Alexandru Mihai Grumezescu



  1. Teleanu D, Chircov C, Grumezescu A, Volceanov A, Teleanu R. Contrast Agents Delivery: An Up-to-Date Review of Nanodiagnostics in Neuroimaging. Nanomaterials (Basel). 2019;9: pubmed publisher
    ..For future directions, several techniques that could benefit from the increased contrast induced by using imaging probes are presented. ..
  2. Teleanu D, Negut I, Grumezescu V, Grumezescu A, Teleanu R. Nanomaterials for Drug Delivery to the Central Nervous System. Nanomaterials (Basel). 2019;9: pubmed publisher
  3. Teleanu D, Chircov C, Grumezescu A, Teleanu R. Neuronanomedicine: An Up-to-Date Overview. Pharmaceutics. 2019;11: pubmed publisher
    ..Additionally, the main challenges and limitations associated with the use of these nanocarriers are briefly presented. ..
  4. Grumezescu A, Gestal M, Holban A, Grumezescu V, Vasile B, Mogoanta L, et al. Biocompatible Fe3O4 increases the efficacy of amoxicillin delivery against Gram-positive and Gram-negative bacteria. Molecules. 2014;19:5013-27 pubmed publisher
    ..Fe3O4@AMO represents also a suitable approach for the development of new alternative strategies for improving the activity of therapeutic agents by targeted delivery and controlled release. ..
  5. Liakos I, Grumezescu A, Holban A. Magnetite nanostructures as novel strategies for anti-infectious therapy. Molecules. 2014;19:12710-26 pubmed publisher
    ..Recent promising applications of MNPs, as the development of delivery nanocarriers and improved nanovehicles for the therapy of different diseases are discussed, together with the mechanisms of microbial inhibition. ..
  6. Teleanu D, Chircov C, Grumezescu A, Teleanu R. Neurotoxicity of Nanomaterials: An Up-to-Date Overview. Nanomaterials (Basel). 2019;9: pubmed publisher
    ..Therefore, the purpose of this review is to emphasize the main neurotoxic effects induced by nanoparticles, liposomes, dendrimers, carbon nanotubes, and quantum dots, as well as the key neurotoxicology assays to evaluate them. ..
  7. Teleanu D, Chircov C, Grumezescu A, Volceanov A, Teleanu R. Blood-Brain Delivery Methods Using Nanotechnology. Pharmaceutics. 2018;10: pubmed publisher
    ..However, the development of nanotechnology-based approaches for brain delivery, such as nanoparticles, liposomes, dendrimers, micelles, and carbon nanotubes, might be the solution for improved brain therapies. ..
  8. Teleanu D, Chircov C, Grumezescu A, Volceanov A, Teleanu R. Impact of Nanoparticles on Brain Health: An Up to Date Overview. J Clin Med. 2018;7: pubmed publisher
    ..The focus of this review is to emphasize both the beneficial and negative effects of nanoparticles on brain health. ..
  9. Negut I, Grumezescu V, Grumezescu A. Treatment Strategies for Infected Wounds. Molecules. 2018;23: pubmed publisher
    ..Silver, gold, and zinc nanoparticles alone or functionalized with diverse antimicrobial compounds have been integrated into wound dressings and demonstrated therapeutic effects on wounds. ..

More Information


  1. Burdușel A, Gherasim O, Grumezescu A, Mogoanta L, Ficai A, Andronescu E. Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview. Nanomaterials (Basel). 2018;8: pubmed publisher
  2. Ficai D, Grumezescu V, Fufă O, Popescu R, Holban A, Ficai A, et al. Antibiofilm Coatings Based on PLGA and Nanostructured Cefepime-Functionalized Magnetite. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..The PLGA/Fe?O?@CEF materials proved significant and sustained anti-biofilm activity against staphylococcal and Escherichia coli colonisation. ..
  3. Balaure P, Grumezescu A. Methods for synthesizing the macromolecular constituents of smart nanosized carriers for controlled drug delivery. Curr Med Chem. 2014;21:3333-74 pubmed
    ..Both divergent and convergent approaches to dendrimer synthesis are described along with the therapeutic applications taking advantage of the unique branched tree-like globular structure of dendrimers to treat cancer. ..
  4. Mogosanu G, Grumezescu A, Huang K, Bejenaru L, Bejenaru C. Prevention of microbial communities: novel approaches based natural products. Curr Pharm Biotechnol. 2015;16:94-111 pubmed
    ..In this regard, an interdisciplinary approach is needed due to the large number of natural derivatives alone or in combination with biocompatible and biodegradable micro-/ nano-engineered materials. ..
