James F Hainfeld

Summary

Publications

  1. ncbi Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions
    J F Hainfeld
    Nanoprobes, Inc, 95 Horseblock Road, Yaphank, NY 11980, USA
    Br J Radiol 84:526-33. 2011
  2. ncbi The use of gold nanoparticles to enhance radiotherapy in mice
    James F Hainfeld
    Nanoprobes, Inc, 95 Horse Block Rd, Yaphank, NY 11980, USA
    Phys Med Biol 49:N309-15. 2004
  3. ncbi Radiotherapy enhancement with gold nanoparticles
    James F Hainfeld
    Nanoprobes, Inc, 95 Horseblock Road, Yaphank, NY 11980 9710, USA
    J Pharm Pharmacol 60:977-85. 2008
  4. ncbi Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma
    James F Hainfeld
    Nanoprobes, Inc, Yaphank, NY 11980, USA
    Phys Med Biol 55:3045-59. 2010
  5. ncbi Preparation and high-resolution microscopy of gold cluster labeled nucleic acid conjugates and nanodevices
    Richard D Powell
    Nanoprobes, Incorporated, 95 Horseblock Road, Unit 1, Yaphank, NY 11980, United States
    Micron 42:163-74. 2011
  6. ncbi Metallographic in situ hybridization
    Richard D Powell
    Nanoprobes, Incorporated, 95 Horseblock Road, Unit 1, Yaphank, NY 11980, USA
    Hum Pathol 38:1145-59. 2007
  7. ncbi Murine EMT-6 carcinoma: high therapeutic efficacy of microbeam radiation therapy
    F Avraham Dilmanian
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Radiat Res 159:632-41. 2003
  8. ncbi Assembly of nanoparticle-protein binding complexes: from monomers to ordered arrays
    Minghui Hu
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Angew Chem Int Ed Engl 46:5111-4. 2007
  9. ncbi Gold nanoparticle-protein arrays improve resolution for cryo-electron microscopy
    Minghui Hu
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Struct Biol 161:83-91. 2008
  10. ncbi Gold nanoparticle size controlled by polymeric Au(I) thiolate precursor size
    Raymond P Briñas
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Am Chem Soc 130:975-82. 2008

