Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human researchAdam J Guastella
Brain and Mind Research Institute, University of Sydney, Sydney 2006, Australia Electronic address
Psychoneuroendocrinology 38:612-25. 2013
..We hope that these recommendations assist in establishing a scientific standard that can improve the rigor and subsequent reliability of reported effects of oxytocin nasal spray in humans...
Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorderHelen Christensen
Centre for Mental Health Research, The Australian National University, Canberra, Australia
Trials 11:48. 2010
..This study aims to determine the effectiveness of a web-based program for treating GAD relative to sertraline and attention placebo...
- Arginine Vasopressin selectively enhances recognition of sexual cues in male humans
Adam J Guastella
Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, NSW, Australia
Psychoneuroendocrinology 36:294-7. 2011
..They further extend animal and human genetic studies linking Arginine Vasopressin to sexual behavior in males. Findings suggest an important cognitive mechanism that could enhance sexual behaviors in humans...
- Intranasal arginine vasopressin enhances the encoding of happy and angry faces in humans
Adam J Guastella
Brain and Mind Research Institute, University of Sydney, Sydney, Australia
Biol Psychiatry 67:1220-2. 2010
..There has been little research in humans exploring its effect on social cognition, including the encoding of social memories...
- Does oxytocin influence the early detection of angry and happy faces?
Adam J Guastella
Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
Psychoneuroendocrinology 34:220-5. 2009
..Oxytocin may have greater influence in altering the cognitive processing of social valence at more conceptual and elaborate levels of processing...
- Biased attentional processing of positive stimuli in social anxiety disorder: an eye movement study
Nigel T M Chen
Brain and Mind Research Institute, University of Sydney, Sydney, Australia
Cogn Behav Ther 41:96-107. 2012
..No differential pattern of engagement was evident between groups. We conclude that social anxiety is maintained in part by the aberrant processing of positive social stimuli...
- A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
Adam J Guastella
School of Psychology, University of New South Wales, Sydney, Australia
Psychoneuroendocrinology 34:917-23. 2009
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- Effects of oxytocin on human social approach measured using intimacy equilibriums
Jean C J Liu
School of Psychology, University of New South Wales, Sydney, Australia
Horm Behav 62:585-91. 2012
..Based on this notion, our results suggest that oxytocin does not facilitate social approach by increasing the intimacy equilibrium between two strangers...
- Reduced eye gaze explains "fear blindness" in childhood psychopathic traits
Mark R Dadds
School of Psychology, University of New South Wales, Sydney, Australia
J Am Acad Child Adolesc Psychiatry 47:455-63. 2008
..This study tested whether psychopathic traits are associated with reduced attention to the eye region of other people's faces...
- Oxytocin enhances the encoding of positive social memories in humans
Adam J Guastella
Brain and Mind Research Institute, University of New South Wales, Sydney, Australia
Biol Psychiatry 64:256-8. 2008
..In nonhuman mammals, oxytocin has a critical role in social recognition and the development of long-term bonds. There has been limited research evaluating effects of oxytocin on the encoding and recognition of faces in humans...
- Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus
Dean S Carson
Brain and Mind Research Institute, University of Sydney, NSW, Australia
Addict Biol 15:448-63. 2010
..Overall, these results give further insight into the way in which oxytocin might moderate compulsive behaviors and demonstrate the capacity of peripherally administered oxytocin to induce widespread central effects...
- Thoughts of death or suicidal ideation are common in young people aged 12 to 30 years presenting for mental health care
Elizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
BMC Psychiatry 12:234. 2012
..This study determines the socio-demographic, psychopathological and illness-stage correlates of suicidal ideation in young persons attending headspace services...
- Applying clinical staging to young people who present for mental health care
Ian B Hickie
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health Centre for Youth Mental Health, University of Melbourne Orygen Youth Health Research Centre, Melbourne, Victoria, Australia School of Psychology, University of Birmingham, Edgbaston, UK
Early Interv Psychiatry 7:31-43. 2013
..Conclusion: Among young people presenting for mental health care, most are clinically staged as having 'attenuated syndromes'. Despite access to specialized treatment, a significant number progress to more severe or persistent disorders...
- Clinical staging model applied to young people presenting with social anxiety
Patrick J F Clarke
Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
Early Interv Psychiatry 6:256-64. 2012
..The goal was to provide a detailed description of common clinical stage of those presenting for treatment of social anxiety, and to delineate the associations between symptom type, severity and clinical stage...
- A critical review of the influence of oxytocin nasal spray on social cognition in humans: evidence and future directions
Adam J Guastella
Brain and Mind Research Institute, University of Sydney, 2050, Australia
Horm Behav 61:410-8. 2012
..This should now be a major focus for future research. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior...
