Alexandru Mihai Grumezescu

Summary

Publications

  1. ncbi In vivo evaluation of Fe3O4 nanoparticles
    Roxana Cristina Popescu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:1013-8. 2014
  2. ncbi Methods for synthesizing the macromolecular constituents of smart nanosized carriers for controlled drug delivery
    Paul Catalin Balaure
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Material Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, G Polizu Street 1 7, 011061, Bucharest, Romania
    Curr Med Chem 21:3333-74. 2014
  3. ncbi Prevention of microbial biofilms - the contribution of micro and nanostructured materials
    Alexandru Mihai Grumezescu
    Faculty of Applied Chemistry and Materials Science Politehnica, University of Bucharest Department of Science and Engineering of Oxide Materials and Nanomaterials 1 7 Polizu Street, 011061 Bucharest Romania
    Curr Med Chem 21:3311. 2014
  4. ncbi Silica network improve the effect of fludarabine and paclitaxel on HCT8 cell line
    Georgeta Voicu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:545-51. 2014
  5. ncbi Iron oxide nanoparticles modulate the interaction of different antibiotics with cellular membranes
    Claudia Mihaela Istrate
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:849-56. 2014
  6. ncbi New molecular strategies for reducing implantable medical devices associated infections
    Alina Maria Holban
    Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Department of Science and Engineering of Oxide Materials and Nanomaterials, 1 7 Polizu Street, 011061 Bucharest, Romania
    Curr Med Chem 21:3375-82. 2014
  7. ncbi Prevention of microbial communities: novel approaches based natural products
    George D Mogosanu
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1 7 Polizu Street, 011061 Bucharest, Romania
    Curr Pharm Biotechnol 16:94-111. 2015
  8. ncbi Prosthetic devices with nanostructurated surfaces for increased resistance to microbial colonization
    Alina M Holban
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1 7, 011061 Bucharest, Romania
    Curr Pharm Biotechnol 16:112-20. 2015
  9. ncbi Magnetite nanostructures functionalized with cytostatic drugs exhibit great anti-tumoral properties without application of high amplitude alternating magnetic fields
    Georgeta Voicu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:357-62. 2014
  10. doi Biocompatible Fe3O4 increases the efficacy of amoxicillin delivery against Gram-positive and Gram-negative bacteria
    Alexandru Mihai Grumezescu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1 7, 011061 Bucharest, Romania
    Molecules 19:5013-27. 2014

Collaborators

  • Ion Anghel
  • Crina Saviuc
  • Chih Hui Yang
  • Bianca Galateanu
  • Yung Sheng Lin
  • Carmen Chifiriuc
  • Veronica Lazar
  • Eugenia Kovacs
  • Georgeta Voicu
  • Alina Maria Holban
  • Ecaterina Andronescu
  • Mariana Carmen Chifiriuc
  • Valentina Grumezescu
  • Paul Catalin Balaure
  • Carmen Limban
  • George D Mogosanu
  • Roxana Cristina Popescu
  • Coralia Bleotu
  • George Dan Mogoşanu
  • Anton Ficai
  • Alina M Holban
  • Laurentiu Mogoanta
  • Florin Iordache
  • Alexandra Elena Oprea
  • Anicuta Stoica Guzun
  • Keng Shiang Huang
  • Mihaela Vlad
  • Serban Bertesteanu
  • Gabriel Socol
  • Claudia Mihaela Istrate
  • Bogdan Stefan Vasile
  • Alina Georgiana Anghel
  • Alexey Iordanskii
  • Cornelia Bejenaru
  • Ludovic E Bejenaru
  • Anna Bychkova
  • Greta Cristina Vochiţoaia
  • Bogdan Cristian Nicolae
  • Miron Teodor Caproiu
  • Adrian Gabriel Anghel
  • Alexandru Vasile Missir
  • Livia Elena Crică
  • Oana Fufă
  • Tudor Savopol
  • Raluca Ionela Gavrilă
  • Denisa Ana Maria Jercan
  • Monica Cartelle Gestal
  • Gabriela Purcel
  • Marieta Costache
  • Laurenţiu Morusciag
  • Lavinia Iuliana Moraru
  • Raluca Grigore
  • Roxana Trusca
  • Marta Stroescu
  • Diana Camelia Nuță
  • Mihaela Moisescu
  • Alexandru Grecu
  • Vlad Mihaela
  • Sorin Ion Jinga
  • Atnanasia G Printza
  • Minodora Iordache
  • Thill Marie-Paule
  • Georgiana Crantea
  • Gratiela Pîrcălăbioru
  • Mihaela Badea
  • Miruna CodruŢa Stoilescu
  • Kuete Tchinda
  • Emanoil Bordei
  • Mariana Chirea
  • Irina Gheorghe
  • Cristina Daniela Ghitulica
  • Denisa Ficai
  • Robert Sakizlian
  • Gentiana Predan

