Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarctionSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
Cardiovasc Res 59:715-22. 2003
..This study tests the effects of regional hypothermia, initiated late during ischemia and maintained for 2 h of reperfusion, on the no-reflow phenomenon...
- Acetaminophen and experimental acute myocardial infarction
Sharon L Hale
The Heart Institute of Good Samaritan Hospital, and the University of Southern California, Department of Medicine, Division of Cardiovascular Medicine, Los Angeles, CA 90017, USA
Cardiovasc Drugs Ther 18:121-5. 2004
..We conclude that acetaminophen has a neutral effect in this experimental model of ischemia/reperfusion and appears to be safe in the course of experimental myocardial infarction...
- Elevated body temperature during myocardial ischemia/reperfusion exacerbates necrosis and worsens no-reflow
Sharon L Hale
Heart Institute of Good Samaritan Hospital and Department of Medicine, University of Southern California, Los Angeles, California 90017, USA
Coron Artery Dis 13:177-81. 2002
..The effects of an elevated body temperature on infarct size were tested in a rabbit model of ischemia/reperfusion...
- Combination therapy for maximal myocardial infarct size reduction
S L Hale
Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
Heart Dis 3:351-6. 2001
..After 90 minutes of ischemia, infarct was 55% lower in CHIP hearts, suggesting that this therapeutic approach dramatically reduces ischemia/reperfusion cell death, even during long occlusions...
- Ethanol does not exert myocardial preconditioning in an intact rabbit model of ischemia/reperfusion
S L Hale
Heart Institute of Good Samaritan Hospital and the University of Southern California, Department of Medicine, Division of Cardiology, Los Angeles, CA, USA
Heart Dis 3:293-6. 2001
..57). These data indicate that alcohol + washout did not precondition hearts against ischemia in this model, adding evidence to the theory that acute alcohol administration has no direct beneficial effect on ischemic myocardium...
- Effect of combined K(ATP) channel activation and Na(+)/H(+) exchange inhibition on infarct size in rabbits
S L Hale
Division of Cardiology, The Heart Institute of Good Samaritan Hospital Los Angeles, California 90017, USA
Am J Physiol Heart Circ Physiol 279:H2673-7. 2000
..Because the effect of cariporide was not blocked by 5-HD, it is unlikely that K(ATP) channels play a role as an end effector in cariporide's mechanism...
- Effects of resveratrol, a flavinoid found in red wine, on infarct size in an experimental model of ischemia/reperfusion
S L Hale
The Heart Institute, Good Samaritan Hospital, and the Department of Medicine, University of Southern California, Los Angeles 90017, USA
J Stud Alcohol 62:730-5. 2001
..The aim of this study was to test whether resveratrol could provide direct cardioprotection to myocytes during acute myocardial infarction...
- An adenosine A1 receptor agonist, R(-)-N-(2-phenylisopropyl)-adenosine (PIA), but not adenosine itself, acts as a therapeutic preconditioning-mimetic agent in rabbits
S L Hale
Heart Institute of the Hospital of the Good Samaritan, Los Angeles, CA 90017
Cardiovasc Res 27:2140-5. 1993
..The ability of adenosine-receptor activation to mimic ischaemic preconditioning was tested in an in vivo rabbit model...
- Myocardial temperature reduction attenuates necrosis after prolonged ischemia in rabbits
S L Hale
Heart Institute, Good Samaritan Hospital, Los Angeles, CA 90017, USA
Cardiovasc Res 40:502-7. 1998
..This study tests the hypothesis that a local reduction in cardiac temperature protects myocardium during prolonged ischemia (2 h) even if begun well after coronary artery occlusion...
- Ischemic preconditioning and myocardial hypothermia in rabbits with prolonged coronary artery occlusion
S L Hale
The Heart Institute, Good Samaritan Hospital, Los Angeles, CA 90017, USA
Am J Physiol 276:H2029-34. 1999
..The combination therapy significantly improved regional myocardial blood flow in the previously ischemic region to a greater extent than either treatment alone...