Research Grants

  1. Improved MRI Contrast Agents
    James Hainfeld; Fiscal Year: 2002
  2. Gold Nanoparticle Contrast Agents: MicroCT of Colon Cancer
    James Hainfeld; Fiscal Year: 2007
  3. High Resolution Gold Labels for EM
    James Hainfeld; Fiscal Year: 2007
  4. Molecular Mammography of Her-2 Cancers using Gold Nanoparticles
    James Hainfeld; Fiscal Year: 2006
  5. Nanogold-Enhanced Head & Neck Cancer Radiotherapy
    James Hainfeld; Fiscal Year: 2005
  6. GOLD ENHANCED ANGIOGRAPHY
    James Hainfeld; Fiscal Year: 2005
  7. High Resolution Labels for EM
    James F Hainfeld; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions
    J F Hainfeld
    Nanoprobes, Inc, 95 Horseblock Road, Yaphank, NY 11980, USA
    Br J Radiol 84:526-33. 2011
    ..The aim of this study was to quantitatively determine their targeting and microlocalisation in mouse tumour models after intravenous injection by using micro-CT...
  2. ncbi The use of gold nanoparticles to enhance radiotherapy in mice
    James F Hainfeld
    Nanoprobes, Inc, 95 Horse Block Rd, Yaphank, NY 11980, USA
    Phys Med Biol 49:N309-15. 2004
    ..This novel use of small gold nanoparticles permitted achievement of the high metal content in tumours necessary for significant high-Z radioenhancement...
  3. ncbi Radiotherapy enhancement with gold nanoparticles
    James F Hainfeld
    Nanoprobes, Inc, 95 Horseblock Road, Yaphank, NY 11980 9710, USA
    J Pharm Pharmacol 60:977-85. 2008
    ..The clinical potential of this approach is also discussed...
  4. ncbi Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma
    James F Hainfeld
    Nanoprobes, Inc, Yaphank, NY 11980, USA
    Phys Med Biol 55:3045-59. 2010
    ..The data show that radiation dose, energy and hyperthermia influence efficacy and better define the potential utility of gold nanoparticles for cancer x-ray therapy...
  5. ncbi Preparation and high-resolution microscopy of gold cluster labeled nucleic acid conjugates and nanodevices
    Richard D Powell
    Nanoprobes, Incorporated, 95 Horseblock Road, Unit 1, Yaphank, NY 11980, United States
    Micron 42:163-74. 2011
    ....
  6. ncbi Metallographic in situ hybridization
    Richard D Powell
    Nanoprobes, Incorporated, 95 Horseblock Road, Unit 1, Yaphank, NY 11980, USA
    Hum Pathol 38:1145-59. 2007
    ..Metallographic staining also provides excellent results for immunohistochemistry and may be combined with other staining procedures for the simultaneous detection of more than one gene or combinations of genes and proteins...
  7. ncbi Murine EMT-6 carcinoma: high therapeutic efficacy of microbeam radiation therapy
    F Avraham Dilmanian
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Radiat Res 159:632-41. 2003
    ..02), but severe leg dysfunction was also lower (P < 0.003). These findings suggest that single-fraction microbeams can ablate tumors at high rates with relatively little normal-tissue toxicity...
  8. ncbi Assembly of nanoparticle-protein binding complexes: from monomers to ordered arrays
    Minghui Hu
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Angew Chem Int Ed Engl 46:5111-4. 2007
  9. ncbi Gold nanoparticle-protein arrays improve resolution for cryo-electron microscopy
    Minghui Hu
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Struct Biol 161:83-91. 2008
    ..The applicability of this labeling method for three-dimensional reconstruction of biological macromolecules is discussed...
  10. ncbi Gold nanoparticle size controlled by polymeric Au(I) thiolate precursor size
    Raymond P Briñas
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Am Chem Soc 130:975-82. 2008
    ..These Ni-NTA functionalized Au NPs exhibited specific binding to 6x-histidine-tagged Adenovirus serotype 12 knob proteins, demonstrating their utility in biomolecular labeling applications...
  11. ncbi High-resolution immunophenotyping of subcellular compartments in tissue microarrays by enzyme metallography
    Raymond Tubbs
    Department of Anatomic and Clinical Pathology, The Cleveland Clinic Foundation, OH 44195, USA
    Appl Immunohistochem Mol Morphol 13:371-5. 2005
    ..This preliminary study shows the utility of using enzyme metallography for high-resolution immunophenotyping in TMAs...
  12. ncbi Enzymatic control of metal deposition as key step for a low-background electrical detection for DNA chips
    Robert Moller
    Institute for Physical High Technology, P O Box 100239, 07702 Jena, Germany
    Nano Lett 5:1475-82. 2005
    ..The enzymatic enhancement leads to a significant increase in sensitivity, and the detection of single base mismatches demonstrates the high specificity of the novel enhancement approach...
  13. ncbi "Plugging into Enzymes": nanowiring of redox enzymes by a gold nanoparticle
    Yi Xiao
    Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Science 299:1877-81. 2003
    ..The gold nanoparticle acts as an electron relay or "electrical nanoplug" for the alignment of the enzyme on the conductive support and for the electrical wiring of its redox-active center...

Research Grants16

  1. Improved MRI Contrast Agents
    James Hainfeld; Fiscal Year: 2002
    ..Furthermore, the development of targeted agents could functionally distinguish between benign and malignant tumors and be used to diagnose many other conditions...
  2. Gold Nanoparticle Contrast Agents: MicroCT of Colon Cancer
    James Hainfeld; Fiscal Year: 2007
    ..If successful, this effort will produce superior blood pool agents and the first targeted CT contrast agent, goals that have been difficult to achieve by other approaches. ..
  3. High Resolution Gold Labels for EM
    James Hainfeld; Fiscal Year: 2007
    ..The gold labels will additionally be used to better align the complexes to improve reconstructions from conical tilt pairs using cryoEM. ..
  4. Molecular Mammography of Her-2 Cancers using Gold Nanoparticles
    James Hainfeld; Fiscal Year: 2006
    ..Such a need exists to detect Her2 breast cancers, which account for about 30% of breast cancers, where the specific drug Herceptin(r) is available and improves survival. ..
  5. Nanogold-Enhanced Head & Neck Cancer Radiotherapy
    James Hainfeld; Fiscal Year: 2005
    ..abstract_text> ..
  6. GOLD ENHANCED ANGIOGRAPHY
    James Hainfeld; Fiscal Year: 2005
    ..A further objective of this work to be explored in Phase II is the development of targeted contrast agents that would be able to discriminate high-risk atherosclerotic plaques. ..
  7. High Resolution Labels for EM
    James F Hainfeld; Fiscal Year: 2010
    ..The ultimate aim of these studies is to understand life processes, which in turn, can lead to effective treatment of disease. ..