Elias Zinzaras

Summary

Affiliation: University of Thessaly
Country: Greece

Publications

  1. pmc XbaI GLUT1 gene polymorphism and the risk of type 2 diabetes with nephropathy
    Ioannis Stefanidis
    Department of Nephrology, University of Thessaly, School of Medicine, Larissa, Greece
    Dis Markers 27:29-35. 2009
  2. pmc Factors affecting the quality of life after total knee arthroplasties: a prospective study
    Ippolyti Papakostidou
    Department of Orthopaedic Surgery, University of Thessalia, Larissa, Greece
    BMC Musculoskelet Disord 13:116. 2012
  3. doi request reprint METRADISC-XL: a program for meta-analysis of multidimensional ranked discovery oriented datasets including microarrays
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Comput Methods Programs Biomed 108:1243-6. 2012
  4. pmc The reporting quality of studies investigating the diagnostic accuracy of anti-CCP antibody in rheumatoid arthritis and its impact on diagnostic estimates
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Larissa, 41110, Greece
    BMC Musculoskelet Disord 13:113. 2012
  5. doi request reprint Gamma-aminobutyric acid A receptor, α-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Psychiatr Genet 22:189-96. 2012
  6. doi request reprint Network analysis of randomized controlled trials in multiple sclerosis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Larissa, Greece
    Clin Ther 34:857-869.e9. 2012
  7. doi request reprint Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: a synthesis of genetic association studies
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Cancer Epidemiol 36:169-76. 2012
  8. pmc Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Biopolis, Larissa 41110, Greece
    BMC Med Res Methodol 11:171. 2011
  9. doi request reprint Bone mineral density and genetic markers involved in three connected pathways (focal adhesion, actin cytoskeleton regulation and cell cycle): the CUMAGAS-BMD information system
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Biomarkers 16:698-708. 2011
  10. doi request reprint Is there evidence to claim or deny association between variants of the multidrug resistance gene (MDR1 or ABCB1) and inflammatory bowel disease?
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Inflamm Bowel Dis 18:562-72. 2012

Detail Information

Publications105 found, 100 shown here

  1. pmc XbaI GLUT1 gene polymorphism and the risk of type 2 diabetes with nephropathy
    Ioannis Stefanidis
    Department of Nephrology, University of Thessaly, School of Medicine, Larissa, Greece
    Dis Markers 27:29-35. 2009
    ..12 (0.55-2.26). Thus, the GLUT1 XbaI(-) allele is associated with DM, and possibly with a more severe form of the disease that can lead to development of DN...
  2. pmc Factors affecting the quality of life after total knee arthroplasties: a prospective study
    Ippolyti Papakostidou
    Department of Orthopaedic Surgery, University of Thessalia, Larissa, Greece
    BMC Musculoskelet Disord 13:116. 2012
    ..The purpose of the study is to evaluate the self-reported outcomes in the first year after primary total knee arthroplasty (TKA), and to determine factors influencing the quality of life (QoL) 6 weeks, 3, 6, and 12 months after TKA...
  3. doi request reprint METRADISC-XL: a program for meta-analysis of multidimensional ranked discovery oriented datasets including microarrays
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Comput Methods Programs Biomed 108:1243-6. 2012
    ..Furthermore, it performs heterogeneity analyses restricted to probes with similar average ranks. The program allows both unweighted and weighted analysis. Statistical inferences are based on Monte Carlo permutation tests...
  4. pmc The reporting quality of studies investigating the diagnostic accuracy of anti-CCP antibody in rheumatoid arthritis and its impact on diagnostic estimates
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Larissa, 41110, Greece
    BMC Musculoskelet Disord 13:113. 2012
    ..The aim of the present study was to evaluate the reporting quality of studies used anti-CCP2 for the diagnosis of RA and to explore the impact of reporting quality on pooled estimates of diagnostic measures...
  5. doi request reprint Gamma-aminobutyric acid A receptor, α-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Psychiatr Genet 22:189-96. 2012
    ..To interpret these results, a meticulous meta-analysis of all available studies was carried out...
  6. doi request reprint Network analysis of randomized controlled trials in multiple sclerosis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Larissa, Greece
    Clin Ther 34:857-869.e9. 2012
    ..The optimal treatment of multiple sclerosis (MS) is not yet well-defined...
