Our findings suggest that dysregulation of factors regulating TrkB pre-mRNA splicing may contribute to gene expression changes that occur in AD...
  13. doi Cortical atrophy differentiates Richardson's syndrome from the parkinsonian form of progressive supranuclear palsy
    Emma C Schofield
    Neuroscience Research Australia and the University of New South Wales, Sydney, New South Wales, Australia
    Mov Disord 26:256-63. 2011
    ..Interestingly, there is a disassociation between tau pathology and atrophy in the brain regions affected in PSP-RS that requires further investigation...
  14. doi Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community
    Prachi Mehta
    Department of Neurology and Neurogenetics, Kolling Institute, Royal North Shore Hospital and University of Sydney, Sydney, Australia
    Mov Disord 24:290-2. 2009
    ..There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD...
  15. ncbi Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease
    Glenda M Halliday
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
    Brain 128:2654-64. 2005
    ..Overall, these changes may trigger a cascade of events leading to larger intracellular aggregates of alpha-synuclein and the dispersement of protective pigment to precipitate cell death in Parkinson's disease...
  16. doi Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression
    Yun Ju C Song
    Prince of Wales Medical Research Institute and the University of New South Wales, Barker Street, Randwick, Sydney, Australia
    J Neuropathol Exp Neurol 68:1073-83. 2009
    ..These heterogeneous astroglial responses in PD, MSA, PSP, and CBD indicate distinct underlying pathogenic mechanisms in each disorder...
  17. pmc Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis
    Carol Dobson-Stone
    Neuroscience Research Australia, Barker St, Randwick, Sydney, NSW 2031, Australia
    Acta Neuropathol 125:523-33. 2013
    ..This region overlaps with a separate locus on 16q12.1-q12.2 reported in an independent ALS family, indicating that this region may harbour a second major locus for FTD-ALS...
  18. ncbi A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease
    Glenda M Halliday
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    Brain 128:2272-80. 2005
    ..The selective involvement of the VLp and primary motor cortex in PSP implicates these cerebellothalamocortical pathways as differentiating this disease, possibly contributing to the early falls...
  19. ncbi GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
    John B J Kwok
    Garvan Institute of Medical Research, University of New South Wales, Barker Street, Randwick, Sydney NSW 2031, Australia
    Ann Neurol 58:829-39. 2005
    ..64; p = 0.007; (H1/H1 individuals: odds ratio, 0.68; p < 0.001). Ours results suggest GSK3B polymorphisms alter transcription and splicing and interact with Tau haplotypes to modify disease risk in PD...
  20. ncbi Distribution of brain atrophy in behavioral variant frontotemporal dementia
    Jillian J Kril
    Centre for Education and Research on Ageing, The University of Sydney, Concord Hospital, Concord 2139, Sydney, Australia
    J Neurol Sci 232:83-90. 2005
    ..This suggests that the regional pattern of neurodegeneration, rather than the type of histopathology influences the clinical syndrome in FTD...
  21. doi Frontotemporal dementia and dementia with Lewy bodies in a case-control study of Alzheimer's disease
    Olivier Piguet
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    Int Psychogeriatr 21:688-95. 2009
    ..We aimed to determine the frequency of clinical diagnosis of FTD and DLB and the underlying pathology in a well-characterized cohort of patients with a clinical diagnosis of probable or possible AD...
  22. doi The relationship between clinical and pathological variables in Richardson's syndrome
    Emma C Schofield
    Neuroscience Research Australia and the University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Neurol 259:482-90. 2012
    ..Global cognitive dysfunction related most to the severity of tau deposition in the supramarginal gyrus warranting further research on the role of this brain region in PSP-RS...
  23. ncbi Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques
    Claire E Shepherd
    Prince of Wales Medical Research Institute, Randwick, 2031 Sydney, Australia
    Neurobiol Dis 15:115-9. 2004
    ..These findings suggest that PS-1 mutations increase tau deposition while mutation-specific cellular responses determine phosphorylation events and may influence cell death mechanisms...