  5. Istrate C, Holban A, Grumezescu A, Mogoantă L, Mogoşanu G, Savopol T, et al. Iron oxide nanoparticles modulate the interaction of different antibiotics with cellular membranes. Rom J Morphol Embryol. 2014;55:849-56 pubmed
  6. Popescu R, Andronescu E, Grumezescu A. In vivo evaluation of Fe₃O₄ nanoparticles. Rom J Morphol Embryol. 2014;55:1013-8 pubmed
    ..Several commercial Fe3O4 systems used as contrast agents for medical imaging and cancer treatment by hyperthermia are briefly presented in the last section. ..
  7. Voicu G, Anghel A, Badea M, Bordei E, Crantea G, Gavrilă R, et al. Silica network improve the effect of fludarabine and paclitaxel on HCT8 cell line. Rom J Morphol Embryol. 2014;55:545-51 pubmed
    ..These data represent preliminary study on the impact on silica nano-networks in targeted delivery and controlled release of antitumor drugs and they may be efficiently used for future biomedical applications in cancer therapy. ..
  8. Limban C, Missir A, Grumezescu A, Oprea A, Grumezescu V, Vasile B, et al. Bioevaluation of novel anti-biofilm coatings based on PVP/Fe3O4 nanostructures and 2-((4-ethylphenoxy)methyl)-N- (arylcarbamothioyl)benzamides. Molecules. 2014;19:12011-30 pubmed publisher
  9. Marin S, Vlasceanu G, Tiplea R, Bucur I, Lemnaru M, Marin M, et al. Applications and toxicity of silver nanoparticles: a recent review. Curr Top Med Chem. 2015;15:1596-604 pubmed
    ..The authors report an up to date review related to the toxicity of AgNPs and their applications in antimicrobial activity and biosensors for gene therapy. ..
  10. Mogoşanu G, Grumezescu A, Chifiriuc M. Keratin-based biomaterials for biomedical applications. Curr Drug Targets. 2014;15:518-30 pubmed
  11. Cabuzu D, Cirja A, Puiu R, Grumezescu A. Biomedical applications of gold nanoparticles. Curr Top Med Chem. 2015;15:1605-13 pubmed
  12. Holban A, Gestal M, Grumezescu A. New molecular strategies for reducing implantable medical devices associated infections. Curr Med Chem. 2014;21:3375-82 pubmed
  13. Grumezescu A, Chifiriuc C. Prevention of microbial biofilms - the contribution of micro and nanostructured materials. Curr Med Chem. 2014;21:3311 pubmed
  14. Holban A, Iordanskii A, Grumezescu A, Bychkova A, Andronescu E, Mogoantă L, et al. Prosthetic devices with nanostructurated surfaces for increased resistance to microbial colonization. Curr Pharm Biotechnol. 2015;16:112-20 pubmed
    ..The main aspects regarding the biocompatibility and the application of these nanomodified prosthetic devices in tissue engineering are also highlighted. ..
  15. Chircov C, Grumezescu A, Bejenaru L. Hyaluronic acid-based scaffolds for tissue engineering. Rom J Morphol Embryol. 2018;59:71-76 pubmed
    ..Depending on the processing technique, scaffolds can be prepared in the form of hydrogels, sponges, cryogels, and injectable hydrogels, all discussed in this review. ..
  16. Meliţă E, Purcel G, Grumezescu A. Carbon nanotubes for cancer therapy and neurodegenerative diseases. Rom J Morphol Embryol. 2015;56:349-56 pubmed
    ..Also, we highlight the in vitro and in vivo applications of CNTs-mediated cancer therapy and we will explain why CNTs are used for the treatment of difficult tumors. ..
  17. Popescu R, Grumezescu A. Metal based frameworks for drug delivery systems. Curr Top Med Chem. 2015;15:1532-42 pubmed
    ..Moreover, AuNPs posses special properties which make them useful in concomitant diagnostic by medical imaging and tumor ablation by means of photothermal activation. ..
  18. Bilcu M, Grumezescu A, Oprea A, Popescu R, Mogoşanu G, Hristu R, et al. Efficiency of vanilla, patchouli and ylang ylang essential oils stabilized by iron oxide@C14 nanostructures against bacterial adherence and biofilms formed by Staphylococcus aureus and Klebsiella pneumoniae clinical strains. Molecules. 2014;19:17943-56 pubmed publisher
  19. MogoÅŸanu G, Grumezescu A, Bejenaru C, Bejenaru L. Polymeric protective agents for nanoparticles in drug delivery and targeting. Int J Pharm. 2016;510:419-29 pubmed publisher
  20. Balaure P, Popa R, Grumezescu A, Voicu G, Radulescu M, Mogoanta L, et al. Biocompatible hybrid silica nanobiocomposites for the efficient delivery of anti-staphylococcal drugs. Int J Pharm. 2016;510:532-42 pubmed publisher
  21. Radulescu M, Holban A, Mogoanta L, Bălşeanu T, Mogoşanu G, Savu D, et al. Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications. Molecules. 2016;21: pubmed publisher
    ..The evaluation of antimicrobial potential was evaluated by the viable cell count assay on strains belonging to two clinically relevant bacterial species (i.e., Escherichia coli and Staphylococcus aureus). ..