  7. doi request reprint Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: a synthesis of genetic association studies
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Cancer Epidemiol 36:169-76. 2012
    ..The genetic association studies (GAS) that investigated the association between ALL and the MTHFR C677T and A1298C gene variants have produced contradictory or inconclusive results...
  8. pmc Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Biopolis, Larissa 41110, Greece
    BMC Med Res Methodol 11:171. 2011
    ..Then, the mode of inheritance is approximated by investigating a number of non-orthogonal genetic contrasts making the interpretation of results difficult...
  9. doi request reprint Bone mineral density and genetic markers involved in three connected pathways (focal adhesion, actin cytoskeleton regulation and cell cycle): the CUMAGAS-BMD information system
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Biomarkers 16:698-708. 2011
    ..In meta-analysis, significant results were shown for the variants COL1A1 rs1800012 (in lumbar spine and femoral neck), COL1A1 rs1107946 (in lumbar spine), TGFB1 rs1982073 (in femoral neck and hip) and TGFB1 rs1800469 (in lumbar spine)...
  10. doi request reprint Is there evidence to claim or deny association between variants of the multidrug resistance gene (MDR1 or ABCB1) and inflammatory bowel disease?
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Inflamm Bowel Dis 18:562-72. 2012
    ..However, the 20 published genetic association studies (GAS) for the three most popular variants in the MDR1 gene (C3435T, G2677T/A, and C1236T) have produced inclusive results...
  11. pmc Quality of reporting of randomized controlled trials in polycystic ovary syndrome
    Anna Partsinevelou
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Trials 10:106. 2009
    ..The purpose of this study was to assess the reporting quality of RCTs involving patients with PCOS using a standardized tool based on the Consolidated Standards of Reporting Trials (CONSORT) statement...
  12. pmc The prevalence of rheumatic diseases in central Greece: a population survey
    Ioannis Anagnostopoulos
    Department of Rheumatology and Biomathematics, Thessaly University School of Medicine and Hospital, Larissa 41 110, Greece
    BMC Musculoskelet Disord 11:98. 2010
    ..The prevalence of rheumatic diseases may change over time, and therefore, we sought to estimate the prevalence of rheumatic diseases in an adult population of central Greece...
  13. pmc Prevalence of chronic diseases and morbidity in primary health care in central Greece: an epidemiological study
    Markos Minas
    Respiratory Medicine Department, University of Thessaly Medical School, Larissa, Greece
    BMC Health Serv Res 10:252. 2010
    ..The aim of the present study was to estimate the prevalence and morbidity of the most common diseases in a large population sample from primary health care...
  14. ncbi request reprint Brain-derived neurotrophic factor gene polymorphisms and schizophrenia: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Psychiatr Genet 17:69-75. 2007
    ..To evaluate whether the G196A and C270T polymorphisms of the brain-derived neurotrophic factor gene are associated with increased risk of schizophrenia...
  15. ncbi request reprint Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece
    J Hum Genet 52:943-53. 2007
    ..Large and rigorous case-control studies that investigate gene-gene and gene-environment interactions need to be performed before conclusive claims about the genetics of DS can be made...
  16. pmc BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and the risk of osteoporosis: a meta-analysis
    Elias Zintzaras
    Evidence Based Medicine Unit, Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Dis Markers 22:317-26. 2006
    ..Therefore, the relationship between the VDR polymorphisms and osteoporosis remains an unresolved issue and other probable genetic-environmental risk factors interacting with the above polymorphisms should be investigated...
  17. ncbi request reprint Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece
    J Hum Genet 52:881-90. 2007
    ..In conclusion, although there is some evidence of association between MTHFR C677T gene polymorphism and DN, the above findings reinforce the need for further and more rigorous association studies...
  18. ncbi request reprint Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, 41222 Larissa, Greece
    Psychiatr Genet 17:267-73. 2007
    ..To shed some light on these results a meta-analysis of all available case-control studies was conducted...
  19. doi request reprint Randomized trials of dopamine agonists in restless legs syndrome: a systematic review, quality assessment, and meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Clin Ther 32:221-37. 2010
    ..The use of dopamine agonists (DAs) for the treatment of restless legs syndrome (RLS) has been assessed in numerous randomized clinical trials (RCTs)...
