Khaled Greish

Summary

Publications

  1. ncbi request reprint Macromolecular therapeutics: advantages and prospects with special emphasis on solid tumour targeting
    Khaled Greish
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto, Japan
    Clin Pharmacokinet 42:1089-105. 2003
  2. ncbi request reprint High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor
    Arun K Iyer
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860 0082, Japan
    Biomaterials 28:1871-81. 2007
  3. ncbi request reprint Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines
    Khaled Greish
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    J Drug Target 15:457-64. 2007
  4. doi request reprint HSP32 (HO-1) inhibitor, copoly(styrene-maleic acid)-zinc protoporphyrin IX, a water-soluble micelle as anticancer agent: In vitro and in vivo anticancer effect
    Jun Fang
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Eur J Pharm Biopharm 81:540-7. 2012
  5. ncbi request reprint Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation
    Arun K Iyer
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    J Drug Target 15:496-506. 2007
  6. ncbi request reprint Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase
    Jun Fang
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4 22 1, Kumamoto, Japan
    Int J Cancer 122:1135-44. 2008
  7. doi request reprint Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors
    Akinori Nagamitsu
    Kumamoto Hakuaikai Hospital, Kumamoto, Japan
    Jpn J Clin Oncol 39:756-66. 2009
  8. doi request reprint SMA-copolymer conjugate of AHPP: a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect
    Jun Fang
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4 22 1, Kumamoto, Japan
    J Control Release 135:211-7. 2009
  9. ncbi request reprint Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin
    Jun Fang
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Cancer 109:1-8. 2004
  10. ncbi request reprint Evaluation of the effect of SMA-pirarubicin micelles on colorectal cancer liver metastases and of hyperbaric oxygen in CBA mice
    Jurstine Daruwalla
    Department of Surgery, Austin Health Hospital, University of Melbourne, Heidelberg, Vic, Australia
    J Drug Target 15:487-95. 2007

Collaborators

  • Hiroshi Maeda
  • Jun Fang
  • Hideaki Nakamura
  • Dawei Deng
  • Keizo Takeshita
  • Jurstine Daruwalla
  • Ian Millar
  • Arun K Iyer
  • Matthias Mayerhofer
  • Akinori Nagamitsu
  • Winfried F Pickl
  • Karoline V Gleixner
  • Peter Valent
  • Karl J Aichberger
  • Harald Esterbauer
  • Puchit Samorapoompichit
  • Christian Sillaber
  • Rudin Kondo
  • Gregor Hoermann
  • Sophia Derdak
  • Julia Mayerhofer
  • Eva Jaeger
  • Ilse Schwarzinger
  • Rene G Ott
  • Veronika Sexl
  • Maria Theresa Krauth
  • Anja Vales
  • Alexander Gruze
  • Ryoichi Murakami
  • Shoko Okazaki
  • Takahiro Seki

Detail Information

Publications14

  1. ncbi request reprint Macromolecular therapeutics: advantages and prospects with special emphasis on solid tumour targeting
    Khaled Greish
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto, Japan
    Clin Pharmacokinet 42:1089-105. 2003
    ..This article discusses these and other polymeric drugs in the setting of targeting to solid tumours...
  2. ncbi request reprint High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor
    Arun K Iyer
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860 0082, Japan
    Biomaterials 28:1871-81. 2007
    ..The unique features of SMA-ZnPP micelles are that they are nanoparticles in aqueous solution having high water solubility and loading, yet macromolecular in nature, which can be beneficial in targeted release of a potent HO-1 inhibitor...
  3. ncbi request reprint Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines
    Khaled Greish
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    J Drug Target 15:457-64. 2007
    ..In this review the mechanisms and factors involved in the EPR effect, as well as the uniqueness of nanoscale drugs for tumor targeting through EPR effect, will be discussed in detail...
  4. doi request reprint HSP32 (HO-1) inhibitor, copoly(styrene-maleic acid)-zinc protoporphyrin IX, a water-soluble micelle as anticancer agent: In vitro and in vivo anticancer effect
    Jun Fang
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Eur J Pharm Biopharm 81:540-7. 2012
    ..These findings suggest a potential of SMA-ZnPP as a tool for anticancer therapy toward clinical development, whereas further investigations are warranted...
  5. ncbi request reprint Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation
    Arun K Iyer
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    J Drug Target 15:496-506. 2007
    ....
  6. ncbi request reprint Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase
    Jun Fang
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4 22 1, Kumamoto, Japan
    Int J Cancer 122:1135-44. 2008
    ..These findings suggest a potential of PEG-rDAO as a novel anticancer strategy toward clinical development...
  7. doi request reprint Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors
    Akinori Nagamitsu
    Kumamoto Hakuaikai Hospital, Kumamoto, Japan
    Jpn J Clin Oncol 39:756-66. 2009
    ..This is the first clinical proof that modulations of vascular pathophysiology can uniquely accomplish enhanced tumor selective delivery of polymeric drugs and thus yielded better clinical outcome...
  8. doi request reprint SMA-copolymer conjugate of AHPP: a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect
    Jun Fang
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4 22 1, Kumamoto, Japan
    J Control Release 135:211-7. 2009
    ..These findings strongly suggest the potential value of SMA-AHPP as an antihypertensive agent with sustained in vivo activity, which warrants further investigations...
  9. ncbi request reprint Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin
    Jun Fang
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Cancer 109:1-8. 2004
    ..Further study of the effect of PEG-ZnPP plus conventional anticancer drugs that generate ROS, such as cisplatin, camptothecin, doxorubicin, mitomycin C and etoposide, is warranted...
  10. ncbi request reprint Evaluation of the effect of SMA-pirarubicin micelles on colorectal cancer liver metastases and of hyperbaric oxygen in CBA mice
    Jurstine Daruwalla
    Department of Surgery, Austin Health Hospital, University of Melbourne, Heidelberg, Vic, Australia
    J Drug Target 15:487-95. 2007
    ..The data also suggests a potential benefit of combined therapy of HBO with micellar anthracyclins...
  11. ncbi request reprint Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells
    Rudin Kondo
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Blood 110:661-9. 2007
    ..Furthermore, both drugs were found to cooperate with PKC412 in producing growth inhibition. Together, these data show that Hsp32 is an important survival factor and interesting new therapeutic target in neoplastic MCs...
  12. ncbi request reprint Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib
    Matthias Mayerhofer
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Blood 111:2200-10. 2008
    ..In summary, these data show that HO-1 is a promising novel target in imatinib-resistant CML...
  13. ncbi request reprint Copoly(styrene-maleic acid)-pirarubicin micelles: high tumor-targeting efficiency with little toxicity
    Khaled Greish
    Division of Advanced Biomedical Sciences, Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Bioconjug Chem 16:230-6. 2005
    ..These data thus suggest that intravenous administration of the SMA-THP micellar formulation can enhance the therapeutic effect of pirarubicin more than 50-fold...
  14. ncbi request reprint SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours
    Khaled Greish
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    J Control Release 97:219-30. 2004
    ..v. administration of SMA-Dox micellar formulation can enhance the therapeutic effect of doxorubicin while reducing greatly cardiac and bone marrow toxicity, which should allow safe use of high doses of this agent...