Research Topics
Genomes and GenesSpecies | Agathocles TsatsoulisSummaryAffiliation: University of Ioannina Country: Greece Publications
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Publications
Thyroid autoimmunity is associated with higher urinary iodine concentrations in an iodine-deficient area of Northwestern GreeceA Tsatsoulis
Department of Medicine, Endocrine Unit, University of Ioannina, Medical School, Greece
Thyroid 9:279-83. 1999..However, it appears that autoimmune thyroiditis is emerging as a frequent cause of goiter in those children with sufficient iodine intake...- Study of growth hormone secretion and action in growth-retarded children with juvenile chronic arthritis (JCA)A Tsatsoulis
Endocrine Unit, Department of Medicine, Department of Paediatrics, University of Ioannina, Ioannina, Greece
Growth Horm IGF Res 9:143-9. 1999.... - The effect of thyrotoxicosis on adrenocortical reserveA Tsatsoulis
Endocrine Unit, Department of Medicine, University of Ioannina School of Medicine, Ioannina, 451 10, Greece
Eur J Endocrinol 142:231-5. 2000..This study aimed to assess adrenocortical reserve in response to low-dose ACTH, following dexamethasone suppression, in patients with severe thyrotoxicosis... - Turner's syndrome with concomitant hypopituitarism: case reportZ Efstathiadou
Endocrine Unit, Department of Internal Medicine, University Hospital of Ioannina, Ioannina, Greece
Hum Reprod 15:2388-9. 2000..This case illustrates that the co-existence of primary and secondary hypogonadism may obscure and delay the diagnosis of Turner's syndrome, a diagnosis which alters the counselling of the patient from the reproductive perspective... - The role of stress in the clinical expression of thyroid autoimmunityAgathocles Tsatsoulis
Department of Endocrinology, University of Ioannina, 45110, Ioannina, Greece
Ann N Y Acad Sci 1088:382-95. 2006..Conversely, recovery from stress or the immune suppressive effect of pregnancy may induce a Th2 to Th1 "return shift" leading to autoimmune (sporadic) or postpartum thyroiditis, respectively... - The role of apoptosis in thyroid diseaseA Tsatsoulis
Department of Medicine, Division of Endocrinology, University of Ioannina, Ioannina, Greece
Minerva Med 93:169-80. 2002..However, the exact mechanisms involved in the regulation of apoptosis in thyroid disease remain unclear. Further investigation is needed that may provide new strategies in the prevention and treatment of these diseases... 
Effects of pioglitazone and metformin on vascular endothelial function in patients with type 2 diabetes treated with sulfonylureasKaterina K Naka
Department of Cardiology, University of Ioannina, Ioannina, Greece
Diab Vasc Dis Res 9:52-8. 2012..The beneficial effects of pioglitazone and metformin on endothelial function in T2DM patients did not differ greatly. Larger studies are needed to explore whether a potentially greater benefit with pioglitazone may exist...- Effect of the insulin sensitizers metformin and pioglitazone on endothelial function in young women with polycystic ovary syndrome: a prospective randomized studyKaterina K Naka
Michaelidion Cardiac Center, Department of Cardiology, University of Ioannina, Ioannina, Greece
Fertil Steril 95:203-9. 2011..To compare the effect of two different insulin sensitizers, metformin and pioglitazone, on endothelial function in women with polycystic ovary syndrome (PCOS)... - Rosiglitazone improves endothelial function in patients with type 2 diabetes treated with insulinKaterina K Naka
Michaelidion Cardiac Centre, University of Ioannina, Greece
Diab Vasc Dis Res 8:195-201. 2011..Further research is needed to investigate why this beneficial effect does not translate into improved cardiovascular prognosis in these patients... 