  24. ncbi Variable phenotype of Alzheimer's disease with spastic paraparesis
    Helena Karlstrom
    Garvan Institute of Medical Research, Sydney, Australia, and Karolinska Institutet, Stockholm, Sweden
    J Neurochem 104:573-83. 2008
    ..Variations in neuropathology and neurological symptoms in PSEN1 AD raise the prospect that modifier genes may underlie this phenotypic heterogeneity...
  25. ncbi Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease
    Yue Huang
    Prince of Wales Medical Research Institute, University of New South Wales, Australia
    Mov Disord 22:982-9. 2007
    ..Our results demonstrate that the G2019S mutation carriers share the same ancestors who migrated to Australia originally from Europe and that other LRRK2 mutations (R1441H and A1442P) can be found in this population...
  26. doi Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease
    Stefanie Reyes
    Neuroscience Research Australia and the School of Medical Sciences, The University of New South Wales, Randwick, Sydney, New South Wales, Australia
    Neurobiol Aging 34:873-86. 2013
    ....
  27. pmc C9ORF72 repeat expansion in clinical and neuropathologic frontotemporal dementia cohorts
    Carol Dobson-Stone
    Neuroscience Research Australia, Sydney, Australia
    Neurology 79:995-1001. 2012
    ....
  28. doi Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease
    David A Elliott
    Neuroscience Research Australia, Barker St, Randwick, Sydney, NSW 2031, Australia
    Mov Disord 27:1004-11. 2012
    ..9-fold; P < 0.001) and DST genes (log(2) 2.3-fold; P = 0.005) was observed in a cohort of PD, compared with neurologically healthy, brains. This suggests that aberrant RNA metabolism is an important contributor to idiopathic PD...
  29. doi Relative preservation of thalamic centromedian nucleus in parkinsonian patients with dystonia
    Linda Truong
    Prince of Wales Medical Research Institute, University of New South Wales, Randwick, Australia
    Mov Disord 24:2128-35. 2009
    ..Overall this data provides evidence for pathway-specific neurodegeneration as an underlying feature of the clinical variability observed in patients with PD...
  30. doi Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons
    Woojin Scott Kim
    Prince of Wales Medical Research Institute, Randwick, NSW, Australia
    J Alzheimers Dis 21:193-205. 2010
    ..However, hippocampal Apoe and Puma gene expression were not correlated with increased Abca1 expression in mice. Our data indicate that ABCA1 is upregulated in AD hippocampal neurons potentially via an amyloid-beta-mediated pathway...
  31. ncbi Anticipation of onset age in familial Parkinson's disease without SCA gene mutations
    Yue Huang
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, NSW 2031, Australia
    Parkinsonism Relat Disord 12:309-13. 2006
    ....
  32. ncbi Differences in regional brain atrophy in genetic forms of Alzheimer's disease
    Gillian C Gregory
    Prince of Wales Medical Research Institute and the University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Neurobiol Aging 27:387-93. 2006
    ..This effect may be due to the influence of presenilin-1 on tau phosphorylation and metabolism. These differences may explain the earlier onset ages in these different forms of Alzheimer's disease...
  33. doi Excessive dopamine neuron loss in progressive supranuclear palsy
    Karen E Murphy
    Prince of Wales Medical Research Institute, Randwick, Australia
    Mov Disord 23:607-10. 2008
    ..These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy...
  34. doi Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease
    Jinxia Zhou
    Neuroscience Research Australia, The University of New South Wales, Sydney, Australia
    Acta Neuropathol 121:695-704. 2011
    ....
  35. doi Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease
    Agnes A Luty
    Neuroscience Research Australia, Randwick, Sydney, New South Wales, Australia
    Ann Neurol 68:639-49. 2010
    ..Our objective was to identify the causative gene in an FTLD-MND pedigree with no mutations in known dementia genes...
  36. ncbi Identification of families with cortical Lewy body disease
    Antony J Harding
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Am J Med Genet B Neuropsychiatr Genet 128:118-22. 2004
    ....
  37. doi Retrosplenial cortex (BA 29) volumes in behavioral variant frontotemporal dementia and Alzheimer's disease
    Rachel H Tan
    Neuroscience Research Australia, Sydney, N S W, Australia
    Dement Geriatr Cogn Disord 35:177-82. 2013
    ..Importantly, RSC atrophy is a predilection site of Alzheimer's (AD) pathology, but there have been no studies assessing structural changes in the RSC in behavioral variant frontotemporal dementia (bvFTD)...