  22. Liakos I, Grumezescu A, Holban A, Florin I, D Autilia F, Carzino R, et al. Polylactic Acid-Lemongrass Essential Oil Nanocapsules with Antimicrobial Properties. Pharmaceuticals (Basel). 2016;9: pubmed publisher
  23. Popescu R, Fufă M, Grumezescu A. Metal-based nanosystems for diagnosis. Rom J Morphol Embryol. 2015;56:635-49 pubmed
  24. Holban A, Gestal M, Grumezescu A. Control of biofilm-associated infections by signaling molecules and nanoparticles. Int J Pharm. 2016;510:409-18 pubmed publisher
  25. Oprea A, Pandel L, Dumitrescu A, Andronescu E, Grumezescu V, Chifiriuc M, et al. Bioactive ZnO Coatings Deposited by MAPLE-An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces. Molecules. 2016;21: pubmed publisher
  26. Limban C, Missir A, Caproiu M, Grumezescu A, Chifiriuc M, Bleotu C, et al. Novel Hybrid Formulations Based on Thiourea Derivatives and Core@Shell Fe?O?@C18 Nanostructures for the Development of Antifungal Strategies. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..albicans infections. ..
  27. Ion A, Andronescu E, Rădulescu D, Radulescu M, Iordache F, Vasile B, et al. Biocompatible 3D Matrix with Antimicrobial Properties. Molecules. 2016;21:E115 pubmed publisher
    ..Our data strongly recommend the obtained 3D matrix to be used as a successful alternative for the fabrication of three dimensional (3D) anti-infective regeneration matrix for bone tissue engineering. ..
  28. Radulescu M, Andronescu E, Cirja A, Holban A, Mogoanta L, Bălşeanu T, et al. Antimicrobial coatings based on zinc oxide and orange oil for improved bioactive wound dressings and other applications. Rom J Morphol Embryol. 2016;57:107-14 pubmed
  29. Anghel A, Grumezescu A, Chirea M, Grumezescu V, Socol G, Iordache F, et al. MAPLE fabricated Fe3O4@Cinnamomum verum antimicrobial surfaces for improved gastrostomy tubes. Molecules. 2014;19:8981-94 pubmed publisher
    ..Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization. ..
  30. Grumezescu A, Andronescu E, Ficai A, Bleotu C, Mihaiescu D, Chifiriuc M. Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells. Int J Pharm. 2012;436:771-7 pubmed publisher
    ..The obtained systems are not cytotoxic and do not influence the eukaryotic HCT8 cell cycle, representing potential tools for the delivery of drugs in a safe, effective and less expensive manner...
  31. Balaure P, Boarca B, Popescu R, Savu D, Trusca R, Vasile B, et al. Bioactive mesoporous silica nanostructures with anti-microbial and anti-biofilm properties. Int J Pharm. 2017;531:35-46 pubmed publisher
  32. Radulescu M, Andronescu E, Dolete G, Popescu R, Fufă O, Chifiriuc M, et al. Silver Nanocoatings for Reducing the Exogenous Microbial Colonization of Wound Dressings. Materials (Basel). 2016;9: pubmed publisher
    ..The reported data recommend this type of coatings to obtain modified WDs with antibacterial properties, able to prevent the exogenous microbial contamination of the wound tissue, colonization and further biofilm development. ..
  33. Popescu R, Andronescu E, Vasile B, Trusca R, Boldeiu A, Mogoanta L, et al. Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles. Molecules. 2017;22: pubmed publisher
    ..These results indicate that our Gemcitabine-functionalized nanoparticles are a promising targeted system for applications in cancer therapy. ..
  34. Liakos I, Holban A, Carzino R, Lauciello S, Grumezescu A. Electrospun Fiber Pads of Cellulose Acetate and Essential Oils with Antimicrobial Activity. Nanomaterials (Basel). 2017;7: pubmed publisher
    ..This work describes an effective and simple method to prepare CA/EOs ESFs and opens up many new applications of micro/nanofibers such as improved antimicrobial wound dressings, anti-biofilm surfaces, sensors and packaging alternatives. ..
  35. Grigore M, Biscu E, Holban A, Gestal M, Grumezescu A. Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles. Pharmaceuticals (Basel). 2016;9: pubmed
    ..It is also believed that these nanosystems could represent efficient alternatives in the development of smart systems utilized both for the detection of pathogens and for the treatment of infections. ..