Bayat A, Haghparast A. Effect of insulin deficiency on the rewarding properties of methamphetamine in streptozotocin-induced diabetic rats. Pharmacol Biochem Behav. 2015;128:8-13 pubmed publisher
Roohi N, Sarihi A, Shahidi S, Zarei M, Haghparast A. Microinjection of the mGluR5 antagonist MTEP into the nucleus accumbens attenuates the acquisition but not expression of morphine-induced conditioned place preference in rats. Pharmacol Biochem Behav. 2014;126:109-15 pubmed publisher
..Our findings indicated that blockade of mGluR5 reduces rewarding properties of morphine. Further studies are needed to know the involved mechanisms. ..
Moradi M, Yazdanian M, Haghparast A. Role of dopamine D2-like receptors within the ventral tegmental area and nucleus accumbens in antinociception induced by lateral hypothalamus stimulation. Behav Brain Res. 2015;292:508-14 pubmed publisher
..It seems that this pain modulating system is more relevant to D2-like receptors in the nucleus accumbens. ..
Yazdi Ravandi S, Razavi Y, Haghparast A, Goudarzvand M, Haghparast A. Orexin A induced antinociception in the ventral tegmental area involves D1 and D2 receptors in the nucleus accumbens. Pharmacol Biochem Behav. 2014;126:1-6 pubmed publisher
..It is supposed that orexin A can induce the antinociception through activation of orexinergic receptors which activate the dopaminergic inputs to the NAc in rats. ..
Haghparast A, Fatahi Z, Alamdary S, Reisi Z, Khodagholi F. Changes in the levels of p-ERK, p-CREB, and c-fos in rat mesocorticolimbic dopaminergic system after morphine-induced conditioned place preference: the role of acute and subchronic stress. Cell Mol Neurobiol. 2014;34:277-88 pubmed publisher
..It has been shown that morphine induces the enhancement of the mentioned factors; on the other hand, our result demonstrates that stress can amplify these changes. ..
Ezzatpanah S, Babapour V, Sadeghi B, Haghparast A. Chemical stimulation of the lateral hypothalamus by carbachol attenuated the formalin-induced pain behaviors in rats. Pharmacol Biochem Behav. 2015;129:105-10 pubmed publisher
..These findings suggest that LH modulates formalin-induced nociception through spinal and/or supraspinal sites. ..
Khaleghzadeh Ahangar H, Haghparast A. Intra-accumbal CB1 receptor blockade reduced extinction and reinstatement of morphine. Physiol Behav. 2015;149:212-9 pubmed publisher
..These results for the first time indicated that CB1 receptors within the NAc are involved in the maintenance of morphine rewarding properties, and morphine seeking behaviors in extinguished morphine-induced CPP rats. ..
Fatahi Z, Assar N, Mahmoudi D, Pahlevani P, Moradi M, Haghparast A. Functional interaction between the orexin-1 and CB1 receptors within the nucleus accumbens in the conditioned place preference induced by the lateral hypothalamus stimulation. Pharmacol Biochem Behav. 2015;132:42-48 pubmed publisher
..Our findings also suggest the existence a functional interaction between OX1 and CB1 receptors within the NAc in place preference. ..
Sadeghzadeh F, Babapour V, Haghparast A. Role of dopamine D1-like receptor within the nucleus accumbens in acute food deprivation- and drug priming-induced reinstatement of morphine seeking in rats. Behav Brain Res. 2015;287:172-81 pubmed publisher
..It is concluded that FD- and drug priming-induced reinstatement may be mediated, at least in some way, by activation of dopamine D1-like receptors in the NAc. ..
Sadeghzadeh F, Namvar P, Naghavi F, Haghparast A. Differential effects of intra-accumbal orexin-1 and -2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats. Pharmacol Biochem Behav. 2016;142:8-14 pubmed publisher
..Therefore, orexins may be considered as a promising therapeutic agent in preventing the expression and maintenance of morphine rewarding effects on dependent individuals. ..
