Christian Hafner

Summary

Publications

  1. pmc Mosaic RASopathies
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Cell Cycle 12:43-50. 2013
  2. ncbi request reprint Keratinocytic epidermal nevi are associated with mosaic RAS mutations
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Med Genet 49:249-53. 2012
  3. pmc Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi
    Christian Hafner
    Department of Dermatology, University of Regensburg, Germany
    J Clin Invest 116:2201-2207. 2006
  4. doi request reprint Identification of new genes associated with melanoma
    Andreas Mauerer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Exp Dermatol 20:502-7. 2011
  5. ncbi request reprint Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 18:1249-57. 2005
  6. ncbi request reprint FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 20:895-903. 2007
  7. ncbi request reprint Antiproliferative effects of rapamycin and celecoxib in angiosarcoma cell lines
    Annika Bundscherer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Anticancer Res 30:4017-23. 2010
  8. ncbi request reprint Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 18:565-72. 2005
  9. ncbi request reprint Targeting the tumor stroma with peroxisome proliferator activated receptor (PPAR) agonists
    Annika Bundscherer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Anticancer Agents Med Chem 9:816-21. 2009
  10. ncbi request reprint Ephrin-B2 overexpression enhances integrin-mediated ECM-attachment and migration of B16 melanoma cells
    Stefanie Meyer
    Department of Dermatology, University of Regensburg, D 93042 Regensburg, Germany
    Int J Oncol 27:1197-206. 2005