- Acute effects of intranasal oxytocin on subjective and behavioral responses to social rejection
Gail A Alvares
Brain and Mind Research Institute, University of Sydney, NSW, Australia
Exp Clin Psychopharmacol 18:316-21. 2010
..The results suggest that in an explicitly aversive context, oxytocin does not buffer against the immediate impact of blunt social rejection...
- Distinguishing young people with emerging bipolar disorders from those with unipolar depression
Elizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
J Affect Disord 144:208-15. 2013
..To facilitate early intervention, there is a need to distinguish unipolar versus bipolar illness trajectories in adolescents and young adults with adult-type mood disorders...
- Prepared for the best: readiness to modify attentional processing and reduction in anxiety vulnerability in response to therapy
Patrick J F Clarke
Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
Emotion 12:487-94. 2012
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- Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders
Adam J Guastella
Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
Biol Psychiatry 67:692-4. 2010
..Deficits in the ability to recognize the emotions of others are believed to contribute to this. There is currently no effective treatment for these problems...
- Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats
Dean S Carson
Brain and Mind Research Institute, University of Sydney, Australia
Neuropharmacology 58:38-43. 2010
..These results point to the potential utility of human trials of oxytocin as a therapeutic treatment for methamphetamine addiction...
- A role for autonomic cardiac control in the effects of oxytocin on social behavior and psychiatric illness
Daniel S Quintana
SCAN Research and Teaching Unit, School of Psychology, The University of Sydney Sydney, NSW, Australia Brain and Mind Research Institute, The University of Sydney Sydney, NSW, Australia
Front Neurosci 7:48. 2013
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- A meta-analysis on the impact of alcohol dependence on short-term resting-state heart rate variability: implications for cardiovascular risk
Daniel S Quintana
School of Psychology, University of Sydney, Sydney, NSW, Australia
Alcohol Clin Exp Res 37:E23-9. 2013
..However, prior studies on the impact of alcohol dependence on HRV have reported contradictory findings highlighting the need for a meta-analysis...
- Oxytocin increases heart rate variability in humans at rest: implications for social approach-related motivation and capacity for social engagement
Andrew H Kemp
School of Psychology, University of Sydney, Sydney, New South Wales, Australia
PLoS ONE 7:e44014. 2012
..Furthermore, no studies have examined the impact of OT on HRV under resting conditions, which provides an index of maximal capacity for social engagement...
- Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males
Gail A Alvares
Brain and Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW 2050, Australia
Psychoneuroendocrinology 37:2022-31. 2012
..It adds to a growing body of evidence that oxytocin seems to attenuate negative cognitive responses to stress in anxious individuals...
- Heart rate variability is associated with emotion recognition: direct evidence for a relationship between the autonomic nervous system and social cognition
Daniel S Quintana
SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia
Int J Psychophysiol 86:168-72. 2012
..Our data suggests that increased HRV may provide a novel marker of one's ability to recognize emotions in humans. Implications for understanding the biological basis of emotion recognition, and social impairment in humans are discussed...
- Exploring the role of intra-nasal oxytocin on the partner preference effect in humans
Jean C J Liu
School of Psychology, University of New South Wales, Sydney, New South Wales, Australia
Psychoneuroendocrinology 38:587-91. 2013
..Taken together, our findings suggest that oxytocin might not promote human bond formation in ways analogous to prairie voles - that is, by inducing a partner preference effect...
- Oxytocin as a moderator of hypnotizability
Richard A Bryant
School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia
Psychoneuroendocrinology 37:162-6. 2012
..This is the first demonstration of a neurochemical basis for hypnotic responding, and points to a potential neural mechanism to explain hypnotizability...
- A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder
Adam J Guastella
School of Psychology, University of New South Wales, Sydney, Australia
Biol Psychiatry 63:544-9. 2008
..The aim of this study was to determine whether 50 mg of DCS enhances ET for social anxiety disorder (SAD) according to a comprehensive set of symptom and life impairment measures...
Oxytocin increases gaze to the eye region of human facesAdam J Guastella
School of Psychology, University of New South Wales, Kensington, Sydney, Australia
Biol Psychiatry 63:3-5. 2008
..In humans, oxytocin has been found to enhance trust and the ability to interpret the emotions of others. It has been suggested that oxytocin may enhance facial processing by increasing focus on the eye region of human faces...
- Targeted primary care-based mental health services for young Australians
Elizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, Sydney, NSW
Med J Aust 196:136-40. 2012
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