Andreas Tzakos

Summary

Affiliation: University of Ioannina
Location: Ioannina, Greece

Publications

  1. doi request reprint Unprecedented ultra-high-resolution hydroxy group (1)H NMR spectroscopic analysis of plant extracts
    Pantelis Charisiadis
    Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, GR 45110, Greece
    J Nat Prod 74:2462-6. 2011
  2. pmc Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets
    Valentinos Kounnis
    Cancer Biobank Center of the University of Ioannina, Greece
    Onco Targets Ther 4:27-32. 2011
  3. doi request reprint Domain architecture of the DRpp29 protein and its interaction with the RNA subunit of Dictyostelium discoideum RNase P
    Vassiliki Stamatopoulou
    Department of Biochemistry, School of Medicine, University of Patras, 26500 Patras, Greece
    Biochemistry 49:10714-27. 2010
  4. ncbi request reprint Current concerns and challenges regarding tailored anti-angiogenic therapy in cancer
    Dimitrios H Roukos
    Expert Rev Anticancer Ther 9:1413-6. 2009
  5. doi request reprint Structure and organization of drug-target networks: insights from genomic approaches for drug discovery
    Sarath Chandra Janga
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    Mol Biosyst 5:1536-48. 2009
  6. ncbi request reprint Preparation of large RNA oligonucleotides with complementary isotope-labeled segments for NMR structural studies
    Andreas G Tzakos
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nat Protoc 2:2139-47. 2007
  7. ncbi request reprint Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit
    Latifa ElAntak
    Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 282:8165-74. 2007
  8. ncbi request reprint Complementary segmental labeling of large RNAs: economic preparation and simplified NMR spectra for measurement of more RDCs
    Andreas G Tzakos
    MRC, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Am Chem Soc 128:13344-5. 2006
  9. ncbi request reprint NMR techniques for very large proteins and rnas in solution
    Andreas G Tzakos
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Annu Rev Biophys Biomol Struct 35:319-42. 2006
  10. ncbi request reprint Domain-selective ligand-binding modes and atomic level pharmacophore refinement in angiotensin I converting enzyme (ACE) inhibitors
    Andreas G Tzakos
    Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece
    Chembiochem 6:1089-103. 2005