Molaei M, Fatahi Z, Zaringhalam J, Haghparast A. CB1 Cannabinoid Agonist (WIN55,212-2) Within the Basolateral Amygdala Induced Sensitization to Morphine and Increased the Level of Î¼-Opioid Receptor and c-fos in the Nucleus Accumbens. J Mol Neurosci. 2016;58:446-55 pubmed publisher
..It seems that c-fos is one of the important factors involved in the induction of sensitization to antinociceptive effect of morphine. ..
Charmchi E, Zendehdel M, Haghparast A. The effect of forced swim stress on morphine sensitization: Involvement of D1/D2-like dopamine receptors within the nucleus accumbens. Prog Neuropsychopharmacol Biol Psychiatry. 2016;70:92-9 pubmed publisher
..Our findings suggest that FSS can potentiate the effect of morphine and causes morphine sensitization which induces antinociception. ..
Faramarzi G, Zendehdel M, Haghparast A. D1- and D2-like dopamine receptors within the nucleus accumbens contribute to stress-induced analgesia in formalin-related pain behaviours in rats. Eur J Pain. 2016;20:1423-32 pubmed publisher
..Stress-induced analgesia is dose-dependently reduced by dopamine receptor antagonists in both phases, although it is more prominent during the late phase. ..
Farahimanesh S, Karimi S, Haghparast A. Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats. Peptides. 2018;101:25-31 pubmed publisher
..Moreover, blockade of OX1rs could facilitate extinction and may extinguish the ability of drug-related cues. It seems that the antagonist might be considered as a propitious therapeutic agent in suppressing drug-seeking behaviors. ..
Sadeghi B, Ezzatpanah S, Haghparast A. Effects of dorsal hippocampal orexin-2 receptor antagonism on the acquisition, expression, and extinction of morphine-induced place preference in rats. Psychopharmacology (Berl). 2016;233:2329-41 pubmed publisher
Siahposht Khachaki A, Fatahi Z, Yans A, Khodagholi F, Haghparast A. Involvement of AMPA/Kainate Glutamate Receptor in the Extinction and Reinstatement of Morphine-Induced Conditioned Place Preference: A Behavioral and Molecular Study. Cell Mol Neurobiol. 2017;37:315-328 pubmed publisher
..Modulation of the drug memory reconsolidation may be useful for faster extinction of drug-induced reward and attenuation of drug-seeking behavior. ..
Esmaeili M, Reisi Z, Ezzatpanah S, Haghparast A. Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats. Eur J Pain. 2016;20:1753-1762 pubmed publisher
..Concurrent administration of SB334867 and AM251 into the vlPAG did not reinforce the antinociceptive responses. ..
Sahafzadeh M, Karimi Haghighi S, Mousavi Z, Haghparast A. Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats. Brain Res Bull. 2018;137:217-224 pubmed publisher
..These findings indicate that the NAc is a brain area within which orexin has a fundamental role in the effect of stress on morphine-induced reinstatement and the effect of food deprivation- on the reinstatement of morphine. ..
Assar N, Mahmoudi D, Farhoudian A, Farhadi M, Fatahi Z, Haghparast A. D1- and D2-like dopamine receptors in the CA1 region of the hippocampus are involved in the acquisition and reinstatement of morphine-induced conditioned place preference. Behav Brain Res. 2016;312:394-404 pubmed publisher
..These findings suggested that D1- and D2-like dopamine receptors in the CA1 are involved in the acquisition and reinstatement of morphine-CPP, and antagonism of these receptors can reduce the rewarding properties of morphine. ..
Haghparast A, Fatahi Z, Arezoomandan R, Karimi S, Taslimi Z, Zarrabian S. Functional roles of orexin/hypocretin receptors in reward circuit. Prog Brain Res. 2017;235:139-154 pubmed publisher
..The complex circuits involved in reward processing are only beginning to be understood and we need to deepen our understanding regarding the nature of the interactions between all brain areas involved. ..
Fatahi Z, Sadeghi B, Haghparast A. Involvement of cannabinoid system in the nucleus accumbens on delay-based decision making in the rat. Behav Brain Res. 2018;337:107-113 pubmed publisher
..These finding clarified that cannabinoid system activation in the entire NAc plays a critical role in the regulation of delay-based decision making. ..
