Murray Grossman

Summary

Publications

  1. ncbi request reprint Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 57:721-9. 2005
  2. pmc Clinical and pathological continuum of multisystem TDP-43 proteinopathies
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 66:180-9. 2009
  3. pmc Neuropsychological decline in frontotemporal lobar degeneration: a longitudinal analysis
    David J Libon
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuropsychology 23:337-46. 2009
  4. pmc White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration
    Corey T McMillan
    Department of Neurology, Perelman School of Medicine, Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurol Neurosurg Psychiatry 84:949-55. 2013
  5. pmc Deficits in concept formation in amyotrophic lateral sclerosis
    David J Libon
    Department of Neurology, Drexel University College of Medicine, New College Building, 245 North 15th Street, Philadelphia, PA 19102, USA
    Neuropsychology 26:422-9. 2012
  6. pmc The organization and anatomy of narrative comprehension and expression in Lewy body spectrum disorders
    Sharon Ash
    University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychology 26:368-84. 2012
  7. pmc Impairments of speech fluency in Lewy body spectrum disorder
    Sharon Ash
    Department of Neurology, University of Pennsylvania School of Medicine, United States
    Brain Lang 120:290-302. 2012
  8. pmc Some is not enough: quantifier comprehension in corticobasal syndrome and behavioral variant frontotemporal dementia
    Brianna Morgan
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, United States
    Neuropsychologia 49:3532-41. 2011
  9. pmc Numerosity impairment in corticobasal syndrome
    Shira Koss
    Department of Neurology, University of Pennsylvania, PA, USA
    Neuropsychology 24:476-92. 2010
  10. pmc Stages of pTDP-43 pathology in amyotrophic lateral sclerosis
    Johannes Brettschneider
    Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    Ann Neurol 74:20-38. 2013

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 57:721-9. 2005
    ..We conclude that CSF tau levels are significantly reduced in many patients with FTD...
  2. pmc Clinical and pathological continuum of multisystem TDP-43 proteinopathies
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 66:180-9. 2009
    ....
  3. pmc Neuropsychological decline in frontotemporal lobar degeneration: a longitudinal analysis
    David J Libon
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuropsychology 23:337-46. 2009
    ..These data indicate that distinct patterns of neuropsychological impairment are maintained longitudinally, reflecting the unique anatomic distribution of relative disease burden in AD and FTLD...
  4. pmc White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration
    Corey T McMillan
    Department of Neurology, Perelman School of Medicine, Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurol Neurosurg Psychiatry 84:949-55. 2013
    ..In this paper, we investigate the ability of white matter (WM) imaging to help discriminate between FTLD-TAU and FTLD-TDP during life using diffusion tensor imaging (DTI)...
  5. pmc Deficits in concept formation in amyotrophic lateral sclerosis
    David J Libon
    Department of Neurology, Drexel University College of Medicine, New College Building, 245 North 15th Street, Philadelphia, PA 19102, USA
    Neuropsychology 26:422-9. 2012
    ..The aim of the current research was to test the hypothesis that concept formation deficits associated with an extramotor neurocognitive network involving executive and semantic resources can be found in some ALS patients...
  6. pmc The organization and anatomy of narrative comprehension and expression in Lewy body spectrum disorders
    Sharon Ash
    University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychology 26:368-84. 2012
    ..We predicted that comprehension and expression of narrative would be similarly affected and that deficits in both expression and comprehension of narrative would be related to the same anatomic distribution of prefrontal disease...
  7. pmc Impairments of speech fluency in Lewy body spectrum disorder
    Sharon Ash
    Department of Neurology, University of Pennsylvania School of Medicine, United States
    Brain Lang 120:290-302. 2012
    ..These findings indicate that multiple factors contribute to slowed speech in LBSD, and this is mediated in part by disease in frontal brain regions...
  8. pmc Some is not enough: quantifier comprehension in corticobasal syndrome and behavioral variant frontotemporal dementia
    Brianna Morgan
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, United States
    Neuropsychologia 49:3532-41. 2011
    ....
  9. pmc Numerosity impairment in corticobasal syndrome
    Shira Koss
    Department of Neurology, University of Pennsylvania, PA, USA
    Neuropsychology 24:476-92. 2010
    ..We assessed the representation of numerosity in corticobasal syndrome (CBS), a neurodegenerative condition affecting the parietal lobe...