Collaborators

Detail Information

Publications46

  1. pmc Mosaic RASopathies
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Cell Cycle 12:43-50. 2013
    ..For syndromes caused by mosaic mutations of the Ras/MAPK signaling pathway, the term "mosaic RASopathies" has been proposed. In the following article, genetic and phenotypic aspects of mosaic RASopathies will be discussed...
  2. ncbi request reprint Keratinocytic epidermal nevi are associated with mosaic RAS mutations
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Med Genet 49:249-53. 2012
    ..Keratinocytic epidermal nevi (KEN) represent benign congenital skin lesions arranged along Blaschko's lines. A subgroup of KEN is caused by hotspot oncogenic FGFR3 and PIK3CA mutations in mosaicism, but the majority lack these mutations...
  3. pmc Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi
    Christian Hafner
    Department of Dermatology, University of Regensburg, Germany
    J Clin Invest 116:2201-2207. 2006
    ..The R248C mutation appears to be a hot spot for FGFR3 mutations in epidermal nevi...
  4. doi request reprint Identification of new genes associated with melanoma
    Andreas Mauerer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Exp Dermatol 20:502-7. 2011
    ..In this study, we aim to provide a more comprehensive understanding of the transcriptional profiles and signalling pathways associated with melanoma...
  5. ncbi request reprint Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 18:1249-57. 2005
    ..Since a direct interaction of RBP2-H1 and pRb seems possible, the loss of RBP2-H1 may possibly contribute to uncontrolled growth in malignant melanomas...
  6. ncbi request reprint FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 20:895-903. 2007
    ..Increased age appears to be a risk factor for these mutations. The preferential occurrence of FGFR3 mutations in seborrheic keratoses of the head and neck suggests a causative role for cumulative lifetime ultraviolet light exposure...
  7. ncbi request reprint Antiproliferative effects of rapamycin and celecoxib in angiosarcoma cell lines
    Annika Bundscherer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Anticancer Res 30:4017-23. 2010
    ..The aim of this study was to investigate the effects of the COX2 inhibitor celecoxib and the mTOR antagonist rapamycin on angiosarcoma cell lines...
  8. ncbi request reprint Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 18:565-72. 2005
    ..We conclude that the evaluation of phosphorylated retinoblastoma protein in melanocytic tumors could become a helpful adjunct in clinicopathological routine...
  9. ncbi request reprint Targeting the tumor stroma with peroxisome proliferator activated receptor (PPAR) agonists
    Annika Bundscherer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Anticancer Agents Med Chem 9:816-21. 2009
    ..This review will focus on the stroma-mediated anticancer activities of PPAR agonists...
  10. ncbi request reprint Ephrin-B2 overexpression enhances integrin-mediated ECM-attachment and migration of B16 melanoma cells
    Stefanie Meyer
    Department of Dermatology, University of Regensburg, D 93042 Regensburg, Germany
    Int J Oncol 27:1197-206. 2005
    ..We conclude that ephrin-B2 can act as a major modulator of cell migration and matrix interactions of MM cells, which possibly contributes to the expansion and metastatic spread of MM in vivo...
  11. ncbi request reprint FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Exp Cell Res 316:2008-16. 2010
    ..Our results suggest that an increased cell number at confluence along with a decreased apoptosis may contribute to the development of acanthotic tumors in FGFR3 mutant skin in vivo...
  12. ncbi request reprint Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro
    Christian Hafner
    Department of Dermatology, University of Regensburg, D 93042 Regensburg, Germany
    World J Gastroenterol 11:4024-31. 2005
    ..The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD)...
  13. ncbi request reprint Gene expression profiling of melanocytes following Q-Switched Ruby laser irradiation
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Dermatology 216:6-13. 2008
    ..The Q-switched Ruby laser (QSRL) is used for the treatment of pigmented lesions. The influence of QSRL treatment on gene expression of nontransformed primary melanocytes has not been addressed in vitro...
  14. ncbi request reprint Antiproliferative and proapoptotic effects of rapamycin and celecoxib in malignant melanoma cell lines
    Annika Bundscherer
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, Germany
    Oncol Rep 19:547-53. 2008
    ..Both rapamycin and celecoxib represent promising drugs for the palliative therapy of metastasised malignant melanoma and should be considered for future trials...
  15. ncbi request reprint Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg D 93042, Germany
    World J Gastroenterol 11:4511-8. 2005
    ..Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells...
  16. ncbi request reprint Antiangiogenic therapy with pioglitazone, rofecoxib, and trofosfamide in a patient with endemic kaposi sarcoma
    Brigitte Coras
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Arch Dermatol 140:1504-7. 2004
    ..It accounts for 50% of all tumors reported in central African countries. Owing to the rising number of patients and the limitations of current therapies, there is an urgent demand for new strategies to treat KS...
  17. ncbi request reprint FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    J Invest Dermatol 127:1572-3. 2007
    ..The report by Hernandez et al. strongly supports this concept. However, further studies are required for a better pathogenetic understanding of FGFR3 related tumors in urothelium and skin...
  18. pmc Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Proc Natl Acad Sci U S A 107:20780-5. 2010
    ..Furthermore, our data provide clues on the origin and spread of oncogenic mutations in tissues, suggesting that apparently independent (multicentric) adult benign tumors may have a clonal origin...
  19. ncbi request reprint Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 19:1369-77. 2006
    ..EphA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer...
  20. ncbi request reprint Antiangiogenic therapy in metastatic prostate carcinoma complicated by cutaneous lupus erythematodes
    Thomas Vogt
    Department of Dermatology, University of Regensburg, Germany
    Lancet Oncol 7:695-7. 2006
  21. doi request reprint Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome
    Leopold Groesser
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Nat Genet 44:783-7. 2012
    ..Our results indicate that nevus sebaceous and Schimmelpenning syndrome are caused by postzygotic HRAS and KRAS mutations. These mutations may predispose individuals to the development of secondary tumors in nevus sebaceous...
  22. ncbi request reprint Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Clin Chem 50:490-9. 2004
    ..Their role in healthy adult tissues and in human disease is still largely unknown, although diverse roles in carcinogenesis have been postulated...
  23. ncbi request reprint PTCH mutations are not mainly involved in the pathogenesis of sporadic trichoblastomas
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Hum Pathol 38:1496-500. 2007
    ..The genetic basis of this rare appendageal tumor remains elusive...
  24. ncbi request reprint Discrimination of melanocytic tumors by cDNA array hybridization of tissues prepared by laser pressure catapulting
    Bernd Becker
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 122:361-8. 2004
    ..Expression patterns of marker genes defined in unequivocal histopathologic entities may improve the diagnostic and prognostic assessment of difficult melanocytic lesions, which is still the hardest problem in dermatopathology...