Detail Information

Publications32

  1. ncbi In vivo evaluation of Fe3O4 nanoparticles
    Roxana Cristina Popescu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:1013-8. 2014
    ..Several commercial Fe3O4 systems used as contrast agents for medical imaging and cancer treatment by hyperthermia are briefly presented in the last section. ..
  2. ncbi Methods for synthesizing the macromolecular constituents of smart nanosized carriers for controlled drug delivery
    Paul Catalin Balaure
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Material Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, G Polizu Street 1 7, 011061, Bucharest, Romania
    Curr Med Chem 21:3333-74. 2014
    ..Both divergent and convergent approaches to dendrimer synthesis are described along with the therapeutic applications taking advantage of the unique branched tree-like globular structure of dendrimers to treat cancer. ..
  3. ncbi Prevention of microbial biofilms - the contribution of micro and nanostructured materials
    Alexandru Mihai Grumezescu
    Faculty of Applied Chemistry and Materials Science Politehnica, University of Bucharest Department of Science and Engineering of Oxide Materials and Nanomaterials 1 7 Polizu Street, 011061 Bucharest Romania
    Curr Med Chem 21:3311. 2014
    ....
  4. ncbi Silica network improve the effect of fludarabine and paclitaxel on HCT8 cell line
    Georgeta Voicu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:545-51. 2014
    ..These data represent preliminary study on the impact on silica nano-networks in targeted delivery and controlled release of antitumor drugs and they may be efficiently used for future biomedical applications in cancer therapy...
  5. ncbi Iron oxide nanoparticles modulate the interaction of different antibiotics with cellular membranes
    Claudia Mihaela Istrate
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:849-56. 2014
    ....
  6. ncbi New molecular strategies for reducing implantable medical devices associated infections
    Alina Maria Holban
    Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Department of Science and Engineering of Oxide Materials and Nanomaterials, 1 7 Polizu Street, 011061 Bucharest, Romania
    Curr Med Chem 21:3375-82. 2014
    ....
  7. ncbi Prevention of microbial communities: novel approaches based natural products
    George D Mogosanu
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1 7 Polizu Street, 011061 Bucharest, Romania
    Curr Pharm Biotechnol 16:94-111. 2015
    ..In this regard, an interdisciplinary approach is needed due to the large number of natural derivatives alone or in combination with biocompatible and biodegradable micro-/ nano-engineered materials. ..
  8. ncbi Prosthetic devices with nanostructurated surfaces for increased resistance to microbial colonization
    Alina M Holban
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1 7, 011061 Bucharest, Romania
    Curr Pharm Biotechnol 16:112-20. 2015
    ..The main aspects regarding the biocompatibility and the application of these nanomodified prosthetic devices in tissue engineering are also highlighted. ..
  9. ncbi Magnetite nanostructures functionalized with cytostatic drugs exhibit great anti-tumoral properties without application of high amplitude alternating magnetic fields
    Georgeta Voicu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania
    Rom J Morphol Embryol 55:357-62. 2014
    ..The most significant result was obtained in the case of Epi, where the tested magnetite nanostructured material enhanced the cytotoxic effect of this drug with more than 50%. ..
  10. doi Biocompatible Fe3O4 increases the efficacy of amoxicillin delivery against Gram-positive and Gram-negative bacteria
    Alexandru Mihai Grumezescu
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1 7, 011061 Bucharest, Romania
    Molecules 19:5013-27. 2014
    ..Fe3O4@AMO represents also a suitable approach for the development of new alternative strategies for improving the activity of therapeutic agents by targeted delivery and controlled release. ..
  11. ncbi Keratin-based biomaterials for biomedical applications
    George Dan Mogoşanu
    Department of Science and Engineering of Oxidice Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1 7 Polizu Street, 011061 Bucharest, Romania
    Curr Drug Targets 15:518-30. 2014
    ....
  12. pmc Hybrid nanostructured coating for increased resistance of prosthetic devices to staphylococcal colonization