  10. pmc Stages of pTDP-43 pathology in amyotrophic lateral sclerosis
    Johannes Brettschneider
    Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    Ann Neurol 74:20-38. 2013
    ..To see whether the distribution patterns of phosphorylated 43kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropathological stages...
  11. pmc Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis
    David J Irwin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 84:163-9. 2013
    ..To clarify this issue, we compared a large C9P cohort with carefully matched non-expansion (C9N) cases with a known or highly-suspected underlying TAR DNA-binding protein 43 (TDP-43) proteinopathy...
  12. ncbi request reprint Quantifier comprehension in corticobasal degeneration
    Corey T McMillan
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain Cogn 62:250-60. 2006
    ..29; p<.001]. An important implication of these findings is that the meaning of generalized quantifiers appears to involve two dissociable components, number knowledge and working memory, which are supported by distinct brain regions...
  13. pmc Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies
    Kunihiro Uryu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 67:555-64. 2008
    ..These findings provide further insight into the burden and clinical significance of TDP-43 pathology in disorders other than FTLD-U and amyotrophic lateral sclerosis...
  14. pmc Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer's disease
    Sharon X Xie
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Int Neuropsychol Soc 16:278-86. 2010
    ..These data suggest the presence of specific longitudinal patterns of impairment for episodic and semantic memory in AD and FTLD patients suggesting that all forms of dementia do not necessarily converge into a single phenotype...
  15. pmc Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 119:669-78. 2010
    ..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone...
  16. pmc Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 79:897-905. 2012
    ..Here we aim to determine plasma biomarkers associated with AD in 2 independent cohorts and validate the findings in the multicenter Alzheimer's Disease Neuroimaging Initiative (ADNI)...
  17. pmc CSF biomarkers cutoffs: the importance of coincident neuropathological diseases
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 124:23-35. 2012
    ....
  18. pmc Too much to count on: impaired very small numbers in corticobasal degeneration
    Casey Halpern
    Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain Cogn 64:144-9. 2007
    ..Difficulty judging very small numbers is impaired in CBD, suggesting degraded representation of precise number knowledge that does not depend on language functioning...
  19. ncbi request reprint Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations
    Vivianna M Van Deerlin
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1148-53. 2007
    ..Patients with frontotemporal dementia due to mutation of progranulin may have a distinct phenotype...
  20. ncbi request reprint Large-scale neural network for sentence processing
    Ayanna Cooke
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain Lang 96:14-36. 2006
    ....
  21. pmc The role of ventral medial prefrontal cortex in social decisions: converging evidence from fMRI and frontotemporal lobar degeneration
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neuropsychologia 48:3505-12. 2010
    ..These converging results support the role of vmPFC in social decision-making where potentially negative consequences must be considered...
  22. pmc Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Lionel M Igaz
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor, Maloney Bldg, Philadelphia, PA 19104, USA
    Am J Pathol 173:182-94. 2008
    ..Therefore, regionally different pathogenic processes may underlie the development of abnormal TDP-43 proteinopathies...
  23. pmc Brain progranulin expression in GRN-associated frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Acta Neuropathol 119:111-22. 2010
    ....
  24. pmc Phosphorylated tau as a candidate biomarker for amyotrophic lateral sclerosis
    Murray Grossman
    Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    JAMA Neurol 71:442-8. 2014
    ..An increasingly varied clinical spectrum of cases with amyotrophic lateral sclerosis (ALS) has been identified, and objective criteria for clinical trial eligibility are necessary...
  25. pmc Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms
    David J Irwin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Arch Neurol 69:1018-25. 2012
    ..To use values of cerebrospinal fluid tau and β-amyloid obtained from 2 different analytical immunoassays to differentiate Alzheimer disease (AD) from frontotemporal lobar degeneration (FTLD)...
  26. pmc The Philadelphia Brief Assessment of Cognition (PBAC): a validated screening measure for dementia
    David J Libon
    Department of Neurology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA
    Clin Neuropsychol 25:1314-30. 2011
    ..The PBAC is a valid tool and able to assesses differential patterns neuropsychological/behavioral impairment in a broad range of neurodegenerative conditions...