Collaborators

Detail Information

Publications22

  1. doi request reprint Unprecedented ultra-high-resolution hydroxy group (1)H NMR spectroscopic analysis of plant extracts
    Pantelis Charisiadis
    Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, GR 45110, Greece
    J Nat Prod 74:2462-6. 2011
    ....
  2. pmc Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets
    Valentinos Kounnis
    Cancer Biobank Center of the University of Ioannina, Greece
    Onco Targets Ther 4:27-32. 2011
    ..Identification of new molecular targets and discovery of novel targeted therapies is top priority for pancreatic cancer, which lacks any effective therapy...
  3. doi request reprint Domain architecture of the DRpp29 protein and its interaction with the RNA subunit of Dictyostelium discoideum RNase P
    Vassiliki Stamatopoulou
    Department of Biochemistry, School of Medicine, University of Patras, 26500 Patras, Greece
    Biochemistry 49:10714-27. 2010
    ..Furthermore, we tested the ability of wild-type and mutant DRpp29 to form active RNase P enzymatic particles with the Escherichia coli RNase P RNA...
  4. ncbi request reprint Current concerns and challenges regarding tailored anti-angiogenic therapy in cancer
    Dimitrios H Roukos
    Expert Rev Anticancer Ther 9:1413-6. 2009
  5. doi request reprint Structure and organization of drug-target networks: insights from genomic approaches for drug discovery
    Sarath Chandra Janga
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    Mol Biosyst 5:1536-48. 2009
    ..We also discuss the potential and scope network pharmacology promises in harnessing the vast amount of data from high-throughput approaches for therapeutic advantage...
  6. ncbi request reprint Preparation of large RNA oligonucleotides with complementary isotope-labeled segments for NMR structural studies
    Andreas G Tzakos
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nat Protoc 2:2139-47. 2007
    ..The procedure is expected to take 3-4 weeks to implement...
  7. ncbi request reprint Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit
    Latifa ElAntak
    Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 282:8165-74. 2007
    ..Our results provide the first structure of an important subdomain of a core eIF3 subunit and detailed insights into protein-protein interactions between two eIF3 subunits required for stable eIF3 recruitment to the 40 S subunit...
  8. ncbi request reprint Complementary segmental labeling of large RNAs: economic preparation and simplified NMR spectra for measurement of more RDCs
    Andreas G Tzakos
    MRC, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Am Chem Soc 128:13344-5. 2006
    ..Applying this method to the 25 kDa BC1-DTE RNA, we were able to resolve severe chemical shift degeneracy, thereby almost doubling the number of RDC restraints in comparison to the conventional 13C,15N uniform-labeled RNA...
  9. ncbi request reprint NMR techniques for very large proteins and rnas in solution
    Andreas G Tzakos
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Annu Rev Biophys Biomol Struct 35:319-42. 2006
    ..Physical pictures of the novel techniques, their experimental applications, as well as labeling and assignment strategies are discussed and accompanied by future perspectives...
  10. ncbi request reprint Domain-selective ligand-binding modes and atomic level pharmacophore refinement in angiotensin I converting enzyme (ACE) inhibitors
    Andreas G Tzakos
    Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece
    Chembiochem 6:1089-103. 2005
    ..Pharmacophore refinement was achieved at an atomic level, and might provide an improved basis for structure-based rational design of second-generation, domain-selective inhibitors...
  11. ncbi request reprint NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist: structural implications for the MHC II (I-Au)-peptide complex from docking calculations
    Andreas G Tzakos
    Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Greece
    Eur J Biochem 271:3399-413. 2004
    ..Lys75, Arg78 and Asp81 are prominent, solvent-exposed residues and, thus, may be of importance in the formation of the trimolecular T-cell receptor-MBP(74-85)-MHC II complex...
  12. ncbi request reprint Structure-function discrimination of the N- and C- catalytic domains of human angiotensin-converting enzyme: implications for Cl- activation and peptide hydrolysis mechanisms
    Andreas G Tzakos
    Department of Chemistry, University of Ioannina, GR 45110 Ioannina, Grece
    Protein Eng 16:993-1003. 2003
    ..Currently available mutational and substrate hydrolysis data for both domains are evaluated and are consistent with the predicted model...
  13. ncbi request reprint On the structural basis of the hypertensive properties of angiotensin II: a solved mystery or a controversial issue?
    Andreas G Tzakos
    Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina GR 45110, Greece
    Curr Top Med Chem 4:431-44. 2004
    ..These investigations, with particular emphasis to recent developments, have greatly assisted in the identification of pharmacophoric groups for receptor activation and the development of several models of AII-receptor complexes...
  14. ncbi request reprint Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship
    Georgios A Spyroulias
    Department of Pharmacy, University of Patras, Greece
    Eur J Biochem 270:2163-73. 2003
    ....
  15. ncbi request reprint Zinc binding in peptide models of angiotensin-I converting enzyme active sites studied through 1H-NMR and chemical shift perturbation mapping
    Athanassios S Galanis
    Department of Pharmacy, University of Patras, GR 26500, Patras, Greece
    Biopolymers 69:244-52. 2003
    ..The obtained data were analyzed in terms of chemical shift differences. The results indicate that zinc binds to the HEMGH and the EAIGD characteristic motifs, and suggest possible coordination modes of zinc in the native enzyme...
  16. doi request reprint Novel imatinib derivatives with altered specificity between Bcr-Abl and FMS, KIT, and PDGF receptors
    Konstantinos Skobridis
    Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece
    ChemMedChem 5:130-9. 2010
    ..These new compounds provide a platform for further drug development against the therapeutically important PDGF receptor family and they also provide insight into the engineering of drugs with altered biological activity...
  17. ncbi request reprint On the molecular basis of the recognition of angiotensin II (AII). NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131
    Andreas G Tzakos
    Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, GR 45110 Greece
    Eur J Biochem 270:849-60. 2003
    ..These data are interpreted in terms of a biological "nucleus" conformation of the hormone in solution, which requires a limited number of structural rearrangements for receptor-antigen recognition and binding...
  18. pmc Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs
    Ioannis Sainis
    Human Cancer Biobank Center, University of Ioannina, Greece
    Mar Drugs 8:629-57. 2010
    ..In this article, we revisit cyanobacterial cyclopeptides as potential novel targets for anticancer drugs by summarizing existing biomedical evidence, presenting structure-activity data and discussing developmental perspectives...
  19. doi request reprint Unexpected enzyme-catalyzed regioselective acylation of flavonoid aglycones and rapid product screening
    Eleni Kyriakou
    Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina GR 45110, Greece
    Org Biomol Chem 10:1739-42. 2012
    ..The rapid screening of product formation was performed by the use of the high resolution phenol-type OH (1)H NMR spectral region recorded after the addition of picric acid...
  20. doi request reprint Targeting oncogenic protein-protein interactions by diversity oriented synthesis and combinatorial chemistry approaches
    Andreas G Tzakos
    Human Cancer Biobank Center, University of Ioannina, Ioannina, GR 45110, Greece
    Molecules 16:4408-27. 2011
    ....