  20. doi request reprint Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Street, Biopolis, Larissa 41110, Greece
    Am J Epidemiol 171:851-8. 2010
    ..CUMAGAS-OSTEO may be a useful tool for identifying pertinent gene-osteoarthritis associations and providing an updated summary of risk effects...
  21. doi request reprint Forest classification trees and forest support vector machines algorithms: Demonstration using microarray data
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Comput Biol Med 40:519-24. 2010
    ..The proposed methodologies may be used for identifying important variables in high dimensional data. Furthermore, the FCT allows exploring the data structure and provides a decision rule...
  22. ncbi request reprint Sleep-disordered breathing and blood pressure in children: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Arch Pediatr Adolesc Med 161:172-8. 2007
    ..To estimate the risk of elevated blood pressure (BP) in children with obstructive sleep-disordered breathing (SDB) and to explore heterogeneity among published studies...
  23. doi request reprint Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studies
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Biomarkers 15:69-79. 2010
    ..12-1.97) and OR 1.55 (1.12-2.15), respectively). The effect sizes for Crohn's disease and ulcerative colitis were similar to IBD. Cumulative meta-analysis for C677T indicated a downward trend of association as information accumulates...
  24. ncbi request reprint Meta-analysis for ranked discovery datasets: theoretical framework and empirical demonstration for microarrays
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Comput Biol Chem 32:38-46. 2008
    ..We offer a new tool for combining complex datasets derived from massive testing, discovery-oriented research and for examining the diversity of results across the combined studies...
  25. ncbi request reprint A field synopsis and meta-analysis of genetic association studies in peripheral arterial disease: The CUMAGAS-PAD database
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly, Larissa, Greece
    Am J Epidemiol 170:1-11. 2009
    ....
  26. doi request reprint Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Am J Epidemiol 169:523-32. 2009
    ..Tests for bias revealed no evidence of biases. Rigorous genetic association studies investigating gene-gene-environment interactions may generate more conclusive claims about the genetics of stroke...
  27. doi request reprint Inhibin alpha gene and susceptibility to premature ovarian failure: a data synthesis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece
    Mol Hum Reprod 15:551-5. 2009
    ..There was no differential magnitude of effect in large versus small studies. In conclusion, there is no evidence of association between the studied polymorphisms and POF...
  28. doi request reprint MTHFR gene polymorphisms and response to chemotherapy in colorectal cancer: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece
    Pharmacogenomics 10:1285-94. 2009
    ..In an attempt to interpret these results, a meta-analysis of all eligible studies published up until January 2009 was carried out...
  29. doi request reprint Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa41222, Greece
    Am J Epidemiol 170:671-8. 2009
    ..CUMAGAS-CLL would be a useful tool for current genomic epidemiology research in the field of CLL...
  30. doi request reprint Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches
    Elias Zintzaras
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, USA
    J Clin Epidemiol 61:634-45. 2008
    ..Although the basic statistical issues for performing meta-analysis are well described in the literature, there are remaining methodological issues...
  31. doi request reprint Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis
    Elias Zintzaras
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Arch Intern Med 168:1077-89. 2008
    ..To shed light on these inconclusive findings, we conducted a meta-analysis of studies relating the ACE I/D polymorphic variant to the risk of CAD...
  32. ncbi request reprint Variance estimation of allele-based odds ratio in the absence of Hardy-Weinberg equilibrium
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece
    Eur J Epidemiol 23:323-6. 2008
    ..The proposed variance adjustment provided better power than the unadjusted one to detect significant estimates of odds ratio and it improved the variance estimation...
  33. doi request reprint The role of MTHFR gene in multiple myeloma
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, 41222 Larissa, Greece
    J Hum Genet 53:499-507. 2008
    ..In conclusion, the accumulated evidence indicated an association between MTHFR C677T polymorphism and MM in Caucasians under a dominant model...
  34. ncbi request reprint APOE gene polymorphisms and response to statin therapy
    E Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Pharmacogenomics J 9:248-57. 2009
    ..There was significant heterogeneity among the studies. Given these non-significant effects of APOE genotypes on lipid responses, there is little reason to consider the use of APOE genetic testing for guiding treatment with statins...
  35. ncbi request reprint Trends in meta-analysis of genetic association studies
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa, 41222, Greece
    J Hum Genet 53:1-9. 2008
    ....