- Can moderate alcohol intake limit the size of myocardial infarction?
J S Dow
The Heart Institute of Good Samaritan Hospital, and the University of Southern California, Division of Cardiology, Los Angeles 90017, USA
J Cardiovasc Pharmacol 37:662-7. 2001
..Moderate consumption of alcohol failed to alter infarct size compared with control and thus it is unlikely that alcohol drinking has a direct myocardial-protecting effect on the outcome of ischemia and reperfusion...
- Regional hypothermia reduces myocardial necrosis even when instituted after the onset of ischemia
S L Hale
Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017, USA
Basic Res Cardiol 92:351-7. 1997
..This study tests the hypothesis that reducing myocardial temperature locally, after coronary occlusion, reduces infarct size...
- Myocardial hypothermia: a potential therapeutic technique for acute regional myocardial ischemia
S L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, California 90017, USA
J Cardiovasc Electrophysiol 10:405-13. 1999
..This technique also protects myocardium during ischemia. Myocardial hypothermia might be a useful technique to limit ischemic damage during infarction or as adjunctive therapy during minimally invasive cardiac surgery...
- Location as a determinant of myocardial infarction in rabbits
S L Hale
Division of Cardiology, The Heart Institute of Good Samaritan Hospital, and the University of Southern California, Los Angeles, CA 90017, USA
J Mol Cell Cardiol 32:505-10. 2000
..A larger part of the AR undergoes necrosis toward the apex of the heart. This phenomenon is independent of collateral flow or temperature, and suggests that other as yet unknown factors contribute to infarct size...
- Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusion
Thorsten Reffelmann
The Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, California 90017-2395, USA
Am J Physiol Heart Circ Physiol 282:H766-72. 2002
..Thus microvascular reperfusion injury led to a striking decrease in RMBF within the first 2 h of reperfusion, with infarct size as the major determinant of reflow at a given time point of reperfusion...
- Administration of erythropoietin fails to improve long-term healing or cardiac function after myocardial infarction in the rat
Sharon L Hale
The Heart Institute of Good Samaritan Hospital and the Keck School of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California 90017, USA
J Cardiovasc Pharmacol 46:211-5. 2005
..Thus, in our model, treatment with epo had no long-term beneficial effect on LV remodeling after myocardial infarction but may have exerted some positive effect on LV function...
- Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channel
Sharon L Hale
The Heart Institute, Good Samaritan Hospital, 1225 Wilshire Blvd, and the Keck School of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90017, USA
J Pharmacol Exp Ther 318:418-23. 2006
..Ranolazine treatment led to better ejection fraction, stroke volume and less wall motion abnormality after reperfusion, and less myocardial necrosis...
- Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit
Sharon L Hale
Heart Institute of Good Samaritan Hospital and the Keck School of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles 90017, USA
J Cardiovasc Pharmacol Ther 11:249-55. 2006
..Ranolazine treatment reduced myocardial stunning following brief ischemia/reperfusion suggesting that inhibiting the late sodium channel current may be a novel approach to treating stunning independent of effects on hemodynamics...
- Role of a paracrine action of mesenchymal stem cells in the improvement of left ventricular function after coronary artery occlusion in rats
Wangde Dai
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90017 2395, USA
Regen Med 2:63-8. 2007
..We aimed to determine whether soluble factors released by cultured mesenchymal stem cells (MSCs) improved cardiac function in an experimental model of myocardial infarction...
- Postconditioning fails to improve no reflow or alter infarct size in an open-chest rabbit model of myocardial ischemia-reperfusion
Sharon L Hale
Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, Los Angeles, CA 90017, USA
Am J Physiol Heart Circ Physiol 294:H421-5. 2008
..PoC did not reduce infarct size in this model, nor did it reduce the extent of the anatomic zone of no reflow, suggesting that this intervention may not impact postreperfusion microvascular damage due to ischemia...
