Research Topics
Species | D VassilopoulosSummaryAffiliation: University of Athens Country: Greece Publications
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Publications
Hepatitis C virus infection and vasculitis: implications of antiviral and immunosuppressive therapiesDimitrios Vassilopoulos
Hippokration General Hospital, Athens University, Athens, Greece
Arthritis Rheum 46:585-97. 2002
Risks of immunosuppressive therapies including biologic agents in patients with rheumatic diseases and co-existing chronic viral infectionsDimitrios Vassilopoulos
Assistant Professor of Medicine Rheumatology, 2nd Department of Medicine, Hippokration General Hospital, Athens University School of Medicine, Athens, Greece
Curr Opin Rheumatol 19:619-25. 2007....
Performance characteristics of microparticle enzyme and chemiluminescence immunoassays for measurement of anti-HBc immunoglobulin M in sera of patients with HBeAg-negative chronic hepatitis B virus infectionEmilia Hadziyannis
Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, 114 Vas Sophias Ave, Athens 11527, Greece
Clin Vaccine Immunol 15:385-7. 2008..Association and cutoff values for distinguishing patients with viral replication should be established for all methods...
Long-term safety of anti-TNF treatment in patients with rheumatic diseases and chronic or resolved hepatitis B virus infectionD Vassilopoulos
2nd Department of Medicine, Hippokration General Hospital, Athens University School of Medicine, 114 Vass Sophias Avenue, Athens 115 27, Greece
Ann Rheum Dis 69:1352-5. 2010..The aim of this prospective study was to examine the safety of anti-tumour necrosis factor (TNF) therapy in patients with rheumatic disease and hepatitis B virus (HBV) infection...
Viral hepatitis: review of arthritic complications and therapy for arthritis in the presence of active HBV/HCVDimitrios Vassilopoulos
2nd Department of Medicine, Hippokration General Hospital, Athens University School of Medicine, 114 Vass Sophias Ave, 115 27, Athens, Greece
Curr Rheumatol Rep 15:319. 2013..In this review, the latest data regarding HBV or HCV-related arthritic complications and treatment of rheumatic diseases in the presence of chronic HBV or HCV infection will be critically presented...
Dialogue between the brain and the immune system in inflammatory arthritisDimitrios Vassilopoulos
Academic Department of Medicine, Hippokration General Hospital, Athens University School of Medicine, 115 27 Athens, Greece
Ann N Y Acad Sci 1088:132-8. 2006..Furthermore, the effect of the most recently available biologic therapies like anti-tumor necrosis factor (TNF-a) on the neuroendocrine function in patients with RA will be reviewed...
Usefulness of enzyme-linked immunospot assay (Elispot) compared to tuberculin skin testing for latent tuberculosis screening in rheumatic patients scheduled for anti-tumor necrosis factor treatmentDimitrios Vassilopoulos
2nd Department of Medicine, Hippokration General Hospital, Athens University School of Medicine, Athens, Greece
J Rheumatol 35:1271-6. 2008..Diagnosis of LTBI is based mainly on the tuberculin skin test (TST), which has certain limitations...
Rheumatic manifestations of hepatitisDimitrios Vassilopoulos
2nd Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, Athens, Greece
Curr Opin Rheumatol 22:91-6. 2010..In this review the most common clinical rheumatic manifestations of HBV or HCV infection and their management will be critically presented with a special emphasis on the efficacy and safety of the new biologic agents...
Comparison of two gamma interferon release assays and tuberculin skin testing for tuberculosis screening in a cohort of patients with rheumatic diseases starting anti-tumor necrosis factor therapyDimitrios Vassilopoulos
2nd Department of Medicine, Hippokration General Hospital, Athens University School of Medicine, Athens, Greece
Clin Vaccine Immunol 18:2102-8. 2011..In view of the high risk of TB in these patients, a combination of one IGRA and TST is probably more appropriate for LTBI diagnosis...