  38. pmc Eating and hypothalamus changes in behavioral-variant frontotemporal dementia
    Olivier Piguet
    Neuroscience Research Australia, Sydney, Australia
    Ann Neurol 69:312-9. 2011
    ..The hypothalamus plays a critical role in feeding regulation, yet the relation between pathology in this region and eating behavior in FTD is unknown. This study aimed to address this issue using 2 complementary approaches...
  39. ncbi Clinicopathological staging of frontotemporal dementia severity: correlation with regional atrophy
    Jillian J Kril
    Centre for Education and Research on Ageing, The University of Sydney, Sydney, Australia
    Dement Geriatr Cogn Disord 17:311-5. 2004
    ..Much of the frontal lobe, the amygdala and hippocampus are severely atrophic by stage 2, suggesting that they are some of the earliest areas affected in FTD...
  40. ncbi Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies
    Prudence M Stanford
    Garvan Institute for Medical Research, 384 Victoria Street, Sydney, 2010, Australia
    J Neurol 251:1098-104. 2004
    ..Although tauopathies have been considered to result from genetic defects, screening for tau gene mutations in sporadic cases is not likely to identify pathogenic mutations...
  41. ncbi Preserved cognition and functional independence after a large right posterior cerebral artery infarct: longitudinal clinical and neuropathological findings
    Olivier Piguet
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
    Neurocase 12:81-90. 2006
    ..Postmortem investigations revealed additional recent vascular lesions in the occipital region. This case study underscores the importance of comprehensive assessment methods combining neurological, neuroimaging and cognitive tools...
  42. doi Intralaminar nuclei of the thalamus in Lewy body diseases
    Daniel Brooks
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
    Brain Res Bull 78:97-104. 2009
    ..The significant degeneration demonstrated in the intralaminar thalamus is likely to contribute to the movement and cognitive dysfunction observed in Lewy body disorders...
  43. ncbi A possible role for humoral immunity in the pathogenesis of Parkinson's disease
    Carolyn F Orr
    Prince of Wales Medical Research Institute, University of New South Wales, Randwick, Sydney, Australia
    Brain 128:2665-74. 2005
    ..This pattern of humoral immune reactivity is consistent with an immune activation of microglia leading to the targeting of dopamine nigral neurons for destruction in both idiopathic and genetic cases of Parkinson's disease...
  44. ncbi Human-based studies on alpha-synuclein deposition and relationship to Parkinson's disease symptoms
    Glenda M Halliday
    Prince of Wales, Medical Research Institute, Randwick, NSW, Australia
    Exp Neurol 209:12-21. 2008
    ..Further correlation studies in prospectively-followed patients and, perhaps more importantly, controls are required in order to determine normal versus pathologic alpha-synuclein and how to detect such differences in clinical situations...
  45. pmc p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy
    Yun Ju C Song
    Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
    Am J Pathol 171:1291-303. 2007
    ....
  46. ncbi Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease
    Antony J Harding
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW, Australia
    Brain 125:2431-45. 2002
    ..Thus, the impact of Parkinson's disease on the amygdala is highly selective and correlates with both early and late clinical features...
  47. doi The case of a 48 year-old woman with bizarre and complex delusions
    Clement T Loy
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Nat Rev Neurol 6:175-9. 2010
    ..Her psychosis progressed despite receiving high doses of antipsychotics. The patient's father also had a psychotic episode in his 40s. He subsequently developed motor neuron disease, which caused his death at 68 years of age...
  48. doi Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease
    Anna Sokolova
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, Australia
    Brain Pathol 19:392-8. 2009
    ..Our data support previous work on significant increases in IL-6 and IL-8 in AD but indicate that MCP-1 may play a more dominant role in chronic inflammation in AD...
  49. ncbi Regional and cellular pathology in frontotemporal dementia: relationship to stage of disease in cases with and without Pick bodies
    Cindy Kersaitis
    Centre for Education and Research on Ageing, The University of Sydney, Concord Hospital, 2139 Concord, NSW, Australia
    Acta Neuropathol 108:515-23. 2004
    ..These results show that the earliest cellular changes in FTD occur in glia, and that disease stage rather than FTD subtype determines the pattern and extent of neuronal degeneration...