  36. doi request reprint Impact of Hardy-Weinberg equilibrium deviation on allele-based risk effect of genetic association studies and meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Biopolis, Larissa, 41110, Greece
    Eur J Epidemiol 25:553-60. 2010
    ..05) whereas seven meta-analyses (16%) were no longer significant. Adjustment for HWE deviation could be an effective strategy for dealing with HWE violations in GAS and meta-analyses...
  37. ncbi request reprint Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis
    E Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Clin Genet 69:327-36. 2006
    ..BC is a complex disease with multifactorial etiology, and therefore, case-control studies that investigate gene-environment interaction might elucidate further the genetics of the disease...
  38. ncbi request reprint Non-parametric classification of protein secondary structures
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Greece
    Comput Biol Med 36:145-56. 2006
    ..The presented algorithm might be suitable for a rapid preliminary classification of proteins into their corresponding families...
  39. doi request reprint A mathematical model of HIV dynamics in the presence of a rescuing virus with replication deficiency
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Biopolis Str, Larissa 41110, Greece
    Theory Biosci 130:127-34. 2011
    ..The proposed model may provide new insights in the dynamical behavior and future alternative treatments of HIV...
  40. ncbi request reprint Estimating genetic correlations based on phenotypic data: a simulation-based method
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Biopolis, Larissa 41110, Greece
    J Genet 90:51-8. 2011
    ..Extensive numerical results suggest that the propose method may provide relatively efficient estimates regardless of sample sizes and contributions from common environmental effects...
  41. ncbi request reprint The role of G196A polymorphism in the brain-derived neurotrophic factor gene in the cause of Parkinson's disease: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, 41222, Larissa, Greece
    J Hum Genet 50:560-6. 2005
    ..The meta-analysis results suggest that the involvement of the BDNF gene in susceptibility to PD merits further exploration with larger and more rigorous population association studies...
  42. ncbi request reprint Statistical aspects of bioequivalence testing between two medicinal products
    E Zintzaras
    Department of Biomathematics, School of Medicine, University of Thessaly, Larisa, Greece
    Eur J Drug Metab Pharmacokinet 30:41-6. 2005
    ....
  43. ncbi request reprint The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa, 41222, Greece
    J Hum Genet 50:267-75. 2005
    ..There is a source of bias in the selected studies: the largest studies failed to show association while the smallest study claimed an association. The above findings reinforce the need for larger and more rigourous studies in this area...
  44. doi request reprint Is catechol-O-methyl transferase 472G/A gene polymorphism a marker associated with alcoholism?
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Psychiatr Genet 21:29-36. 2011
    ..To interpret these results, a meta-analysis of all available studies was conducted...
  45. ncbi request reprint Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazy 22, Larissa, 41222, Greece
    J Hum Genet 50:84-91. 2005
    ..Although there is evidence of association between GLUT1 and DN, the above findings reinforce the need for further and more rigorous association studies...
  46. ncbi request reprint HEGESMA: genome search meta-analysis and heterogeneity testing
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa 41222, Greece
    Bioinformatics 21:3672-3. 2005
    ..The program allows both unweighted and weighted analysis, with the weights for each study as specified by the user. Furthermore, the program performs heterogeneity analyses restricted to the bins with similar average ranks...
  47. doi request reprint Glutathione S-transferase M1 and T1 genes and susceptibility to chronic myeloid leukemia: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Genet Test Mol Biomarkers 13:791-7. 2009
    ..There was a differential magnitude of effect in large versus small studies. In conclusion, the accumulated evidence indicated an association between GSTT1 null genotype and CML...
  48. ncbi request reprint Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Hepatology 43:352-61. 2006
    ..The above findings reinforce the need for more rigorous studies, and for regular synthesis of studies' results...
  49. pmc Performance of antibodies against tissue transglutaminase for the diagnosis of celiac disease: meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, GR 41222 Larissa, Greece
    Clin Vaccine Immunol 13:187-92. 2006
    ..Human tTG ELISA is sensitive and specific, and it can be used for mass screening. Sensitivity analysis showed that ph-tTG might perform better...
  50. ncbi request reprint A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia
    Elias Zintzaras
    Evidence Based Medicine Unit, Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Eur J Epidemiol 21:501-10. 2006
    ..Overall, there is high heterogeneity between the studies in both polymorphisms. A differential magnitude of effect in large versus small studies and alteration of early extremes effects existed...