Should we routinely treat patients with autoimmune/rheumatic diseases and chronic hepatitis B virus infection starting biologic therapies with antiviral agents? YesDimitrios Vassilopoulos
Athens University School of Medicine, 2nd Department of Medicine, Athens, Greece
Eur J Intern Med 22:572-5. 2011..Similar data are available for B-cell depleting agents like rituximab from the hematology literature, indicating the need for a similar approach in patients with autoimmune diseases receiving such agents...
Serum uric acid and multiple sclerosisM Rentzos
Department of Neurology, Aeginition Hospital Athens Medical School, 72 74 Vas Sophias Av, Greece
Clin Neurol Neurosurg 108:527-31. 2006..We also tried to investigate serum UA changes during treatment with immunomodulating or immunosuppressing drugs in the last 6 months...
Pseudodominant Friedreich's ataxia with phenotypic heterogeneityM Panas
Department of Neurology, Athens National University, Eginition Hospital, Athens, Greece
Acta Neurol Scand 115:364-6. 2007..A family with a clinically heterogeneous progressive ataxia in two generations is presented...
Chronic inflammatory demyelinating polyneuropathy: a 6-year retrospective clinical study of a hospital-based populationM Rentzos
Department of Neurology, Aeginition Hospital, Athens Medical School, Vass Sophias av 72 74, 11528, Athens, Greece
J Clin Neurosci 14:229-35. 2007..In conclusion, CIDP is a clinically heterogeneous disorder. It is one of the few serious chronic neuropathies that has a good (although not permanent) treatment response...
IL-15 is elevated in serum and cerebrospinal fluid of patients with multiple sclerosisM Rentzos
Department of Neurology, Aeginition Hospital Athens Medical School, 72 74 Vas So phias Av, Greece
J Neurol Sci 241:25-9. 2006..CSF IL-15/Serum IL-15 ratio (c/s IL-15 ratio) was introduced to assess the origin of elevated IL-15 levels...
Polyneuropathies in teenagers: a clinicopathological study of 45 casesE Kararizou
Section of Neuropathology, Neurological Clinic of University of Athens, Aeginition Hospital, 72 74, Vass Sofias Avenue, 11528 Athens, Greece
Neuromuscul Disord 16:304-7. 2006..In our study, CIDP appears to be a frequent cause of neuropathy in teenagers, while the other causes are broadly similar to those found in studies concerning children rather than adults...
IL-15 is elevated in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementiaM Rentzos
Department of Neurology, Aeginition Hospital Athens Medical School
J Geriatr Psychiatry Neurol 19:114-7. 2006..48, P = .05). Our findings suggest that interleukin-15 may be implicated in the pathophysiology of Alzheimer's disease and frontotemporal dementia...
Circulating interleukin-15 and RANTES chemokine in Parkinson's diseaseM Rentzos
Department of Neurology, School of Medicine, Athens National University, Aeginition Hospital, 72 74 Vas Sophias Avenue, Athens, Greece
Acta Neurol Scand 116:374-9. 2007..RANTES is a C-C beta chemokine with strong chemoattractant activity for T lymphocytes and monocytes...
CSF biomarker profile and diagnostic value in vascular dementiaG P Paraskevas
Department of Neurology, School of Medicine, Athens National University, Athens, Greece
Eur J Neurol 16:205-11. 2009....
Circulating interleukin-10 and interleukin-12 in Parkinson's diseaseM Rentzos
Department of Neurology, School of Medicine, Athens National University, Athens, Greece
Acta Neurol Scand 119:332-7. 2009..Recent studies demonstrated the neuroprotective effect of IL-10. There is little information about the involvement of IL-12 or IL-10 in the pathophysiology of Parkinson's disease (PD)...
Dietary lipids and geriatric depression scale score among elders: the EPIC-Greece cohortA Kyrozis
Department of Neurology, Eginition Hospital, University of Athens Medical School, Athens, Greece
J Psychiatr Res 43:763-9. 2009..Olive oil intake, in particular, predicts a lower chance of scoring in the highest part of the GDS...
