Jian Wei Gu

Summary

Publications

  1. pmc EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression
    Jian Wei Gu
    Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Vasc Cell 5:9. 2013
  2. pmc Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice
    Jian Wei Gu
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA
    Cancer Biol Ther 11:910-7. 2011
  3. pmc SU11248, a selective tyrosine kinases inhibitor suppresses breast tumor angiogenesis and growth via targeting both tumor vasculature and breast cancer cells
    Emily Young
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi USA
    Cancer Biol Ther 10:703-11. 2010
  4. ncbi request reprint Long-term high salt diet causes hypertension and alters renal cytokine gene expression profiles in Sprague-Dawley rats
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center Jackson, Mississippi 39216, USA
    Beijing Da Xue Xue Bao 41:505-15. 2009
  5. ncbi request reprint Cytokine gene expression profiles in kidney medulla and cortex of obese hypertensive dogs
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Kidney Int 66:713-21. 2004
  6. pmc Increased plasma levels of soluble vascular endothelial growth factor receptor 1 (sFlt-1) in women by moderate exercise and increased plasma levels of vascular endothelial growth factor in overweight/obese women
    Kristina L Makey
    Cancer Institute, and Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Eur J Cancer Prev 22:83-9. 2013
  7. ncbi request reprint Increased expression of vascular endothelial growth factor and capillary density in hearts of spontaneously hypertensive rats
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Microcirculation 11:689-97. 2004
  8. ncbi request reprint Exercise increases soluble vascular endothelial growth factor receptor-1 (sFlt-1) in circulation of healthy volunteers
    Amelia Purser Bailey
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Med Sci Monit 12:CR45-50. 2006
  9. pmc Exercise increases endostatin in circulation of healthy volunteers
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    BMC Physiol 4:2. 2004
  10. ncbi request reprint Renal NF-kappaB activation and TNF-alpha upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1817-24. 2006

Collaborators

Detail Information

Publications16

  1. pmc EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression
    Jian Wei Gu
    Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Vasc Cell 5:9. 2013
    ....
  2. pmc Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice
    Jian Wei Gu
    Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA
    Cancer Biol Ther 11:910-7. 2011
    ....
  3. pmc SU11248, a selective tyrosine kinases inhibitor suppresses breast tumor angiogenesis and growth via targeting both tumor vasculature and breast cancer cells
    Emily Young
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi USA
    Cancer Biol Ther 10:703-11. 2010
    ....
  4. ncbi request reprint Long-term high salt diet causes hypertension and alters renal cytokine gene expression profiles in Sprague-Dawley rats
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center Jackson, Mississippi 39216, USA
    Beijing Da Xue Xue Bao 41:505-15. 2009
    ..The present study examines whether a long-term high salt diet causes hypertension and renal injury in normal subjects [Sprague-Dawley (SD) rats] and alters renal cytokine-related gene expression profiles...
  5. ncbi request reprint Cytokine gene expression profiles in kidney medulla and cortex of obese hypertensive dogs
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Kidney Int 66:713-21. 2004
    ..The molecular mechanisms linking abnormal kidney function and obesity hypertension are poorly understood. This study compared gene expression profiles in the kidney medulla and cortex of obese and lean dogs...
  6. pmc Increased plasma levels of soluble vascular endothelial growth factor receptor 1 (sFlt-1) in women by moderate exercise and increased plasma levels of vascular endothelial growth factor in overweight/obese women
    Kristina L Makey
    Cancer Institute, and Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Eur J Cancer Prev 22:83-9. 2013
    ....
  7. ncbi request reprint Increased expression of vascular endothelial growth factor and capillary density in hearts of spontaneously hypertensive rats
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Microcirculation 11:689-97. 2004
    ....
  8. ncbi request reprint Exercise increases soluble vascular endothelial growth factor receptor-1 (sFlt-1) in circulation of healthy volunteers
    Amelia Purser Bailey
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Med Sci Monit 12:CR45-50. 2006
    ..We hypothesize that exercise increases circulating sFlt-1, an endogenous VEGF inhibitor, which may functionally decrease plasma levels of free VEGF...
  9. pmc Exercise increases endostatin in circulation of healthy volunteers
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    BMC Physiol 4:2. 2004
    ..We hypothesize that exercise can elevate the circulatory endostatin level. Hence, exercise can protect against one of the mechanisms of atherosclerosis...
  10. ncbi request reprint Renal NF-kappaB activation and TNF-alpha upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1817-24. 2006
    ..These findings support the hypothesis that activation of NF-kappaB and upregulation of TNF-alpha are the important renal mechanisms linking proinflammatory response to SS hypertension...
  11. ncbi request reprint Ethanol stimulates tumor progression and expression of vascular endothelial growth factor in chick embryos
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Cancer 103:422-31. 2005
    ..The mechanisms by which alcohol consumption causes cancer have not been established due to a lack of experimental studies...
  12. ncbi request reprint Tissue endostatin correlates inversely with capillary network in rat heart and skeletal muscles
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Angiogenesis 9:93-9. 2006
    ....
  13. pmc Obesity promotes melanoma tumor growth: role of leptin
    Elizabeth L Brandon
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
    Cancer Biol Ther 8:1871-9. 2009
    ..Although tumor growth does not require host leptin, melanoma tumor growth may be accelerated by leptin...
  14. ncbi request reprint Chronic alcohol consumption stimulates VEGF expression, tumor angiogenesis and progression of melanoma in mice
    Wei Tan
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Cancer Biol Ther 6:1211-7. 2007
    ..01). These results suggest that progression of melanoma growth and angiogenesis may be mediated by upregulation of VEGF and Flt-1, especially under the influence of EtOH...
  15. pmc Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy
    Jian Wei Gu
    University of Mississippi Cancer Institute, Jackson, MS, USA
    Vasc Cell 4:7. 2012
    ..Understanding how Notch interacts with other factors that control endothelial cell functions and angiogenesis in cancers could pave the way to innovative therapeutic strategies that simultaneously target angiogenesis and CSC...
  16. pmc Vascular endothelial growth factor receptor inhibitor enhances dietary salt-induced hypertension in Sprague-Dawley rats
    Jian Wei Gu
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 297:R142-8. 2009
    ..These results suggest that VEGF receptor inhibition enhances dietary salt-induced hypertension and kidney injury, possibly by direct damage on renal cells and decreasing NO production by eNOS...