Cysteinyl leukotriene receptor antagonism alleviates renal injury induced by ischemia-reperfusion in ratsHanan H Hagar
Department of Pharmacology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
J Surg Res 178:e25-34. 2012
..The aim of this study was to investigate the ability of the cysteinyl leukotriene receptor blocker, zafirlukast, to alleviate renal dysfunction and injury in a rat model of renal ischemia-reperfusion injury...
A biochemical, histochemical, and ultrastructural evaluation of the effect of dimethoate intoxication on rat pancreasHanan H Hagar
Department of Pharmacology, College of Medicine, King Khalid University Hospital, King Saud University, P O Box 2925, Riyadh 11461, Saudi Arabia
Toxicol Lett 133:161-70. 2002
..Public health education is necessary to raise people awareness about the hazards accompanying the use of such compounds...
- The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats
Hanan H Hagar
Department of Pharmacology, College of Medicine and KHUH, King Saud University, P O Box 2925, Riyadh 11461, Saudi Arabia
Toxicol Lett 151:335-43. 2004
..These results indicate that taurine has a protective action against CsA hepatotoxicity and suggest that taurine may find clinical application against a variety of toxins where cellular damage is a consequence of reactive oxygen species...
- Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats
Hanan H Hagar
Department of Pharmacology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Clin Exp Pharmacol Physiol 33:189-96. 2006
..5. These data clearly indicate the protective potential of taurine against CsA-induced hypertension and nephrotoxicity and suggest a significant contribution of its anti-oxidant property to this beneficial effect...
- Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats
Hanan H Hagar
Department of Pharmacology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Eur J Pharmacol 554:69-77. 2007
..Finally, histopathological changes were nearly restored by PDTC pretreatment. The findings of the present study provide evidence that PDTC may be beneficial in patients with inflammatory bowel disease...
- Nuclear factor-kappaB inhibition by pyrrolidinedithiocarbamate attenuates gastric ischemia-reperfusion injury in rats
Eman El Eter
Physiology Department, Medical College and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Can J Physiol Pharmacol 83:483-92. 2005
..PDTC protects against gastric I/R injury by an antioxidant, NF-kappaB inhibition, and by reduction of pro-apoptotic protein p53 expression, which seems to be downstream to NF-kappaB, thus promoting cell survival...
- Ginkgo biloba attenuates mucosal damage in a rat model of ulcerative colitis
Ali Mustafa
Department of Pharmacology, College of Medicine and KKUH, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia
Pharmacol Res 53:324-30. 2006
..These results suggest that Ginkgo biloba may be effective in the treatment of UC through its scavenging effect on oxygen-derived free radicals...
- Folic acid and vitamin B(12) supplementation attenuates isoprenaline-induced myocardial infarction in experimental hyperhomocysteinemic rats
Hanan H Hagar
Department of Pharmacology, College of Medicine and KHUH, King Saud University, PO Box 2925, Riyadh 11461, Saudi Arabia
Pharmacol Res 46:213-19. 2002
..These results suggest that Hhcy aggravates MI via oxidative stress mechanisms and that lowering Hcy level with folic acid and Vitamin B(12) can ameliorate the detrimental effects of Hhcy and may reduce the risk of MI...
- Attenuation of bleomycin-induced lung fibrosis in rats by mesna
Azza El-Medany
Department of Pharmacology, College of Medicine and KHUH, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia
Eur J Pharmacol 509:61-70. 2005
..Thus, the findings of the present study provide evidence that mesna may serve as a novel target for potential therapeutic treatment of lung fibrosis...
