The role of the kallikrein-kinin system genes in the salt sensitivity of blood pressure: the GenSalt StudyDongfeng Gu
Department of Evidence Based Medicine, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China
Am J Epidemiol 176:S72-80. 2012
..0004 to 0.002). In summary, genetic variants of the genes involved in the regulation of KKS may contribute to the salt sensitivity of blood pressure...
- Association between polymorphisms in the adiponectin gene and cardiovascular disease: a meta-analysis
Huan Zhang
State Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine and Division of Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China
BMC Med Genet 13:40. 2012
..The aim of this study was to access the relationship between three single nucleotide polymorphisms (SNPs), +45 T > G (rs2241766), +276 G > T (rs1501299) and -11377 C > G (rs266729) in ADIPOQ and CVD...
- Classical risk factors of cardiovascular disease among Chinese male steel workers: a prospective cohort study for 20 years
Jingfeng Ji
Department of Evidence Based Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
BMC Public Health 11:497. 2011
..Cardiovascular disease (CVD) constitutes a major public health problem in China and worldwide. We aimed to examine classical risk factors and their magnitudes for CVD in a Chinese cohort with over 20 years follow-up...
- Blood pressure, body mass index and risk of cardiovascular disease in Chinese men and women
Hongwei Wang
Department of Evidence Based Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
BMC Public Health 10:189. 2010
..We tested it using a data set collected from a large cohort of Chinese adults...
- The future impact of population growth and aging on coronary heart disease in China: projections from the Coronary Heart Disease Policy Model-China
Andrew Moran
Division of General Internal Medicine, Columbia University Medical Center, New York, USA
BMC Public Health 8:394. 2008
..China will experience an overall growth and aging of its adult population in coming decades. We used a computer model to forecast the future impact of these demographic changes on coronary heart disease (CHD) in China...
- Functional analysis of the C-reactive protein (CRP) gene -717A>G polymorphism associated with coronary heart disease
Laiyuan Wang
Department of Evidence Based Medicine and Division of Population Genetics, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
BMC Med Genet 10:73. 2009
..In the present study, we tried to investigate the biological significance of this genetic variation in vitro...
- Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population
Chong Shen
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College P eople s Republic of China, NO, 167 BeiLiShi Rd, Beijing 100037, PR China
BMC Med Genet 10:118. 2009
..Recently relevant advances urge further researches to investigate the role of Emilin1 gene in regulating TGF-beta signals involved in elastogenesis and vascular cell defects of essential hypertension (EH)...
Incidence and predictors of hypertension over 8 years among Chinese men and womenDongfeng Gu
The Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
J Hypertens 25:517-23. 2007
..To determine the 8-year incidence of hypertension and its risk factors among Chinese adults...
Mortality attributable to smoking in ChinaDongfeng Gu
Department of Evidence Based Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
N Engl J Med 360:150-9. 2009
..Smoking is a risk factor for many diseases and has been increasingly prevalent in economically developing regions of the world. We aimed to estimate the number of deaths attributable to smoking in China...
- Haplotypic analyses of the aldosterone synthase gene CYP11B2 associated with stage-2 hypertension in northern Han Chinese
D Gu
Division of Population Genetics and Prevention, Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing
Clin Genet 66:409-16. 2004
..60 (95% CI, 1.21-5.58) and for 3-3, 0.20 (95% CI, 0.03-0.77). These results indicate that the Lys173 and the IC-conversion allele of the CYP11B2 gene confer an increased risk for stage-2 hypertension in northern Han Chinese women...
- Blood pressure and risk of cardiovascular disease in Chinese men and women
Dongfeng Gu
Department of Evidence Based Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Diseases, Beijing, China
Am J Hypertens 21:265-72. 2008
..We examined the relationship between systolic and diastolic blood pressure (BP) and the incidence of cardiovascular disease (CVD) in a nationally representative cohort of 169,871 men and women > or = 40 years of age in China...
- Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese
Dongfeng Gu
Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Hypertension 47:1147-54. 2006
..These findings support the multigenic nature of the etiology of essential hypertension and propose a potential gene-gene interactive model for future studies...
- Linkage analysis of 2q14-q23 and 5q32 with blood pressure quantitative traits in Chinese sib pairs
Dongliang Ge
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
J Hypertens 21:305-10. 2003
..The current study aimed to examine the linkage of qualitative and blood pressure quantitative traits in essential hypertension with these genomic regions in a large sample of Chinese hypertensive families...
- Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension
Dongfeng Gu
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
J Hypertens 24:1049-56. 2006
..2, with essential hypertension in a northern Han Chinese population...
- [Study on the relationship between methylenetetrahydrofolate reductase gene C677T mutation and coronary heart disease]
X Wang
Department of Population Genetics and Prevention, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037 P R China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18:206-8. 2001
..To investigate whether methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism is linked with coronary heart disease (CHD)...
- beta2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese
D Ge
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China
Ann Hum Genet 69:36-44. 2005
..001). These results indicate that the Gly16 and Gln27 alleles of the ADRB2 gene confer an increased risk for stage-2 hypertension in this northern Han Chinese population...
- Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese
W Huang
Bioinformatics Laboratory and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
J Hum Hypertens 20:968-71. 2006
- Effect of potassium supplementation on blood pressure in Chinese: a randomized, placebo-controlled trial
D Gu
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR
J Hypertens 19:1325-31. 2001
..Our findings suggest that increased potassium intake may play an important role in the prevention and treatment of hypertension in China...
- Association analysis of the variant in the regulatory subunit of phosphoinositide 3-kinase (p85alpha) with Type 2 diabetes mellitus and hypertension in the Chinese Han population
S Chen
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Diabet Med 22:737-43. 2005
..To determine whether variants in the gene for the regulatory subunit of phosphoinositide 3-kinase (p85alpha) are associated with Type 2 diabetes mellitus (Type 2 DM) and hypertension in a Chinese population...
- Gender-specific association between the kininogen 1 gene variants and essential hypertension in Chinese Han population
Weiyan Zhao
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
J Hypertens 27:484-90. 2009
..Kininogens serve as the precursors of potent vasoactive kinin peptides and also function as cysteine proteinase inhibitors...
- Linkage analysis of chromosome 1 with essential hypertension and blood pressure quantitative traits in Chinese families
D Ge
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China
Ann Hum Genet 69:45-54. 2005
..42). These findings suggest linkage of 1p31 with essential hypertension in the ethnic Chinese, and provide a potential clue for future studies involving candidate genes for hypertension...
- Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese
Yaping Wang
Division of Population Genetics and Prevention, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China
Ann Hum Genet 70:778-83. 2006
..001). A total of 6 haplotypes were observed in the entire population, with the haplotypes L-V-A and R-A-A being found to be significantly related to hypertension (P= 0.001)...
- Polymorphisms of tumor necrosis factor alpha gene and coronary heart disease in a Chinese Han population: interaction with cigarette smoking
Liping Hou
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, People s Republic of China
Thromb Res 123:822-6. 2009
..Relationship between polymorphisms in TNF-alpha gene and coronary heart disease (CHD) has been reported, but remains a controversial one...
- Hypertension and cardiovascular diseases intervention in the capital steel and iron company and Beijing Fangshan community
J Chen
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China
Obes Rev 9:142-5. 2008
..These data show the value and effectiveness of combining a population and high-risk strategy for controlling blood pressure and cardiovascular diseases in both a rural setting and in the work place in China...
- A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population
Laiyuan Wang
Department of Evidence Based Medicine, Division of Population Genetics, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Clin Sci (Lond) 115:151-8. 2008
..These results provide evidence for an association of the functional intronic rs2070762 with essential hypertension...
- Renalase gene is a novel susceptibility gene for essential hypertension: a two-stage association study in northern Han Chinese population
Qi Zhao
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
J Mol Med (Berl) 85:877-85. 2007
..These findings may provide novel genetic susceptibility markers for EH and lead to a better understanding of EH pathophysiology. In addition, further replications in other populations and functional studies would be warranted...
- Extensive association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese Han population
Xiaoling Wang
Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
Arterioscler Thromb Vasc Biol 23:328-34. 2003
..An extensive association analysis of PON gene cluster (PONs) with coronary heart disease (CHD) was performed in Chinese Han population...
- Interactions among genetic variants from contractile pathway of vascular smooth muscle cell in essential hypertension susceptibility of Chinese Han population
Qi Zhao
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
Pharmacogenet Genomics 18:459-66. 2008
..This study aimed to explore the individual and interactive effects of five genes from the contractile pathway of VSMC (KCNMB1, RGS2, PRKG, ROCK2, and MYLK) on the risk of essential hypertension...
- Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population
Xiaoli Liu
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China
Atherosclerosis 208:421-6. 2010
..Our results suggested that the INSIG1 gene was associated with CHD; there might be potential interactive effect on CHD among genes from SREBP2 activating-related pathway; and the SREBP2 gene might be associated with plasma lipid level...
- Common variation in KLKB1 and essential hypertension risk: tagging-SNP haplotype analysis in a case-control study
Xiangfeng Lu
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, People s Republic of China
Hum Genet 121:327-35. 2007
..Our findings suggested that common genetic variation in the KLKB1 gene might contribute to the risk of hypertension in the northern Han Chinese population...
- Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population
Li Yun
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China
Clin Exp Hypertens 31:534-43. 2009
..No association was observed between the HMOX2 gene and EH. The multifactor-dimensionality reduction analyses results did not show any interaction between the HMOX1 and HMOX2 genes underlying the development of hypertension...
- Prevalence and risk factors of prehypertension among Chinese adults
Dahai Yu
Department of Evidence Based Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
J Cardiovasc Pharmacol 52:363-8. 2008
..We aimed to estimate the prevalence of prehypertension and to identify its risk factors among Chinese adults...
- The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study
Xiaoli Liu
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular, Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, 100037, China
Thromb Haemost 100:886-92. 2008
..74 +/- 2.03 mM) than AA genotype carriers (5.45 +/- 1.37 mM, p = 0.015). The present study indicated that the INSIG1 gene, but not the INSIG2 gene, was associated with CHD in the Chinese population...
- Peroxisome proliferator-activated receptor-gamma coactivator-1alpha polymorphism is not associated with essential hypertension and type 2 diabetes mellitus in Chinese population
Shufeng Chen
Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
Hypertens Res 27:813-20. 2004
..In conclusion, these results indicated that these two variations in the PGC-1alpha gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here...
- Association between prehypertension and clustering of cardiovascular disease risk factors among Chinese adults
Dahai Yu
Department of Evidence Based Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
J Cardiovasc Pharmacol 53:388-400. 2009
..We aimed to estimate the association between prehypertension (PHT) and clustering of cardiovascular disease (CVD) risk factors among Chinese adults...
- Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population
Xiaoyang Zhou
Division of Population Genetics, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, PR China
Thromb Res 113:181-6. 2004
..We investigated a possible association between the N700S polymorphism and MI in a Chinese Han population...
- Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese
Weili Yan
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Obes Res 12:1733-7. 2004
..48; 95% confidence interval, 1.14 approximately 1.91; p = 0.003). Polymorphism 1243 in the PLIN gene did not seem to be associated with HO but with TC levels in Chinese. The PLIN gene may be involved in human lipid metabolism...
- Prevalence of isolated systolic and isolated diastolic hypertension subtypes in China
Jianfeng Huang
Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China
Am J Hypertens 17:955-62. 2004
..CONCLUSIONS: These data document high rates of ISH in China. Given the risk of cardiovascular disease associated with ISH, our findings underscore the critical need for enhanced hypertension screening and treatment programs in China...
- Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA)
D Gu
Cardiovascular Institute and Fuwai Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Diabetologia 46:1190-8. 2003
..These results indicate that diabetes has become a major public health problem in China and underscore the need for national strategies aimed at prevention and treatment of diabetes...
- [Job strain and hypertension risk in Capital Steel and Iron Company in Beijing]
X Xin
Fuwai Hospital Cardiovascular Institute, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100037, China
Zhonghua Yi Xue Za Zhi 81:1110-2. 2001
..31 (1.45, 3.81). Such a phenomenon was not typical among females. CONCLUSION: The risk of hypertension was elevated with the increase of job strain in men...
- Polymorphisms of MMP-2 gene are associated with systolic heart failure risk in Han Chinese
Yihong Hua
Department of Cardiology, Fu Wai Hospital, Beijing, China
Am J Med Sci 337:344-8. 2009
..MMP-2 has been demonstrated to play a pivotal role in myocardial remodeling process that occurs in congestive heart failure (HF). We hypothesized that MMP-2 genetic variations could be associated with systolic HF risk...
- Prehypertension and risk of cardiovascular disease in Chinese adults
Dongfeng Gu
Department of Evidence Based Medicine, Cardiovascular Institute, Fu Wai Hospital of the Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
J Hypertens 27:721-9. 2009
..To examine the excess risks associated with prehypertension and absolute benefit of treatment...
- Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese
Xiaoling Wang
Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Int J Mol Med 13:445-50. 2004
..The results illustrate the complexity of polymorphism-phenotype associations. The observed interactions constitute concrete examples of gene-environment and environment-environment interactions...
- Lipoprotein lipase gene polymorphisms and blood pressure levels in the Northern Chinese Han population
Biao Li
Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China
Hypertens Res 27:373-8. 2004
....
- Angiotensin II type I receptor gene and myocardial infarction: tagging SNPs and haplotype based association study. The Beijing atherosclerosis study
Shaoyong Su
The Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China
Pharmacogenetics 14:673-81. 2004
..The present study aimed to assess the effect of haplotype variation in angiotensin II type I receptor (AGTR1) gene on the risk of myocardial infarction (MI) in Chinese males...
- Plasminogen activator inhibitor-1 gene: selection of tagging single nucleotide polymorphisms and association with coronary heart disease
Shaoyong Su
Division of Population Genetics and Prevention, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Arterioscler Thromb Vasc Biol 26:948-54. 2006
..To explore the effect of plasminogen activator inhibitor-1 (PAI-1) gene variations on the risk of coronary heart disease (CHD) in Chinese Han population...
- Associations of PLA2G7 gene polymorphisms with plasma lipoprotein-associated phospholipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis study
Liping Hou
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, 100037 Beijing, China
Hum Genet 125:11-20. 2009
..Lp-PLA(2) activity appears to influence the CHD and MI risk in Chinese Han population...
- Polymorphisms in the GNB3 and ADD1 genes and blood pressure in a Chinese population
Shufeng Chen
Division of Population Genetics, Department of Evidence Based Medicine, Cardiovascular Institute, Fu Wai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 167 Beilishi Road, Beijing, 100037, China
Hum Genet 128:137-43. 2010
..In summary, these data support a role for the GNB3 gene in BP regulation in the Chinese population. Future studies aimed at replicating these novel findings are warranted...
- Haplotype analysis of the stromelysin-1 (MMP3) and gelatinase B (MMP9) genes in relation to coronary heart disease
Naqiong Wu
Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No 167 Beilishi Road, Beijing, China
Ann Hum Genet 73:404-10. 2009
..Our study suggests that common genetic variations in the MMP3 gene may affect the risk of CHD in the Chinese population...
- A coding polymorphism of the kallikrein 1 gene is associated with essential hypertension: a tagging SNP-based association study in a Chinese Han population
Weiyan Zhao
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
J Hypertens 25:1821-7. 2007
..The aim of this study was to investigate the association between common variants in the human tissue kallikrein 1 (KLK1) gene and susceptibility to essential hypertension in Chinese Han...
- Prevalence of cardiovascular disease risk factor clustering among the adult population of China: results from the International Collaborative Study of Cardiovascular Disease in Asia (InterAsia)
Dongfeng Gu
Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medial College, Beijing, China
Circulation 112:658-65. 2005
..CONCLUSIONS: Clustering of CVD risk factors is common in China. Prevention, detection, and treatment of CVD risk factor clustering should be an important component of a national strategy to reduce the increasing burden of CVD in China...
- Association study of the thrombomodulin -33G>A polymorphism with coronary artery disease and myocardial infarction in Chinese Han population
Jiangong Zhao
Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road 167, Beijing 100037, China
Int J Cardiol 100:383-8. 2005
..We investigated this polymorphism in northern Han Chinese...
- Linkage and linkage disequilibrium analysis of the lipoprotein lipase gene with lipid profiles in Chinese hypertensive families
Wenjie Yang
Division of Population Genetics and Prevention, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China
Clin Sci (Lond) 108:137-42. 2005
..Replication studies both in Chinese and other populations are warranted to confirm these results...
- Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study
Xiaoyang Zhou
Division of Popluation Genetics and Prevention, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Thromb Haemost 92:867-73. 2004
..We conclude that the MMP3 -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering MI...
- Prevalence, awareness, treatment, and control of hypertension in china
Dongfeng Gu
Cardiovascular Institute and Fuwai Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Hypertension 40:920-7. 2002
..These results underscore the urgent need to develop national strategies to improve prevention, detection, and treatment of hypertension in China...
- Lipoprotein lipase gene is in linkage with blood pressure phenotypes in Chinese pedigrees
Wenjie Yang
Division of Population Genetics and Prevention, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, 100037, Beijing, China
Hum Genet 115:8-12. 2004
..The LPL gene itself might explain our results or the LPL gene region might harbor some genes to explain the observed results to some degree and might contribute to the variation of BP in the Chinese population...