  27. pmc Hierarchical organization of scripts: converging evidence from FMRI and frontotemporal degeneration
    Christine Farag
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Cereb Cortex 20:2453-63. 2010
    ..Our findings suggest that frontal cortex contributes to clustering events during script comprehension, underlining the role of frontal cortex in the hierarchical organization of a script...
  28. pmc Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis
    Ryan Vass
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 121:373-80. 2011
    ..These findings implicate the FTLD-TDP risk gene TMEM106B in the development of cognitive impairment in ALS...
  29. ncbi request reprint TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, 2 Gibson, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1449-54. 2007
    ..TDP-43 is a major ubiquitinated disease protein in the pathologic condition of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)...
  30. pmc Everyday action impairment in Parkinson's disease dementia
    Tania Giovannetti
    Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Int Neuropsychol Soc 18:787-98. 2012
    ..jins, 2012, 18, 1-12)...
  31. pmc Category-specific semantic memory: converging evidence from bold fMRI and Alzheimer's disease
    Murray Grossman
    Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Neuroimage 68:263-74. 2013
    ....
  32. pmc Sentence processing in Lewy body spectrum disorder: the role of working memory
    Rachel G Gross
    Department of Neurology, University of Pennsylvania School of Medicine, United States
    Brain Cogn 78:85-93. 2012
    ..These findings are consistent with the hypothesis that patients with PDD and DLB have difficulty processing sentences with increased working memory demands and that this deficit is related in part to their frontal disease...
  33. pmc Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease
    Alice S Chen-Plotkin
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 69:655-63. 2011
    ..Most people with Parkinson disease (PD) eventually develop cognitive impairment (CI). However, neither the timing of onset nor the severity of cognitive symptoms can be accurately predicted. We sought plasma-based biomarkers for CI in PD...
  34. pmc Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease
    William T Hu
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Acta Neuropathol 120:385-99. 2010
    ....
  35. doi request reprint Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinson's disease
    Casey H Halpern
    Department of Neurosurgery, Neurology and Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Int J Geriatr Psychiatry 24:443-51. 2009
    ..The following review sought to provide a clearer understanding of the various cognitive sequelae of bilateral subthalamic nucleus (STN) DBS while taking into account corresponding neuroanatomy and potential confounding variables...
  36. ncbi request reprint Categorization of novel animals by patients with Alzheimer's disease and corticobasal degeneration
    Phyllis Koenig
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neuropsychology 21:193-206. 2007
    ..Moreover, AD patients' impaired categorization correlated with performance on a measure of semantic memory, implicating this categorization deficit in AD patients' semantic memory difficulty...
  37. ncbi request reprint What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration
    Murray Grossman
    Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain 127:628-49. 2004
    ..These findings are consistent with the hypothesis that a large-scale neural network supports naming, and that this network is interrupted in several distinct ways in patients with neurodegenerative diseases...
  38. pmc Impairment of script comprehension in Lewy body spectrum disorders
    Rachel G Gross
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Brain Lang 125:330-43. 2013
    ..These findings extend prior work on script processing to patients with Lewy body spectrum disorders and highlight the potential impact of frontal/executive dysfunction on the daily lives of affected patients...
  39. pmc Comparative semantic profiles in semantic dementia and Alzheimer's disease
    David J Libon
    Department of Neurology, Drexel University, 245 North 15th Street, 7th Floor, Philadelphia, PA 19102, USA
    Brain 136:2497-509. 2013
    ..We discuss factors that may contribute to the semantic memory deficit in semantic variant primary progressive aphasia. ..
  40. pmc Can MRI screen for CSF biomarkers in neurodegenerative disease?
    Corey T McMillan
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Neurology 80:132-8. 2013
    ..In this study, we evaluate the utility of MRI as a noninvasive screening procedure for the differential diagnosis of AD and FTLD...
  41. pmc Whole-brain analysis of amyotrophic lateral sclerosis by using echo-planar spectroscopic imaging
    Gaurav Verma
    Department of Radiology, Hospital of the University of Pennsylvania, B6 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104, USA
    Radiology 267:851-7. 2013
    ..To detect regional metabolic differences in amyotrophic lateral sclerosis (ALS) with whole-brain echo-planar spectroscopic imaging...
  42. pmc Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis
    Johannes Brettschneider
    Center for Neurodegenerative Disease Research CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 123:395-407. 2012
    ..In contrast, AD pathology in ALS is primarily related to increasing age and associated with a poorer performance on the MMSE...
