Elias Zinzaras

Summary

Affiliation: University of Thessaly
Country: Greece

Publications

  1. Zintzaras E, Kowald A. A mathematical model of HIV dynamics in the presence of a rescuing virus with replication deficiency. Theory Biosci. 2011;130:127-34 pubmed publisher
    ..The proposed model may provide new insights in the dynamical behavior and future alternative treatments of HIV. ..
  2. Zintzaras E, Raman G, Kitsios G, Lau J. Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch Intern Med. 2008;168:1077-89 pubmed publisher
    ..The meta-analysis also highlights the heterogeneity of reported results, considerable gaps in research, and the need for future studies focused on certain high-risk patient populations. ..
  3. Zintzaras E, Kitsios G, Papathanasiou A, Konitsiotis S, Miligkos M, Rodopoulou P, et al. Randomized trials of dopamine agonists in restless legs syndrome: a systematic review, quality assessment, and meta-analysis. Clin Ther. 2010;32:221-37 pubmed publisher
    ..6% (1.3% to 18.5%), respectively. In the trial of sumanirole, the PAE value was 2% (0% to 5.4%). Based on the findings from the meta-analysis, DAs were significantly more efficacious in the treatment of RLS compared with placebo. ..
  4. request reprint
    Zintzaras E. Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis. J Hum Genet. 2006;51:618-24 pubmed
    ..In conclusion, there is evidence of association between MTHFR polymorphisms and GC, mainly in East Asians. ..
  5. Zintzaras E, Rodopoulou P, Sakellaridis N. Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. Am J Epidemiol. 2009;169:523-32 pubmed publisher
    ..Tests for bias revealed no evidence of biases. Rigorous genetic association studies investigating gene-gene-environment interactions may generate more conclusive claims about the genetics of stroke. ..
  6. Zintzaras E. Gamma-aminobutyric acid A receptor, ?-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis. Psychiatr Genet. 2012;22:189-96 pubmed publisher
    ..To interpret these results, a meticulous meta-analysis of all available studies was carried out...
  7. Zintzaras E. Is there evidence to claim or deny association between variants of the multidrug resistance gene (MDR1 or ABCB1) and inflammatory bowel disease?. Inflamm Bowel Dis. 2012;18:562-72 pubmed publisher
    ..More evidence is needed to draw safe conclusions regarding the association of MDR1 variants and development of IBD. ..
  8. Zintzaras E. Is catechol-O-methyl transferase 472G/A gene polymorphism a marker associated with alcoholism?. Psychiatr Genet. 2011;21:29-36 pubmed publisher
    ..There is no conclusive evidence that catechol-O-methyl transferase 472G/A is a marker associated with alcoholism. More evidence is needed to draw safe conclusions regarding this association. ..
  9. Zintzaras E, Kitsios G, Ziogas D, Rodopoulou P, Karachalios T. Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system. Am J Epidemiol. 2010;171:851-8 pubmed publisher
    ..CUMAGAS-OSTEO may be a useful tool for identifying pertinent gene-osteoarthritis associations and providing an updated summary of risk effects. ..
  10. Zintzaras E, Kitsios G. Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system. Am J Epidemiol. 2009;170:671-8 pubmed publisher
    ..CUMAGAS-CLL would be a useful tool for current genomic epidemiology research in the field of CLL. ..

