Alexandru Mihai Grumezescu

Summary

Publications

  1. ncbi request reprint Magnetite nanostructures functionalized with cytostatic drugs exhibit great anti-tumoral properties without application of high amplitude alternating magnetic fields
    Georgeta Voicu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:357-62. 2014
  2. ncbi request reprint Biocompatible Fe3O4 increases the efficacy of amoxicillin delivery against Gram-positive and Gram-negative bacteria
    Alexandru Mihai Grumezescu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1 7, 011061 Bucharest, Romania
    Molecules 19:5013-27. 2014
  3. ncbi request reprint Keratin-based biomaterials for biomedical applications
    George Dan Mogoşanu
    Department of Science and Engineering of Oxidice Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1 7 Polizu Street, 011061 Bucharest, Romania
    Curr Drug Targets 15:518-30. 2014
  4. pmc Hybrid nanostructured coating for increased resistance of prosthetic devices to staphylococcal colonization
    Ion Anghel
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street no 1 7, Bucharest 011061, Romania
    Nanoscale Res Lett 8:6. 2013
  5. doi request reprint Hybrid nanomaterial for stabilizing the antibiofilm activity of Eugenia carryophyllata essential oil
    Alexandru Mihai Grumezescu
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, University Politehnica of Bucharest, Bucharest, 011061, Romania
    IEEE Trans Nanobioscience 11:360-5. 2012
  6. pmc Modified wound dressing with phyto-nanostructured coating to prevent staphylococcal and pseudomonal biofilm development
    Ion Anghel
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No, 1 7, Bucharest, 011061, Romania
    Nanoscale Res Lett 7:690. 2012
  7. pmc Optimized Anti-pathogenic Agents Based on Core/Shell Nanostructures and 2-((4-Ethylphenoxy)ethyl)-N-(substituted-phenylcarbamothioyl)-benzamides
    Carmen Limban
    Department of Pharmaceutical Chemistry, Carol Davila University of Medicine and Pharmacy, Traian Vuia no 6, 020956 Bucharest, Romania
    Int J Mol Sci 13:12584-97. 2012
  8. pmc In vitro evaluation of anti-pathogenic surface coating nanofluid, obtained by combining Fe3O4/C12 nanostructures and 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)-benzamides
    Ion Anghel
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, 011061, Romania
    Nanoscale Res Lett 7:513. 2012
  9. pmc Magnetite nanoparticles for functionalized textile dressing to prevent fungal biofilms development
    Ion Anghel
    Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Bucharest, 011061, Romania
    Nanoscale Res Lett 7:501. 2012
  10. ncbi request reprint Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells
    Alexandru Mihai Grumezescu
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxidic Materials and Nanomaterials, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 436:771-7. 2012

Collaborators

  • Ion Anghel
  • Crina Saviuc
  • Chih Hui Yang
  • Yung Sheng Lin
  • Carmen Chifiriuc
  • Veronica Lazar
  • Georgeta Voicu
  • Ecaterina Andronescu
  • Mariana Carmen Chifiriuc
  • Anton Ficai
  • Alina Georgiana Anghel
  • Coralia Bleotu
  • Mihaela Vlad
  • George Dan Mogoşanu
  • Alina Maria Holban
  • Valentina Grumezescu
  • Paul Catalin Balaure
  • Carmen Limban
  • Florin Iordache
  • Mariana Chirea
  • Miruna CodruŢa Stoilescu
  • Alexandra Elena Oprea
  • Livia Elena Crică
  • Lavinia Iuliana Moraru
  • Gabriela Purcel
  • Gabriel Socol
  • Roxana Cristina Popescu
  • Oana Fufă
  • Denisa Ficai
  • Cristina Daniela Ghitulica
  • Keng Shiang Huang
  • Irina Gheorghe
  • Robert Sakizlian
  • Gentiana Predan