  51. ncbi request reprint A tree-based decision rule for identifying profile groups of cases without predefined classes: application in diffuse large B-cell lymphomas
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Comput Biol Med 37:637-41. 2007
    ..The classification tree, as a supplement method, not only identified but also provided decision rules for identifying profile groups. Finally, it also allowed for exploration of the data structure...
  52. doi request reprint The generalized odds ratio as a measure of genetic risk effect in the analysis and meta-analysis of association studies
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Stat Appl Genet Mol Biol 9:Article21. 2010
    ..Application of the ORG could overcome the shortcomings of multiple model testing or erroneous model specification and provides an alternative and robust way for genetic association testing...
  53. ncbi request reprint Endothelial NO synthase gene polymorphisms and hypertension: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, 41222 Larissa, Greece
    Hypertension 48:700-10. 2006
    ..In conclusion, there is evidence of association only between 4b/a polymorphism and hypertension; however, studies exploring combinations of the polymorphisms may help us better understand the genetics of hypertension...
  54. ncbi request reprint Heterogeneity-based genome search meta-analysis for preeclampsia
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa, 41222, Greece
    Hum Genet 120:360-70. 2006
    ..Results should be interpreted with caution as the p values were modest. Further investigation of these regions by genotyping with additional markers and families may help to direct the identification of candidate genes for preeclampsia...
  55. ncbi request reprint Identification of chromosomal regions linked to premature myocardial infarction: a meta-analysis of whole-genome searches
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, 41222 Larissa, Greece
    J Hum Genet 51:1015-21. 2006
    ..3-6p21.1, 14p13-14q13.1, 8q13.2-8q22.2, 8q24.21-8q24.3) were not identified by the individual studies. The meta-analysis suggests that these four regions should be further investigated for genes that confer susceptibility to MI...
  56. ncbi request reprint Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa, 41222, Greece
    J Hum Genet 51:618-24. 2006
    ..In conclusion, there is evidence of association between MTHFR polymorphisms and GC, mainly in East Asians...
  57. ncbi request reprint C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Psychiatr Genet 16:105-15. 2006
    ....
  58. pmc Synopsis and meta-analysis of genetic association studies in osteoporosis for the focal adhesion family genes: the CUMAGAS-OSTEOporosis information system
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    BMC Med 9:9. 2011
    ..To clarify these data, a systematic assessment of GASs for FA genes in osteoporosis was conducted...
  59. doi request reprint Alpha-1 antichymotrypsin gene signal peptide a/t polymorphism and primary intracerebral hemorrhage
    E Dardiotis
    Neurogenetics Unit, Department of Neurology, School of Medicine, University of Thessaly, Larissa, Greece
    Eur Neurol 59:307-14. 2008
    ..We conducted a prospective study to test possible association of ACT signal peptide A/T polymorphism with PICH in a Greek cohort with enough power (80%) to detect a twofold increase in the odds ratio...
  60. ncbi request reprint IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury
    G M Hadjigeorgiou
    Department of Neurology, University Hospital of Larissa, Medical School, University of Thessaly, Larissa 41222, Greece
    Neurology 65:1077-82. 2005
    ..To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI)...
  61. ncbi request reprint Association of paraoxonase 1 gene polymorphisms with risk of Parkinson's disease: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece
    J Hum Genet 49:474-81. 2004
    ..Therefore, the pooled results of the meta-analysis supported that there was an association between PON1-55M/L polymorphism and PD and that PON1-192Q/R polymorphism was unlikely to be a major risk factor for susceptibility to PD...
  62. ncbi request reprint Low RLS prevalence and awareness in central Greece: an epidemiological survey
    G M Hadjigeorgiou
    Department of Neurology, Medical School of Larissa, University of Thessaly, Larissa, Greece
    Eur J Neurol 14:1275-80. 2007
    ..We provide further evidence for low prevalence of RLS in south-east Europe and a low level of awareness of RLS in our region...
  63. ncbi request reprint Heterogeneity testing in meta-analysis of genome searches
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Genet Epidemiol 28:123-37. 2005
    ..Concordance was high between the proposed metrics and between weighted and unweighted analyses. Data from genome searches should be synthesized and interpreted considering both average ranks and heterogeneity between studies...
