Surgical treatment of gallstonesKurinchi S Gurusamy
Department of Surgery, University College London Medical School, Royal Free Hospital, London, UK
Gastroenterol Clin North Am 39:229-44, viii. 2010
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- Prophylactic gastrojejunostomy for unresectable periampullary carcinoma
Kurinchi Selvan Gurusamy
Department of Surgery, Royal Free Campus, UCLMedical School, London, UK
Cochrane Database Syst Rev 2:CD008533. 2013
..The role of prophylactic gastrojejunostomy in patients with unresectable periampullary cancer is controversial...
- Robot assistant versus human or another robot assistant in patients undergoing laparoscopic cholecystectomy
Kurinchi Selvan Gurusamy
Department of Surgery, Royal Free Campus, UCL Medical School, London, UK
Cochrane Database Syst Rev 9:CD006578. 2012
..While some trials have shown distinct advantages of a robotic assistant over a human assistant others have not, and it is unclear which robotic assistant is best...
- Somatostatin analogues for pancreatic surgery
Kurinchi Selvan Gurusamy
Department of Surgery, Royal Free Campus, UCL Medical School, London, UK
Cochrane Database Syst Rev 6:CD008370. 2012
..Synthetic analogues of somatostatin are advocated by some surgeons to reduce complications following pancreatic surgery, however their use is controversial...
- Cardiopulmonary interventions to decrease blood loss and blood transfusion requirements for liver resection
Kurinchi Selvan Gurusamy
Department of Surgery, Royal Free Campus, UCL Medical School, London, UK
Cochrane Database Syst Rev 5:CD007338. 2012
..Blood loss during liver resection is considered one of the most important factors affecting the peri-operative outcomes of patients undergoing liver resection...
- Abdominal lift for laparoscopic cholecystectomy
Kurinchi Selvan Gurusamy
Department of Surgery, Royal Free Campus, UCL Medical School, London, UK
Cochrane Database Syst Rev 5:CD006574. 2012
..These cardiopulmonary changes may not be tolerated in individuals with poor cardiopulmonary reserve...
- Techniques of flushing and reperfusion for liver transplantation
Kurinchi Selvan Gurusamy
Department of Surgery, Royal Free Campus, UCL Medical School, London, UK
Cochrane Database Syst Rev 3:CD007512. 2012
..Various techniques of flushing and reperfusion have been advocated to improve outcomes after liver transplantation. There is considerable uncertainty as to which method is superior...
- Wound drains after incisional hernia repair
Kurinchi Selvan Gurusamy
Department of Surgery, Royal Free Campus, UCL Medical School, London, UK
Cochrane Database Syst Rev 2:CD005570. 2012
..More than 50% of open mesh repairs of ventral hernias have drains inserted. However, there is uncertainty as to whether drains are associated with benefits or harm to the patient...
- Intra-operative vs pre-operative endoscopic sphincterotomy in patients with gallbladder and common bile duct stones: cost-utility and value-of-information analysis
Kurinchi Gurusamy
Hepatopancreatobiliary and Liver Transplant Surgery, University Department of Surgery, Royal Free Campus UCL Medical School, London, UK
Appl Health Econ Health Policy 10:15-29. 2012
..Recently, a meta-analysis has shown that intra-operative ES during laparoscopic cholecystectomy (IOES) results in fewer complications than POES, with similar efficacy. The cost effectiveness of IOES versus POES is unknown...
- Systematic review and meta-analysis of intraoperative versus preoperative endoscopic sphincterotomy in patients with gallbladder and suspected common bile duct stones
K Gurusamy
Hepatopancreatobiliary and Liver Transplant Surgery, University Department of Surgery, Royal Free Campus, University College London Medical School, London, UK
Br J Surg 98:908-16. 2011
..Recently, intraoperative endoscopic sphincterotomy (IOES) during laparoscopic cholecystectomy has been suggested as an alternative treatment...
Current protective strategies in liver surgeryKurinchi S Gurusamy
HPB and Liver Transplantation, Royal Free Campus, University College London Medical School, Royal Free Hospital, 9th Floor, Pond Street, London, NW3 2QG, United Kingdom
World J Gastroenterol 16:6098-103. 2010
..Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection...
- Influence of zinc and zinc chelator on HT-29 colorectal cell line
K S Gurusamy
University Department of Surgery, Royal Free Campus, UCL Medical School, London, UK
Biometals 24:143-51. 2011
..HT-29 cells are not able to counteract the effect of intracellular chelation of zinc by altering zinc transport. Further research into the mechanisms of these findings is necessary and may lead to novel therapeutic options...
Trace element concentration in metastatic liver disease: a systematic reviewK Gurusamy
Department of HPB and Liver Transplant Surgery, University Department of Surgery, Royal Free and University College School of Medicine, UCL and Royal Free Hospital NHS Trust, London, UK
J Trace Elem Med Biol 21:169-77. 2007
..There are conflicting reports about the levels of trace elements in secondary liver cancers. This review summarises the evidence associating secondary liver tumours with trace elements...
