D R Green

Summary

Publications

  1. ncbi request reprint Apoptotic pathways: paper wraps stone blunts scissors
    D R Green
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Cell 102:1-4. 2000
  2. ncbi request reprint The role of Fas ligand in immune privilege
    D R Green
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Rev Mol Cell Biol 2:917-24. 2001
  3. ncbi request reprint The central executioners of apoptosis: caspases or mitochondria?
    D Green
    Division of Cellular Immunology, La Jolla Institute for Allergy, San Diego, CA 92121, USA
    Trends Cell Biol 8:267-71. 1998
  4. pmc Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process
    N J Waterhouse
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Cell Biol 153:319-28. 2001
  5. ncbi request reprint Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation
    B B Wolf
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 274:30651-6. 1999
  6. ncbi request reprint Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway
    M J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 276:12060-7. 2001
  7. ncbi request reprint Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity
    B B Wolf
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 276:34244-51. 2001
  8. ncbi request reprint Apoptosis: checkpoint at the mitochondrial frontier
    E Bossy-Wetzel
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Mutat Res 434:243-51. 1999
  9. pmc Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease
    T Lin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA tesu
    J Clin Invest 101:570-7. 1998
  10. ncbi request reprint p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation
    M Schuler
    Division of Cellular Immunology, La Jolla Institute for Allergy, San Diego, CA, USA
    Cell Death Differ 10:451-60. 2003

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Apoptotic pathways: paper wraps stone blunts scissors
    D R Green
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Cell 102:1-4. 2000
  2. ncbi request reprint The role of Fas ligand in immune privilege
    D R Green
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Rev Mol Cell Biol 2:917-24. 2001
    ..This idea has recently been challenged, and here we review the evidence for and against a role for FasL in immune privilege...
  3. ncbi request reprint The central executioners of apoptosis: caspases or mitochondria?
    D Green
    Division of Cellular Immunology, La Jolla Institute for Allergy, San Diego, CA 92121, USA
    Trends Cell Biol 8:267-71. 1998
    ..They propose a model for initiation of apoptosis in which mitochondria and caspases engage in a self-amplifying pathway of mutual activation...
  4. pmc Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process
    N J Waterhouse
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Cell Biol 153:319-28. 2001
    ....
  5. ncbi request reprint Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation
    B B Wolf
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 274:30651-6. 1999
    ..Together, these data suggest that caspase-3 is the primary inactivator of DFF45/ICAD and therefore the primary activator of apoptotic DNA fragmentation...
  6. ncbi request reprint Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway
    M J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 276:12060-7. 2001
    ..Bcl-2 blocks the rapid destruction of targets by granzyme B by blocking mitochondrial involvement in the process...
  7. ncbi request reprint Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity
    B B Wolf
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 276:34244-51. 2001
    ..Lack of APAF-1 activity correlated in some but not all cell lines with resistance to apoptosis. These data suggest that regulation of APAF-1 activity may be important for apoptosis regulation in some ovarian cancers...
  8. ncbi request reprint Apoptosis: checkpoint at the mitochondrial frontier
    E Bossy-Wetzel
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Mutat Res 434:243-51. 1999
    ..This review discusses recent advances on the role of mitochondria and cytochrome c in the central pathway leading to apoptotic cell death...
  9. pmc Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease
    T Lin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA tesu
    J Clin Invest 101:570-7. 1998
    ..Thus, these results demonstrate that FasL-mediated death of IEC by IEL is a major mechanism of IEC apoptosis seen in GVHD...
  10. ncbi request reprint p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation
    M Schuler
    Division of Cellular Immunology, La Jolla Institute for Allergy, San Diego, CA, USA
    Cell Death Differ 10:451-60. 2003
    ..Hence, in oncogene-expressing MEF p53 induces apoptosis by BH3 protein-dependent caspase activation...
  11. ncbi request reprint Fas ligand, death gene
    M J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California, CA 92121, USA
    Cell Death Differ 6:1174-81. 1999
    ..The FasL gene, which is often transcriptionally inactive, becomes activated in many forms of transcription/translation dependent apoptosis. Here we will discuss FasL as a candidate death gene...
