Simona Gurzu

Summary

Publications

  1. ncbi request reprint The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, 38 Gheorghe Marinescu Street, Targu Mures, Romania
    Rom J Morphol Embryol 48:95-9. 2007
  2. ncbi request reprint The immunohistochemical aspects of protein Mena in cervical lesions
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 50:213-6. 2009
  3. pmc Mesenchymal-to-endothelial transition in Kaposi sarcoma: a histogenetic hypothesis based on a case series and literature review
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania
    PLoS ONE 8:e71530. 2013
  4. pmc The possible role of Mena protein and its splicing-derived variants in embryogenesis, carcinogenesis, and tumor invasion: a systematic review of the literature
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, 38 Ghe Marinescu Street, 540193 Targu Mures, Romania
    Biomed Res Int 2013:365192. 2013
  5. pmc Lethal cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis induced by capecitabine and oxaliplatin in a 36-year-old woman
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania
    Diagn Pathol 8:150. 2013
  6. doi request reprint Practical value of the new system for Maspin assessment, in colorectal cancer
    S Gurzu
    Department of Pathology, University of Medicine and Pharmacy, Targu Mures, Romania
    Neoplasma 60:373-83. 2013
  7. ncbi request reprint Molecular classification of colorectal cancer: a dream that can become a reality
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 54:241-5. 2013
  8. pmc Serrated pathway adenocarcinomas: molecular and immunohistochemical insights into their recognition
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Targu Mures, Romania
    PLoS ONE 8:e57699. 2013
  9. doi request reprint Gastric tricho-wool bezoar in an 18-year-old girl
    S Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    S Afr J Surg 51:33-4. 2013
  10. ncbi request reprint Possible predictive value of maspin expression in colorectal cancer
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy, 38 Ghe Marinescu Street, Targu Mures, 540139, Romania
    Recent Pat Anticancer Drug Discov 8:183-90. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, 38 Gheorghe Marinescu Street, Targu Mures, Romania
    Rom J Morphol Embryol 48:95-9. 2007
    ..For statistical analysis, we used the Statistical Program Graph Pad In Stat 3-Trial Version. We considered the significant association when p<0.05, with 95% confidence interval...
  2. ncbi request reprint The immunohistochemical aspects of protein Mena in cervical lesions
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 50:213-6. 2009
    ..We analyzed 30 cases with CIN (1, 2 and 3), and 10 squamous carcinomas. We used the EnVision system by LabVision. The Mena antibody, izotype mouse IgA, clone 21, provided by BD Biosciences...
  3. pmc Mesenchymal-to-endothelial transition in Kaposi sarcoma: a histogenetic hypothesis based on a case series and literature review
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania
    PLoS ONE 8:e71530. 2013
    ..The aim of our study was to analyze the immunophenotype of Kaposi sarcoma and to present a hypothesis about the histogenesis of this tumor, based on a case series and a review of relevant literature...
  4. pmc The possible role of Mena protein and its splicing-derived variants in embryogenesis, carcinogenesis, and tumor invasion: a systematic review of the literature
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, 38 Ghe Marinescu Street, 540193 Targu Mures, Romania
    Biomed Res Int 2013:365192. 2013
    ....
  5. pmc Lethal cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis induced by capecitabine and oxaliplatin in a 36-year-old woman
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania
    Diagn Pathol 8:150. 2013
    ..Alcohol consumption was denied. The patient died due to associated heart, liver and pancreatic failure. This multiorgan toxicity and death following CAPOX regimen had not yet been reported in the literature...
  6. doi request reprint Practical value of the new system for Maspin assessment, in colorectal cancer
    S Gurzu
    Department of Pathology, University of Medicine and Pharmacy, Targu Mures, Romania
    Neoplasma 60:373-83. 2013
    ..In conclusion, CRC with cytoplasmic predominance and mixed Maspin expression seems to present better prognosis whereas nuclear predominance is connected with high aggressivity...