Determinants of vascular function in patients with type 2 diabetesKaterina K Naka
Michaelidion Cardiac Center, University of Ioannina, Ioannina, Greece
Cardiovasc Diabetol 11:127. 2012..The aim of our study was to investigate the predictors of vascular dysfunction in T2DM patients...- Lack of effects of pioglitazone on cardiac function in patients with type 2 diabetes and evidence of left ventricular diastolic dysfunction: a tissue doppler imaging studyKaterina K Naka
Michaelidion Cardiac Center, University of Ioannina, University Campus, Ioannina, Greece
Cardiovasc Diabetol 9:57. 2010..We sought to investigate the effects of pioglitazone on novel echocardiographic indices of left ventricular (LV) diastolic function in DM2 patients with LV diastolic dysfunction (LVDD)... - HLA-DR expressing peripheral T regulatory cells in newly diagnosed patients with different forms of autoimmune thyroid diseaseStelios Fountoulakis
Department of Endocrinology, University of Ioannina, Medical School, Ioannina, Greece
Thyroid 18:1195-200. 2008..The aim of the present study was to examine whether changes in the number of peripheral CD4 + CD25highHLA-DR + lymphocytes, a subpopulation of Tregs, occur in patients with AITD... - CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotypeNectaria Xita
Department of Endocrinology, University of Ioannina, Ioannina, Greece
Fertil Steril 94:250-4. 2010..To evaluate the possible contribution of the (TTTA)n polymorphism of aromatase gene (CYP19) to the hyperandrogenic phenotype of polycystic ovary syndrome (PCOS)... - Natural course of autoimmune thyroiditis after elimination of iodine deficiency in northwestern GreeceChristos Zois
Department of Endocrinology, University Hospital of Ioannina, Ioannina, Greece
Thyroid 16:289-93. 2006..In conclusion, both antibody types increased in frequency and level, but TPOAbs were the predominant autoimmunity marker predictive of impending thyroid failure in children with AIT, as was thyroid hypoechogenicity on ultrasound... - Effect of ethinylestradiol/cyproterone acetate on endothelial function in young non-obese women with polycystic ovary syndrome: a pilot studyKaterina K Naka
Department of Cardiology, University of Ioannina, Ioannina, Greece
Gynecol Endocrinol 27:615-21. 2011..Combined oral contraceptives are used in polycystic ovary syndrome (PCOS) women for the treatment of hyperandrogenism and menstrual cycle disturbances... - The Pro12Ala polymorphism of the PPAR-gamma gene is not associated with the polycystic ovary syndromeNectaria Xita
Department of Endocrinology, University of Ioannina, Ioannina, Greece
Hormones (Athens) 8:267-72. 2009..The aim of the study was to investigate the possible involvement of the Pro12Ala polymorphism of the PPAR-gamma gene in the pathogenesis of PCOS... - Association of the A1330V and V667M polymorphisms of LRP5 with bone mineral density in Greek peri- and postmenopausal womenAnastasia E Markatseli
Department of Endocrinology, University of Ioannina, Ioannina, Greece
Maturitas 70:188-93. 2011..Wnt signaling through low-density lipoprotein receptor-related protein 5 (LRP5) is an important determinant of bone mass regulation... - Serum levels of soluble fas in patients with multinodular goiterMaria Andrikoula
Department of Endocrinology, University Hospital of Ioannina, Dourouti, Ioannina, Greece
Immunol Invest 38:398-407. 2009..The aim of this study was to examine whether sFas is differentially expressed in multinodular goiter (MNG), which is associated with decreased Fas-mediated apoptosis... - The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotypeNectaria Xita
Department of Endocrinology, University of Ioannina, Ioannina 45110, Greece
Eur J Endocrinol 158:861-5. 2008.... - Thyroid substitution therapy induces high-density lipoprotein-associated platelet-activating factor-acetylhydrolase in patients with subclinical hypothyroidism: a potential antiatherogenic effectHaralampos J Milionis
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Thyroid 15:455-60. 2005..Levothyroxine induces a significant increase in HDL-PAF-AH activity. This action may represent a potential antiatherogenic effect of thyroid replacement therapy... - High prevalence of autoimmune thyroiditis in schoolchildren after elimination of iodine deficiency in northwestern GreeceChristos Zois
Division of Endocrinology, Department of Medicine, University of Ioannina, Greece
Thyroid 13:485-9. 2003..In conclusion, silent iodine prophylaxis has resulted in the elimination of iodine deficiency in Greece, and this has been accompanied by an increase in the prevalence of autoimmune thyroiditis... - Differential expression of Fas system apoptotic molecules in peripheral lymphocytes from patients with Graves' disease and Hashimoto's thyroiditisStelios Fountoulakis
Department of Endocrinology, Medical School, University of Ioannina, 45110 Ioannina, Greece
Eur J Endocrinol 158:853-9. 2008..To examine whether the Fas system apoptotic molecules are differentially expressed in Graves' disease (GD) and Hashimoto's thyroiditis (HT), the two opposite phenotypes of autoimmune thyroid disease (AITD)... - The role of iodine in the evolution of thyroid disease in Greece: from endemic goiter to thyroid autoimmunityStelios Fountoulakis