  64. doi request reprint Urine concentrations of cysteinyl leukotrienes in children with obstructive sleep-disordered breathing
    Athanasios G Kaditis
    Sleep Disorders Laboratory, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece
    Chest 135:1496-501. 2009
    ..Furthermore, CysLTs concentrations in the nasal exhaled breath condensate of children with sleep apnea are elevated...
  65. ncbi request reprint Evaluation of a microsphere-based flow cytometric assay for diagnosis of celiac disease
    Efthalia E Yiannaki
    Department of Immunology and Histocompatibility, Medical School, University of Thessaly, University Hospital of Larissa, Larissa, Greece
    J Immunoassay Immunochem 25:345-57. 2004
    ..Taking our results together with the simplicity and the high throughput of FIDIS assay, its overall performance in the diagnosis of CD seems better than that of ELISA...
  66. ncbi request reprint Genome-wide scans meta-analysis for pulse pressure
    Elias Zintzaras
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Hypertension 50:557-64. 2007
    ..None of the bins showed low heterogeneity (P(Q)>0.05), indicating variation in the strength of association. Further investigation of these regions may help to direct the identification of candidate genes for pulse pressure variation...
  67. doi request reprint Genetic risk factors for placental abruption: a HuGE review and meta-analysis
    Nikos Zdoukopoulos
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Epidemiology 19:309-23. 2008
    ..Although the precise pathophysiology that leads to placental abruption is unknown, there is evidence supporting a genetic etiology...
  68. ncbi request reprint The value of a single combined measurement of VEGF, glycodelin, progesterone, PAPP-A, HPL and LIF for differentiating between ectopic and abnormal intrauterine pregnancy
    A Daponte
    Department of Obstetrics and Gynaecology, University of Thessalia, Larissa, Greece
    Hum Reprod 20:3163-6. 2005
    ....
  69. ncbi request reprint DHLAS: A web-based information system for statistical genetic analysis of HLA population data
    P Thriskos
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece
    Comput Methods Programs Biomed 85:267-72. 2007
    ..In addition, it has an open architecture allowing the inclusion of other functions and procedures...
  70. ncbi request reprint Endothelial nitric oxide synthase gene polymorphisms and diabetic nephropathy: a HuGE review and meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Genet Med 11:695-706. 2009
    ..Studies exploring gene and environment interactions with endothelial nitric oxide synthase polymorphisms may help understand better the genetics of diabetic nephropathy...
  71. pmc Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis
    Aspasia Tsezou
    University of Thessalia, Medical School, Department of Biology, Mezourlo 41 222 Larissa, Greece
    Clin Vaccine Immunol 15:1888-90. 2008
    ....
  72. ncbi request reprint Genetic variation associated with ischemic heart failure: a HuGE review and meta-analysis
    Georgios Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Am J Epidemiol 166:619-33. 2007
    ..Case-control studies that investigate gene-gene and gene-environment interactions might further elucidate the genetics of ischemic heart failure...
  73. ncbi request reprint Liver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients
    Giorgos K Sakkas
    Department of Nephrology, University of Thessaly, Larissa, Greece
    Am J Physiol Regul Integr Comp Physiol 295:R1721-9. 2008
    ..Means of reducing fat depots in the liver and splachnic area might prove promising in combating IR and cardiovascular risk in hemodialysis patients...
  74. ncbi request reprint Metabolic control of diabetes is associated with an improved response of diabetic retinopathy to panretinal photocoagulation
    Maria G Kotoula
    Department of Ophthalmology, University of Thessaly School of Medicine, Larissa, Greece
    Diabetes Care 28:2454-7. 2005
    ..To study the influence of glycemic control and the presence of microalbuminuria on the initial response to panretinal photocoagulation (PRP) in patients with a high-risk proliferative diabetic retinopathy (PDR)...
  75. ncbi request reprint TLR4 single nucleotide polymorphisms and thrombosis risk in patients with myeloproliferative disorders
    M Speletas
    Department of Immunology and Histocompatibility, School of Medicine, University Hospital of Thessaly, Larissa, 41110 Larissa, Greece
    Thromb Res 122:27-32. 2008
  76. ncbi request reprint Discrimination of exudative pleural effusions based on multiple biological parameters
    Z D Daniil
    Department of Respiratory Medicine, University of Thessaly School of Medicine, Larissa, Greece
    Eur Respir J 30:957-64. 2007
    ..The combination of adenosine deaminase and C-reactive protein levels might be sufficient for discriminating between the three different groups of exudative pleural effusion: malignant, tuberculous and parapneumonic...