  7. ncbi request reprint Molecular classification of colorectal cancer: a dream that can become a reality
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 54:241-5. 2013
    ..At the end, we correlated these informations and tried to realize a molecular classification of colorectal cancer, similar to breast carcinomas, in order to establish targeted groups of patients for targeted therapy...
  8. pmc Serrated pathway adenocarcinomas: molecular and immunohistochemical insights into their recognition
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Targu Mures, Romania
    PLoS ONE 8:e57699. 2013
    ..The aim of our paper was to establish some criteria to facilitate their identification...
  9. doi request reprint Gastric tricho-wool bezoar in an 18-year-old girl
    S Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    S Afr J Surg 51:33-4. 2013
    ..On palpation, a painful abdominal mass was identified in the epigastric region, and gastrotomy was performed. A J-shaped hair-wool ball and two large pieces of sheep's wool were removed. No history of trichotillomania was reported...
  10. ncbi request reprint Possible predictive value of maspin expression in colorectal cancer
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy, 38 Ghe Marinescu Street, Targu Mures, 540139, Romania
    Recent Pat Anticancer Drug Discov 8:183-90. 2013
    ....
  11. doi request reprint Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the esophagogastric junction with microsatellite instability, K-ras wild type
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy, Targu Mures, Romania
    Pathol Res Pract 209:128-31. 2013
    ..Real-time PCR analysis showed microsatellite instability without K-ras mutation in codon 12. No recurrences or metastases were reported 6 months after surgical intervention. No adjuvant therapy was performed...
  12. doi request reprint Male breast cellular myofibroblastoma with a rich reticulinic network: case report
    Simona Gurzu
    University of Medicine and Pharmacy, Targu Mures, Romania
    Am J Mens Health 6:344-8. 2012
    ..More than 90% of the cells expressed estrogen receptor. No recurrences were reported 2 years after surgical excision. This case is a variant of cellular myofibroblastoma, with a rich reticulinic network and scanty collagen bands...
  13. ncbi request reprint VEGF and CD31 expression in arthritic synovium and cartilage of human knee joints
    R Melinte
    Department of Orthopedic Surgery, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 53:911-5. 2012
    ..To determine the histological differences and the particular aspects of local angiogenesis in knee joint of the patients with osteoarthritis (OA) and rheumatoid arthritis (RA)...
  14. ncbi request reprint Current data in clinicopathological characteristics of primary hepatic tumors
    S Turdean
    Dr Gheorghe Marinescu Municipal Hospital, and University of Medicine and Pharmacy of Târgu Mureş, Romania
    Rom J Morphol Embryol 53:719-24. 2012
    ..The present study aimed to investigate the status of primary liver tumors diagnosed in the Emergency Hospital of Mures County, Romania...
  15. doi request reprint Aberrant pattern of the cytokeratin 7/cytokeratin 20 immunophenotype in colorectal adenocarcinomas with BRAF mutations
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Pathol Res Pract 208:163-6. 2012
    ..This is the first reported study of the relationship between CK20/CK7 immunophenotype, BRAF mutations and microsatellite status in CRC...
  16. pmc Mena, a new available marker in tumors of salivary glands?
    S Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Eur J Histochem 56:e8. 2012
    ..Its positivity in endothelial cells may suggest its potential role in tumor angiogenesis...
  17. ncbi request reprint Synchronous intestinal tumors: aggressive jejunal carcinoid and sigmoid malignant polyp
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 53:193-6. 2012
    ..In this case, the prognosis was not depending by the colorectal tumors but the aggressive feature of jejunal carcinoid lead to patient's death...
  18. ncbi request reprint The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy, Targu Mures, Romania
    Rom J Morphol Embryol 48:349-53. 2007
    ..To compare the angiogenesis in anal canal carcinomas (ACC) with that in colorectal carcinomas (CRC)...