  12. ncbi request reprint Fas and Fas ligand in gut and liver
    M J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Am J Physiol Gastrointest Liver Physiol 278:G354-66. 2000
    ..host disease, and hepatitis. Here we review the Fas/FasL system and the evidence that it is involved in the pathogenesis of liver and gastrointestinal diseases...
  13. ncbi request reprint Cytochrome c is released in a single step during apoptosis
    J C Goldstein
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Cell Death Differ 12:453-62. 2005
    ..c-GFP. We conclude that there is a general mechanism responsible for cytochrome c release that proceeds in a single step that is independent of changes in DeltaPsi(m)...
  14. ncbi request reprint Caspases induce cytochrome c release from mitochondria by activating cytosolic factors
    E Bossy-Wetzel
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 274:17484-90. 1999
    ..Our data suggest that cytochrome c release, initiated by the action of caspases on a cytosolic substrates, may act to amplify a caspase cascade during apoptosis...
  15. ncbi request reprint How cells die: apoptosis pathways
    K C Zimmermann
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Allergy Clin Immunol 108:S99-103. 2001
    ..The end result of either pathway is caspase activation and the cleavage of specific cellular substrates, resulting in the morphologic and biochemical changes associated with the apoptotic phenotype...
  16. ncbi request reprint Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity
    S J Martin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 271:28753-6. 1996
    ....
  17. ncbi request reprint Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB
    S Kasibhatla
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 274:987-92. 1999
    ..In contrast, the transcription factor AP-1 is not required for activation-induced FasL promoter activity. These results define a role for NF-kappaB in mediating FasL expression during T cell activation...
  18. ncbi request reprint Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation
    B B Wolf
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Blood 94:1683-92. 1999
    ..These data implicate calpain as a potential regulator of caspases and suggest that calpain, not caspases, promotes apoptosis-like events during platelet activation...
  19. ncbi request reprint Role of acidic sphingomyelinase in Fas/CD95-mediated cell death
    T Lin
    Department of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:8657-63. 2000
    ..Susceptibility of aSMase(-/-) mice to anti-Fas antibody was demonstrated with higher antibody doses (>/=4 microg/25 g mouse). These data indicate a role for aSMase in Fas-mediated cell death in some but not all tissues...
  20. ncbi request reprint Cloak and dagger in the avoidance of immune surveillance
    M J Pinkoski
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Curr Opin Genet Dev 10:114-9. 2000
    ..Additionally, factors affecting the pro- and anti-inflammatory effects of CD95L point to a balance of cytokines and growth factors...
  21. ncbi request reprint The machinery of programmed cell death
    K C Zimmermann
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Pharmacol Ther 92:57-70. 2001
    ..Nevertheless, the end result of either pathway is caspase activation and the cleavage of specific cellular substrates, resulting in the morphological and biochemical changes associated with the apoptotic phenotype...
  22. ncbi request reprint A 'non-canonical' DNA-binding element mediates the response of the Fas-ligand promoter to c-Myc
    S Kasibhatla
    Maxim Research, 6650 Nancy Ridge Drive, San Diego, California 92121, USA
    Curr Biol 10:1205-8. 2000
    ..Our findings identify a precise physiological role for c-Myc in the induction of apoptosis as a transcriptional regulator of the FasL gene...
  23. ncbi request reprint Cell survival and proliferation in Drosophila S2 cells following apoptotic stress in the absence of the APAF-1 homolog, ARK, or downstream caspases
    S Kiessling
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Apoptosis 11:497-507. 2006
    ..The apparent absence of mitochondrial outer membrane permeabilization (MOMP) in Drosophila apoptosis may permit the cell to thrive when caspase activation is disrupted...
  24. ncbi request reprint Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells
    E Bonfoco
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 9:711-20. 1998
    ..Thus, some immune responses induce FasL in nonlymphoid tissues, which in turn kills activated lymphocytes, leading to peripheral T cell deletion...
  25. ncbi request reprint Stress management - heat shock protein-70 and the regulation of apoptosis
    H M Beere
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, 92121, San Diego, CA, USA
    Trends Cell Biol 11:6-10. 2001
    ..This article discusses the functional interactions between the stress response and the apoptotic cell death pathway and how these might impact on determining cellular survival...
  26. pmc The role of ARK in stress-induced apoptosis in Drosophila cells
    Katja C Zimmermann
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Cell Biol 156:1077-87. 2002
    ..These results demonstrate the central role of ARK in stress-induced apoptosis, which appears to act independently of cytochrome c. Apoptosis induced by Reaper or Grim can proceed via a distinct pathway, independent of ARK...
