Michel Grothe

Summary

Publications

  1. pmc Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University Rostock, Germany
    Biol Psychiatry 71:805-13. 2012
  2. doi Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University of Rostock, Germany
    Neurobiol Aging 34:1210-20. 2013
  3. doi Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
    Stefan J Teipel
    University Medicine Rostock, Rostock, Germany
    Med Clin North Am 97:399-424. 2013
  4. doi Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
  5. doi The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 32:1349-62. 2011
  6. doi Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011

Detail Information

Publications6

  1. pmc Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University Rostock, Germany
    Biol Psychiatry 71:805-13. 2012
    ..However, there is a controversy regarding how the cholinergic lesion in AD relates to early and incipient stages of the disease. In vivo imaging studies on the structural integrity of the BFCS in normal and pathologic aging are rare...
  2. doi Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University of Rostock, Germany
    Neurobiol Aging 34:1210-20. 2013
    ..Atrophy of the BF was more pronounced in progressive patients compared with those that remained stable. The cholinergic BF undergoes disproportionate degeneration in the aging process, which is further increased by the presence of AD...
  3. doi Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
    Stefan J Teipel
    University Medicine Rostock, Rostock, Germany
    Med Clin North Am 97:399-424. 2013
    ....
  4. doi Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
    ..Critical testing of these predictions will help us to modify or even falsify the currently hold assumptions on the pathogenesis of AD based on in vivo evidence in humans...
  5. doi The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 32:1349-62. 2011
    ..05, corrected for multiple comparisons). Our findings suggest that a multimodal MRI-DTI approach is supportive to determine atrophy of cholinergic nuclei and its effect on intracortical projecting fiber tracts in AD...
  6. doi Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011
    ..The implementation of mixed effects models will enhance the power to detect treatment effects also with other classes of biological endpoints including molecular biomarkers of disease...