Asrat Hailu

Summary

Publications

  1. ncbi request reprint Elevated plasma levels of interferon (IFN)-gamma, IFN-gamma inducing cytokines, and IFN-gamma inducible CXC chemokines in visceral leishmaniasis
    Asrat Hailu
    Faculty of Medicine, Department of Microbiology, Immunology and Parasitology, and Institute of Pathobiology, Addis Ababa University, PO Box 9086, Addis Ababa, Ethiopia
    Am J Trop Med Hyg 71:561-7. 2004
  2. ncbi request reprint Isolation of Leishmania tropica from an Ethiopian cutaneous leishmaniasis patient
    Asrat Hailu
    Faculty of Medicine, Department of Microbiology, Immunology and Parasitology DMIP, Addis Ababa University, P O Box 9086, Addis Ababa, Ethiopia
    Trans R Soc Trop Med Hyg 100:53-8. 2006
  3. doi request reprint Outbreak of cutaneous leishmaniasis in Silti woreda, Ethiopia: risk factor assessment and causative agent identification
    Edessa Negera
    Armauer Hansen Research Institute, P O Box 1005, Addis Ababa, Ethiopia
    Trans R Soc Trop Med Hyg 102:883-90. 2008
  4. ncbi request reprint Leishmaniasis in the middle course of the Ethiopian Rift Valley: II. Entomological observations
    Meshesha Balkew
    Institute of Pathobiology, P O Box 1176, Addis Ababa, Ethiopia
    Ethiop Med J 40:271-82. 2002
  5. pmc Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia
    Tamrat Abebe
    Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia
    PLoS Negl Trop Dis 7:e2134. 2013
  6. ncbi request reprint The development of hepatic granulomas in 20 Krad irradiated Schistosoma mansoni cercaria vaccinated grivet monkeys (Cercopithecus aethiops aethiops)
    Workineh Torben
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Exp Parasitol 117:376-81. 2007
  7. ncbi request reprint T cell subset and cytokine profiles in human visceral leishmaniasis during active and asymptomatic or sub-clinical infection with Leishmania donovani
    Asrat Hailu
    Faculty of Medicine, Department of Microbiology, Immunology and Parasitology, Addis Ababa University, PO Box 9086, Addis Ababa, Ethiopia
    Clin Immunol 117:182-91. 2005
  8. ncbi request reprint Molecular characterization of Cryptosporidium isolates from humans in Ethiopia
    Haileeyesus Adamu
    Department of Biology, Biomedical Sciences Stream, Addis Ababa University, PO Box 42524, Addis Ababa, Ethiopia
    Acta Trop 115:77-83. 2010
  9. pmc Multilocus microsatellite signature and identification of specific molecular markers for Leishmania aethiopica
    Nigatu Kebede
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
    Parasit Vectors 6:160. 2013
  10. ncbi request reprint First record of Phlebotomus (Synphlebotomus) vansomerenae (Diptera: Psychodidae) in Ethiopia
    Teshome Gebre-Michael
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    J Med Entomol 50:659-63. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Elevated plasma levels of interferon (IFN)-gamma, IFN-gamma inducing cytokines, and IFN-gamma inducible CXC chemokines in visceral leishmaniasis
    Asrat Hailu
    Faculty of Medicine, Department of Microbiology, Immunology and Parasitology, and Institute of Pathobiology, Addis Ababa University, PO Box 9086, Addis Ababa, Ethiopia
    Am J Trop Med Hyg 71:561-7. 2004
    ..The underlying causes of immunologic unresponsiveness remain a subject of further investigation...
  2. ncbi request reprint Isolation of Leishmania tropica from an Ethiopian cutaneous leishmaniasis patient
    Asrat Hailu
    Faculty of Medicine, Department of Microbiology, Immunology and Parasitology DMIP, Addis Ababa University, P O Box 9086, Addis Ababa, Ethiopia
    Trans R Soc Trop Med Hyg 100:53-8. 2006
    ..tropica zymodeme MON-71, one of the new zymodemes found in Ethiopia from P. sergenti in the same region so far. The epidemiological implications of the finding are discussed...
  3. doi request reprint Outbreak of cutaneous leishmaniasis in Silti woreda, Ethiopia: risk factor assessment and causative agent identification
    Edessa Negera
    Armauer Hansen Research Institute, P O Box 1005, Addis Ababa, Ethiopia
    Trans R Soc Trop Med Hyg 102:883-90. 2008
    ..The appearance of leishmaniasis in Silti, which was not known to be endemic for the disease, underlines the need to initiate a leishmaniasis control program in Ethiopia to limit its expansion...
  4. ncbi request reprint Leishmaniasis in the middle course of the Ethiopian Rift Valley: II. Entomological observations
    Meshesha Balkew
    Institute of Pathobiology, P O Box 1176, Addis Ababa, Ethiopia
    Ethiop Med J 40:271-82. 2002
    ..However, the reasons for the low level of leishmanin skin-test positivity in this portion of the Rift Valley are not immediately clear in view of the rich sand fly fauna and the presence of potential vectors...