- Body weight and mortality among men and women in China
Dongfeng Gu
Cardiovascular Institute and Fu Wai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China
JAMA 295:776-83. 2006
..The effect of underweight and obesity on mortality has not been well characterized in Asian populations...
- Variation near the region of the lipoprotein lipase gene and hypertension or blood pressure levels in Chinese
Wenjie Yang
Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P R China
Hypertens Res 26:459-64. 2003
....
- [Evaluation on the effect of cardiovascular prevention program in Fangshan, Beijing]
D Gu
Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Collage, Beijing 100037, China
Zhonghua Liu Xing Bing Xue Za Zhi 22:424-7. 2001
..CONCLUSION: The comprehensive community prevention approach was feasible and effective in the prevention and control of cardiovascular diseases in rural populations in China...
- Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis
X Liang
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Diabet Med 28:455-63. 2011
..To assess the effect of mobile phone intervention on glycaemic control in diabetes self-management...
- Genetic susceptibility loci for essential hypertension and blood pressure on chromosome 17 in 147 Chinese pedigrees
Fangyi Gu
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
J Hypertens 22:1511-8. 2004
..82 for qualitative trait using GENEHUNTER. CONCLUSIONS: In the southern population of China, our results demonstrate that a 7-cM interval region flanked by D17S831 (7 cM) and D17S938 (15 cM) is suggestively linked with hypertension...
- Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population
Xiaoyang Zhou
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 BeiLiShi Rd, Beijing 100037, People s Republic of China
Clin Sci (Lond) 106:495-500. 2004
..Additional investigations should be performed in populations at different risk of coronary events in order to elucidate further the possible contribution of this polymorphism to cardiovascular disease...
- Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure
Dongfeng Gu
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China
J Hypertens 28:1210-20. 2010
..To examine the association between renin-angiotensin-aldosterone system (RAAS) genes and salt sensitivity of blood pressure (BP)...
- Relationship between body mass index and major cardiovascular diseases in Chinese population
Dongfeng Gu
Division of Population Genetic and Prevention, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Zhonghua Yi Xue Za Zhi 82:1018-21. 2002
..The BMI values of 25 kg/m(2) and 28 kg/m(2) can be recommended as thresholds of overweight and obesity for Chinese adults aged >/=18 respectively...
- Polymorphisms of MMP-2 gene are associated with systolic heart failure prognosis
Yihong Hua
Department of Cardiology, Fu Wai Hospital, Beijing, People s Republic of China
Clin Chim Acta 404:119-23. 2009
..MMP-2 is a proteolytic enzyme involved in myocardial remodeling that occurs in congestive heart failure (HF). We hypothesized MMP-2 genetic variations could influence the prognosis of systolic HF...
- -717A>G polymorphism of human C-reactive protein gene associated with coronary heart disease in ethnic Han Chinese: the Beijing atherosclerosis study
Jianhong Chen
Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, 100037 Beijing, China
J Mol Med (Berl) 83:72-8. 2005
....
- Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population
Wei Yang
Division of Population Genetics and Prevention, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, People's Republic of China
Clin Sci (Lond) 111:333-40. 2006
..In conclusion, the results of the present study indicate that common genetic variants in the ACE2 gene might impact on MI in females, and may possibly interact with alcohol consumption to affect the risk of CHD and MI in Chinese males...
- The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population
Zhiyu Zeng
Center for Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Cardiology 108:97-103. 2007
..1% respectively, OR = 1.66, p = 0.044). We provided the frequencies of non-synonymous SNPs of KCNQ1 and KCNE1 in Chinese population; none of these SNPs was associated with AF. But KCNE4 E145D may be associated with the AF phenotype...
- Heritability of blood pressure responses to dietary sodium and potassium intake in a Chinese population
Dongfeng Gu
Cardiovascular Institute and Fu Wai Hospital, Beijing, China
Hypertension 50:116-22. 2007
..In addition, the heritabilities of blood pressure responses to dietary sodium and potassium intake were moderate in this study population...
- Association between the metabolic syndrome and chronic kidney disease in Chinese adults
Jing Chen
Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL 45, New Orleans, LA 70112, USA, and the Cardiovascular Institute and Fuwai Hospital, Beijing, China
Nephrol Dial Transplant 22:1100-6. 2007
..The metabolic syndrome is a common risk factor for cardiovascular and chronic kidney disease (CKD) in Western populations. We examined the relationship between the metabolic syndrome and risk of CKD in Chinese adults...
