Genomes and Genes

Species

Panagiotis Vlachostergios

Summary

Affiliation: University of Thessaly, School of Health Sciences, Faculty of Medicine
Location: Larissa, Greece
Summary:
DECEMBER 2009-PRESENT
1st Department of Internal Medicine, General Hospital of Larissa, Greece
National Health System/Teaching Hospital
Resident in Internal Medicine
 Clinical work in the full spectrum of Internal Medicine
 In-patient management
 Emergency cover & management
 Participation in Departmental meetings
 Assistance in the teaching & training of interns and junior residents
AUGUST 2007-PRESENT
Medical Oncology Clinic, University Hospital of Larissa, Greece;
Department of Medical Oncology, School of Medicine, Faculty of Health Sciences University of Thessaly, Greece
National Health System/UniversityTeaching Hospital
Honorary Clinical & Research Associate (Part-time)
• Implementation of clinical and basic research projects; involvement in clinical trials as Co-investigator, attending & participating in daily and on-call activities of the Clinic
OCTOBER 2008-SEPTEMBER 2009
Hellenic Cooperative Oncology Group (HeCOG)
Non-governmental medical organisation (NGO)
Medical Oncology Clinical Study Assistant & Data Manager (Full-time)
• Involvement in HeCOG clinical trials as Sub-investigator, Study Assistant, Data Manager & Translational Research Co-ordinator

Publications

  1. Vlachostergios P, Patrikidou A, Daliani D, Papandreou C. The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation. J Cell Mol Med. 2009;13:3019-31 pubmed publisher
    ..Furthermore, the contribution of UPS to the regulation of localization and accessibility of DNA repair proteins to chromatin, in response to cellular stress is discussed. ..
  2. Vlachostergios P, Daliani D, Dimopoulos V, Patrikidou A, Voutsadakis I, Papandreou C. Nonbacterial thrombotic (marantic) endocarditis in a patient with colorectal cancer. Onkologie. 2010;33:456-9 pubmed publisher
    ..In these cases, it is often difficult to establish a definite diagnosis; however, immediate anticoagulation treatment is mandatory for the prevention of de novo or further thromboembolic events. ..
  3. Vlachostergios P, Voutsadakis I, Papandreou C. Orbital metastasis of breast carcinoma. Breast Cancer (Auckl). 2009;3:91-7 pubmed
    ..Breast cancer accounts for the majority of these cases. The appearance of eye symptoms in patients with a history of cancer should always be investigated with a consideration of ocular metastatic disease. ..
  4. Patrikidou A, Vlachostergios P, Voutsadakis I, Hatzidaki E, Valeri R, Destouni C, et al. Inverse baseline expression pattern of the NEP/neuropeptides and NF?B/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells. Cancer Cell Int. 2011;11:13 pubmed publisher
    ..NEP and ET-1 are inversely and directly related to an activated state of the NF?B/proteasome pathway, respectively. A combination therapy targeting both pathways may ultimately prove to be of benefit in clinical practice. ..
  5. Gioulbasanis I, Georgoulias P, Vlachostergios P, Baracos V, Ghosh S, Giannousi Z, et al. Mini Nutritional Assessment (MNA) and biochemical markers of cachexia in metastatic lung cancer patients: interrelations and associations with prognosis. Lung Cancer. 2011;74:516-20 pubmed publisher
    ..The aim of this study was to evaluate the correlation of MNA with laboratory markers of inflammation/cachexia in patients with metastatic lung cancer. The prognostic value of the measured parameters was also examined...
  6. Vlachostergios P, Patrikidou A, Daliani D, Papandreou C. The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation. J Cell Mol Med. 2009;13:3006-18 pubmed publisher
    ....
  7. Vlachostergios P, Voutsadakis I, Barbanis S, Karasavvidou F, Papandreou C. AFP-producing hepatoid adenocarcinoma of the stomach: a case report. Cases J. 2009;2:9296 pubmed publisher
    ..Poor outcome in most of the cases is due to the fact that, as in our patient, metastatic disease is already present at diagnosis. ..
  8. Vlachostergios P, Karasavvidou F, Patrikidou A, Voutsadakis I, Kakkas G, Moutzouris G, et al. p53 and cyclooxygenase-2 expression are directly associated with cyclin D1 expression in radical prostatectomy specimens of patients with hormone-naïve prostate cancer. Pathol Oncol Res. 2012;18:245-52 pubmed publisher
    ..With respect to COX-2 and cyclin D1, further studies are required to elucidate their role in early prediction of PCa relapse after RP. ..
  9. Vlachostergios P, Papandreou C. The Bmi-1/NF-?B/VEGF story: another hint for proteasome involvement in glioma angiogenesis?. J Cell Commun Signal. 2013;7:235-7 pubmed publisher
    ....
  10. Vlachostergios P, Voutsadakis I, Papandreou C. The role of ubiquitin-proteasome system in glioma survival and growth. Growth Factors. 2013;31:106-13 pubmed publisher
    ..In this review, we discuss the involvement of UPS in the regulation of several mediators and effectors of these pathways in malignant gliomas...