  43. pmc Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
    David J Irwin
    Centre for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Centre, Institute on Ageing, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Brain 135:807-18. 2012
    ..Thus, inhibiting tau acetylation could be a disease-modifying target for drug discovery target in tauopathies...
  44. pmc Neuropsychological patterns in magnetic resonance imaging-defined subgroups of patients with degenerative dementia
    John Listerud
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Int Neuropsychol Soc 15:459-70. 2009
    ..We conclude that classifying patients with degenerative dementia by specific pattern of cortical atrophy has the potential to predict individual patterns of cognitive deficits...
  45. pmc Impaired verbal comprehension of quantifiers in corticobasal syndrome
    Vanessa Troiani
    Department of Neurology, 2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Neuropsychology 25:159-65. 2011
    ..The current study evaluated comprehension of generalized quantifiers using strictly verbal materials...
  46. pmc Is it logical to count on quantifiers? Dissociable neural networks underlying numerical and logical quantifiers
    Vanessa Troiani
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Neuropsychologia 47:104-11. 2009
    ....
  47. ncbi request reprint The neural basis for categorization in semantic memory
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, 19104, USA
    Neuroimage 17:1549-61. 2002
    ..The caudate may support resource demands that are not specific for a particular categorization process. These findings associate partially distinct large-scale neural networks with different forms of categorization in semantic memory...
  48. ncbi request reprint Neural basis for semantic memory difficulty in Alzheimer's disease: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Brain 126:292-311. 2003
    ..Components of the large-scale neural network underlying semantic memory may modify themselves to maintain performance in the face of a neurodegenerative disease...
  49. pmc Impaired information integration contributes to communication difficulty in corticobasal syndrome
    Rachel G Gross
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Cogn Behav Neurol 23:1-7. 2010
    ..To investigate the cognitive and neural correlates of discourse impairment in corticobasal syndrome (CBS)...
  50. pmc Categorization of novel tools by patients with Alzheimer's disease: category-specific content and process
    Phyllis Koenig
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, United States
    Neuropsychologia 48:1877-85. 2010
    ..The results suggest that categorization processes are sensitive to category content, which influences AD patients' success at acquiring a new category...
  51. pmc Knowledge of natural kinds in semantic dementia and Alzheimer's disease
    Katy Cross
    Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain Lang 105:32-40. 2008
    ..We suggest that SD patients may be impaired in part at identifying the features critical to diagnosing membership in a semantic category, while AD patients' performance is consistent with their semantic categorization deficit...
  52. ncbi request reprint Neural basis for sentence comprehension deficits in frontotemporal dementia
    Ayanna Cooke
    Department of Neurology 2 Gibson, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain Lang 85:211-21. 2003
    ..We conclude that FTD subgroups have distinct patterns of sentence comprehension difficulty in part because of selective interruptions of a large-scale neural network for sentence processing...
  53. ncbi request reprint Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 314:130-3. 2006
    ..TDP-43 represents the common pathologic substrate linking these neurodegenerative disorders...
  54. ncbi request reprint TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 66:177-83. 2007
    ..Taken together, these results expand the spectrum of TDP-43 pathology in FTLD-U, suggesting that white matter pathology might contribute to the neurodegenerative process and clinical symptoms in FTLD-U...
  55. ncbi request reprint Memory encoding and retrieval in frontotemporal dementia and Alzheimer's disease
    Guila Glosser
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Neuropsychology 16:190-6. 2002
    ..FTD patients' retained capacity for encoding new information into long-term declarative memory is likely due to relatively spared medial temporal lobe involvement...
  56. ncbi request reprint Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual
    Vivianna M Van Deerlin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research and Institute on Aging, University of Pennsylvania, 3600 Spruce St, 3 Maloney Bldg, Philadelphia, PA, 19104, USA
    Acta Neuropathol 113:471-9. 2007
    ..This is also the first reported case of any MAPT mutation in an individual of African American ethnicity...
  57. pmc Frontotemporal dementia: clinicopathological correlations
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 59:952-62. 2006
    ..This study assessed whether specific clinical features predict the underlying pathology...
