Michel Grothe

Summary

Publications

  1. pmc Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University Rostock, Germany
    Biol Psychiatry 71:805-13. 2012
  2. pmc Basal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects
    Michel J Grothe
    German Center for Neurodegenerative Diseases DZNE, Rostock, Germany Electronic address
    Alzheimers Dement 10:S344-53. 2014
  3. pmc Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University of Rostock, Germany
    Neurobiol Aging 34:1210-20. 2013
  4. doi Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
    Stefan J Teipel
    University Medicine Rostock, Rostock, Germany
    Med Clin North Am 97:399-424. 2013
  5. doi Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
  6. pmc Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study
    Ingo Kilimann
    German Center for Neurodegenerative Diseases DZNE Rostock Greifswald, Rostock, Germany Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany
    J Alzheimers Dis 40:687-700. 2014
  7. pmc Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus
    Stefan J Teipel
    Department of Psychosomatic Medicine, University Medicine Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany Electronic address
    Psychiatry Res 221:187-94. 2014
  8. doi The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 32:1349-62. 2011
  9. doi Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011
  10. pmc Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease
    Stefan Teipel
    Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany DZNE, German Center for Neurodegenerative Disorders, Rostock, Germany Electronic address
    Neurobiol Aging 35:482-91. 2014

Detail Information

Publications11

  1. pmc Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University Rostock, Germany
    Biol Psychiatry 71:805-13. 2012
    ..However, there is a controversy regarding how the cholinergic lesion in AD relates to early and incipient stages of the disease. In vivo imaging studies on the structural integrity of the BFCS in normal and pathologic aging are rare...
  2. pmc Basal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects
    Michel J Grothe
    German Center for Neurodegenerative Diseases DZNE, Rostock, Germany Electronic address
    Alzheimers Dement 10:S344-53. 2014
    ..Associations between increased amyloid pathology and cholinergic atrophy have been described in autopsy studies...
  3. pmc Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University of Rostock, Germany
    Neurobiol Aging 34:1210-20. 2013
    ..Atrophy of the BF was more pronounced in progressive patients compared with those that remained stable. The cholinergic BF undergoes disproportionate degeneration in the aging process, which is further increased by the presence of AD...
  4. doi Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
    Stefan J Teipel
    University Medicine Rostock, Rostock, Germany
    Med Clin North Am 97:399-424. 2013
    ....
  5. doi Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
    ..Critical testing of these predictions will help us to modify or even falsify the currently hold assumptions on the pathogenesis of AD based on in vivo evidence in humans...
  6. pmc Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study
    Ingo Kilimann
    German Center for Neurodegenerative Diseases DZNE Rostock Greifswald, Rostock, Germany Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany
    J Alzheimers Dis 40:687-700. 2014
    ..The data of our study suggest that BFCS morphometry may provide an emerging biomarker in AD. ..
  7. pmc Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus
    Stefan J Teipel
    Department of Psychosomatic Medicine, University Medicine Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany Electronic address
    Psychiatry Res 221:187-94. 2014
    ..Our findings may enhance understanding of the role of cholinergic degeneration for the regional specificity of the cortical destruction leading to the syndrome of PPA...
  8. doi The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 32:1349-62. 2011
    ..05, corrected for multiple comparisons). Our findings suggest that a multimodal MRI-DTI approach is supportive to determine atrophy of cholinergic nuclei and its effect on intracortical projecting fiber tracts in AD...
  9. doi Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011
    ..The implementation of mixed effects models will enhance the power to detect treatment effects also with other classes of biological endpoints including molecular biomarkers of disease...
  10. pmc Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease
    Stefan Teipel
    Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany DZNE, German Center for Neurodegenerative Disorders, Rostock, Germany Electronic address
    Neurobiol Aging 35:482-91. 2014
    ..Our findings suggest that BFCS atrophy is more closely associated with cortical amyloid burden than hippocampus atrophy in predementia AD. ..
  11. doi Decline of fiber tract integrity over the adult age range: a diffusion spectrum imaging study
    Stefan J Teipel
    Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany
    J Magn Reson Imaging 40:348-59. 2014
    ..We applied a novel diffusion spectrum imaging (DSI) acquisition to determine associations between aging and subcortical fiber tract integrity...