  50. doi Isoform-specific proteolysis of apolipoprotein-E in the brain
    David A Elliott
    Prince of Wales Medical Research Institute, Randwick, NSW 2031, Australia
    Neurobiol Aging 32:257-71. 2011
    ..This indicates that proteolytic processing of apoE to form soluble fragments in the human brain is dependent on apoE isoform but not AD status...
  51. ncbi Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation
    Jillian J Kril
    Department of Pathology, The University of Sydney, Sydney, Australia
    Acta Neuropathol 103:370-6. 2002
    ..2-17.2%, mean 8.1%). Analysis of NFT accumulation with duration of dementia showed a linear relationship, supporting the belief that NFTs progressively accumulate with time...
  52. ncbi Neurofilament-immunoreactive neurons in Alzheimer's disease and dementia with Lewy bodies
    Claire E Shepherd
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney 2031, Australia
    Neurobiol Dis 9:249-57. 2002
    ..This increased number of cortical NF-containing neurons reveal novel widespread cortical changes, beyond those explained by Lewy body formation, that are specific for DLB...
  53. doi ABCA8 stimulates sphingomyelin production in oligodendrocytes
    Woojin Scott Kim
    Neuroscience Research Australia, Sydney, NSW 2031, Australia
    Biochem J 452:401-10. 2013
    ....
  54. ncbi Phosphorylation of apolipoprotein-E at an atypical protein kinase CK2 PSD/E site in vitro
    Mark Raftery
    Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney NSW 2052, Australia
    Biochemistry 44:7346-53. 2005
    ..The phosphorylation of apoE by CK2 as well as the activation of CK2 by apoE may be relevant in vivo where apoE, CK2, and tau are co-localized with additional CK2 targets on neuronal microtubules...
  55. doi Small-vessel disease in patients with Parkinson's disease: a clinicopathological study
    Raymond S Schwartz
    Discipline of Pathology, University of Sydney, Sydney, New South Wales, Australia
    Mov Disord 27:1506-12. 2012
    ..03) living in the same community. The results of this study support the need for further research in this area...
  56. ncbi Pallidal stimulation reduces treatment-induced dyskinesias in "minimal-change" multiple system atrophy
    Yue Huang
    Prince of Wales Medical Research Institute and University of New South Wales, Randwick, Australia
    Mov Disord 20:1042-7. 2005
    ..Here, we present an autopsy-confirmed case of "minimal-change" multiple system atrophy in whom pallidal stimulation surgery was effective in abolishing severe levodopa-induced dyskinesia...
  57. pmc Lipid pathway alterations in Parkinson's disease primary visual cortex
    Danni Cheng
    Neuroscience Research Australia, Sydney, New South Wales, Australia
    PLoS ONE 6:e17299. 2011
    ....
  58. doi Low serum progranulin predicts the presence of mutations: a prospective study
    Emma C Schofield
    Neuroscience Research Australia and the University of New South Wales, Randwick, Australia
    J Alzheimers Dis 22:981-4. 2010
    ..Surprisingly, elevated levels were found in 6/16 patients with progressive non-fluent aphasia, the significance of which is unclear. Serum testing is an accurate and cost effective means of predicting PGRN mutations...
  59. ncbi Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders
    Emma Schofield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    Brain 126:827-40. 2003
    ..In frontotemporal lobar degeneration, a significant proportion of the activated white matter microglia were tau-2-immunoreactive, suggesting direct involvement in axonal degeneration, possibly via immune processes...
  60. doi The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer's disease
    Rachel H Tan
    Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW 2206, Australia
    Acta Neuropathol Commun 1:30. 2013
    ..The bvFTD cohort comprised 5 cases with tau pathology (Pick's disease), and 6 with TDP-43 pathology...
  61. doi Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease
    Karen E Murphy
    1 Neuroscience Research Australia, Sydney, NSW 2031, Australia
    Brain 137:834-48. 2014
    ....