  58. pmc TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
    Vivianna M Van Deerlin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Lancet Neurol 7:409-16. 2008
    ..Our aim was to investigate whether TARDBP is a candidate disease gene for familial ALS that is not associated with mutations in superoxide dismutase 1 (SOD1)...
  59. pmc TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways
    Alice S Chen-Plotkin
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 32:11213-27. 2012
    ..Evidence for this pathogenic cascade includes the striking convergence of two independent, genomic-scale screens on a microRNA:mRNA regulatory pair. Our findings open novel directions for elucidating miR-based therapies in FTLD-TDP...
  60. pmc Frontal lobe abnormalities on MRS correlate with poor letter fluency in ALS
    Colin Quinn
    Department of Neurology, University of Pennsylvania, PA, USA
    Neurology 79:583-8. 2012
    ..To examine whether frontal lobe abnormalities on magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis (ALS) correlate with poor letter fluency (LF)...
  61. ncbi request reprint Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia
    Murray Grossman
    Department of Neurology, 2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1601-9. 2007
    ..Clinical-pathologic studies are crucial to understanding brain-behavior relations and improving diagnostic accuracy in neurodegenerative diseases...
  62. pmc Verb acquisition and representation in Alzheimer's disease
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, USA
    Neuropsychologia 45:2508-18. 2007
    ....
  63. pmc Neural processing during older adults' comprehension of spoken sentences: age differences in resource allocation and connectivity
    Jonathan E Peelle
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cereb Cortex 20:773-82. 2010
    ..We conclude that decreased activation of specialized processing regions, and limited ability to coordinate activity between regions, contribute to older adults' difficulty with sentence comprehension under difficult listening conditions...
  64. pmc The organization of narrative discourse in Lewy body spectrum disorder
    Sharon Ash
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Brain Lang 119:30-41. 2011
    ..These findings are consistent with a model of narrative discourse that includes executive as well as language components and with an impairment of the organizational component of narrative discourse in patients with PDD and DLB...
  65. pmc Difficulty processing temporary syntactic ambiguities in Lewy body spectrum disorder
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, United States
    Brain Lang 120:52-60. 2012
    ..These findings emphasize the role of prefrontal disease in the executive limitations that interfere with processing ambiguous sentences in LBSD...
  66. pmc Speech errors in progressive non-fluent aphasia
    Sharon Ash
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Brain Lang 113:13-20. 2010
    ..We conclude that the speech errors produced by PNFA patients are mainly errors at the phonemic level of language processing and are not caused by a motor planning impairment...
  67. ncbi request reprint Sentence processing in frontotemporal dementia
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Cortex 41:764-77. 2005
    ....
  68. pmc Preserved musical semantic memory in semantic dementia
    Jessica Weinstein
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Arch Neurol 68:248-50. 2011
    ..To understand the scope of semantic impairment in semantic dementia...
  69. pmc Neuroanatomy of apathy and disinhibition in frontotemporal lobar degeneration
    Lauren Massimo
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Dement Geriatr Cogn Disord 27:96-104. 2009
    ..To investigate the neural basis for the behavioral symptoms of frontotemporal lobar degeneration (FTLD) that cause the greatest caregiver distress...
  70. ncbi request reprint Neural basis for verb processing in Alzheimer's disease: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neuropsychology 17:658-74. 2003
    ..These findings imply that poor performance with verbs in AD is due in part to altered activation of the large-scale neural network that supports verb processing...
  71. pmc Building an integrated neurodegenerative disease database at an academic health center
    Sharon X Xie
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Alzheimers Dement 7:e84-93. 2011
    ..These comparative studies rely on powerful database tools to quickly generate data sets that match diverse and complementary criteria set by them...
  72. pmc Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 17:1349-62. 2008
    ..In addition, these data from a large number of human brains provide a valuable resource for future testing of disease hypotheses...
  73. pmc Medial temporal lobe involvement in an implicit memory task: evidence of collaborating implicit and explicit memory systems from FMRI and Alzheimer's disease
    Phyllis Koenig
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cereb Cortex 18:2831-43. 2008
    ..These findings suggest that implicit and explicit memory systems collaborate in neurologically intact individuals performing an ostensibly implicit memory task...
  74. ncbi request reprint Left inferior parietal representations for skilled hand-object interactions: evidence from stroke and corticobasal degeneration
    Laurel J Buxbaum
    Moss Rehabilitation Research Institute, Philadelphia, PA 19141, USA
    Cortex 43:411-23. 2007
    ....