  77. doi request reprint Serum nitrite and nitrate levels in children with obstructive sleep-disordered breathing
    Athanasios Kaditis
    Sleep Disorders Laboratory, University of Thessaly School of Medicine, Larissa, Greece
    Sleep Med 11:258-62. 2010
    ..Diminished nitric oxide (NO) levels have been reported in adults with obstructive sleep apnea but no data are available for children with obstructive sleep-disordered breathing (SDB)...
  78. pmc ACE (I/D) polymorphism and response to treatment in coronary artery disease: a comprehensive database and meta-analysis involving study quality evaluation
    Georgios Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    BMC Med Genet 10:50. 2009
    ..The role of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in modifying the response to treatment modalities in coronary artery disease is controversial...
  79. doi request reprint Classification tree based protein structure distances for testing sequence-structure correlation
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Comput Biol Med 38:469-74. 2008
    ..403 (P<0.001). The SSAP method produced similar results. The proposed methodology may assist in assessing whether protein sequence distances can be predictors of protein structure distances...
  80. pmc Genome-wide association studies: hypothesis-"free" or "engaged"?
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Boston, MA, USA Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Transl Res 154:161-4. 2009
    ....
  81. ncbi request reprint Morning levels of fibrinogen in children with sleep-disordered breathing
    A G Kaditis
    Dept of Paediatrics, University of Thessaly School od Medicine, Larissa University Hospital, PO Box 1425, Larissa 41110, Greece
    Eur Respir J 24:790-7. 2004
    ..In conclusion, fibrinogen values are higher in children with snoring than in controls, but there is no association between these values and polysomnography indices...
  82. doi request reprint Increased prevalence of anti-thyroid antibodies in patients with limited scleroderma
    S Danielides
    Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
    Scand J Rheumatol 40:299-303. 2011
    ..We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes...
  83. pmc Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database
    Georgios D Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Am J Hypertens 23:305-13. 2010
    ..To clarify these data, a systematic assessment of GAS for adrenoceptor family genes in hypertension was conducted...
  84. ncbi request reprint Adiposity in relation to age as predictor of severity of sleep apnea in children with snoring
    Athanasios G Kaditis
    Department of Pediatrics, University of Thessaly School of Medicine, Larissa, Greece
    Sleep Breath 12:25-31. 2008
    ..However, it may have a more important contribution to severity of SDB in older children...
  85. ncbi request reprint Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome
    Menelaos N Manoussakis
    Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
    Arthritis Rheum 50:882-91. 2004
    ....
  86. ncbi request reprint The risk of lymphoma development in autoimmune diseases: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Arch Intern Med 165:2337-44. 2005
    ....
  87. doi request reprint Whole-blood interferon-gamma assay for the diagnosis of tuberculosis infection in an unselected Greek population
    Irini Gerogianni
    Department of Respiratory Medicine, Medical School, University of Larissa, Larissa, Greece
    Respirology 13:270-4. 2008
    ..The aim of this study was to compare QFT-G 'In Tube' results, based on stimulation with Mycobacterium tuberculosis-specific antigens, with tuberculin skin test (TST) results in an unselected hospital-based Greek population...
  88. ncbi request reprint Changes in pituitary sensitivity to GnRH in estrogen-treated post-menopausal women: evidence that gonadotrophin surge attenuating factor plays a physiological role
    K Dafopoulos
    Department of Obstetrics and Gynaecology, University of Thessalia, Larissa, Greece
    Hum Reprod 19:1985-92. 2004
    ..The purpose of this study was to investigate changes in pituitary response to GnRH in post-menopausal women during substitution treatment with exogenous estrogen and progesterone...
  89. ncbi request reprint Mesothelioma mortality in Greece from 1983 to 2003
    E Gogou
    Pulmonary Department, Medical School, University of Thessaly, Larisa, Greece
    Int J Clin Pract 63:944-8. 2009
    ..To present summary statistics of the Greek mesothelioma epidemic including summaries by occupation and geographical area...
