Jun ming Guo

Summary

Publications

  1. pmc Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells
    Cheng Jiang
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Breast Cancer Res 9:R77. 2007
  2. ncbi request reprint Effects of daidzein on estrogen-receptor-positive and negative pancreatic cancer cells in vitro
    Jun ming Guo
    School of Medicine, Ningbo University, Ningbo 315211, Zhejiang Province, China
    World J Gastroenterol 10:860-3. 2004
  3. doi request reprint Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues
    Junming Guo
    Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China
    J Gastroenterol Hepatol 24:652-7. 2009
  4. doi request reprint Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells
    Junming Guo
    School of Medicine, Ningbo University, Ningbo, China
    Cancer Invest 26:369-74. 2008
  5. ncbi request reprint Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation
    Jun ming Guo
    Ningbo University School of Medicine, Ningbo 315211, China
    Acta Pharmacol Sin 28:1991-5. 2007
  6. ncbi request reprint Detecting carcinoma cells in peripheral blood of patients with hepatocellular carcinoma by immunomagnetic beads and rt-PCR
    Junming Guo
    Ningbo University School of Medicine, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Clin Gastroenterol 41:783-8. 2007
  7. ncbi request reprint Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin
    Junming Guo
    School of Medicine, Ningbo University, Ningbo, China
    Cancer Biol Ther 6:85-8. 2007
  8. ncbi request reprint The effects of all-trans-retinoic acid on cell cycle and alkaline phosphatase activity in pancreatic cancer cells
    J M Guo
    Ningbo University School of Medicine, Ningbo 315211, China
    Med Chem 2:457-61. 2006
  9. ncbi request reprint Suppression of telomerase activity and arrest at G1 phase in human cervical cancer HeLa cells by all-trans retinoic acid
    J M Guo
    School of Medicine, Ningbo University, Ningbo 315211, China
    Int J Gynecol Cancer 16:341-6. 2006
  10. ncbi request reprint Effect of daidzein on cell growth, cell cycle, and telomerase activity of human cervical cancer in vitro
    J M Guo
    School of Medicine, Ningbo University, Ningbo, China
    Int J Gynecol Cancer 14:882-8. 2004