  27. ncbi request reprint Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis
    Diana Spierings
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 310:66-7. 2005
    ....
  28. pmc How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
    Jerry E Chipuk
    St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Trends Cell Biol 18:157-64. 2008
    ....
  29. pmc Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death
    Christine Bonzon
    Department of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Mol Biol Cell 17:2150-7. 2006
    ..The data are consistent with a model in which Caspase-2 induces apoptosis via cleavage of Bid at D59 and the subsequent engagement of the mitochondrial (intrinsic) pathway...
  30. ncbi request reprint Mitochondria, apoptosis and autoimmunity
    Michael J Pinkoski
    Medical Research Council, Toxicology Unit, Leicester, UK
    Curr Dir Autoimmun 9:55-73. 2006
    ....
  31. ncbi request reprint In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
    Shine Tu
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Nat Cell Biol 8:72-7. 2006
    ..This approach unambiguously identifies the apical caspase activated in response to apoptotic stimuli, and establishes caspase-2 as a proximal mediator of heat shock-induced apoptosis...
  32. pmc Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
    Samuel Sidi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 133:864-77. 2008
    ..The evolutionarily conserved "Chk1-suppressed" pathway defines a novel apoptotic process, whose responsiveness to Chk1 inhibitors and insensitivity to p53 and BCL2 alterations have important implications for cancer therapy...
  33. pmc Pharmacological manipulation of cell death: clinical applications in sight?
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Invest 115:2610-7. 2005
    ....
  34. ncbi request reprint PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 309:1732-5. 2005
    ..Mutant Bcl-xL that bound p53, but not PUMA, rendered cells resistant to p53-induced apoptosis irrespective of PUMA expression. Thus, PUMA couples the nuclear and cytoplasmic proapoptotic functions of p53...
  35. ncbi request reprint Apoptotic pathways: ten minutes to dead
    Douglas R Green
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Cell 121:671-4. 2005
    ..The emerging, if preliminary, perspective these new studies provide may represent either a refinement of our views of how cells die or, perhaps, the beginnings of what amounts to a reformulation of our ideas...
  36. pmc Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein
    Hirotaka Kazama
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 631101, USA
    Immunity 29:21-32. 2008
    ..Similarly, blocking sites of oxidation in HMGB1 prevented tolerance induction by apoptotic cells. These results suggest that caspase-orchestrated mitochondrial events determine the impact of apoptotic cells on the immune response...
  37. ncbi request reprint CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
    Edith M Janssen
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 434:88-93. 2005
    ..Regulation of Trail expression can therefore account for the role of CD4+ T cells in the generation of CD8+ T cell memory and represents a novel mechanism for controlling adaptive immune responses...
  38. doi request reprint Cytochrome c: functions beyond respiration
    Yong Ling P Ow
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 2C1, Canada
    Nat Rev Mol Cell Biol 9:532-42. 2008
    ..As well as its role in canonical intrinsic apoptosis, cytochrome c amplifies signals that are generated by other apoptotic pathways and participates in certain non-apoptotic functions...
  39. ncbi request reprint Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
    Ulrich Maurer
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Mol Cell 21:749-60. 2006
    ..The results demonstrate that the control of MCL-1 stability by GSK-3 is an important mechanism for the regulation of apoptosis by growth factors, PI3K, and AKT...
  40. pmc Measuring apoptosis at the single cell level
    Lisa Bouchier-Hayes
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Methods 44:222-8. 2008
    ..We discuss these techniques here and highlight the advantages and drawbacks of using such approaches to study apoptosis...
  41. pmc A survivor hits the breaks
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell 29:411-2. 2008
    ..In this issue of Molecular Cell, Wang et al. (2008) propose another function for Bcl2: the inhibition of DNA repair by nonhomologous end-joining...
  42. ncbi request reprint Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
    Miguel A Sanjuan
    Department of Immunology, St Jude Children s Research Institute, Memphis, Tennessee 38105, USA
    Nature 450:1253-7. 2007
    ....
