Stephan J Guyenet

Summary

Publications

  1. pmc High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes
    Stephan J Guyenet
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Diabetes and Obesity Center of Excellence, University of Washington, UW Medicine at South Lake Union, 850 Republican Street, Box 358055, Seattle, WA 98109, USA
    Brain Res 1512:97-105. 2013
  2. pmc Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia
    Thomas H Meek
    Diabetes and Obesity Center of Excellence, University of Washington at South Lake Union, 850 Republican Street, N334, Box 358055, Seattle, Washington 98195, USA
    Endocrinology 154:3067-76. 2013
  3. pmc BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production
    Thomas H Meek
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 62:1512-8. 2013
  4. pmc In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue
    Miles E Matsen
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Physiol Endocrinol Metab 304:E734-46. 2013
  5. ncbi request reprint Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study
    Kathryn E Berkseth
    Diabetes and Obesity Center of Excellence K E B, S J G, J P T, M W S and Departments of Medicine E A S, S J M and Radiology D L, University of Washington, Seattle, Washington 98109
    Endocrinology 155:2858-67. 2014
  6. pmc Obesity is associated with hypothalamic injury in rodents and humans
    Joshua P Thaler
    Division of Metabolism, Endocrinology and Nutrition, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington 98109, USA
    J Clin Invest 122:153-62. 2012
  7. pmc Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity
    Stephan J Guyenet
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington School of Medicine, South Lake Union, 815 Mercer Street, N334, Box 358055, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 97:745-55. 2012

Collaborators

Detail Information

Publications7

  1. pmc High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes
    Stephan J Guyenet
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Diabetes and Obesity Center of Excellence, University of Washington, UW Medicine at South Lake Union, 850 Republican Street, Box 358055, Seattle, WA 98109, USA
    Brain Res 1512:97-105. 2013
    ..Our results indicate that astrocytes in the mediobasal hypothalamus respond rapidly and robustly to HFD feeding, activating caspase-3 in the absence of apoptosis, a process that has the potential to influence the course of DIO...
  2. pmc Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia
    Thomas H Meek
    Diabetes and Obesity Center of Excellence, University of Washington at South Lake Union, 850 Republican Street, N334, Box 358055, Seattle, Washington 98195, USA
    Endocrinology 154:3067-76. 2013
    ..Leptin action within a distributed neuronal network may mediate its effects on glucose homeostasis. ..
  3. pmc BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production
    Thomas H Meek
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 62:1512-8. 2013
    ..This action of BDNF likely involves the VMN and is associated with inhibition of glucagon secretion and a decrease in the rate of HGP...
  4. pmc In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue
    Miles E Matsen
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Physiol Endocrinol Metab 304:E734-46. 2013
    ....
  5. ncbi request reprint Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study
    Kathryn E Berkseth
    Diabetes and Obesity Center of Excellence K E B, S J G, J P T, M W S and Departments of Medicine E A S, S J M and Radiology D L, University of Washington, Seattle, Washington 98109
    Endocrinology 155:2858-67. 2014
    ....
  6. pmc Obesity is associated with hypothalamic injury in rodents and humans
    Joshua P Thaler
    Division of Metabolism, Endocrinology and Nutrition, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington 98109, USA
    J Clin Invest 122:153-62. 2012
    ..These findings collectively suggest that, in both humans and rodent models, obesity is associated with neuronal injury in a brain area crucial for body weight control...
  7. pmc Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity
    Stephan J Guyenet
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington School of Medicine, South Lake Union, 815 Mercer Street, N334, Box 358055, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 97:745-55. 2012
    ..Because the growing obesity epidemic is linked to a substantial increase in daily energy intake, a key priority is to delineate how mechanisms governing food intake and body fat content are altered in an obesogenic environment...