    Ion Anghel
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street no 1 7, Bucharest 011061, Romania
    Nanoscale Res Lett 8:6. 2013
    ..Our results demonstrate that this dual nanobiosystem is very efficient also for inhibiting biofilm formation, being a good candidate for the design of novel material surfaces used for prosthetic devices...
  13. doi Hybrid nanomaterial for stabilizing the antibiofilm activity of Eugenia carryophyllata essential oil
    Alexandru Mihai Grumezescu
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, University Politehnica of Bucharest, Bucharest, 011061, Romania
    IEEE Trans Nanobioscience 11:360-5. 2012
    ..carryophyllata EO, which prevented or inhibited the fungal biofilm development on the functionalized catheter, highlighting the opportunity of using these nanosystems to obtain improved, anti-biofilm coatings for biomedical applications...
  14. pmc Modified wound dressing with phyto-nanostructured coating to prevent staphylococcal and pseudomonal biofilm development
    Ion Anghel
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No, 1 7, Bucharest, 011061, Romania
    Nanoscale Res Lett 7:690. 2012
    ..The functionalized surfaces for wound dressing seems to be a very useful tool for the prevention of wound microbial contamination on viable tissues...
  15. pmc Optimized anti-pathogenic agents based on core/shell nanostructures and 2-((4-ethylphenoxy)ethyl)-N-(substituted-phenylcarbamothioyl)-benzamides
    Carmen Limban
    Department of Pharmaceutical Chemistry, Carol Davila University of Medicine and Pharmacy, Traian Vuia no 6, 020956 Bucharest, Romania
    Int J Mol Sci 13:12584-97. 2012
    ..Using the novel core/shell/adsorption-shell to inhibit the microbial adherence could be of a great interest for the biomedical field, opening new directions for the design of film-coated surfaces with improved anti-biofilm properties...
  16. pmc Magnetite nanoparticles for functionalized textile dressing to prevent fungal biofilms development
    Ion Anghel
    Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Bucharest, 011061, Romania
    Nanoscale Res Lett 7:501. 2012
    ....
  17. doi Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells
    Alexandru Mihai Grumezescu
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxidic Materials and Nanomaterials, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 436:771-7. 2012
    ..The obtained systems are not cytotoxic and do not influence the eukaryotic HCT8 cell cycle, representing potential tools for the delivery of drugs in a safe, effective and less expensive manner...
  18. pmc In vitro evaluation of anti-pathogenic surface coating nanofluid, obtained by combining Fe3O4/C12 nanostructures and 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)-benzamides
    Ion Anghel
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, 011061, Romania
    Nanoscale Res Lett 7:513. 2012
    ..These results could be of a great interest for the biomedical field, opening new directions for the design of film-coated surfaces with improved anti-biofilm properties...
  19. doi Inhibitory activity of Fe(3) O(4)/oleic acid/usnic acid-core/shell/extra-shell nanofluid on S. aureus biofilm development
    Alexandru Mihai Grumezescu
    Science and Engineering of Oxidic Materialsand Nanomaterials, University Politehnica of Bucharest, Romania
    IEEE Trans Nanobioscience 10:269-74. 2011
    ....
  20. pmc Hybrid magnetite nanoparticles/Rosmarinus officinalis essential oil nanobiosystem with antibiofilm activity
    Carmen Chifiriuc
    Faculty of Applied Chemistry and Materials Science, Politechnica University of Bucharest, Bucharest, Romania
    Nanoscale Res Lett 7:209. 2012
    ..officinalis to inhibit the fungal adherence could be of a great interest for the biomedical field, opening new directions for the design of film-coated surfaces with antibiofilm properties...
  21. doi Water dispersible cross-linked magnetic chitosan beads for increasing the antimicrobial efficiency of aminoglycoside antibiotics
    Alexandru Mihai Grumezescu
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 454:233-40. 2013
    ..The results obtained in this study recommend these magnetic water dispersible nanocomposite materials for applications in the prevention and treatment of infectious diseases...