Stiff person syndrome: avoiding misdiagnosisE Andreadou
Department of Neurology, Athens National University, Aeginition Hospital, 74, Vas Sophia s Ave, 11528 Athens, Greece
Neurol Sci 28:35-7. 2007..SPS is frequently misdiagnosed as axial dystonia or psychogenic movement disorder. We report a patient with SPS in order to emphasise the reasons for this common misdiagnosis...
The role of soluble intercellular adhesion molecules in neurodegenerative disordersM Rentzos
Department of Neurology, Aeginition Hospital, Athens Medical School, 72 74 Vas Sophias Av, Greece
J Neurol Sci 228:129-35. 2005..Adhesion molecules are markers of activated endothelial cells upregulated by action of cytokines...
Reduced RAGE mRNA in mononuclear blood cells of patients with probable Alzheimer diseaseC Poulopoulou
Laboratory of Experimental Neurophysiology, Neurology Department, Medical School of Athens, Eginition Hospital, 72-74 Vas. Sophias Avenue, Athens, Greece
Neurology 70:1571-3. 2008
Serum levels of soluble intercellular adhesion molecule-1 and soluble endothelial leukocyte adhesion molecule-1 in Alzheimer's diseaseM Rentzos
Department of Neurology, Aeginition Hospital, Athens Medical School, Vass Sophias av 72 74, 11528 Athens, Greece
J Geriatr Psychiatry Neurol 17:225-31. 2004..47 and P< .17, respectively), seem to suggest the neural rather than the endothelial s-ICAM origin in patients with AD...
Polyneuropathies in the elderly: a clinico pathological study of 74 casesE Kararizou
Section of Neuropathology, Neurological Clinic of University of Athens Eginition Hospital, Athens, Greece
Int J Neurosci 116:629-38. 2006..The possible diagnosis of idiopathic axonal neuropathy in the nine cases with neuropathy of unknown origin is discussed...
Immunopathogenesis of hepatitis B e antigen negative chronic hepatitis B infectionS J Hadziyannis
Academic Department of Medicine, Hippokration General Hospital, 114 Vas Sophias Avenue, 115 27 Athens, Greece
Antiviral Res 52:91-8. 2001..e. chronic hepatitis are outlined...
An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosisG Koutsis
Department of Neurology, University of Athens, Aeginition Hospital, Athens, Greece
Mult Scler 15:174-9. 2009..Elevated ApoA1 levels have been associated with decreased dementia risk. The A-allele of the APOA1 -75G/A promoter polymorphism has been associated with elevated ApoA1 levels...
The influence of levodopa and the COMT inhibitor on serum vitamin B12 and folate levels in Parkinson's disease patientsN I Triantafyllou
Neurological Clinic, Eginition Hospital, Athens, Greece
Eur Neurol 58:96-9. 2007..03) and folate levels (p < 0.005) than levodopa + DDC-i treatment alone. We suggest supplementary treatment with vitamin B12 and folic acid in these situations...
A normative study of the trail making test A and B in Greek adultsI Zalonis
Neuropsychological Laboratory, Aeginition Hospital, Neurological Clinic, Medical School, National University of Athens, Athens, Greece
Clin Neuropsychol 22:842-50. 2008..Performance on TMT, especially part B, decreases with increasing age and lower levels of education. Current norms of the Greek version of TMT represent a useful set of norms for clinical practice...
Cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's diseaseE N Kapaki
Department of Neurology, School of Medicine, Athens National University, Athens, Greece
Eur J Neurol 14:168-73. 2007..The present study, despite being clinical, supports the notion that CSF tau(P-181) alone or in combination with tau(T) may be a useful marker in the discrimination of iNPH from AD...
Factors influencing acute blood pressure values in stroke subtypesK N Vemmos
Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, Athens, Greece
J Hum Hypertens 18:253-9. 2004..If the clinical significance of these observations is verified, a differentiated approach in acute BP management based on stroke aetiology may be considered...