  62. pmc Unique transcriptome patterns of the white and grey matter corroborate structural and functional heterogeneity in the human frontal lobe
    James D Mills
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 8:e78480. 2013
    ..Further, this study provides the first reference data set for a normal human frontal lobe, which will be useful in comparative transcriptome studies of cerebral disorders, in particular, neurodegenerative diseases. ..
  63. doi Measurement of LRRK2 and Ser910/935 phosphorylated LRRK2 in peripheral blood mononuclear cells from idiopathic Parkinson's disease patients
    Nicolas Dzamko
    School of Medical Sciences, University of NSW and Neuroscience Research Australia, Sydney, Australia
    J Parkinsons Dis 3:145-52. 2013
    ..However, the invariance of Ser910 and Ser935 phosphorylation in PD PBMC's suggests that these residues could be used as pharmacodynamic biomarkers for the effectiveness of LRRK2 kinase inhibitors in patients. ..
  64. doi Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra
    Stefanie Reyes
    Neuroscience Research Australia and the School of Medical Sciences, University of New South Wales, Randwick, Sydney, New South Wales, Australia
    Mov Disord 28:1351-9. 2013
    ..The expression of excitatory D1 receptors on nigral dopamine neurons in midbrain regions associated with impulsivity, and their variable loss as seen in PD, may be of particular interest for impulse control...
  65. doi Is seladin-1 really a selective Alzheimer's disease indicator?
    Laura J Sharpe
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    J Alzheimers Dis 30:35-9. 2012
    ..Further work is required to determine what link, if any, exists between DHCR24 and AD...
  66. doi Pathological staging of frontotemporal lobar degeneration
    Jillian J Kril
    Discipline of Medicine, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia
    J Mol Neurosci 45:379-83. 2011
    ..Of note, the degree of protein deposition does not relate to disease stage...
  67. doi Thalamic changes in Parkinson's disease
    Glenda M Halliday
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    Parkinsonism Relat Disord 15:S152-5. 2009
    ..Damage to these regions appears to impact on cognition, awareness and perception. These studies suggest that direct thalamic pathology contributes to the symptoms of Parkinson's disease...
  68. ncbi Staging disease severity in movement disorder tauopathies: brain atrophy separates progressive supranuclear palsy from corticobasal degeneration
    Emma C Schofield
    Prince of Wales Medical Research Institute and the University of New South Wales, Randwick, Australia
    Mov Disord 20:34-9. 2005
    ..86; P = 0.03). The degree of global atrophy in PSP appears to be distinct from other tauopathies, while CBD fits the same pattern as other pathological forms of frontotemporal dementia...
  69. pmc Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation
    Jen Hsiang T Hsiao
    Neuroscience Research Australia, Sydney, New South Wales, Australia
    PLoS ONE 8:e74016. 2013
    ..These results when put together indicate that SGMS activity impacts on APP processing to produce Aβ and it could be a contributing factor in Aβ pathology associated with AD. ..
  70. ncbi An emerging role for LRRK2 in the immune system
    Nicolas Dzamko
    Neuroscience Research Australia, Barker Street, Sydney, NSW 2031, Australia
    Biochem Soc Trans 40:1134-9. 2012
    ..These studies and their potential implications for PD are discussed in the present paper...
  71. doi An improved high-throughput lipid extraction method for the analysis of human brain lipids
    Sarah K Abbott
    Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia
    Lipids 48:307-18. 2013
    ....
  72. doi Reduced T helper and B lymphocytes in Parkinson's disease
    Claire H Stevens
    School of Medical Sciences, The University of New South Wales, and Neuroscience Research Australia, Sydney, Australia
    J Neuroimmunol 252:95-9. 2012
    ..These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD...
  73. ncbi What is the dominant Abeta species in human brain tissue? A review
    Gillian C Gregory
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
    Neurotox Res 7:29-41. 2005
    ..These findings are discussed in association with Abeta peptide function and a model of toxicity developed...
  74. ncbi Clinicopathological correlates in frontotemporal dementia
    John R Hodges
    Prince of Wales Medical Research Institute, The University of New South Wales, Randwick, New South Wales, Australia
    Ann Neurol 56:399-406. 2004
    ..Therefore, the pathological substrate can be predicted in a significant proportion of FTD patients, which has important implications for studies targeting mechanistic treatments...