Detail Information

Publications21

  1. ncbi request reprint Magnetite nanostructures functionalized with cytostatic drugs exhibit great anti-tumoral properties without application of high amplitude alternating magnetic fields
    Georgeta Voicu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:357-62. 2014
    ..The most significant result was obtained in the case of Epi, where the tested magnetite nanostructured material enhanced the cytotoxic effect of this drug with more than 50%. ..
  2. ncbi request reprint Biocompatible Fe3O4 increases the efficacy of amoxicillin delivery against Gram-positive and Gram-negative bacteria
    Alexandru Mihai Grumezescu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1 7, 011061 Bucharest, Romania
    Molecules 19:5013-27. 2014
    ..Fe3O4@AMO represents also a suitable approach for the development of new alternative strategies for improving the activity of therapeutic agents by targeted delivery and controlled release. ..
  3. ncbi request reprint Keratin-based biomaterials for biomedical applications
    George Dan Mogoşanu
    Department of Science and Engineering of Oxidice Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1 7 Polizu Street, 011061 Bucharest, Romania
    Curr Drug Targets 15:518-30. 2014
    ....
  4. pmc Hybrid nanostructured coating for increased resistance of prosthetic devices to staphylococcal colonization
    Ion Anghel
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street no 1 7, Bucharest 011061, Romania
    Nanoscale Res Lett 8:6. 2013
    ..Our results demonstrate that this dual nanobiosystem is very efficient also for inhibiting biofilm formation, being a good candidate for the design of novel material surfaces used for prosthetic devices...
  5. doi request reprint Hybrid nanomaterial for stabilizing the antibiofilm activity of Eugenia carryophyllata essential oil
    Alexandru Mihai Grumezescu
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, University Politehnica of Bucharest, Bucharest, 011061, Romania
    IEEE Trans Nanobioscience 11:360-5. 2012
    ..carryophyllata EO, which prevented or inhibited the fungal biofilm development on the functionalized catheter, highlighting the opportunity of using these nanosystems to obtain improved, anti-biofilm coatings for biomedical applications...
  6. pmc Modified wound dressing with phyto-nanostructured coating to prevent staphylococcal and pseudomonal biofilm development
    Ion Anghel
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No, 1 7, Bucharest, 011061, Romania
    Nanoscale Res Lett 7:690. 2012
    ..The functionalized surfaces for wound dressing seems to be a very useful tool for the prevention of wound microbial contamination on viable tissues...
  7. pmc Optimized Anti-pathogenic Agents Based on Core/Shell Nanostructures and 2-((4-Ethylphenoxy)ethyl)-N-(substituted-phenylcarbamothioyl)-benzamides
    Carmen Limban
    Department of Pharmaceutical Chemistry, Carol Davila University of Medicine and Pharmacy, Traian Vuia no 6, 020956 Bucharest, Romania
    Int J Mol Sci 13:12584-97. 2012
    ..Using the novel core/shell/adsorption-shell to inhibit the microbial adherence could be of a great interest for the biomedical field, opening new directions for the design of film-coated surfaces with improved anti-biofilm properties...
  8. pmc In vitro evaluation of anti-pathogenic surface coating nanofluid, obtained by combining Fe3O4/C12 nanostructures and 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)-benzamides
    Ion Anghel
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, 011061, Romania
    Nanoscale Res Lett 7:513. 2012
    ..These results could be of a great interest for the biomedical field, opening new directions for the design of film-coated surfaces with improved anti-biofilm properties...
  9. pmc Magnetite nanoparticles for functionalized textile dressing to prevent fungal biofilms development
    Ion Anghel
    Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Bucharest, 011061, Romania
    Nanoscale Res Lett 7:501. 2012
    ....
  10. ncbi request reprint Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells
    Alexandru Mihai Grumezescu
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxidic Materials and Nanomaterials, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 436:771-7. 2012
    ..The obtained systems are not cytotoxic and do not influence the eukaryotic HCT8 cell cycle, representing potential tools for the delivery of drugs in a safe, effective and less expensive manner...