- Prevalence of the metabolic syndrome and overweight among adults in China
Dongfeng Gu
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Lancet 365:1398-405. 2005
..Little information exists on the prevalence of the metabolic syndrome in China. We aimed to provide up-to-date estimates of the prevalence of the metabolic syndrome and overweight in the general adult population in China...
- Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11
Dongfeng Gu
Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Beijing Union Medical College, 167 Beilishi Road, Beijing 100037, China
Hum Genet 110:173-81. 2002
..This establishes that there must be multiple causal sites impacting on weight in this genomic region...
- Cigarette smoking and erectile dysfunction among Chinese men without clinical vascular disease
Jiang He
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
Am J Epidemiol 166:803-9. 2007
..8 million cases) among Chinese men are attributable to cigarette smoking. This 2000-2001 study of Chinese men documented an independent and dose-response relation between cigarette smoking and risk of erectile dysfunction...
- A population-based, prospective study of blood pressure and risk for end-stage renal disease in China
Kristi Reynolds
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, New Orleans, LA 70112, USA
J Am Soc Nephrol 18:1928-35. 2007
..These results document the importance of high BP as a modifiable risk factor for ESRD in China. Strategies to prevent ESRD should incorporate the prevention, treatment, and control of BP...
- Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits
Santiago Rodriguez
Human Genetics Division, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK
Hum Mol Genet 13:715-25. 2004
..The functional element(s) of *5 for weight-lowering could reside in any of the three genes...
- Factors associated with hypertension awareness, treatment, and control in a representative sample of the chinese population
Paul Muntner
Department of Epidemiology, Tulane University, SPHTM 1430 Tulane Avenue, SL 18 New Orleans, LA 70112, USA
Hypertension 43:578-85. 2004
..59; 1.11, 2.27). These data identify potential methods for improving blood pressure control in China through the identification, follow-up, and lifestyle modification of persons with high blood pressure...
- High-density lipoprotein cholesterol levels increase with age, body mass index, blood pressure and fasting blood glucose in a rural Uygur population in China
Weili Yan
Division of Environmental Health, School of Public Health, Xinjiang Medical University, Xinjiang Uygur Autonomous Region, China
J Hypertens 23:1985-9. 2005
..To investigate the distribution of the serum high-density lipoprotein cholesterol (HDLC) levels and its relationship with obesity, hypertension and diabetes in a Uygur case-control study on hypertension...
- Geographic variations in the prevalence, awareness, treatment and control of hypertension in China
Kristi Reynolds
Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
J Hypertens 21:1273-81. 2003
..The previously reported urban-rural difference in the prevalence of hypertension was not noted, perhaps due to a rapid increase in the prevalence of hypertension in rural China...
- Hypertension subtype and risk of cardiovascular disease in Chinese adults
Tanika N Kelly
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
Circulation 118:1558-66. 2008
..We examined the relationship between hypertension subtype and cardiovascular disease incidence and mortality in Chinese adults...
- Prevalence and risk factors of overweight and obesity in China
Kristi Reynolds
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Avenue SL 18, New Orleans, LA 70112, USA
Obesity (Silver Spring) 15:10-8. 2007
..To examine the prevalence and risk factors of overweight and obesity in China...
- Hypertension: its prevalence and population-attributable fraction for mortality from cardiovascular disease in the Asia-Pacific region
Alexandra L C Martiniuk
The George Institute for International Health at the University of Sydney, Australia
J Hypertens 25:73-9. 2007
....
- Alcohol consumption and risk for stroke among Chinese men
Lydia A Bazzano
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112 2715, USA
Ann Neurol 62:569-78. 2007
..Stroke is a leading cause of death and long-term disability in China. The objective of this study was to examine the relation between alcohol consumption and risk for stroke among Chinese men...
- Effect of soybean protein on blood pressure: a randomized, controlled trial
Jiang He
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Avenue, SL 18, New Orleans, LA 70112 2699, USA
Ann Intern Med 143:1-9. 2005
..Epidemiologic studies suggest that vegetable protein intake is inversely related to blood pressure...