  43. ncbi request reprint Knockdown of actin and caspase gene expression by RNA interference in the symbiotic anemone Aiptasia pallida
    Simon R Dunn
    Department of Zoology, Oregon State University, Corvallis, Oregon 97331, USA
    Biol Bull 212:250-8. 2007
    ..Knockdown was assessed qualitatively with in situ hybridizations for both genes. Quantitative PCR and caspase activity assays were used as a quantitative measure of knockdown for acasp...
  44. ncbi request reprint GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation
    Anna Colell
    Department of Cell Death and Proliferation, Institut d Investigacions Biomediques de Barcelona IIBB CSIC, IDIBAPS, 08036 Barcelona, Spain
    Cell 129:983-97. 2007
    ..Therefore, GAPDH mediates an elevation in glycolysis and enhanced autophagy that cooperate to protect cells from CICD...
  45. pmc Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration
    Cristina Munoz-Pinedo
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 103:11573-8. 2006
    ..The timing and extent of AIF release makes it unlikely that it is involved in the induction of apoptosis, either upstream or downstream of mitochondrial outer membrane permeabilization...
  46. ncbi request reprint Highly conserved caspase and Bcl-2 homologues from the sea anemone Aiptasia pallida: lower metazoans as models for the study of apoptosis evolution
    Simon R Dunn
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    J Mol Evol 63:95-107. 2006
    ..This paves the way for establishing new lower metazoan model systems for the study of apoptosis...
  47. ncbi request reprint At the gates of death
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Cell 9:328-30. 2006
    ..Here, we discuss an emerging view, proposed by Certo et al. in this issue of Cancer Cell, on how these interactions result in MOMP and apoptosis...
  48. ncbi request reprint Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
    Maya Saleh
    Department of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nature 440:1064-8. 2006
    ..In mice, caspase-12 deficiency confers resistance to sepsis and its presence exerts a dominant-negative suppressive effect on caspase-1, resulting in enhanced vulnerability to bacterial infection and septic mortality...
  49. ncbi request reprint Apoptosis in the regulation of immune responses
    Michael J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    J Rheumatol Suppl 74:19-25. 2005
    ..Concepts reviewed here include caspase activation, death pathways, and crosstalk between death ligands and their receptors...
  50. ncbi request reprint BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
    Tomomi Kuwana
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Mol Cell 17:525-35. 2005
    ..In this model, the simple inhibition of antiapoptotic functions is insufficient to induce apoptosis unless a direct activator of Bax or Bak is present...
  51. ncbi request reprint Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins
    Carole Moreau
    INSERM U419, Nantes, France
    J Biol Chem 278:19426-35. 2003
    ..Thus, BH3 domains do not necessarily activate multidomain pro-apoptotic proteins directly but promote apoptosis by releasing active multidomain pro-apoptotic proteins from their anti-apoptotic counterparts...
  52. ncbi request reprint A unified model for apical caspase activation
    Kelly M Boatright
    The Program in Apoptosis and Cell Death Research, Burnham Institute, 10901 North Torrey Pines Road, University of California, San Diego, La Jolla, CA 92037, USA
    Mol Cell 11:529-41. 2003
    ..We propose a unified caspase activation hypothesis whereby apical caspases are activated by dimerization of monomeric zymogens...
  53. pmc Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
    Jean Ehrland Ricci
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Cell Biol 160:65-75. 2003
    ....
  54. ncbi request reprint Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
    Tomomi Kuwana
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Cell 111:331-42. 2002
    ..We conclude that mitochondrial protein release in apoptosis can be mediated by supramolecular openings in the outer mitochondrial membrane, promoted by BH3/Bax/lipid interaction and directly inhibited by Bcl-x(L)...
  55. ncbi request reprint The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways
    Emmanuel Dejardin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunity 17:525-35. 2002
    ..In contrast, IKKalpha controls the induction by LTbetaR ligation of chemokines and cytokines involved in lymphoid organogenesis, including SLC, BLC, ELC, SDF1, and BAFF...
  56. ncbi request reprint Tumor necrosis factor alpha up-regulates non-lymphoid Fas-ligand following superantigen-induced peripheral lymphocyte activation
    Michael J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 277:42380-5. 2002
    ....
  57. ncbi request reprint HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:37820-31. 2002
    ..Bcl-2 overexpressing cells succumb to Vpr-induced apoptosis. These studies illustrate that Vpr induces a mitochondria-dependent apoptotic pathway that is distinct from apoptosis driven by the Fas-FasL pathway...