  25. doi request reprint Nevus marginatus: a distinct type of epidermal nevus or merely a variant of nevus sebaceus?
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Dermatology 216:236-8. 2008
    ..For this peculiar disorder, we propose the term 'nevus marginatus'. So far it is not clear whether nevus marginatus represents a distinct entity or merely an unusual clinical variant of nevus sebaceus...
  26. pmc Activation of the PI3K/AKT pathway in Merkel cell carcinoma
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e31255. 2012
    ..This finding together with our observation that the PI3K/AKT pathway is activated in the majority of human MCCs identifies PI3K/AKT as a potential new therapeutic target for MCC patients...
  27. ncbi request reprint Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 127:1883-5. 2007
    ..Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots...
  28. ncbi request reprint Clonality of basal cell carcinoma arising in an epidermal nevus. New insights provided by molecular analysis
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Dermatology 218:278-81. 2009
    ..The results favour an independent origin of the basal cell carcinoma, although a possible clonal relationship between both lesions cannot be completely excluded on the basis of the molecular genetic findings...
  29. ncbi request reprint Low Incidence of Oncogenic EGFR, HRAS, and KRAS Mutations in Seborrheic Keratosis
    Ivelina A Georgieva
    Department of Dermatology, University of Regensburg, Regensburg, Germany Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany and Molecular Pathology Diagnostic Unit, Institute of Pathology, University of Regensburg, Regensburg, Germany
    Am J Dermatopathol 36:635-42. 2014
    ..FGFR2, PIK3R1, and NRAS mutations obviously do not have a significant role in the development of SK. ..
  30. pmc Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Proc Natl Acad Sci U S A 104:13450-4. 2007
    ..The remarkable genotype-phenotype correlation as observed in this study points to a distinct etiopathogenesis of the mutations in keratinocytes occuring either during fetal development or in adult life...
  31. ncbi request reprint FGFR3 mutations in benign skin tumors
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Cell Cycle 5:2723-8. 2006
    ..Further studies are required to provide insights in the pathogenesis of benign skin tumors caused by FGFR3 mutations. These studies will add to new non-invasive therapeutical strategies for benign acanthotic skin tumors in dermatology...
  32. ncbi request reprint Loss of EphB6 expression in metastatic melanoma
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Int J Oncol 23:1553-9. 2003
    ....
  33. ncbi request reprint Congenital cartilaginous rests of the neck (wattles)
    Brigitte Coras
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Dermatol Surg 31:1349-50. 2005
    ..Congenital cartilaginous rests of the neck (wattles) are very rare, probably branchiogenic malformations...
  34. ncbi request reprint High frequency of FGFR3 mutations in adenoid seborrheic keratoses
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 126:2404-7. 2006
    ..The mechanism for the high rate of somatic FGFR3 mutations in these benign skin tumors remains elusive, but UV light exposure may play a potential role, especially in the R248C mutations...
  35. ncbi request reprint Phacomatosis pigmentokeratotica is caused by a postzygotic HRAS mutation in a multipotent progenitor cell
    Leopold Groesser
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 133:1998-2003. 2013
    ..In contrast, PPK is best explained by a postzygotic-activating HRAS mutation in a multipotent progenitor cell that gives rise to both a sebaceous and a melanocytic nevus. Therefore, PPK is a mosaic RASopathy. ..
  36. doi request reprint Low incidence of EGFR and HRAS mutations in cutaneous squamous cell carcinomas of a German cohort
    Andreas Mauerer
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee, Regensburg Molecular Pathology Diagnostic Unit, Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee, Regensburg, Germany
    Exp Dermatol 20:848-50. 2011
    ....
  37. ncbi request reprint New indications for established drugs: combined tumor-stroma-targeted cancer therapy with PPARgamma agonists, COX-2 inhibitors, mTOR antagonists and metronomic chemotherapy
    Christian Hafner
    Department of Dermatology, University of Regensburg, Franz Josef Strasse Allee 11, 93042 Regensburg, Germany
    Curr Cancer Drug Targets 5:393-419. 2005
    ..However, larger randomized clinical trials are required for further evaluation and optimization of this concept...
  38. ncbi request reprint Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutations
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Exp Dermatol 19:e222-7. 2010
    ..PIK3CA and AKT1 hotspot mutations are obviously not caused by UV light exposure, the main risk factor in non-melanoma skin cancer...
  39. ncbi request reprint Permanent make-up colorants may cause severe skin reactions
    Sabrina M Wenzel
    Department of Dermatology, Regensburg University Medical Centre, Regensburg 93053, Germany
    Contact Dermatitis 63:223-7. 2010
    ..However, most colorants are manufactured for non-medical purposes, without any established history of safe use in humans...
  40. doi request reprint Mutational activation of FGFR3 is not involved in the development of prostate cancer
    Stella Koufou
    Department of Urology, University of Regensburg, Regensburg, Germany
    Pathobiology 77:249-52. 2010
    ..Most recently, activating FGFR3 mutations were described as being associated with low-grade prostate tumors. Therefore, we investigated the FGFR3 mutation status in a comprehensive series of prostate tumors...
  41. ncbi request reprint Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors
    Thomas Vogt
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Cancer 98:2251-6. 2003
    ....
  42. doi request reprint Skin alterations due to illegal drug abuse
    Bianca Fink
    Department of Dermatology, University of Regensburg, Germany
    J Dtsch Dermatol Ges 9:633-8; quiz 639. 2011
    ..The objective of this paper is to draw particular attention to typical skin lesions and diseases which may be associated with drug abuse...
  43. doi request reprint Generalized solar lentigines in a patient with a history of radon exposure
    Andreas Mauerer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Dermatology 221:206-10. 2010
    ..It remains elusive whether the occupational exposure to radon-containing water in addition to the recreational UV light exposure caused the unusual distribution of the SLs in this patient...
  44. doi request reprint Seborrheic keratosis
    Christian Hafner
    Clinic and Polyclinic for Dermatology, University of Regensburg, Germany
    J Dtsch Dermatol Ges 6:664-77. 2008
    ..In the last years new molecular genetic insights into seborrheic keratoses have been gained. The current knowledge about seborrheic keratosis with respect to epidemiology, pathogenesis, diagnosis and therapy is summarized...
  45. ncbi request reprint Molecular genetic analysis excludes implantation metastasis of basal cell carcinomas
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Arch Pathol Lab Med 127:1221-4. 2003
    ..3. Molecular genetic analysis clearly demonstrated different genetic alterations of the two BCCs and therefore most likely excludes a mechanism of implantation metastasis...
  46. pmc Kyrle disease and acquired perforating collagenosis secondary to chronic renal failure and diabetes mellitus
    Stephan Schreml
    Department of Dermatology, University Hospital Regensburg, Regensburg
    Case Rep Dermatol 3:209-11. 2011
    ..Additionally, we question the concept of perforation, as epidermal damage and exposure of subepidermal substances may artificially present as perforation...