Michel Grothe

Summary

Publications

  1. ncbi Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University of Rostock, Germany Institute for Biostatistics and Informatics in Medicine and Ageing Research, University of Rostock, Rostock, Germany Electronic address
    Neurobiol Aging 34:1210-20. 2013
  2. ncbi Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University Rostock, Germany
    Biol Psychiatry 71:805-13. 2012
  3. ncbi The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 32:1349-62. 2011
  4. ncbi Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011
  5. ncbi Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
    Stefan J Teipel
    University Medicine Rostock, Rostock, Germany DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany Electronic address
    Med Clin North Am 97:399-424. 2013
  6. ncbi Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013

Detail Information

Publications6

  1. ncbi Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University of Rostock, Germany Institute for Biostatistics and Informatics in Medicine and Ageing Research, University of Rostock, Rostock, Germany Electronic address
    Neurobiol Aging 34:1210-20. 2013
    ..Atrophy of the BF was more pronounced in progressive patients compared with those that remained stable. The cholinergic BF undergoes disproportionate degeneration in the aging process, which is further increased by the presence of AD...
  2. ncbi Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University Rostock, Germany
    Biol Psychiatry 71:805-13. 2012
    ..However, there is a controversy regarding how the cholinergic lesion in AD relates to early and incipient stages of the disease. In vivo imaging studies on the structural integrity of the BFCS in normal and pathologic aging are rare...
  3. ncbi The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 32:1349-62. 2011
    ..05, corrected for multiple comparisons). Our findings suggest that a multimodal MRI-DTI approach is supportive to determine atrophy of cholinergic nuclei and its effect on intracortical projecting fiber tracts in AD...
  4. ncbi Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011
    ..The implementation of mixed effects models will enhance the power to detect treatment effects also with other classes of biological endpoints including molecular biomarkers of disease...
  5. ncbi Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
    Stefan J Teipel
    University Medicine Rostock, Rostock, Germany DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany Electronic address
    Med Clin North Am 97:399-424. 2013
    ..The selection of an appropriate technique needs to consider its suitability for specific applications...
  6. ncbi Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
    ..Critical testing of these predictions will help us to modify or even falsify the currently hold assumptions on the pathogenesis of AD based on in vivo evidence in humans...