  75. ncbi request reprint The neural basis for novel semantic categorization
    Phyllis Koenig
    Department of Neurology, University of Pennsylvania 19104 4283, USA
    Neuroimage 24:369-83. 2005
    ..These findings suggest that large-scale networks support relatively distinct categorization processes during the acquisition and judgment of semantic category knowledge...
  76. pmc How necessary are the stripes of a tiger? Diagnostic and characteristic features in an fMRI study of word meaning
    Murray Grossman
    Department of Neurology 2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neuropsychologia 45:1055-64. 2007
    ....
  77. ncbi request reprint Categorization of object descriptions in Alzheimer's disease and frontotemporal dementia: limitation in rule-based processing
    Murray Grossman
    Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Cogn Affect Behav Neurosci 3:120-32. 2003
    ..These findings suggest that semantic memory difficulty in AD is due in part to a deficit in executive processes that are central to rule-based categorization in semantic memory...
  78. pmc Dementia induces correlated reductions in white matter integrity and cortical thickness: a multivariate neuroimaging study with sparse canonical correlation analysis
    Brian B Avants
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
    Neuroimage 50:1004-16. 2010
    ..We conclude that SCCA is a potentially valuable approach in image analysis that can be applied productively to distinguishing between neurodegenerative conditions...
  79. pmc Reversal of the concreteness effect in semantic dementia
    Michael F Bonner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Cogn Neuropsychol 26:568-79. 2009
    ..These observations raise the possibility that degraded visual feature knowledge contributes in part to the impaired comprehension of concrete words in SD...
  80. ncbi request reprint Confrontation naming and morphometric analyses of structural MRI in frontotemporal dementia
    Corey McMillan
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Dement Geriatr Cogn Disord 17:320-3. 2004
    ..These findings suggest that confrontation naming is supported by a large-scale neural network, and that naming is compromised in FTD due to interruption of the network in several different ways...
  81. ncbi request reprint Spatiotemporal normalization for longitudinal analysis of gray matter atrophy in frontotemporal dementia
    Brian Avants
    Dept of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
    Med Image Comput Comput Assist Interv 10:303-10. 2007
    ..This paper shows the statistical power of symmetric diffeomorphic normalization for performing deformation-based studies of longitudinal atrophy...
  82. pmc Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
    Vivianna M Van Deerlin
    1 Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA 2 These authors contributed equally to this work
    Nat Genet 42:234-9. 2010
    ..TMEM106B variants also contribute to genetic risk for FTLD-TDP in individuals with mutations in GRN. Our data implicate variants in TMEM106B as a strong risk factor for FTLD-TDP, suggesting an underlying pathogenic mechanism...
  83. ncbi request reprint Lexical acquisition in progressive aphasia and frontotemporal dementia
    Ryan Murray
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Cogn Neuropsychol 24:48-69. 2007
    ....
  84. ncbi request reprint Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
    Hanae Nakashima-Yasuda
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 114:221-9. 2007
    ..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders...
  85. pmc Interaction between process and content in semantic memory: an fMRI study of noun feature knowledge
    Jonathan E Peelle
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neuropsychologia 47:995-1003. 2009
    ..Together, these results support the hypothesis that various classes of nouns are represented differently in semantic memory, and emphasize the dynamic interaction of process and content in semantic memory...
  86. ncbi request reprint Alzheimer's disease and frontotemporal dementia exhibit distinct atrophy-behavior correlates: a computer-assisted imaging study
    James Gee
    Department of Radiology, University of Pennsylvania, 3600 Market Street, Suite 370, Philadelphia, PA 19104 2644, USA
    Acad Radiol 10:1392-401. 2003
    ..The purpose of this study was to test the hypothesis that distinct patterns of gray matter atrophy are responsible for unique interruptions of the naming process in Alzheimer's disease (AD) and frontotemporal dementia (FTD)...
  87. pmc Patient care and management of frontotemporal lobar degeneration
    Lauren Massimo
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Am J Alzheimers Dis Other Demen 23:125-31. 2008
    ..Nonpharmacologic management such as behavioral interventions and environmental engineering are also efficacious in optimizing quality of life...