  19. ncbi request reprint The angiogenesis in colorectal carcinomas with and without lymph node metastases
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy, Targu Mures, Romania
    Rom J Morphol Embryol 49:149-52. 2008
    ..We studied 187 CRC, with and without lymph node metastases, 128 from left and 59 from right colon...
  20. ncbi request reprint The expression of cytoskeleton regulatory protein Mena in colorectal lesions
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy, Targu Mures, Romania
    Rom J Morphol Embryol 49:345-9. 2008
    ..This is the first study in the literature about Mena expression in colorectal lesions...
  21. ncbi request reprint Practical value of the complex analysis of sentinel lymph nodes in colorectal carcinomas
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 52:593-8. 2011
    ..Sentinel lymph nodes (SLNs) mapping is a very controversial method, which can increase the number of identified LN...
  22. ncbi request reprint The differences between the endothelial area marked with CD31 and CD105 in colorectal carcinomas by computer-assisted morphometrical analysis
    I Jung
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 50:239-43. 2009
    ..Two hundred and eleven surgical specimens with CRC were immunohistochemical analyzed with markers for angiogenesis CD31 and CD105 (Endoglin). We determined the area of endothelial cells occupied in the microscope field (EA)...
  23. doi request reprint Counting of angiogenesis in colorectal carcinomas using double immunostain
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Tumori 98:485-90. 2012
    ..Double-labeling immunostaining is indispensable to study vessel maturation grade...
  24. ncbi request reprint [Preliminary results regarding vascular endothelial growth factor (VEGF-A) levels in the serum of gastric cancer patients]
    Ioana Hălmaciu
    Departamentul de Anatomic şi Embriologie, Universitatea de Medicina si Farmacie, Targu Mures, Romania
    Rev Med Chir Soc Med Nat Iasi 116:446-51. 2012
    ..The most studied VEGF molecule is VEGF-A (Vascular Endothelial Growth Factor). Its involvement in various neoplastic processes represents an intensely controversial hypothesis...
  25. ncbi request reprint Microvascular density in non-Hodgkin B-cell lymphomas measured using digital morphometry
    T Mezei
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 53:67-71. 2012
    ..The microvascular component of a tumor also plays a role in the metastatic capacity of the tumor, enabling the tumor cells to spread to distant locations by providing a large endothelial surface...
  26. ncbi request reprint CD105/Ki67 double immunostaining expression in liver metastasis from colon carcinoma
    Raluca Amalia Ceauşu
    Department of Histology, Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
    Rom J Morphol Embryol 52:613-6. 2011
    ..We conclude that in liver metastasis principal mechanism of neovascularisation formation is based on intussusception...
  27. doi request reprint Metaplastic bone formation in the abdominal wall--an incidental finding in a patient with gastric cancer. Case report and hypothesis about its histogenesis
    Simona Gurzu
    Departments of Pathology Surgery, University of Medicine and Pharmacy of Targu Mures, Romania
    Am J Dermatopathol 35:844-6. 2013
    ..The final diagnosis was localized metaplastic bone formation. This is a rare condition which can be related to trauma or surgery and should be differentiated by foreign-body granuloma and osteosarcoma...
  28. ncbi request reprint Immunohistochemical comparative study of fibrosis and biliary ductular reaction in alcoholic and viral chronic hepatitis
    I Egyed-Zsigmond
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 51:265-9. 2010
    ..We have concluded that patients with C viral hepatitis can benefit most from a correctly indicated hepatic biopsy since in these cases the lesions might be observed in an early and potentially curable phase...
  29. ncbi request reprint Clinico-pathological particularities of the shock-related pancreatitis
    Judit Kovacs
    Department of Anesthesia and Intensive Care, University of Medicine and Pharmacy Tg Mures, Targu Mures, Romania
    Pathol Oncol Res 18:977-81. 2012
    ..We therefore recommend in patients with shock to consider the possible development of ischemic pancreatitis for prompt and efficient treatment...