Collaborators

Detail Information

Publications34

  1. pmc Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells
    Cheng Jiang
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Breast Cancer Res 9:R77. 2007
    ..Because the ER and the androgen receptor belong to the steroid receptor superfamily, we examined whether these compounds affected ER expression and signaling in breast cancer cells...
  2. ncbi request reprint Effects of daidzein on estrogen-receptor-positive and negative pancreatic cancer cells in vitro
    Jun ming Guo
    School of Medicine, Ningbo University, Ningbo 315211, Zhejiang Province, China
    World J Gastroenterol 10:860-3. 2004
    ..To study the effects of daidzein on human pancreatic cancer cells in vitro...
  3. doi request reprint Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues
    Junming Guo
    Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China
    J Gastroenterol Hepatol 24:652-7. 2009
    ..MicroRNAs (miRNAs) play important roles in carcinogenesis. The global miRNA expression profile of gastric cancer has not been reported. The purpose of the present study was to determine the miRNA expression profile of gastric cancer...
  4. doi request reprint Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells
    Junming Guo
    School of Medicine, Ningbo University, Ningbo, China
    Cancer Invest 26:369-74. 2008
    ..More importantly, aloe-emodin inhibited the expressions of protein kinase C and c-myc. In conclusion, the anticancer effect of aloe-emodin on gastric cancer cells involves suppression of c-myc expression...
  5. ncbi request reprint Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation
    Jun ming Guo
    Ningbo University School of Medicine, Ningbo 315211, China
    Acta Pharmacol Sin 28:1991-5. 2007
    ..The aim of this study was to investigate the effects of aloe-emodin, a natural compound from the root and rhizome of Rheum palmatum, on the growth of human cervical cancer cells, HeLa...
  6. ncbi request reprint Detecting carcinoma cells in peripheral blood of patients with hepatocellular carcinoma by immunomagnetic beads and rt-PCR
    Junming Guo
    Ningbo University School of Medicine, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Clin Gastroenterol 41:783-8. 2007
    ..Increasing the sensitivity and specificity of detecting circulating carcinoma cells of patients with hepatocellular carcinoma (HCC) is very important for monitoring recurrence...
  7. ncbi request reprint Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin
    Junming Guo
    School of Medicine, Ningbo University, Ningbo, China
    Cancer Biol Ther 6:85-8. 2007
    ..These results indicate that aloe-emodin has a potential value for the treatment of gastric cancer and its mechanisms are by means of cell cycle interruption and induce differentiation...
  8. ncbi request reprint The effects of all-trans-retinoic acid on cell cycle and alkaline phosphatase activity in pancreatic cancer cells
    J M Guo
    Ningbo University School of Medicine, Ningbo 315211, China
    Med Chem 2:457-61. 2006
    ..In conclusion, ATRA has an inhibitory effect on the cell growth of MiaPaCa-2, and its tumor suppressive effect is by means of cell cycle arrest and apoptosis induction...
  9. ncbi request reprint Suppression of telomerase activity and arrest at G1 phase in human cervical cancer HeLa cells by all-trans retinoic acid
    J M Guo
    School of Medicine, Ningbo University, Ningbo 315211, China
    Int J Gynecol Cancer 16:341-6. 2006
    ..Our results provide a possible mechanistic explanation for the growth inhibitory effect of ATRA on HeLa cells. Therefore, retinoids may have therapeutic potential to complement current treatments of cervical cancers...
  10. ncbi request reprint Effect of daidzein on cell growth, cell cycle, and telomerase activity of human cervical cancer in vitro
    J M Guo
    School of Medicine, Ningbo University, Ningbo, China
    Int J Gynecol Cancer 14:882-8. 2004
    ..These meant that daidzein affected human nonhormone-dependent cervical cancer cells in several ways, including cell growth, cell cycle, and telomerase activity in vitro...
  11. ncbi request reprint Combined use of positive and negative immunomagnetic isolation followed by real-time RT-PCR for detection of the circulating tumor cells in patients with colorectal cancers
    Junming Guo
    School of Medicine, Ningbo University, 315211, Ningbo, China
    J Mol Med (Berl) 82:768-74. 2004
    ..Applying negative and positive immunomagnetic beads successively yields the highest correlation with amount of tumor cells...
  12. ncbi request reprint Biphasic effect of daidzein on cell growth of human colon cancer cells
    J M Guo