  5. pmc Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia
    Tamrat Abebe
    Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia
    PLoS Negl Trop Dis 7:e2134. 2013
    ....
  6. ncbi request reprint The development of hepatic granulomas in 20 Krad irradiated Schistosoma mansoni cercaria vaccinated grivet monkeys (Cercopithecus aethiops aethiops)
    Workineh Torben
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Exp Parasitol 117:376-81. 2007
    ..This study underlines the significant role of irradiated cercariae vaccination on the establishment of female adults and consequent reduction of pathology in the grivet Cercopithecus aethiops aethiops...
  7. ncbi request reprint T cell subset and cytokine profiles in human visceral leishmaniasis during active and asymptomatic or sub-clinical infection with Leishmania donovani
    Asrat Hailu
    Faculty of Medicine, Department of Microbiology, Immunology and Parasitology, Addis Ababa University, PO Box 9086, Addis Ababa, Ethiopia
    Clin Immunol 117:182-91. 2005
    ..Plasma concentrations of IFN-gamma and IL-10 were elevated in VL...
  8. ncbi request reprint Molecular characterization of Cryptosporidium isolates from humans in Ethiopia
    Haileeyesus Adamu
    Department of Biology, Biomedical Sciences Stream, Addis Ababa University, PO Box 42524, Addis Ababa, Ethiopia
    Acta Trop 115:77-83. 2010
    ..hominis (Ib). These data identify C. parvum as the major cause of human cryptosporidiosis in Ethiopia and suggest a zoonotic transmission of the disease in contrast to reports from other developing countries...
  9. pmc Multilocus microsatellite signature and identification of specific molecular markers for Leishmania aethiopica
    Nigatu Kebede
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
    Parasit Vectors 6:160. 2013
    ..The current study was aimed at developing multilocus microsatellite markers for L. aethiopica isolated from human cutaneous leishmaniasis patients in Ethiopia...
  10. ncbi request reprint First record of Phlebotomus (Synphlebotomus) vansomerenae (Diptera: Psychodidae) in Ethiopia
    Teshome Gebre-Michael
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    J Med Entomol 50:659-63. 2013
    ..This is the first record of the species in Ethiopia and the first time it has been found outside of Kenya where it was originally described, extending the known distribution of this species in East Africa...
  11. ncbi request reprint Serum cytokines of the 20 Krad-irradiated S. mansoni cercariae vaccinated, primary and superinfected Cercopethicus aethiops aethiops
    Workineh Torben
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Exp Parasitol 115:121-6. 2007
    ..049) and these findings can be associated with more liver pathogenesis in the group. Thus, this work has indicated the potential importance of anti-schistosome vaccine studies on the grivet monkeys...
  12. ncbi request reprint Molecular characterization of human isolates of Giardia duodenalis from Ethiopia
    Tesfaye Gelanew
    Department of Microbiology, Immunology and Parasitology, Faculty of Medicine, Addis Ababa University, P O Box 9086, Addis Ababa, Ethiopia
    Acta Trop 102:92-9. 2007
    ..duodenalis, yet it was distinct from the established A and F sequences; thus the exact genetic identity of these isolates remains unclear...
  13. pmc Diagnosis of latent tuberculosis infection in healthy young adults in a country with high tuberculosis burden and BCG vaccination at birth
    Alemnew F Dagnew
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    BMC Res Notes 5:415. 2012
    ..The aim of this study was therefore to evaluate the use of QFT-GIT assay as compared with TST in the diagnosis of LTBI in Ethiopia, a country with a high burden of TB and routine BCG vaccination at birth...
  14. pmc Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia
    Tamrat Abebe
    Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia
    PLoS Negl Trop Dis 6:e1684. 2012
    ..Persistent nonhealing cutaneous leishmaniasis has been associated with poor T cell mediated responses; however, the underlying mechanisms are not well understood...
  15. doi request reprint Lymphatic filariasis in western Ethiopia with special emphasis on prevalence of Wuchereria bancrofti antigenaemia in and around onchocerciasis endemic areas
    Welelta Shiferaw
    Department of Microbiology, Immunology and Parasitology DMIP Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    Trans R Soc Trop Med Hyg 106:117-27. 2012
    ..The other five were from Amhara (two districts) and Oromia (three districts) regions. A tentative distribution map has been drawn to facilitate the launching of the Ethiopia LF elimination program...
  16. pmc Further studies on the phlebotomine sandflies of the kala-azar endemic lowlands of Humera-Metema (north-west Ethiopia) with observations on their natural blood meal sources
    Teshome Gebre-Michael
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
    Parasit Vectors 3:6. 2010
    ..All Phlebotomus collections were identified to species...