Detail Information

Publications10

  1. Vlachostergios P, Patrikidou A, Daliani D, Papandreou C. The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation. J Cell Mol Med. 2009;13:3019-31 pubmed publisher
    ..Furthermore, the contribution of UPS to the regulation of localization and accessibility of DNA repair proteins to chromatin, in response to cellular stress is discussed. ..
  2. Vlachostergios P, Daliani D, Dimopoulos V, Patrikidou A, Voutsadakis I, Papandreou C. Nonbacterial thrombotic (marantic) endocarditis in a patient with colorectal cancer. Onkologie. 2010;33:456-9 pubmed publisher
    ..In these cases, it is often difficult to establish a definite diagnosis; however, immediate anticoagulation treatment is mandatory for the prevention of de novo or further thromboembolic events. ..
  3. Vlachostergios P, Voutsadakis I, Papandreou C. Orbital metastasis of breast carcinoma. Breast Cancer (Auckl). 2009;3:91-7 pubmed
    ..Breast cancer accounts for the majority of these cases. The appearance of eye symptoms in patients with a history of cancer should always be investigated with a consideration of ocular metastatic disease. ..
  4. Patrikidou A, Vlachostergios P, Voutsadakis I, Hatzidaki E, Valeri R, Destouni C, et al. Inverse baseline expression pattern of the NEP/neuropeptides and NF?B/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells. Cancer Cell Int. 2011;11:13 pubmed publisher
    ..NEP and ET-1 are inversely and directly related to an activated state of the NF?B/proteasome pathway, respectively. A combination therapy targeting both pathways may ultimately prove to be of benefit in clinical practice. ..
  5. Gioulbasanis I, Georgoulias P, Vlachostergios P, Baracos V, Ghosh S, Giannousi Z, et al. Mini Nutritional Assessment (MNA) and biochemical markers of cachexia in metastatic lung cancer patients: interrelations and associations with prognosis. Lung Cancer. 2011;74:516-20 pubmed publisher
    ..The aim of this study was to evaluate the correlation of MNA with laboratory markers of inflammation/cachexia in patients with metastatic lung cancer. The prognostic value of the measured parameters was also examined...
  6. Vlachostergios P, Patrikidou A, Daliani D, Papandreou C. The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation. J Cell Mol Med. 2009;13:3006-18 pubmed publisher
    ....
  7. Vlachostergios P, Voutsadakis I, Barbanis S, Karasavvidou F, Papandreou C. AFP-producing hepatoid adenocarcinoma of the stomach: a case report. Cases J. 2009;2:9296 pubmed publisher
    ..Poor outcome in most of the cases is due to the fact that, as in our patient, metastatic disease is already present at diagnosis. ..
  8. Vlachostergios P, Karasavvidou F, Patrikidou A, Voutsadakis I, Kakkas G, Moutzouris G, et al. p53 and cyclooxygenase-2 expression are directly associated with cyclin D1 expression in radical prostatectomy specimens of patients with hormone-naïve prostate cancer. Pathol Oncol Res. 2012;18:245-52 pubmed publisher
    ..With respect to COX-2 and cyclin D1, further studies are required to elucidate their role in early prediction of PCa relapse after RP. ..
  9. Vlachostergios P, Papandreou C. The Bmi-1/NF-?B/VEGF story: another hint for proteasome involvement in glioma angiogenesis?. J Cell Commun Signal. 2013;7:235-7 pubmed publisher
    ....
  10. Vlachostergios P, Voutsadakis I, Papandreou C. The role of ubiquitin-proteasome system in glioma survival and growth. Growth Factors. 2013;31:106-13 pubmed publisher
    ..In this review, we discuss the involvement of UPS in the regulation of several mediators and effectors of these pathways in malignant gliomas...