Time-frequency analysis methods to quantify the time-varying microstructure of sleep EEG spindles: possibility for dementia biomarkers?P Y Ktonas
Department of Psychiatry, University of Athens, Athens, Greece
J Neurosci Methods 185:133-42. 2009..Preliminary results indicate that the proposed parameterization may be promising, since it can quantify specific differences in IE and IF characteristics between sleep spindles from dementia subjects and those from aged controls...
The onset of multiple sclerosis in Greece: a single-center study of 1,034 consecutive patientsG Koutsis
1st Department of Neurology, University of Athens, Eginitio Hospital, Athens, Greece
Eur Neurol 63:350-6. 2010..We sought to provide data on the onset of MS in Greece with detailed information regarding initial symptoms, and to confirm the prognostic significance of demographic and clinical factors at onset...
Associations of the Expanded Disability Status Scale with anxiety and depression in multiple sclerosis outpatientsG Tsivgoulis
Department of Neurology Eginition Hospital, University of Athens, Athens, Greece
Acta Neurol Scand 115:67-72. 2007....
Huntington's disease in Greece: the experience of 14 yearsM Panas
Department of Neurology, Eginition Hospital, University of Athens, Athens, Greece
Clin Genet 80:586-90. 2011..Of interest is the identification of clusters of HD in Greece. The presence or absence of a family history of HD should be interpreted cautiously, during the diagnostic process...
Churg-Strauss syndrome complicated by neuropathy: a clinicopathological study of nine casesE Kararizou
Section of Neuropathology, Neurological Clinic of University of Athens, Aeginition Hospital, Athens, Greece
Clin Neuropathol 30:11-7. 2011..The purpose of this study was to investigate the clinical, electrophysiological and pathological features of Churg Strauss syndrome (CSS) neuropathy...
Cellular immune responses in hepatitis B virus e antigen negative chronic hepatitis BD Vassilopoulos
Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, Athens, Greece
J Viral Hepat 15:817-26. 2008....
Stereoanesthesia or astereognosia?E Kararizou
Department of Neurology, Athens National University, Eginition Hospital, 72 74 Vas Sofias av, 11528, Athens, Greece
Neurol Sci 30:409-11. 2009..However, a thorough clinical examination and the results of neurophysiological and neuroimaging testing demonstrated that it involved a case of stereoanesthesia due to a demyelinating lesion at the cervical region of the spinal cord...
Thyroid gland neurofibroma in a NF1 patientM Anagnostouli
Department of Neurology, Medical School, Athens National University, Eginition Hospital, Athens, Greece
Acta Neurol Scand 106:58-61. 2002..The rarity of thyroid gland neurofibroma is discussed here, emphasizing the importance of early detection of these and other NF1 complications, also including the risk of malignant transformation with lethal outcome...
An unusual case of insomnia associated with Whipple encephalopathy: first case reported from GreeceM Papadopoulou
Department of Neurology, University of Athens Medical School, Eginition Hospital, 74 Vas Sophias Av, 11528, Athens, Greece
Neurol Sci 26:174-7. 2005..Our case supports the finding that carbamazepine might be useful in the treatment of insomnia associated with Whipple encephalopathy...
Rare association of multiple sclerosis and systemic lupus erythematosusA Kyrozis
Department of Neurology, Eginition Hospital, Athens, Greece
Lupus 16:991-2. 2007..We here present a case of a young woman with a history of MS from many years who diagnosed as suffering as well from SLE...
Working memory deficits in multiple sclerosis: a controlled study with auditory P600 correlatesC Sfagos
Department of Neurology, Eginition Hospital, University of Athens, Athens, Greece
J Neurol Neurosurg Psychiatry 74:1231-5. 2003..Dysfunction of this mechanism may contribute to the identification of basic cognitive processes that could account for the cognitive deficits in multiple sclerosis...
Severe rhabdomyolysis with hypoglycemia in an adult patient with carnitine palmitoyltransferase II deficiencyM Deutsch
Academic Department of Internal Medicine, Hippokration General Hospital, Athens, Greece
Eur J Intern Med 19:289-91. 2008..We present here a case of severe rhabdomyolysis with acute renal failure and hypoglycemia in an adult patient with CPT2 deficiency...