    School of Medicine, Ningbo University, Ningbo 315211, China
    Food Chem Toxicol 42:1641-6. 2004
    ..These results indicate that daidzein has a biphasic effect on LoVo cell growth and its tumor suppressive effect is by means of cell cycle arrest and apoptosis but not through cell differentiation...
  13. ncbi request reprint [Gene studies and nobel prize]
    Jun ming Guo
    School of Medicine, Ningbo University, Zhengjiang Province, Ningbo 315211, China
    Yi Chuan 27:101-9. 2005
    ....
  14. ncbi request reprint Detection of cytokeratin 20 mRNA in the peripheral blood of patients with colorectal cancer by immunomagnetic bead enrichment and real-time reverse transcriptase-polymeras chain reaction
    Junming Guo
    School of Medicine, Ningbo University, Ningbo 315211, China
    J Gastroenterol Hepatol 20:1279-84. 2005
    ..This method is based on a combination of isolation of epithelial cell by a combination of negative and positive immunomagnetic beads with detection of cytokeratin 20 (CK20) mRNA by reverse transcriptase-polymeras chain reaction (RT-PCR)...
  15. ncbi request reprint Suppression of CDK2 expression by siRNA induces cell cycle arrest and cell proliferation inhibition in human cancer cells
    Xiang E Long
    School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo 315211, People s Republic of China
    BMB Rep 43:291-6. 2010
    ..These results demonstrate that suppression of CDK2 activity by RNAi may be an effective strategy for gene therapy in human cancers...
  16. ncbi request reprint Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cells
    De Jian Dai
    Department of Surgery, Second Affiliated Hospital of Zhejiang University Medical School, Hangzhou, Zhejiang Province, China
    World J Gastroenterol 11:193-9. 2005
    ..To evaluate the effects of survivin on cell proliferation and apoptosis in liver cancer...
  17. doi request reprint piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells
    Jia Cheng
    Ningbo University School of Medicine, Ningbo, China
    Clin Chim Acta 412:1621-5. 2011
    ..They are involved in germline development, in silencing of selfish DNA elements, and in maintaining germline DNA integrity. The relationship between piRNAs and carcinogenesis has not been shown yet...
  18. doi request reprint Glutamic acid decarboxylase epitope protects against autoimmune diabetes through activation of Th2 immune response and induction of possible regulatory mechanism
    Zhaohui Gong
    Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo 315211, China
    Vaccine 28:4052-8. 2010
    ..This study demonstrates the CTB-3p531 fusion protein protects against autoimmune diabetes by generation of regulatory T cells and induction of immunological tolerance...
  19. doi request reprint Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance
    Yuanyuan Zhang
    Ningbo University School of Medicine, 315211, Ningbo, China
    Med Oncol 27:685-9. 2010
    ..This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer...
  20. ncbi request reprint Detecting AFP mRNA in peripheral blood of the patients with hepatocellular carcinoma, liver cirrhosis and hepatitis
    Feng Yao
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Clin Chim Acta 361:119-27. 2005
    ..The low frequency of disseminated carcinoma cells in the blood now makes immunomagnetic bead sorting and reverse transcriptase-polymerase chain reaction (RT-PCR) technique more popular...
  21. doi request reprint Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker
    Hui Zhou
    Ningbo University School of Medicine, Ningbo 315211, China
    J Mol Med (Berl) 88:709-17. 2010
    ..684 (p = 0.0066), 0.743 (p = 0.0001), and 0.741 (p = 0.0002), respectively. Our results indicate that the detection of miRNA in peripheral blood may be a novel tool for monitoring circulating tumor cells in patients with gastric cancers...
  22. doi request reprint Increased expression of miR-421 in human gastric carcinoma and its clinical association
    Zhen Jiang
    Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China
    J Gastroenterol 45:17-23. 2010
    ..The purpose of this study was to investigate the relationships between miR-421 expression patterns in human gastric cancer tissues with clinicopathological features...
  23. pmc Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest
    Long Zhu Li
    Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China
    World J Gastroenterol 18:79-83. 2012
    ..To investigate the growth effects of 4-phenyl butyric acid (PBA) on human gastric carcinoma cells and their mechanisms...
  24. doi request reprint Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide
    Ying Miao
    The Affiliated Ningbo No 2 Hospital, Ningbo University School of Medicine, Ningbo, 315010, China