  22. doi Fabrication, characterization and in vitro profile based interaction with eukaryotic and prokaryotic cells of alginate-chitosan-silica biocomposite
    Paul Catalin Balaure
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Organic Chemistry Department, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 441:555-61. 2013
    ....
  23. doi New silica nanostructure for the improved delivery of topical antibiotics used in the treatment of staphylococcal cutaneous infections
    Alexandru Mihai Grumezescu
    Politehnica University of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 463:170-6. 2014
    ....
  24. doi Caprolactam-silica network, a strong potentiator of the antimicrobial activity of kanamycin against gram-positive and gram-negative bacterial strains
    Georgeta Voicu
    Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest 011061, Romania
    Int J Pharm 446:63-9. 2013
    ..The ε-SiO2 network could be feasibly obtained and represents an alternative for the design of new antibiotic drug carriers or delivery systems to control bacterial infections...
  25. pmc Biohybrid nanostructured iron oxide nanoparticles and Satureja hortensis to prevent fungal biofilm development
    Ion Anghel
    Otorhinolaryngology, Carol Davila University of Medicine and Pharmacy, Traian Vuia no 6, Bucharest 020956, Romania
    Int J Mol Sci 14:18110-23. 2013
    ..Our data demonstrate that the obtained phytonanocoating improve the resistance of wound dressing surface to C. albicans colonization, which is often an etiological cause of local infections, impairing the appropriate wound healing. ..
  26. doi Bioevaluation of novel anti-biofilm coatings based on PVP/Fe3O4 nanostructures and 2-((4-ethylphenoxy)methyl)-N- (arylcarbamothioyl)benzamides
    Carmen Limban
    Department of Pharmaceutical Chemistry, Carol Davila University of Medicine and Pharmacy, Traian Vuia no 6, 020956 Bucharest, Romania
    Molecules 19:12011-30. 2014
    ....
  27. doi Anionic polymers and 10 nm Fe₃O₄@UA wound dressings support human foetal stem cells normal development and exhibit great antimicrobial properties
    Alexandru Mihai Grumezescu
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 463:146-54. 2014
    ..The great antimicrobial properties exhibited by the newly synthesized nano-bioactive coatings are recommending them as successful candidates for improving the implanted devices surfaces used in regenerative medicine...
  28. doi MAPLE fabricated Fe3O4@Cinnamomum verum antimicrobial surfaces for improved gastrostomy tubes
    Alina Georgiana Anghel
    ENT, Carol Davila University of Medicine and Pharmacy, Traian Vuia no 6, Bucharest 020956, Romania
    Molecules 19:8981-94. 2014
    ..Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization. ..
  29. doi Carboxymethyl-cellulose/Fe3O4 nanostructures for antimicrobial substances delivery
    Mihaela Vlad
    Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania
    Biomed Mater Eng 24:1639-46. 2014
    ..The obtained results proved that CMC/Fe3O4/ATBs might be a promising candidate for the development of efficient and cheap antimicrobial drugs carriers under magnetic field...
  30. doi Efficient surface functionalization of wound dressings by a phytoactive nanocoating refractory to Candida albicans biofilm development
    Ion Anghel
    ENT, Carol Davila University of Medicine and Pharmacy, TraianVuia no 6, Bucharest, 020956, Romania
    Biointerphases 8:12. 2013
    ....
  31. ncbi Biomedical applications of synthetic, biodegradable polymers for the development of anti-infective strategies
    Serban Bertesteanu
    University of Bucharest, Faculty of Biology, Microbiology Department, Ale Portocalelor 1 3, 60101, Bucharest, Romania
    Curr Med Chem 21:3383-90. 2014
    ..e., antimicrobial and anti-inflammatory agents and vaccines) activity, as well as for the design of biomaterials with increased biocompatibility and resistance to microbial colonization. ..
  32. doi Plackett-Burman experimental design for bacterial cellulose-silica composites synthesis
    Anicuta Stoica Guzun
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Polizu 1 3, Bucharest 011061, Romania
    Mater Sci Eng C Mater Biol Appl 42:280-8. 2014
    ..The antimicrobial behavior on Staphylococcus aureus of BC-silica composites functionalized with usnic acid (UA) was also studied, in order to create improved surfaces with antiadherence and anti-biofilm properties...