Twenty four hour pulse pressure predicts long term recurrence in acute stroke patientsG Tsivgoulis
Acute Stroke Unit of the Department of Clinical Therapeutics and Neurology, University of Athens Medical School, Athens, Greece
J Neurol Neurosurg Psychiatry 76:1360-5. 2005..Further research is required to investigate whether the risk of recurrent stroke can be reduced to a greater extent by decreasing the pulsatile component of BP in patients with acute stroke...
Modulation of voltage-gated potassium channels in human T lymphocytes by extracellular glutamateCornelia Poulopoulou
Laboratory of Experimental Neurophysiology, Eginition Hospital, 72 74 Vas Sophias Avenue, Athens, Greece
Mol Pharmacol 67:856-67. 2005..Therefore, the antiproliferative effects of high glutamate may, at least in part, result from its inhibitory effect on the potassium current, suggesting an in vivo immunosuppressive role of elevated plasma glutamate...
Morphometric study of the human muscle spindleEvangelia Kararizou
Department of Neurology, Athens National University, Eginition Hospital, Athens, Greece
Anal Quant Cytol Histol 27:1-4. 2005..To study the morphometric characteristics of the human muscle spindle in normal muscle and to investigate the influence of aging...
Reduced expression of metabotropic glutamate receptor 2mRNA in T cells of ALS patientsCornelia Poulopoulou
Department of Neurology, Laboratory of Experimental Neurophysiology, Medical School, University of Athens, Eginition Hospital, 72 74 Vas Sofias Avenue, Athens, Greece
Ann Neurol 58:946-9. 2005..Our findings may provide a reliable peripheral marker of the glutamatergic dysfunction that characterizes ALS...
Higher levels of extroverted hostility detected in gene carriers at risk for Huntington's diseaseEvangelos Vassos
Neurogenetics Unit, Department of Neurology, Eginition Hospital, Medical School, University of Athens, Athens, Greece
Biol Psychiatry 62:1347-52. 2007..The objective of the present study was to detect behavioral and psychological features that differentiate gene carriers from non-carriers...
Morphologic and morphometrical study of the muscle spindle in muscular dystrophyEvangelia G Kararizou
Myopathology Laboratory, Department of Neurology, Athens National University, Eginition Hospital, Athens, Greece
Anal Quant Cytol Histol 29:148-52. 2007..To determine the morphologic and the morphometrical features of spindles in biopsies of patients with different types of muscular dystrophy and investigate the possible involvement of the spindle in the pathologic process of these diseases...
Nonsystemic vasculitic neuropathy: a clinicopathological study of 22 casesEvangelia Kararizou
Section of Neuropathology, Neurological Clinic of the University of Athens, Aeginition Hospital, Athens, Greece
J Rheumatol 32:853-8. 2005....
Morphological and morphometrical study of human muscle spindles in Werdnig-Hoffmann disease (infantile spinal muscular atrophy type I)Evangelia Kararizou
Myopathology Laboratory, Department of Neurology, Athens National University, Eginition Hospital, 74 Vas Sofias Ave, GR 11528 Athens, Greece
Acta Histochem 108:265-9. 2006..03, 0.01 and 0.02, respectively), while the thickness of the capsule was greater in patients than in controls (p=0.01). Our results indicate that the muscle spindle participates in the pathological processes of Werdnig-Hoffmann disease...
Cochlear function in facioscapulohumeral muscular dystrophyDimitrios G Balatsouras
Department of Otolaryngology Head and Neck Surgery, Tzanion General Hospital, Piraeus, Greece
Otol Neurotol 28:7-10. 2007..Facioscapulohumeral muscular dystrophy (FSHD) is commonly associated with high-frequency hearing impairment. Our objective was to evaluate a group of normally hearing patients with FSHD using otoacoustic emissions...