Karimi S, Mesdaghinia A, Farzinpour Z, Hamidi G, Haghparast A. Reversible inactivation of the lateral hypothalamus reversed high reward choices in cost-benefit decision-making in rats. Neurobiol Learn Mem. 2017;145:135-142 pubmed publisher
..This was not caused by a spatial memory or motor deficit. PeF-LH inactivation modified decision behavior. The results imply that PeF-LH is important for allowing the animal to pay a cost to acquire greater rewards. ..
Alizamini M, Farzinpour Z, Ezzatpanah S, Haghparast A. Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats. Neurosci Lett. 2017;660:1-5 pubmed publisher
..It seems that orexin-1 receptors in this region are more effective in development of drug seeking behaviors in the rats. ..
Parsania S, Moradi M, Fatahi Z, Haghparast A. Involvement of orexin-1 and orexin-2 receptors within the dentate gyrus of the hippocampus in the acquisition, expression and extinction of lateral hypothalamic-induced conditioned place preference in the rats. Brain Res. 2016;1639:149-60 pubmed publisher
..We conclude that the orexinergic projections from the LH to DG are involved in the development, expression and extinction of CPP induced by LH stimulation...
Yazdi F, Jahangirvand M, Pirasteh A, Moradi M, Haghparast A. Functional interaction between OX2 and CB1 receptors in the ventral tegmental area and the nucleus accumbens in response to place preference induced by chemical stimulation of the lateral hypothalamus. Pharmacol Biochem Behav. 2015;139:39-46 pubmed publisher
..Moreover, we suggest the existence of an interaction between orexinergic and cannabinoid systems within the VTA and NAc in place preference induced by LH stimulation. ..
Haghparast A, Shafiei I, Alizadeh A, Ezzatpanah S, Haghparast A. Blockade of the orexin receptors in the CA1 region of hippocampus decreased the lateral hypothalamic-induced antinociceptive responses in the model of orofacial formalin test in the rats. Peptides. 2018;99:217-222 pubmed publisher
..Clinical studies are recommended to study the probable effectiveness of orexinergic system in modulation of the orofacial nociceptive responses. ..
Siahposht Khachaki A, Ezzatpanah S, Razavi Y, Haghparast A. NMDA receptor dependent changes in c-fos and p-CREB signaling following extinction and reinstatement of morphine place preference. Neurosci Lett. 2018;662:147-151 pubmed publisher
..Therefore, it can be assumed that consolidation and reconsolidation of morphine memory via intra-PFC, -NAc and -HIP NMDA glutamate receptors are in accordance with changes in p-CREB/CREB ratio and c-fos levels. ..
Farzinpour Z, Mousavi Z, Karimi Haghighi S, Haghparast A. Antagonism of the D1- and D2-like dopamine receptors in the nucleus accumbens attenuates forced swim stress- and morphine priming-induced reinstatement of extinguished rats. Behav Brain Res. 2018;341:16-25 pubmed publisher
..These findings suggested that the D1- and D2-like dopamine receptors in the NAc involve in morphine-seeking behaviors and antagonism of these receptors can reduce the effect of stress on rewarding properties of morphine. ..
Fatahi Z, Zibaii M, Haghparast A. Effect of acute and subchronic stress on electrical activity of basolateral amygdala neurons in conditioned place preference paradigm: An electrophysiological study. Behav Brain Res. 2017;335:19-25 pubmed publisher
..However, effect of AS and SS on the firing rate of BLA neurons in morphine-treated animals was more remarkable than that of saline-treated animals. ..
Khaleghzadeh Ahangar H, Haghparast A. Intra-accumbal Cannabinoid Agonist Attenuated Reinstatement but not Extinction Period of Morphine-Induced Conditioned Place Preference; Evidence for Different Characteristics of Extinction Period and Reinstatement. Neurochem Res. 2017;42:3321-3330 pubmed publisher
..Our findings suggest that the extinction period and reinstatement could occur through different mechanisms. ..
Haghparast A, Khani A, Naderi N, Alizadeh A, Motamedi F. Repeated administration of nicotine attenuates the development of morphine tolerance and dependence in mice. Pharmacol Biochem Behav. 2008;88:385-92 pubmed
..The data suggests that the inhibitory effect of nicotine on the morphine tolerance and dependence is mediated by central nicotinic receptors and there is a cross-dependence between nicotine and morphine...