    Med Oncol 27:785-90. 2010
    ..This study suggests that induction of cell-cycle arrest participates in the anticancer activity of LBP on gastric cancer cells...
  25. doi request reprint Detection of miR-106a in gastric carcinoma and its clinical significance
    Bingxiu Xiao
    Ningbo University, School of Medicine, Ningbo 315211, China
    Clin Chim Acta 400:97-102. 2009
    ..miRNA-106a (miR-106a) has oncogenic activity in humans, and often has altered expression. The clinical significance of miR-106a in the diagnosis of gastric carcinoma is poorly understood...
  26. doi request reprint Cloning, expression, purification and characterization of the cholera toxin B subunit and triple glutamic acid decarboxylase epitopes fusion protein in Escherichia coli
    Zhaohui Gong
    School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo 315211, China
    Protein Expr Purif 66:191-7. 2009
    ..The results presented here demonstrate that the bacteria bioreactor is an ideal production system for an oral protein vaccine designed to develop immunological tolerance against autoimmune diabetes...
  27. ncbi request reprint Antitumor effects of all-trans-retinoic acid on cultured human pancreatic cancer cells
    Junming Guo
    Ningbo University School of Medicine, Ningbo, China
    J Gastroenterol Hepatol 21:443-8. 2006
    ..The aim of the present study was to determine the inhibitory effects of all-trans-retinoic acid (ATRA) on cell growth, cell cycle and alkaline phosphatase (ALP) activity in the human pancreatic cancer cell line PANC-1 in vitro...
  28. ncbi request reprint [Acting mechanisms and research methods of long noncoding RNAs]
    Tian Xia
    Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo, China
    Yi Chuan 35:269-80. 2013
    ..e., fast predictions of RNA and protein interactions and domains (catRAPID), chromatin isolation by RNA purification (ChIRP), and combined knockdown and localization analysis of non-coding RNAs (c-KLAN)...
  29. ncbi request reprint [Antitumor effects and the mechanism of two kinds of bromophenols from marine algae]
    Xue Sun
    Faculty of Life Sciences and Biotechnology, Key Laboratory of Marine Biotechnology, Ningbo University, Ningbo 315211, China
    Zhongguo Zhong Yao Za Zhi 35:1173-6. 2010
    ..To investigate the antitumor effects of two kinds of bromophenols isolated from marine algae Rhodomela confervoides on three tumor cells of Hela, MGC and BGC-823 and their antitumor mechanism in vitro...
  30. ncbi request reprint Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells
    Bingxiu Xiao
    School of Medicine, Ningbo University, Ningbo 315211, China
    Oral Oncol 43:905-10. 2007
    ..These results indicate that aloe-emodin has anti-cancer effect on oral cancer, which may lead to its use in chemotherapy and chemopreventment of oral cancer...
  31. ncbi request reprint [Effect of microRNA on proliferation of human tongue carcinoma Tca8113 cells]
    Bing Xiu Xiao
    Department of Histology and Embryology, School of Medicine, Ningbo University, Ningbo Zhejiang 315211, China
    Zhonghua Kou Qiang Yi Xue Za Zhi 45:152-4. 2010
    ..To investigate the effects of microRNA (miRNA) on proliferation of cultured human squamous cell carcinoma of tongue Tca8113 cells...
  32. doi request reprint Increase in cytosolic calcium maintains plasma membrane integrity through the formation of microtubule ring structure in apoptotic cervical cancer cells induced by trichosanthin
    Ping Wang
    Medical School, Ningbo University, Ningbo 315211, China
    Cell Biol Int 33:1149-54. 2009
    ..The data suggest that TCS-elevated [Ca(2+)]c maintains plasma membrane integrity via the formation of the MT ring structure in apoptotic HeLa cells...
  33. ncbi request reprint [Effect of survivin targeting on cell proliferation and apoptosis in pancreatic cancer cells]
    De Jian Dai
    Department of Surgery, Lihuili Hospital of Ningbo Medical Center, Ningbo University Medical School, Ningbo 315040, China
    Zhonghua Yi Xue Za Zhi 84:1894-8. 2004
    ..To investigate the effects of antisense survivin-Lip compound on pancreatic cancer cell proliferation and apoptosis and its mechanism...
  34. ncbi request reprint [Effect of inhibiting survivin expression with antisense oligodeoxynucleotides on sensitivity of hepatocellular carcinoma cell lines HepG2 and HepG2/ADM to adriamycin]
    De Jian Dai
    Department of General Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P R China
    Ai Zheng 24:951-7. 2005
    ..This study was to investigate the effect of inhibiting survivin expression with ASODN on sensitivity of hepatocellular carcinoma cell lines HepG2 and HepG2/ADM to Adriamycin (ADM)...