Marcelo E Guerin

Summary

Publications

  1. pmc Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria
    Marcelo E Guerin
    Unidad de Biofisica, Centro Mixto Consejo Superior de Investigaciones Cientificas Universidad del País Vasco Euskal Herriko Unibertsitatea, Leioa, Bizkaia 48940, Spain
    J Biol Chem 285:33577-83. 2010
  2. pmc Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis
    Marcelo E Guerin
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 284:21613-25. 2009
  3. pmc New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis
    Marcelo E Guerin
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 284:25687-96. 2009
  4. pmc Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria
    David Giganti
    From the Unidad de Biofísica, Consejo Superior de Investigaciones Científicas Universidad del País Vasco Euskal Herriko Unibertsitatea, Barrio Sarriena s n, Leioa, Bizkaia 48940, Spain
    J Biol Chem 288:29797-808. 2013
  5. pmc Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis
    Petra Gest
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 168, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:1121-4. 2008
  6. pmc Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis
    Devinder Kaur
    Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523 1682, USA
    Adv Appl Microbiol 69:23-78. 2009
  7. pmc Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria
    Saioa Urresti
    Unidad de Biofisica, Centro Mixto Consejo Superior de Investigaciones Cientificas Universidad del País Vasco Euskal Herriko Unibertsitatea, Barrio Sarriena s n, Leioa, Bizkaia, 48940, Spain
    J Biol Chem 287:24649-61. 2012
  8. pmc Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria
    Devinder Kaur
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    PLoS ONE 4:e5447. 2009
  9. doi request reprint Structure-function relationships of membrane-associated GT-B glycosyltransferases
    David Albesa-Jové
    Unidad de Biofisica, Centro Mixto Consejo Superior de Investigaciones Científicas Universidad del País Vasco Euskal Herriko Unibertsitatea CSIC, UPV EHU, Barrio Sarriena s n, Leioa, Bizkaia 48940, Spain
    Glycobiology 24:108-24. 2014
  10. pmc Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli
    María de la Paz Santangelo
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 286:40219-31. 2011

Collaborators

Detail Information

Publications10

  1. pmc Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria
    Marcelo E Guerin
    Unidad de Biofisica, Centro Mixto Consejo Superior de Investigaciones Cientificas Universidad del País Vasco Euskal Herriko Unibertsitatea, Leioa, Bizkaia 48940, Spain
    J Biol Chem 285:33577-83. 2010
    ....
  2. pmc Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis
    Marcelo E Guerin
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 284:21613-25. 2009
    ..The proposed mechanism has implications for the comprehension of the peripheral membrane-binding GTs at the molecular level...
  3. pmc New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis
    Marcelo E Guerin
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 284:25687-96. 2009
    ..The essentiality of these three enzymes emphasizes the interest of novel anti-tuberculosis drugs targeting the initial steps of PIM biosynthesis...
  4. pmc Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria
    David Giganti
    From the Unidad de Biofísica, Consejo Superior de Investigaciones Científicas Universidad del País Vasco Euskal Herriko Unibertsitatea, Barrio Sarriena s n, Leioa, Bizkaia 48940, Spain
    J Biol Chem 288:29797-808. 2013
    ..Based on these results and on our previous experimental data, we propose a model wherein the conformational transitions are important for the mannosyltransferase to interact with the donor and acceptor substrates/membrane. ..
  5. pmc Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis
    Petra Gest
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 168, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:1121-4. 2008
    ..85, b = 98.85, c = 127.64 A, and diffracted to 2.6 A resolution. GpgS-UDP complex crystals belonged to space group I4, with unit-cell parameters a = 98.32, b = 98.32, c = 127.96 A, and diffracted to 3.0 A resolution...
  6. pmc Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis
    Devinder Kaur
    Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523 1682, USA
    Adv Appl Microbiol 69:23-78. 2009
    ..In this review, the laboratory personnel who have been the focal point of some to these developments review recent progress towards a comprehensive understanding of the basic physiology and functions of the cell wall of M. tuberculosis...
  7. pmc Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria
    Saioa Urresti
    Unidad de Biofisica, Centro Mixto Consejo Superior de Investigaciones Cientificas Universidad del País Vasco Euskal Herriko Unibertsitatea, Barrio Sarriena s n, Leioa, Bizkaia, 48940, Spain
    J Biol Chem 287:24649-61. 2012
    ..This model of action may be applicable to a broad range of GT-A glycosyltransferases...
  8. pmc Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria
    Devinder Kaur
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    PLoS ONE 4:e5447. 2009
    ..Towards defining the roles of these polysaccharides in mycobacterial physiology, we generated knock-out mutations of genes in their putative biosynthetic pathways...
  9. doi request reprint Structure-function relationships of membrane-associated GT-B glycosyltransferases
    David Albesa-Jové
    Unidad de Biofisica, Centro Mixto Consejo Superior de Investigaciones Científicas Universidad del País Vasco Euskal Herriko Unibertsitatea CSIC, UPV EHU, Barrio Sarriena s n, Leioa, Bizkaia 48940, Spain
    Glycobiology 24:108-24. 2014
    ....
  10. pmc Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli
    María de la Paz Santangelo
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 286:40219-31. 2011
    ..Altogether, our results highlight the potential of FBA-tb as a novel therapeutic target against both replicating and non-replicating bacilli...