Extrahepatic immunological complications of hepatitis C virus infectionDimitrios Vassilopoulos
Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, Athens, Greece
AIDS 19:S123-7. 2005..g. sialadenitis, lichen planus). In this review, the latest data on the pathogenesis and clinical manifestations of the most common autoimmune extrahepatic manifestations of chronic HCV infection are presented...
Thrombotic thrombocytopenic purpura with fatal outcome in a patient with chronic hepatitis C treated with pegylated interferon-a/2bMelanie Deutsch
Academic Department of Internal Medicine, Hippokration General Hospital, Athens, Greece
Scand J Gastroenterol 42:408-9. 2007
Treatment of HBeAg-negative chronic hepatitis BStephanos J Hadziyannis
Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
Semin Liver Dis 23:81-8. 2003..Many other antiviral agents and immunomodulatory approaches are currently evaluated for CHB, but, besides IFN-alpha, none has yet been convincingly shown to induce sustained off-therapy responses...
Rheumatic manifestations of hepatitis C infectionDimitrios Vassilopoulos
Department of Rheumatic and Immunologic Diseases, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Curr Rheumatol Rep 5:200-4. 2003..In this review, the recent advances in the epidemiology, pathogenesis, clinical findings, and treatment of HCV-associated rheumatic conditions are presented...
Plasma testosterone, dehydroepiandrosterone sulfate, and cortisol in female patients with Huntington's diseaseManolis Markianos
Department of Neurology, Eginition Hospital, Athens University Medical School, Athens, Greece
Neuro Endocrinol Lett 28:199-203. 2007..While in male HD patients low plasma testosterone levels have been reported, information on female patients is lacking...
Hashimoto encephalopathy with pegylated interferon alfa-2b and ribavirinMelanie Deutsch
Academic Department of Internal Medicine, Hippocration General Hospital Athens, Greece
Ann Pharmacother 39:1745-8. 2005..To report an instance of Hashimoto encephalopathy probably resulting from pegylated interferon alfa-2b and ribavirin...
Possible everolimus-induced, severe, reversible encephalopathy after cardiac transplantationEleftheria P Tsagalou
Department of Clinical Therapeutics, University of Athens School of Medicine, Alexandra Hospital, Athens, Greece
J Heart Lung Transplant 26:661-4. 2007..We describe a patient who developed severe neurologic complications, consistent with CsA-induced neurotoxicity, developing 7.5 years after cardiac transplantation, 3 months after everolimus was added to the immunosuppressive regimen...
Precore mutant chronic hepatitis B - approach to managementStephanos J Hadziyannis
Department of Medicine Hepatology, Henry Dunant Hospital, Athens, Greece
MedGenMed 5:1. 2003
NRAMP1 polymorphism and viral factors in Sardinian multiple sclerosis patientsMaria Gazouli
Department of Neurology, School of Medicine, University of Athens, Athens, Greece
Can J Neurol Sci 35:491-4. 2008..In the present study we aimed to evaluate the contribution of the allelic variation in the NRAMPI promoter to MS susceptibility and to study the role of viral infection in relation to specific NRAMP1 genotypes, in a Sardinian cohort...
Effect of CAG repeat length on psychiatric disorders in Huntington's diseaseEvangelos Vassos
Neurogenetics Unit, Department of Neurology, Eginition Hospital, University of Athens, 74 Vas Sofias Ave, Athens 11528, Greece
J Psychiatr Res 42:544-9. 2008..It is hypothesized that alternative genetic or environmental factors underlie the pathogenesis of the psychiatric phenotype...
Plasma testosterone in male patients with Huntington's disease: relations to severity of illness and dementiaManolis Markianos
Department of Neurology, Athens University Medical School, Eginition Hospital, Athens, Greece
Ann Neurol 57:520-5. 2005....
Angioimmunoblastic T-cell lymphoma-associated arthritis: case report and literature reviewEmmanuel Tsochatzis
2nd Department of Medicine, Hippokration General Hospital, Athens University School of Medicine, Greece
J Clin Rheumatol 11:326-8. 2005..This type of arthritis should be included in the differential diagnosis of patients presenting with an inflammatory polyarthritis...