  88. ncbi request reprint Frontotemporal lobar degeneration: recent progress in antemortem diagnosis
    Hong Bian
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Acta Neuropathol 114:23-9. 2007
    ..This review summarizes the epidemiologic, clinical, neuropsychological, imaging and cerebrospinal fluid (CSF) biomarker features that can help identify these pathologically defined conditions during life...
  89. pmc Signature tau neuropathology in gray and white matter of corticobasal degeneration
    Mark S Forman
    Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 160:2045-53. 2002
    ..Thus, although clinically heterogeneous, CBD is a distinct lobar and basal ganglionic tauopathy with selective aggregation of 4R-tau...
  90. ncbi request reprint Frontotemporal dementia: a review
    Murray Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    J Int Neuropsychol Soc 8:566-83. 2002
    ..The clinical, neuroimaging and neuropathological profiles associated with these clinically defined subgroups are examined...
  91. ncbi request reprint Visual perceptual functions predict instrumental activities of daily living in patients with dementia
    Guila Glosser
    Department of Neurology, University of Pennsylvannia School of Medicine, Philadelphia 19104 4283, USA
    Neuropsychiatry Neuropsychol Behav Neurol 15:198-206. 2002
    ..To assess relations between discrete visual perceptual functions commonly affected in patients with neurodegenerative dementia and the performance of instrumental activities of daily living (IADL)...
  92. ncbi request reprint Reversal of the concreteness effect for verbs in patients with semantic dementia
    Hyon Ah Yi
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neuropsychology 21:9-19. 2007
    ..Second, visual feature knowledge is degraded in patients with SD because of the anatomic distribution of the disease in visual association cortex, causing relatively greater difficulty for concrete verbs compared to abstract verbs...
  93. ncbi request reprint Verbal mediation of number knowledge: evidence from semantic dementia and corticobasal degeneration
    Casey Halpern
    Department of Neurology, University of Pennsylvania, USA
    Brain Cogn 56:107-15. 2004
    ..CBD patients' impairment with larger numbers despite minimal aphasia, and SD patients' intact performance despite an aphasia, challenge the proposal that understanding larger numbers depends on verbal mediation...
  94. ncbi request reprint TDP-43 and frontotemporal dementia
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19106, USA
    Curr Neurol Neurosci Rep 9:353-8. 2009
    ....
  95. ncbi request reprint The correlation of cognitive decline with frontotemporal dementia induced annualized gray matter loss using diffeomorphic morphometry
    Brian Avants
    University of Pennsylvania School of Medicine, Philadelphia, 19104 6389, USA
    Alzheimer Dis Assoc Disord 19:S25-8. 2005
    ..This study gives insight into the relationship between FTD-related progressive cortical atrophy and loss in cognitive function...
  96. ncbi request reprint Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter
    Victoria Zhukareva
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Ann Neurol 51:730-9. 2002
    ....
  97. pmc Registration based cortical thickness measurement
    Sandhitsu R Das
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neuroimage 45:867-79. 2009
    ..Evaluation of this method is presented on synthetic images. As an application to brain images, a longitudinal study of thickness change in frontotemporal dementia (FTD) spectrum disorder is reported...
  98. pmc Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies
    Deepak M Sampathu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor Maloney Bldg, Philadelphia, PA 19104, USA
    Am J Pathol 169:1343-52. 2006
    ..Identification of the disease proteins recognized by these mAbs will further advance understanding of molecular substrates of FTLD-U neurodegenerative pathways...
  99. ncbi request reprint Frontotemporal dementia: genetics and genetic counseling dilemmas
    Jill S Goldman
    Memory and Aging Center, University of California, San Francisco, Department of Neurology, San Francisco, California 94143 1207, USA
    Neurologist 10:227-34. 2004
    ..The objective of this paper is to enable physicians to recognize hereditary patterns and genetic concerns of FTD families and to understand genetic counseling strategies...
  100. ncbi request reprint Sentence processing strategies in healthy seniors with poor comprehension: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Brain Lang 80:296-313. 2002
    ..Moreover, these observations emphasize the crucial role of the left perisylvian network for grammatically guided sentence processing in subjects with good comprehension...
  101. ncbi request reprint Neural basis for sentence comprehension: grammatical and short-term memory components
    Ayanna Cooke
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Hum Brain Mapp 15:80-94. 2002
    ....