Klaus Görlinger

Summary

Publications

  1. doi request reprint First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
    Anesthesiology 115:1179-91. 2011
  2. ncbi request reprint Coagulation management in patients undergoing mechanical circulatory support
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinkum Essen, Universitat Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Best Pract Res Clin Anaesthesiol 26:179-98. 2012
  3. doi request reprint Management of hemorrhage in cardiothoracic surgery
    Klaus Görlinger
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg Essen, Essen, Germany
    J Cardiothorac Vasc Anesth 27:S20-34. 2013
  4. ncbi request reprint Potential value of transfusion protocols in cardiac surgery
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
    Curr Opin Anaesthesiol 26:230-43. 2013
  5. doi request reprint Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability
    K Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrase 55, D 45122 Essen, Germany
    Br J Anaesth 110:222-30. 2013
  6. doi request reprint Mini-epidemic of erroneous central venous pressure measurements resulting from the malproduction of a specific part of a pressure transducer system
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitat Duisburg Essen, Universitatsklinikum Essen, Essen, Germany
    Anesthesiology 110:1417-8; discussion 1418-9. 2009
  7. doi request reprint [Platelet function analysis with point-of-care methods]
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen
    Herz 33:297-305. 2008
  8. ncbi request reprint [Coagulation management during liver transplantation]
    K Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen
    Hamostaseologie 26:S64-76. 2006
  9. doi request reprint Recombinant tissue-type plasminogen activator-evoked hyperfibrinolysis is enhanced by acidosis and inhibited by hypothermia but still can be blocked by tranexamic acid
    Daniel Dirkmann
    Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen and Universitätsklinikum Essen, Germany
    J Trauma Acute Care Surg 74:482-8. 2013
  10. doi request reprint Factor XIII and tranexamic acid but not recombinant factor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in human whole blood
    Daniel Dirkmann
    Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen and Universitätsklinikum Essen, Essen, Germany
    Anesth Analg 114:1182-8. 2012