  58. ncbi request reprint Apoptosis: letting slip the dogs of war
    Beni B Wolf
    Department of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Curr Biol 12:R177-9. 2002
    ....
  59. ncbi request reprint Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils
    Isabelle Daigle
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Nat Med 8:61-7. 2002
    ..Thus, we provide molecular and functional evidence for negative signaling by death receptors...
  60. ncbi request reprint Lymphocyte apoptosis: refining the paths to perdition
    Michael J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Curr Opin Hematol 9:43-9. 2002
    ..In addition, the intricacies of the mitochondrial role in apoptosis are starting to unravel with reports of novel proteins, such as Smac/DIABLO, and old proteins, such as heat shock proteins, playing new roles in regulating cell death...
  61. ncbi request reprint Death fold domain interaction in apoptosis
    Armin Lahm
    Cell Death Differ 10:10-2. 2003
  62. ncbi request reprint RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100
    Emmanuel Derudder
    Laboratoire Oncogenese, Differenciation et Transduction du Signal, CNRS UPR 9079, Institut Andre Lwoff, 7 rue Guy Moquet, 94801 Villejuif, France
    J Biol Chem 278:23278-84. 2003
    ....
  63. ncbi request reprint Overview: apoptotic signaling pathways in the immune system
    Douglas R Green
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Rev 193:5-9. 2003
  64. ncbi request reprint Do inducers of apoptosis trigger caspase-independent cell death?
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Rev Mol Cell Biol 6:268-75. 2005
    ..Here, we present recent findings and discuss the physiological relevance of caspase-independent cell death...
  65. ncbi request reprint The pathophysiology of mitochondrial cell death
    Douglas R Green
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 305:626-9. 2004
    ..The general rules governing the pathophysiology of MOMP and controversial issues regarding its regulation are discussed...
  66. ncbi request reprint Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain
    Jean Ehrland Ricci
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Cell 117:773-86. 2004
    ..Therefore, caspase cleavage of NDUFS1 is required for several mitochondrial changes associated with apoptosis...
  67. ncbi request reprint Cytoplasmic p53: bax and forward
    Jerry E Chipuk
    La Jolla Institute for Allergy and Immunology, Division of Cellular Immunology, San Diego, California 92121, USA
    Cell Cycle 3:429-31. 2004
    ..In parallel, p53 can release pro-apoptotic Bcl-2 proteins sequestered by Bcl-x(L). These data suggest that cytoplasmic p53 functions analogously to the BH3-only proteins, a subset of pro-apoptotic Bcl-2 proteins...
  68. ncbi request reprint Role of Bcl-2 family members in immunity and disease
    Nathalie M Droin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Biochim Biophys Acta 1644:179-88. 2004
    ..In this review, we describe current knowledge of the functions of different Bcl-2 members and their potential roles in disease and immunity...
  69. ncbi request reprint Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 303:1010-4. 2004
    ..We propose that when p53 accumulates in the cytosol, it can function analogously to the BH3-only subset of proapoptotic Bcl-2 proteins to activate Bax and trigger apoptosis...
  70. pmc Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation
    Clare L Scott
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 164:89-96. 2004
    ..Moreover, loss of Apaf-1 did not promote oncogene-induced transformation of mouse embryo fibroblasts. Thus, Apaf-1 and caspase-9 do not suppress c-myc-induced lymphomagenesis and embryo fibroblast transformation...
  71. ncbi request reprint Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Cancer Cell 4:371-81. 2003
    ..Hence, pharmacologic p53 modulators can activate a transcription-independent apoptotic program...
  72. ncbi request reprint Introduction: apoptosis in the development and function of the immune system
    Douglas R Green
    Semin Immunol 15:121-3. 2003
  73. pmc Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses
    Nathalie M Droin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Mol Cell Biol 23:7638-47. 2003
    ..These results support a role for Egr family members in nonlymphoid expression of FasL, TRAIL, and TNF...
  74. ncbi request reprint Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release
    Ichiro Kuwabara
    Divisions of Allergy and Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 277:3487-97. 2002
    ..Some of them are potentially contributory to this lectin's proapoptotic function and these include redox-related genes monoamine oxidase B, ryanodine receptor 2, and glutathione S-transferase Mu 3...