Wenjun Guo

Summary

Publications

  1. ncbi request reprint Integrin signalling during tumour progression
    Wenjun Guo
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences, Sloan Kettering Institute Cornell University, New York, New York, USA
    Nat Rev Mol Cell Biol 5:816-26. 2004
  2. pmc Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration
    Sotiris N Nikolopoulos
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Box 216, 1275 York Avenue, New York, New York 10021, USA
    Mol Cell Biol 25:6090-102. 2005
  3. ncbi request reprint Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis
    Wenjun Guo
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    Cell 126:489-502. 2006
  4. pmc p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow
    Anxo Vidal
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:6890-5. 2005
  5. ncbi request reprint Integrin beta4 signaling promotes tumor angiogenesis
    Sotiris N Nikolopoulos
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Cell 6:471-83. 2004
  6. ncbi request reprint Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression
    Yuliya Pylayeva
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, and Sloan Kettering Division, Weill Graduate School of Medical Sciences, Cornell University, New York, New York, USA
    Methods Enzymol 426:439-61. 2007

Collaborators

  • William J Muller
  • Giorgio Inghirami
  • Shahin Rafii
  • Filippo Giancotti
  • Sotiris N Nikolopoulos
  • Yuliya Pylayeva
  • Anxo Vidal
  • Toshiaki Yoshioka
  • Pamela Blaikie
  • Daniel D MacDonald
  • Lawrence A Frohman
  • Carmen de la Hoz
  • Stergios Zacharoulis
  • Claudia Puri
  • Nancy Yeh
  • Daniel Kato
  • Joseph Knowles
  • Carlo Tacchetti
  • Kristian K Jensen
  • David Lyden
  • Andrew Koff
  • Anna H Bramley
  • David Shaffer

Detail Information

Publications6

  1. ncbi request reprint Integrin signalling during tumour progression
    Wenjun Guo
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences, Sloan Kettering Institute Cornell University, New York, New York, USA
    Nat Rev Mol Cell Biol 5:816-26. 2004
    ..The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs...
  2. pmc Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration
    Sotiris N Nikolopoulos
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Box 216, 1275 York Avenue, New York, New York 10021, USA
    Mol Cell Biol 25:6090-102. 2005
    ..These findings provide evidence that beta4 signaling promotes epidermal growth and wound healing through a previously unrecognized effect on nuclear translocation of NF-kappaB and mitogen-activated protein kinases...
  3. ncbi request reprint Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis
    Wenjun Guo
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    Cell 126:489-502. 2006
    ..These results indicate that beta 4 integrin promotes tumor progression by amplifying ErbB2 signaling and identify beta 4 as a potential target for molecular therapy of breast cancer...
  4. pmc p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow
    Anxo Vidal
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:6890-5. 2005
    ..This article documents the role of these molecules in angiogenesis and further suggests that cell expansion and mobilization from the bone marrow of angiogenic precursors are separable events...
  5. ncbi request reprint Integrin beta4 signaling promotes tumor angiogenesis
    Sotiris N Nikolopoulos
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Cell 6:471-83. 2004
    ..These results provide genetic evidence that alpha6beta4 signaling promotes the onset of the invasive phase of pathological angiogenesis and hence identify a novel target for antiangiogenic therapy...
  6. ncbi request reprint Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression
    Yuliya Pylayeva
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, and Sloan Kettering Division, Weill Graduate School of Medical Sciences, Cornell University, New York, New York, USA
    Methods Enzymol 426:439-61. 2007
    ..In this chapter, we describe a collection of cell biological and genetic methods that may aid in characterizing the roles of integrin signals in mammary tumorigenesis...