- Risk factors for chronic obstructive pulmonary disease mortality in Chinese adults
Kathleen H Reilly
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
Am J Epidemiol 167:998-1004. 2008
..This study indicated that cigarette smoking, low educational level, physical inactivity, and underweight are important modifiable risk factors for chronic obstructive pulmonary disease-related mortality in China...
- Cigarette smoking, systolic blood pressure, and cardiovascular diseases in the Asia-Pacific region
Koshi Nakamura
Nutrition and Lifestyle Division, The George Institute for International Health, PO Box M201, Missenden Road, Camperdown, NSW 2050, Australia
Stroke 39:1694-702. 2008
..If these 2 risk factors have a synergistic impact on cardiovascular events, lowering BP and quitting smoking will contribute more to reducing CVD than would be expected from ignoring their interaction...
- Trends in overweight and obesity in Chinese adults: between 1991 and 1999-2000
Rachel P Wildman
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA
Obesity (Silver Spring) 16:1448-53. 2008
..The aim of this study was to evaluate trends in BMI and the prevalence of overweight (BMI > or = 25 kg/m(2)) and obesity (BMI > or = 30 kg/m(2)) between 1991 and 1999-2000 among Chinese adults...
- Blood pressure and mortality among Chinese patients with cardiovascular disease
Jing Chen
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
J Hypertens 26:859-65. 2008
..To examine the association between blood pressure (BP) and mortality among patients with a history of cardiovascular disease (CVD) in China...
- Major causes of death among men and women in China
Jiang He
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
N Engl J Med 353:1124-34. 2005
..We studied the major causes of death and modifiable risk factors in a nationally representative cohort of 169,871 men and women 40 years of age and older in China...
- Therapeutic lifestyle changes and drug treatment for high blood cholesterol in China and application of the Adult Treatment Panel III guidelines
Paul Muntner
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
Am J Cardiol 96:1260-5. 2005
..3 million (4.1% of adults). In conclusion, most adults in China with an elevated LDL cholesterol remain untreated...
- Are waist circumference and body mass index independently associated with cardiovascular disease risk in Chinese adults?
Rachel P Wildman
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
Am J Clin Nutr 82:1195-202. 2005
..In Western populations, waist circumference (WC) is more predictive of cardiovascular disease (CVD) risk than is body mass index (BMI). It is unclear whether the same is true in Asian populations...
- G protein beta 3 subunit gene variants and essential hypertension in the northern Chinese Han population
Biao Li
Institute of Biophysics, Chinese Academy of Sciences, Datun Road 15, Chaoyang District, Beijing 100101, China
Ann Hum Genet 69:468-73. 2005
....
- Central rather than overall obesity is related to diabetes in the Chinese population: the InterASIA study
Dongsheng Hu
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China
Obesity (Silver Spring) 15:2809-16. 2007
..The objective was to compare central and overall obesity measurements for identifying diabetes mellitus (DM) and impaired fasting glucose (IFG) level in the Chinese population...
- Alcohol intake and hypertension subtypes in Chinese men
Rachel P Wildman
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
J Hypertens 23:737-43. 2005
..To examine the associations between alcohol intake and isolated systolic hypertension (ISH), systolic-diastolic hypertension (SDH), and isolated diastolic hypertension (IDH)...
- Appropriate body mass index and waist circumference cutoffs for categorization of overweight and central adiposity among Chinese adults
Rachel P Wildman
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, USA
Am J Clin Nutr 80:1129-36. 2004
..Recent data suggest that current overweight and central adiposity guidelines based on Western populations are not appropriate for Asian populations. The published data among Chinese are insufficient to address this issue...
- Cigarette smoking and risk of stroke in the chinese adult population
Tanika N Kelly
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Avenue SL18, New Orleans, LA 70112, USA
Stroke 39:1688-93. 2008
..We studied the relationship between cigarette smoking and stroke incidence and mortality in the Chinese adult population...
- Body mass index and risk of ESRD in China
Kristi Reynolds
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
Am J Kidney Dis 50:754-64. 2007
..The relationship between body mass index (BMI) and risk of end-stage renal disease (ESRD) in Asians has not been well established...
- Association between blood pressure responses to the cold pressor test and dietary sodium intervention in a Chinese population
Jing Chen
Department of Medicine, Tulane University School of Medicine, 1443 Tulane Ave SL45, New Orleans, LA 70112, USA
Arch Intern Med 168:1740-6. 2008
..We examined the association between BP responses to the CPT and to dietary sodium and potassium interventions...