- Assessment of risk of bias in randomized clinical trials in surgery
K S Gurusamy
University Department of Surgery, Royal Free Hospital and University College School of Medicine, London, UK
Br J Surg 96:342-9. 2009
..Bias in RCTs may overestimate or underestimate the true effectiveness of an intervention...
- Trace element concentration in primary liver cancers--a systematic review
Kurinchi Gurusamy
HBP and Liver Transplant Surgery, University Department of Surgery, Royal Free and University College School of Medicine, London, UK
Biol Trace Elem Res 118:191-206. 2007
..Development of hepatocellular carcinoma has been linked to levels of trace elements. This review summarizes the evidence associating HCC with trace elements...
- Design of surgical randomized controlled trials involving multiple interventions
Kurinchi S Gurusamy
University Department of Surgery, Royal Free Campus, UCL Medical School, London, United Kingdom
J Surg Res 165:118-27. 2011
..Surgical trials evaluating multiple interventions can be carried out by using parallel or factorial trial design. The optimal trial method has not been established...
- Meta-analysis of randomized controlled trials on the safety and effectiveness of early versus delayed laparoscopic cholecystectomy for acute cholecystitis
K Gurusamy
Hepatopancreatobiliary and Liver Transplant Surgery, University Department of Surgery, Royal Free and University College School of Medicine, London, UK
Br J Surg 97:141-50. 2010
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- An evaluation study of trace element content in colorectal liver metastases and surrounding normal livers by X-ray fluorescence
Kurinchi S Gurusamy
HPB and Liver Transplant Surgery, University Department of Surgery, Royal Free and University College School of Medicine, UCL and Royal Free Hospital NHS Trust, Pond Street, London, NW3 2QG, UK
Biometals 21:373-8. 2008
..Trace elements are involved in many key pathways involving cell cycle control. The levels of trace metals such as iron, copper, and zinc in colorectal liver metastases have not previously been assessed...
- Meta-analysis of randomized controlled trials on the safety and effectiveness of day-case laparoscopic cholecystectomy
K Gurusamy
Hepatopancreatobiliary and Liver Transplant Surgery, University Department of Surgery, Royal Free and University College School of Medicine, University College London and Royal Free Hospital NHS Trust, London, UK
Br J Surg 95:161-8. 2008
..The aim of this meta-analysis is to assess the advantages and disadvantages of day-case surgery compared with overnight stay in patients undergoing elective laparoscopic cholecystectomy...
- Systematic review of randomized controlled trials on the effectiveness of virtual reality training for laparoscopic surgery
K Gurusamy
Hepatopancreatobiliary and Liver Transplant Surgery, University Department of Surgery, Royal Free and University College School of Medicine, University College London and Royal Free Hospital NHS Trust, London NW32QG, UK
Br J Surg 95:1088-97. 2008
..The aim of this review was to determine whether virtual reality (VR) training can supplement and/or replace conventional laparoscopic training in surgical trainees with limited or no laparoscopic experience...
- Systematic review of randomized controlled trials of pharmacological interventions to reduce ischaemia-reperfusion injury in elective liver resection with vascular occlusion
Mahmoud Abu-Amara
Hepatopancreatobiliary and Liver Transplant Surgery, University Department of Surgery, Royal Free and University College School of Medicine, Royal Free Hospital Campus, London, UK
HPB (Oxford) 12:4-14. 2010
..We performed a systematic review and meta-analysis to assess the benefits and harms of using various pharmacological agents to decrease IR injury during liver resection with vascular occlusion...
- Clinical outcomes of radiofrequency ablation, percutaneous alcohol and acetic acid injection for hepatocelullar carcinoma: a meta-analysis
Giacomo Germani
The Royal Free Sheila Sherlock Liver Centre and University Department of Surgery, Royal Free Hospital, Pond Street, London, UK
J Hepatol 52:380-8. 2010
..Robust evidence showing benefit of one therapy versus another is lacking. Our aim was to evaluate the evidence comparing RFA, PEI and PAI using meta-analytical techniques...
- Prevention of parastomal herniation with biologic/composite prosthetic mesh: a systematic review and meta-analysis of randomized controlled trials
Sanjaya Prabhath Wijeyekoon
Academic Surgical Unit, Barts and the London School of Medicine and Dentistry, Whitechapel, London, United Kingdom
J Am Coll Surg 211:637-45. 2010
..A systematic review with meta-analysis of randomized clinical trials was performed to determine the benefits and risks of mesh reinforcement versus conventional stoma formation in preventing parastomal herniation...
- A meta-analysis of the impact of the two-layer method of preservation on human pancreatic islet transplantation
Aditya Agrawal
Department of HPB and Liver Transplant Surgery, Royal Free Hospital, Royal Free and University College School of Medicine, Hampstead, London NW3 2PF, UK
Cell Transplant 17:1315-22. 2008
..There is currently no clear evidence that the TLM is beneficial in human islet transplantation. It may improve the preservation of marginal organs...