Detail Information

Publications17

  1. Zintzaras E, Kowald A. A mathematical model of HIV dynamics in the presence of a rescuing virus with replication deficiency. Theory Biosci. 2011;130:127-34 pubmed publisher
    ..The proposed model may provide new insights in the dynamical behavior and future alternative treatments of HIV. ..
  2. Zintzaras E, Raman G, Kitsios G, Lau J. Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch Intern Med. 2008;168:1077-89 pubmed publisher
    ..The meta-analysis also highlights the heterogeneity of reported results, considerable gaps in research, and the need for future studies focused on certain high-risk patient populations. ..
  3. Zintzaras E, Kitsios G, Papathanasiou A, Konitsiotis S, Miligkos M, Rodopoulou P, et al. Randomized trials of dopamine agonists in restless legs syndrome: a systematic review, quality assessment, and meta-analysis. Clin Ther. 2010;32:221-37 pubmed publisher
    ..6% (1.3% to 18.5%), respectively. In the trial of sumanirole, the PAE value was 2% (0% to 5.4%). Based on the findings from the meta-analysis, DAs were significantly more efficacious in the treatment of RLS compared with placebo. ..
  4. request reprint
    Zintzaras E. Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis. J Hum Genet. 2006;51:618-24 pubmed
    ..In conclusion, there is evidence of association between MTHFR polymorphisms and GC, mainly in East Asians. ..
  5. Zintzaras E, Rodopoulou P, Sakellaridis N. Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. Am J Epidemiol. 2009;169:523-32 pubmed publisher
    ..Tests for bias revealed no evidence of biases. Rigorous genetic association studies investigating gene-gene-environment interactions may generate more conclusive claims about the genetics of stroke. ..
  6. Zintzaras E. Gamma-aminobutyric acid A receptor, ?-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis. Psychiatr Genet. 2012;22:189-96 pubmed publisher
    ..To interpret these results, a meticulous meta-analysis of all available studies was carried out...
  7. Zintzaras E. Is there evidence to claim or deny association between variants of the multidrug resistance gene (MDR1 or ABCB1) and inflammatory bowel disease?. Inflamm Bowel Dis. 2012;18:562-72 pubmed publisher
    ..More evidence is needed to draw safe conclusions regarding the association of MDR1 variants and development of IBD. ..
  8. Zintzaras E. Is catechol-O-methyl transferase 472G/A gene polymorphism a marker associated with alcoholism?. Psychiatr Genet. 2011;21:29-36 pubmed publisher
    ..There is no conclusive evidence that catechol-O-methyl transferase 472G/A is a marker associated with alcoholism. More evidence is needed to draw safe conclusions regarding this association. ..
  9. Zintzaras E, Kitsios G, Ziogas D, Rodopoulou P, Karachalios T. Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system. Am J Epidemiol. 2010;171:851-8 pubmed publisher
    ..CUMAGAS-OSTEO may be a useful tool for identifying pertinent gene-osteoarthritis associations and providing an updated summary of risk effects. ..
  10. Zintzaras E, Kitsios G. Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system. Am J Epidemiol. 2009;170:671-8 pubmed publisher
    ..CUMAGAS-CLL would be a useful tool for current genomic epidemiology research in the field of CLL. ..
  11. Zintzaras E, Ziogas D, Kitsios G, Papathanasiou A, Lau J, Raman G. MTHFR gene polymorphisms and response to chemotherapy in colorectal cancer: a meta-analysis. Pharmacogenomics. 2009;10:1285-94 pubmed publisher
    ..The available evidence indicates that MTHFR C677T and A1298C gene polymorphisms cannot be considered as reliable predictors of response to fluorouracil-based chemotherapy in patients with colorectal cancer. ..
  12. request reprint
    Zintzaras E, Stefanidis I. Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a meta-analysis. J Hum Genet. 2005;50:84-91 pubmed
    ..Although there is evidence of association between GLUT1 and DN, the above findings reinforce the need for further and more rigorous association studies. ..
  13. request reprint
    Zintzaras E. Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis. J Hum Genet. 2007;52:943-53 pubmed
    ..Large and rigorous case-control studies that investigate gene-gene and gene-environment interactions need to be performed before conclusive claims about the genetics of DS can be made. ..
  14. request reprint
    Zintzaras E, Sakelaridis N. Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?. Psychiatr Genet. 2007;17:267-73 pubmed
    ..Large and more rigorous association studies investigating also the interaction with other genetic/environmental factors might provide more conclusive evidence. ..
  15. request reprint
    Zintzaras E. Brain-derived neurotrophic factor gene polymorphisms and schizophrenia: a meta-analysis. Psychiatr Genet. 2007;17:69-75 pubmed
    ..The above findings reinforce the need for large and more rigorous association studies. ..
  16. Zintzaras E, Rodopoulou P, Koukoulis G. BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and the risk of osteoporosis: a meta-analysis. Dis Markers. 2006;22:317-26 pubmed
    ..Therefore, the relationship between the VDR polymorphisms and osteoporosis remains an unresolved issue and other probable genetic-environmental risk factors interacting with the above polymorphisms should be investigated. ..
  17. request reprint
    Zintzaras E, Stefanidis I, Santos M, Vidal F. Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?. Hepatology. 2006;43:352-61 pubmed
    ..The above findings reinforce the need for more rigorous studies, and for regular synthesis of studies' results. ..