Detail Information

Publications22

  1. doi request reprint First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
    Anesthesiology 115:1179-91. 2011
    ..We developed and implemented an algorithm for coagulation management in cardiovascular surgery based on first-line administration of coagulation factor concentrates combined with point-of-care thromboelastometry/impedance aggregometry...
  2. ncbi request reprint Coagulation management in patients undergoing mechanical circulatory support
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinkum Essen, Universitat Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Best Pract Res Clin Anaesthesiol 26:179-98. 2012
    ..However, coagulation management in patients undergoing mechanical circulatory support therapy is somehow like navigating between Scylla and Charybdis, and development of protocols based on POC testing seems to be beneficial...
  3. doi request reprint Management of hemorrhage in cardiothoracic surgery
    Klaus Görlinger
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg Essen, Essen, Germany
    J Cardiothorac Vasc Anesth 27:S20-34. 2013
    ....
  4. ncbi request reprint Potential value of transfusion protocols in cardiac surgery
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
    Curr Opin Anaesthesiol 26:230-43. 2013
    ..The 16 studies fitting these search criteria have evaluated the impact of the implementation of ROTEM/TEG based coagulation management algorithms on transfusion requirement and outcome in overall 8507 cardiovascular surgical patients...
  5. doi request reprint Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability
    K Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrase 55, D 45122 Essen, Germany
    Br J Anaesth 110:222-30. 2013
    ..However, the reliability of early ROTEM(®) variables to predict maximum clot firmness (MCF) in non-cardiac surgery patients with subnormal, normal, and supranormal MCF has not yet been evaluated...
  6. doi request reprint Mini-epidemic of erroneous central venous pressure measurements resulting from the malproduction of a specific part of a pressure transducer system
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitat Duisburg Essen, Universitatsklinikum Essen, Essen, Germany
    Anesthesiology 110:1417-8; discussion 1418-9. 2009
    ..We report a mini-epidemic of erroneous central venous pressure measurements due to faulty pressure transducer manufacturing resulting in wrong therapeutic decisions...
  7. doi request reprint [Platelet function analysis with point-of-care methods]
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen
    Herz 33:297-305. 2008
    ..On the other hand, this medication can result in an increased risk of perioperative bleeding. In both situations control of the efficiency of therapy or rather the assessment of the impairment of hemostasis is of vital importance...
  8. ncbi request reprint [Coagulation management during liver transplantation]
    K Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen
    Hamostaseologie 26:S64-76. 2006
    ..However, therapy with an antifibrinolytic drug only was necessary in 40% of the patients. Our experience is summarised in an algorithm for ROTEM-based perioperative coagulation management for liver transplantation...
  9. doi request reprint Recombinant tissue-type plasminogen activator-evoked hyperfibrinolysis is enhanced by acidosis and inhibited by hypothermia but still can be blocked by tranexamic acid
    Daniel Dirkmann
    Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen and Universitätsklinikum Essen, Germany
    J Trauma Acute Care Surg 74:482-8. 2013
    ....
  10. doi request reprint Factor XIII and tranexamic acid but not recombinant factor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in human whole blood
    Daniel Dirkmann
    Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen and Universitätsklinikum Essen, Essen, Germany
    Anesth Analg 114:1182-8. 2012
    ....
  11. doi request reprint Methods to evaluate the pharmacology of oral antiplatelet drugs
    Artur Aron Weber
    Institute of Pharmacology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Herz 33:287-96. 2008
    ....
  12. doi request reprint Comparison of thrombelastometry with simplified acute physiology score II and sequential organ failure assessment scores for the prediction of 30-day survival: a cohort study
    Michael Adamzik
    Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen and Universitätsklinikum Essen, Essen, Germany
    Shock 35:339-42. 2011
    ..01; odds ratio, 4.1), respectively, emphasizing the importance of the coagulation system in sepsis...
  13. doi request reprint Thrombophilia in cardiac surgery-patients with symptomatic factor V Leiden
    Parwis Massoudy
    Department for Thoracic and Cardiovascular Surgery, West German Heart Center Essen, Hufelandstrasse 55, Essen, Germany
    J Card Surg 24:379-82. 2009
    ..Thrombophilia may cause severe complications in cardiac surgical patients. We analyzed our experience with symptomatic factor V Leiden patients...
  14. ncbi request reprint Uneventful removal of an epidural catheter guided by impedance aggregometry in a patient with recent coronary stenting and treated with clopidogrel and acetylsalicylic acid
    Lars Bergmann
    Klinik für Anästhesiologie und Intensivmedizin, Universitat Duisburg Essen, Universitatsklinikum Essen, Essen, Germany
    Reg Anesth Pain Med 32:354-7. 2007
    ..This report suggests that impedance aggregometry can be helpful to assess optimum time for and minimize the risk of catheter removal during double antiplatelet therapy...
  15. doi request reprint The GNB3 C825T polymorphism influences platelet aggregation in human whole blood
    Fabian Dusse
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital, University of Duisburg Essen, Essen, Germany
    Pharmacogenet Genomics 22:43-9. 2012
    ..We tested the hypothesis that the C825T polymorphism of the gene GNB3 encoding the G-protein β-3 subunit and the platelet GPIIIa Pl(A1)/(A2) polymorphism of the glycoprotein IIIa influence platelet aggregation...
  16. pmc Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults
    Michael Adamzik
    Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen und Universität Duisburg Essen, Hufelandstr, 55, 45130 Essen, Germany
    Crit Care 14:R178. 2010
    ..We investigated whether thromboelastometry variables are suitable as biomarkers for severe sepsis in critically ill adults...
  17. doi request reprint Hypothermia and acidosis synergistically impair coagulation in human whole blood
    Daniel Dirkmann
    Klinik für Anästhesiologie und Intensivmedizin, Universitat Duisburg Essen, Universitatsklinikum Essen, Essen, Germany
    Anesth Analg 106:1627-32. 2008
    ..Hypothermia and acidosis were reported to influence coagulopathy in different clinical settings. We evaluated whole blood coagulation to determine the effects of hypothermia and/or acidosis on hemostasis...
  18. ncbi request reprint Delicate balance of bleeding and thrombosis in end-stage liver disease and liver transplantation
    Fuat Hakan Saner
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Digestion 88:135-44. 2013
    ..However, this is a very delicate balance, which may be shifted to either of these pathways by different treatments thereby causing bleeding or thrombosis, respectively...
  19. ncbi request reprint Argatroban in extracorporeal membrane oxygenation
    Martin Beiderlinden
    Klinik für Anästhesiologie und Intensivmedizin Universitätsklinikum Essen, Universitat Duisburg Essen, Germany
    Artif Organs 31:461-5. 2007
    ..However, a dose 10-fold lower than that recommended by the manufacturer is sufficient to achieve appropriate anticoagulation in critically ill patients undergoing ECMO...
  20. ncbi request reprint Blood-transfusion requirements and blood salvage in donors undergoing right hepatectomy for living related liver transplantation
    Jürgen T Lutz
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
    Anesth Analg 96:351-5, table of contents. 2003
    ..Transfusion of banked blood can be avoided in most patients when intraoperative cell salvage, preoperative autologous blood donation, and intraoperative hemodilution are combined...
  21. doi request reprint Novel approaches in management of perioperative coagulopathy
    Kenichi A Tanaka
    aDepartment of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA bClinic of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Curr Opin Anaesthesiol 27:72-80. 2014
    ..The recent advances in hemostatic monitoring, and discussion of the clinical implications of hemostatic therapies based on different blood components and factor concentrates...
  22. ncbi request reprint Peri-operative filtration of disseminated cytokeratin positive cells in patients with colorectal liver metastasis
    Nils R Fruhauf
    Department of General Surgery and Transplantation, University of Essen, Hufelandstrasse 55, 45147, Essen, Germany
    Langenbecks Arch Surg 390:15-20. 2005
    ..As prevention of cell dissemination is barely obtainable, alternative concepts have to be discussed...