Xiaoping Gu

Summary

Publications

  1. ncbi request reprint The efficacy of NMDA receptor antagonists for preventing remifentanil-induced increase in postoperative pain and analgesic requirement: a meta-analysis
    Y Liu
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu Province, China
    Minerva Anestesiol 78:653-67. 2012
  2. pmc Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model
    Xiaoping Gu
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Mol Pain 6:64. 2010
  3. pmc Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model
    Yu E Sun
    Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu Province, China
    PLoS ONE 7:e39897. 2012
  4. ncbi request reprint Intrathecal injection of JWH015 attenuates remifentanil-induced postoperative hyperalgesia by inhibiting activation of spinal glia in a rat model
    Yu E Sun
    From the Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu Province, China
    Anesth Analg 118:841-53. 2014
  5. doi request reprint Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit
    Yaguo Zheng
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Brain Res Bull 87:427-31. 2012
  6. doi request reprint The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain
    Xiaoping Gu
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, 210008 Jiangsu Province, China
    Eur J Pain 14:496-502. 2010
  7. doi request reprint Intrathecal administration of the cannabinoid 2 receptor agonist JWH015 can attenuate cancer pain and decrease mRNA expression of the 2B subunit of N-methyl-D-aspartic acid
    Xiaoping Gu
    Department of Anesthesiology, Drum Tower Hospital, Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Anesth Analg 113:405-11. 2011
  8. doi request reprint Intrathecal administration of roscovitine attenuates cancer pain and inhibits the expression of NMDA receptor 2B subunit mRNA
    Rui Zhang
    Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Pharmacol Biochem Behav 102:139-45. 2012
  9. ncbi request reprint Activation of GRs-Akt-nNOs-NR2B signaling pathway by second dose GR agonist contributes to exacerbated hyperalgesia in a rat model of radicular pain
    Jing Zhang
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, People s Republic of China
    Mol Biol Rep 41:4053-61. 2014
  10. pmc Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats
    Weibin Xie
    Drum Tower Clinical College of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
    PLoS ONE 7:e45575. 2012

Collaborators

Detail Information

Publications12

  1. ncbi request reprint The efficacy of NMDA receptor antagonists for preventing remifentanil-induced increase in postoperative pain and analgesic requirement: a meta-analysis
    Y Liu
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu Province, China
    Minerva Anestesiol 78:653-67. 2012
    ..Meta-analysis was performed to evaluate the preventive effects of N-methyl-D-aspartate (NMDA) receptor antagonists on remifentanil-induced increase in postoperative pain and analgesic requirement in patients...
  2. pmc Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model
    Xiaoping Gu
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Mol Pain 6:64. 2010
    ..Therefore, in the present study, we investigated the effect of thalidomide on bone cancer-induced hyperalgesia and up-regulated expression of spinal TNF-α in a mouse model...
  3. pmc Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model
    Yu E Sun
    Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu Province, China
    PLoS ONE 7:e39897. 2012
    ..This study sought to investigate whether selective MR antagonist spironolactone develop antinociceptive effects on radicular pain by inhibition neuroinflammation induced by spinal microglia activation...
  4. ncbi request reprint Intrathecal injection of JWH015 attenuates remifentanil-induced postoperative hyperalgesia by inhibiting activation of spinal glia in a rat model
    Yu E Sun
    From the Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu Province, China
    Anesth Analg 118:841-53. 2014
    ..In this study, we used a selective cannabinoid receptor type 2 (CB2) agonist JWH015 to investigate remifentanil-induced postoperative hyperalgesia...
  5. doi request reprint Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit
    Yaguo Zheng
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Brain Res Bull 87:427-31. 2012
    ..Our data also provide evidence that dexmedetomidine's anti-hyperalgesic effect may depend on its ability to modulate spinal cord NMDAR activation via suppression of NR2B phosphorylation...
  6. doi request reprint The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain
    Xiaoping Gu
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, 210008 Jiangsu Province, China
    Eur J Pain 14:496-502. 2010
    ..The findings may lead to novel strategies for the treatment of bone cancer pain...
  7. doi request reprint Intrathecal administration of the cannabinoid 2 receptor agonist JWH015 can attenuate cancer pain and decrease mRNA expression of the 2B subunit of N-methyl-D-aspartic acid
    Xiaoping Gu
    Department of Anesthesiology, Drum Tower Hospital, Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Anesth Analg 113:405-11. 2011
    ..Our previous study showed that the 2B subunit of N-methyl-D-aspartate (NR2B) receptor in the spinal cord participates in bone cancer pain in mice. In the present study, we also tested the cannabinoid effect on the expression of NR2B...
  8. doi request reprint Intrathecal administration of roscovitine attenuates cancer pain and inhibits the expression of NMDA receptor 2B subunit mRNA
    Rui Zhang
    Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Pharmacol Biochem Behav 102:139-45. 2012
    ..These results suggest that roscovitine may be a useful adjunct therapy for bone cancer pain, and NR2B in spinal cord may participate in this effect...
  9. ncbi request reprint Activation of GRs-Akt-nNOs-NR2B signaling pathway by second dose GR agonist contributes to exacerbated hyperalgesia in a rat model of radicular pain
    Jing Zhang
    Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, People s Republic of China
    Mol Biol Rep 41:4053-61. 2014
    ..GRs activated spinal Akt-nNOS/NR2B pathway play important roles in the development of neuropathic pain in a time-dependent manner...
  10. pmc Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats
    Weibin Xie
    Drum Tower Clinical College of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
    PLoS ONE 7:e45575. 2012
    ..In this study, we investigated the protective effects of senegenin, an component of Polygala tenuifolia root extracts, on cognitive dysfunction induced by hepatic ischemia-reperfusion...
  11. doi request reprint The respective and interaction effects of spinal GRs and MRs on radicular pain induced by chronic compression of the dorsal root ganglion in the rat
    Xiaoping Gu
    Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Jiangsu Province, China
    Brain Res 1396:88-95. 2011
    ..Spironolactone can enhance the analgesic effects of dexamethasone via complex mechanisms...
  12. pmc Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine
    Xiaoping Gu
    Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Mol Pain 5:76. 2009
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