  11. doi request reprint Inhibitory activity of Fe(3) O(4)/oleic acid/usnic acid-core/shell/extra-shell nanofluid on S. aureus biofilm development
    Alexandru Mihai Grumezescu
    Science and Engineering of Oxidic Materialsand Nanomaterials, University Politehnica of Bucharest, Romania
    IEEE Trans Nanobioscience 10:269-74. 2011
    ....
  12. pmc Hybrid magnetite nanoparticles/Rosmarinus officinalis essential oil nanobiosystem with antibiofilm activity
    Carmen Chifiriuc
    Faculty of Applied Chemistry and Materials Science, Politechnica University of Bucharest, Bucharest, Romania
    Nanoscale Res Lett 7:209. 2012
    ..officinalis to inhibit the fungal adherence could be of a great interest for the biomedical field, opening new directions for the design of film-coated surfaces with antibiofilm properties...
  13. doi request reprint Water dispersible cross-linked magnetic chitosan beads for increasing the antimicrobial efficiency of aminoglycoside antibiotics
    Alexandru Mihai Grumezescu
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 454:233-40. 2013
    ..The results obtained in this study recommend these magnetic water dispersible nanocomposite materials for applications in the prevention and treatment of infectious diseases...
  14. ncbi request reprint New silica nanostructure for the improved delivery of topical antibiotics used in the treatment of staphylococcal cutaneous infections
    Alexandru Mihai Grumezescu
    Politehnica University of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 463:170-6. 2014
    ....
  15. doi request reprint Caprolactam-silica network, a strong potentiator of the antimicrobial activity of kanamycin against gram-positive and gram-negative bacterial strains
    Georgeta Voicu
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest 011061, Romania
    Int J Pharm 446:63-9. 2013
    ..The ε-SiO2 network could be feasibly obtained and represents an alternative for the design of new antibiotic drug carriers or delivery systems to control bacterial infections...
  16. doi request reprint Fabrication, characterization and in vitro profile based interaction with eukaryotic and prokaryotic cells of alginate-chitosan-silica biocomposite
    Paul Catalin Balaure
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Organic Chemistry Department, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 441:555-61. 2013
    ....
  17. pmc Biohybrid nanostructured iron oxide nanoparticles and Satureja hortensis to prevent fungal biofilm development
    Ion Anghel
    Otorhinolaryngology, Carol Davila University of Medicine and Pharmacy, Traian Vuia no 6, Bucharest 020956, Romania
    Int J Mol Sci 14:18110-23. 2013
    ..Our data demonstrate that the obtained phytonanocoating improve the resistance of wound dressing surface to C. albicans colonization, which is often an etiological cause of local infections, impairing the appropriate wound healing. ..
  18. ncbi request reprint Anionic polymers and 10nm Fe3O4@UA wound dressings support human foetal stem cells normal development and exhibit great antimicrobial properties
    Alexandru Mihai Grumezescu
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 463:146-54. 2014
    ..The great antimicrobial properties exhibited by the newly synthesized nano-bioactive coatings are recommending them as successful candidates for improving the implanted devices surfaces used in regenerative medicine. ..
  19. ncbi request reprint MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes
    Alina Georgiana Anghel
    ENT, Carol Davila University of Medicine and Pharmacy, Traian Vuia no 6, Bucharest 020956, Romania
    Molecules 19:8981-94. 2014
    ..Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization. ..
  20. ncbi request reprint Carboxymethyl-cellulose/Fe3O4 nanostructures for antimicrobial substances delivery
    Mihaela Vlad
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania
    Biomed Mater Eng 24:1639-46. 2014
    ..The obtained results proved that CMC/Fe3O4/ATBs might be a promising candidate for the development of efficient and cheap antimicrobial drugs carriers under magnetic field...
  21. doi request reprint Efficient surface functionalization of wound dressings by a phytoactive nanocoating refractory to Candida albicans biofilm development
    Ion Anghel
    ENT, Carol Davila University of Medicine and Pharmacy, TraianVuia no 6, Bucharest, 020956, Romania
    Biointerphases 8:11. 2013
    ....