  17. pmc Visceral leishmaniasis: new health tools are needed
    Asrat Hailu
    Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    PLoS Med 2:e211. 2005
  18. pmc Geographical variation in the response of visceral leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trial
    Asrat Hailu
    Addis Ababa University, Addis Ababa, Ethiopia
    PLoS Negl Trop Dis 4:e709. 2010
    ..Improved treatment options are needed. Paromomycin was shown to be an efficacious first-line treatment with low toxicity in India...
  19. ncbi request reprint Increased expression of HIV co-receptor CXCR4 on CD4+ T-cells in patients with active visceral leishmaniasis
    Asrat Hailu
    Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    Scand J Infect Dis 36:56-8. 2004
    ..We demonstrate that patients with active visceral leishmaniasis have a higher proportion of circulating CD4+ T-cells expressing CXCR4 than healthy controls, suggesting that Leishmania may facilitate HIV infection of CD4+ lymphocytes...
  20. ncbi request reprint Identification, sequencing and expression of peroxidoxin genes from Leishmania aethiopica
    Dagim Jirata
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    Acta Trop 99:88-96. 2006
    ..This pattern of RNA expression is consistent with patterns seen in some Leishmania species, but not all. Data from this study will be helpful in enhancing vaccine strategies and drug studies targeted towards peroxidoxins...
  21. ncbi request reprint The use of direct agglutination test (DAT) in serological diagnosis of Ethiopian cutaneous leishmaniasis
    Asrat Hailu
    Institute of Pathobiology, Addis Ababa University PO Box 1176, Addis Ababa, Ethiopia
    Diagn Microbiol Infect Dis 42:251-6. 2002
    ..Eighteen sera of VL patients were positive irrespective of the different antigen sources. The data show that DAT can be a useful addition to the diagnosis of ECL...
  22. ncbi request reprint Molecular surveillance of mutations in dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum in Ethiopia
    Tamirat Gebru-Woldearegai
    Faculty of Medicine, Department of Microbiology, Immunology and Parasitology, Addis Ababa University Addis Ababa, Ethiopia
    Am J Trop Med Hyg 73:1131-4. 2005
    ..All isolates carried mutations G437 and E540 in the DHPS gene. Two isolates (1.61%) had additional mutations at codon 581 (A581)...
  23. doi request reprint Current status of bovine cysticercosis of slaughtered cattle in Addis Ababa Abattoir, Ethiopia
    Nigatu Kebede
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box, 56478, Addis Ababa, Ethiopia
    Trop Anim Health Prod 41:291-4. 2009
    ..The animals slaughtered were all adults. No significant difference in prevalence rates was recorded between the sexes. The prevalence of bovine cysticercosis was higher in local zebu cattle breeds than Holstein-Frisian cattle...
  24. ncbi request reprint Prevalence of onchocercal skin disease and infection among workers of coffee plantation farms in Teppi, southwestern Ethiopia
    Asrat Hailu
    Institute of Pathobiology, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
    Ethiop Med J 40:259-69. 2002
    ..8. The community microfilarial load (CMFL) was estimated to be 14.0 per mg skin snip. The study showed that SOSD is prevalent in Teppi and affects a substantial number of the working population. An intervention program is called for...
  25. pmc Parasitological and clinico-epidemiological features of onchocerciasis in West Wellega, Ethiopia
    Geme Urge Dori
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy School of Medical Laboratory Sciences, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    J Parasit Dis 36:10-8. 2012
    ..The situation in the Anfilo District should call for continued CDTI, owing to success of similar recommendations for such programmes in other parts of the country and elsewhere...
  26. ncbi request reprint Histofarcin test for the diagnosis of epizootic lymphangitis in Ethiopia: development, optimisation, and validation in the field
    Gobena Ameni
    Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Vet J 171:358-62. 2006
    ..After proper validation, we conclude that the histofarcin test could play a significant role in detecting early infection, and differentiating of EL from glanders, ulcerative lymphangitis, and sporotrichosis...
  27. ncbi request reprint Trichinella zimbabwensis in wild reptiles of Zimbabwe and Mozambique and farmed reptiles of Ethiopia
    Edoardo Pozio
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Vet Parasitol 143:305-10. 2007
    ....
  28. ncbi request reprint Field evaluation of FD-DAT, rK39 dipstick and KATEX (urine latex agglutination) for diagnosis of visceral leishmaniasis in northwest Ethiopia
    Ermias Diro
    Gondar University, Amhara Regional State, Gondar, Ethiopia
    Trans R Soc Trop Med Hyg 101:908-14. 2007
    ..The sensitivity of KATEX and rK39 dipstick tests needs to be improved to promote their use as first-line diagnostic tests in the field setting of northwestern Ethiopia...
  29. ncbi request reprint Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Nat Rev Microbiol 5:873-82. 2007
    ..New diagnostic tools and new treatment strategies will only have an impact if they are made widely available to patients...