- Acetaminophen and myocardial stunning after transient ischemia in rabbit hearts
Sharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
J Cardiovasc Pharmacol Ther 10:121-9. 2005
..This study was conducted to determine whether treatment with acetaminophen results in enhanced myocardial tolerance to transient ischemia-reperfusion by improving left ventricular function and decreasing stunning in an in vivo model...
- Metabolic mechanism by which mild regional hypothermia preserves ischemic tissue
Boris Z Simkhovich
Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017, USA
J Cardiovasc Pharmacol Ther 9:83-90. 2004
..We hypothesized that a moderate reduction in regional myocardial temperature could preserve cardiac energy metabolism and thus protect the myocardium from sustained ischemic insult...
- Gene activity changes in ischemically preconditioned rabbit heart gene: discovery array study
Boris Z Simkhovich
Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017, USA
Heart Dis 4:63-9. 2002
..None of the identified genes had been previously reported to be involved in ischemic preconditioning...
- Transplantation of neonatal cardiomyocytes after permanent coronary artery occlusion increases regional blood flow of infarcted myocardium
Thorsten Reffelmann
The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Boulevard, CA 90017-2395, Los Angeles, USA
J Mol Cell Cardiol 35:607-13. 2003
..CONCLUSIONS: Transplantation of neonatal cardiomyocytes induced neo-angiogenesis in zones of successful cell engraftment within the scar, which effectively enhanced tissue perfusion...
- Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function
Mu Yao
Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, CA 90017, Los Angeles, USA
J Mol Cell Cardiol 35:661-70. 2003
..Thus, fetal cell-transplant therapy mitigated the longer-term adverse effects of LV remodeling following a myocardial infarction...
- No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion
Thorsten Reffelmann
The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Blvd, Los Angeles, CA 90017, USA
Circulation 108:2911-7. 2003
....
Late sodium current inhibition as a new cardioprotective approachSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
J Mol Cell Cardiol 44:954-67. 2008
..This article reviews published data describing the role of late sodium current and its inhibition by ranolazine in clinical and experimental studies of myocardial ischemia...
- Granulocyte colony-stimulating factor and stem cell factor improve contractile reserve of the infarcted left ventricle independent of restoring muscle mass
Casilde Sesti
Heart Institute, Good Samaritan Hospital, Cardiovascular Division, Keck School of Medicine at the University of Southern California, Los Angeles, California 90017-2395, USA
J Am Coll Cardiol 46:1662-9. 2005
..CONCLUSIONS: Because we did not find evidence of new muscle cells in the infarct area, our conclusion is that G-CSF and SCF enhanced the LV functional reserve of the heart without replacing scar tissue...
Development of a spontaneously beating vein by cardiomyocyte transplantation in the wall of the inferior vena cava in a rat: a pilot studyWangde Dai
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of the Keck School of Medicine at University of Southern California, Los Angeles, CA 90017, USA
J Vasc Surg 45:817-20. 2007
..This study was conducted to determine whether it is feasible to develop a vein that rhythmically beats by implanting immature cardiomyocytes in its wall...
- Implantation of immature neonatal cardiac cells into the wall of the aorta in rats: a novel model for studying morphological and functional development of heart cells in an extracardiac environment
Wangde Dai
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California, USA
Circulation 110:324-9. 2004
..CONCLUSIONS: Grafted neonatal cardiomyocytes survive, differentiate, grow, develop a blood supply, and spontaneously contract within the wall of the aorta in rats...
- Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts
Wangde Dai
The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Boulevard, Los Angeles, CA 90017 2395, USA
J Mol Cell Cardiol 43:504-16. 2007
..However, hESC-derived cells did not escape immune surveillance in the xenograft setting in that they elicited a rejection phenomenon in immune competent rats...
- Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects
Wangde Dai
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of Keck School of Medicine at University of Southern California, Los Angeles, CalifA 90017, USA
Circulation 112:214-23. 2005
..MSCs improved global LV function at 4 weeks; however, this benefit was transient, which suggests a possible early paracrine effect...