  90. doi request reprint Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial
    E Keranis
    Dept of Respiratory Medicine, University of Thessaly School of Medicine, Biopolis, 4110 Larissa, Thessaly, Greece
    Eur Respir J 36:774-80. 2010
    ..These findings suggest that a dietary shift to higher-antioxidant food intake may be associated with improvement in lung function, and, in this respect, dietary interventions might be considered in COPD management...
  91. pmc Genomic convergence of genome-wide investigations for complex traits
    Georgios D Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa 41222, Greece
    Ann Hum Genet 73:514-9. 2009
    ....
  92. ncbi request reprint Left ventricular mass and mechanics in mild-to-moderate hypertension: effect of nebivolol versus telmisartan
    Katerina Fountoulaki
    Department of Cardiology, Larissa University Hospital, Larissa, Greece
    Am J Hypertens 18:171-7. 2005
    ..The aim of this study was to compare the effects of nebivolol and telmisartan on left ventricular mass (LVM) and midwall mechanics in mild-to-moderate hypertension...
  93. doi request reprint Spirometric values in Gypsy (Roma) children
    Athanasios G Kaditis
    Department of Pediatrics, Larissa University Hospital, University of Thessaly School of Medicine, P O Box 1425, Larissa 41110, Greece
    Respir Med 102:1321-8. 2008
    ..79). Mean predicted values were 5-10% lower than values for Caucasians. In Gypsy children, FVC and expiratory flow function increase linearly with standing height and predicted values are lower than those for Caucasians of similar height...
  94. ncbi request reprint Variation in the life cycle and morphology of the tobacco host-race of Myzus persicae (Hemiptera: Aphididae) in relation to its geographical distribution
    T E Kephalogianni
    Laboratory of Entomology and Agricultural Zoology, Faculty of Crop and Animal Production, University of Thessaly, Fytokou St, Nea Ionia, Magnesia, 38446, Greece
    Bull Entomol Res 92:301-7. 2002
    ..The results are discussed in relation to factors responsible for genetic divergence in M. persicae populations...
  95. ncbi request reprint "Living" under the challenge of information decay: the stochastic corrector model vs. hypercycles
    Elias Zintzaras
    Collegium Budapest, Institute for Advanced Study, Szentháromság u 2, H 1014, Budapest, Hungary
    J Theor Biol 217:167-81. 2002
    ..However, a population of SCM protocells can tolerate higher deleterious mutation rates and reaches an equilibrium mutational load lower than that in a population of HPC protocells...
  96. ncbi request reprint CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: a meta-analysis
    Nikolaos A Patsopoulos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Pharmacogenet Genomics 15:151-8. 2005
    ..003). CYP2D6 loss of function alleles may predispose to tardive dyskinesia in patients with schizophrenia under treatment, but bias cannot be excluded...
  97. ncbi request reprint Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis
    Clio P Mavragani
    Department of Pathophysiology, National University of Athens School of Medicine, Greece
    Amyloid 14:271-5. 2007
    ..To address whether or not the rarity of amyloidosis in Greek patients with rheumatoid arthritis (RA) is related to specific alleles of single nucleotide polymorphisms (SNPs) in the 5'-flanking region and the exon 3 of the SSA1 gene...
  98. ncbi request reprint Extreme between-study homogeneity in meta-analyses could offer useful insights
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Epidemiol 59:1023-32. 2006
    ..Meta-analyses are routinely evaluated for the presence of large between-study heterogeneity. We examined whether it is also important to probe whether there is extreme between-study homogeneity...
  99. ncbi request reprint Comparison of blood pressure measurements in children with and without habitual snoring
    Athanasios G Kaditis
    Pediatric Pulmonology Unit, Department of Pediatrics, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece
    Pediatr Pulmonol 39:408-14. 2005
    ..In a community sample of children, habitual snorers do not have higher morning systolic or diastolic blood pressure than nonhabitual snorers...
  100. ncbi request reprint Recombination in primeval genomes: a step forward but still a long leap from maintaining a sizable genome
    Mauro Santos
    Collegium Budapest, Institute for Advanced Study, Szentháromság u 2, H 1014 Budapest, Hungary
    J Mol Evol 59:507-19. 2004
    ..However, the upper bound of informational length would still be far from the "minimal life" provisions...
  101. doi request reprint Meta-analysis methods
    Thomas A Trikalinos
    Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Adv Genet 60:311-34. 2008
    ..A major challenge is to differentiate genuine between-study heterogeneity from systematic errors and biases...