  75. ncbi Tau isoform expression in frontotemporal dementia without tau deposition
    Greg T Sutherland
    Centre for Education and Research on Ageing, The University of Sydney, Sydney, 2006, New South Wales, Australia
    J Clin Neurosci 14:1182-5. 2007
    ..There were no differences in total tau mRNA or 4R versus 3R isoform expression. Our study suggests that perturbed tau mRNA expression is unlikely to be involved in the pathogenesis of tau-negative FTD...
  76. doi Effect of age on proliferation-regulating factors in human adult neurogenic regions
    Eryn L Werry
    Brain Sciences University of New South Wales, Randwick, NSW, Australia
    J Neurochem 115:956-64. 2010
    ..These findings suggest regulation of the adult neurogenic environment in the human brain may differ over time from that in other species...
  77. doi Visual misperceptions and hallucinations in Parkinson's disease: dysfunction of attentional control networks?
    James M Shine
    Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia
    Mov Disord 26:2154-9. 2011
    ....
  78. ncbi Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease
    Virginia Macdonald
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
    Mov Disord 17:1166-73. 2002
    ..Our results implicate the degeneration of the premotor projection from the pre-SMA, along with dopaminergic basal ganglia dysfunction, in the pathogenesis of Parkinson's disease...
  79. doi Neuropathologic correlates of white matter hyperintensities
    Vanessa G Young
    Discipline of Medicine, University of Sydney, Sydney, Australia
    Neurology 71:804-11. 2008
    ..Study 2 compared the histopathology of WMH with normal WM...
  80. ncbi Cognitive, extrapyramidal, and magnetic resonance imaging predictors of functional impairment in nondemented older community dwellers: the Sydney Older Person Study
    Hayley P Bennett
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    J Am Geriatr Soc 54:3-10. 2006
    ..To identify the clinical correlates of functional incapacity in the community living "old-old."..
  81. ncbi Dolichol is the major lipid component of human substantia nigra neuromelanin
    Heidi Fedorow
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    J Neurochem 92:990-5. 2005
    ..Furthermore, these studies identify a potential novel role for the isoprenoid pathway in the regulation of neuromelanin function and neurodegeneration within the SN...
  82. ncbi Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test
    Kay L Double
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
    Arch Neurol 60:545-9. 2003
    ..Olfactory testing may be a useful diagnostic aid for Parkinson disease, but the types of odors most commonly affected need to be identified...
  83. pmc Aspects of innate immunity and Parkinson's disease
    Yue Huang
    Neuroscience Research Australia Sydney, NSW, Australia
    Front Pharmacol 3:33. 2012
    ..Overall, a complex interplay between different types of immunity appear to be involved in the underlying pathology of PD...
  84. ncbi Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia
    Prudence M Stanford
    Garvan Institute of Medical Research, Sydney, NSW, Australia
    Brain 126:814-26. 2003
    ..The increase in tau proteolysis was associated with increased evidence of apoptosis. This mechanism of neurodegeneration may be more applicable to the majority of FTD cases, which do not accumulate insoluble tau deposits...
  85. ncbi Selective hippocampal neuron loss in dementia with Lewy bodies
    Antony J Harding
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    Ann Neurol 51:125-8. 2002
    ..These findings suggest a selective loss of frontally projecting hippocampal neurons in dementia with Lewy bodies versus those projecting to temporal lobe regions in Alzheimer's disease...
  86. ncbi Postmortem analysis of bilateral subthalamic electrode implants in Parkinson's disease
    Jasmine M Henderson
    Prince of Wales Medical Research Institute, Sydney, NSW, Australia
    Mov Disord 17:133-7. 2002
    ..Tissue changes associated with the subthalamic electrode tracts included mild cell loss, astrogliosis, and some tissue vacuolation. Our postmortem analysis indicates little tissue damage associated with STN stimulation for PD...
  87. doi Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study)
    W G J Reid
    Neuroscience Research Australia and the University of New South Wales, Sydney, Australia
    J Neurol Neurosurg Psychiatry 82:1033-7. 2011
    ....