Department of Endocrinology, University of Ioannina, Ioannina, Greece
Hormones (Athens) 6:25-35. 2007.... - Pioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetesKaterina Papathanassiou
Michaelidion Cardiac Center, University of Ioannina, Ioannina, Greece
Atherosclerosis 205:221-6. 2009..The aim of this study was to compare the effect of glimepiride and pioglitazone on endothelial function in patients with type 2 diabetes already on metformin... - Genetic variants of sex hormone-binding globulin and their biological consequencesNectaria Xita
Department of Endocrinology, University of Ioannina, Ioannina, Greece
Mol Cell Endocrinol 316:60-5. 2010..However, the weight of evidence suggests that some common genetic variants of SHBG may influence SHBG levels and in part contribute to the phenotypic expression of human diseases... - Hypokalemic paralysis following administration of intravenous methylprednisolone in a patient with Graves' thyrotoxicosis and ophthalmopathyStelios Tigas
Department of Endocrinology, University of Ioannina, Greece
Hormones (Athens) 10:313-6. 2011..Clinicians should exercise caution when administering high-dose glucocorticoids during thyrotoxicosis as there is a risk of provoking hypokalemic paralysis in susceptible patients... - The protective role of exercise on stress system dysregulation and comorbiditiesAgathocles Tsatsoulis
Department of Endocrinology, University of Ioannina, Ioannina 45110, Greece
Ann N Y Acad Sci 1083:196-213. 2006..The way to prevent and combat this burden is by regular exercise... - Association of serum and follicular fluid SHBG levels and SHBG (TAAAA)n polymorphism with follicle size in women undergoing ovarian stimulationElissavet Hatzi
Department of Obstetrics Gynecology, Medical School, University of Ioannina, Ioannina, Greece
Gynecol Endocrinol 27:27-32. 2011..The aim of this study was to investigate whether serum and follicular fluid SHBG levels and SHBG (TAAAA)(n) polymorphism are related to follicle size and pregnancy rate in women undergoing in vitro fertilisation... - A study of the growth-promoting and metabolic effects of growth hormone (GH) in a patient with the "growth without GH" syndromeM Pavlou
Department of Paediatrics, University of Ioannina, 45110 Ioannina, Greece
Growth Horm IGF Res 11:225-30. 2001..In conclusion, our case study suggests that, in the "growth without GH" syndrome, the excessive growth is independent of GH and dissociated from other GH-dependent metabolic effects, which are decreased... - The adiponectin-to-leptin ratio in women with polycystic ovary syndrome: relation to insulin resistance and proinflammatory markersNectaria Xita
Department of Endocrinology, University of Ioannina, 45110 Ioannina, Greece
Metabolism 56:766-71. 2007..570, P = .001 in overweight-obese women). In conclusion, the A/L ratio may serve as a biomarker of both insulin resistance and low-grade inflammation, providing the link between these cardiovascular risk factors in women with PCOS... - On the pathogenesis of autoimmune thyroid disease: a unifying hypothesisStelios Fountoulakis
Division of Endocrinology, Department of Medicine, University of Ioannina, Ioannina, Greece
Clin Endocrinol (Oxf) 60:397-409. 2004 - Molecular genetic aspects and pathophysiology of endocrine hypertensionStelios Fountoulakis
Department of Endocrinology, University of Ioannina Medical School, Ioannina, Greece
Hormones (Athens) 5:90-106. 2006 - Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?Z Efstathiadou
Division of Endocrinology, University of Ioannina School of Medicine, University Hospital of Ioannina, Ioannina, Greece
Eur J Endocrinol 145:705-10. 2001..The present study aimed to assess the association of SH with lipid abnormalities and to quantify the effect of L-thyroxine therapy on serum lipid profiles... - Fas and Bcl-2 protein expression in thyrocytes of patients with nodular goiterM Andrikoula
Division of Endocrinology, Department of Medicine, University of Ioannina, 45 110 Ioannina, Greece
Eur J Endocrinol 145:403-7. 2001..The regulation of Bcl-2 protein differs between adenomatous and colloid nodules, suggesting that this protein may play a role in the differentiation of thyroid nodules... - Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studiesNectaria Xita
Department of Endocrinology, University of Ioannina, Ioannina 45110, Greece
J Clin Endocrinol Metab 91:1660-6. 2006..CONCLUSION: Prenatal androgenization of the female fetus induced by genetic and environmental factors, or the interaction of both, may program differentiating target tissues toward the development of PCOS phenotype in adult life... - Lipoprotein (a) levels and apolipoprotein (a) isoform size in patients with subclinical hypothyroidism: effect of treatment with levothyroxineHaralampos J Milionis
Department of Internal Medicine, Medical School of Ioannina, Ioannina, Greece
Thyroid 13:365-9. 2003.... - Phenotypic and molecular genetic aspects of pseudohypoparathyroidism type Ib in a Greek kindred: evidence for enhanced uric acid excretion due to parathyroid hormone resistanceElena Laspa
Department of Medicine, Division of Endocrinology, University of Ioannina, 45110 Ioannina, Greece
J Clin Endocrinol Metab 89:5942-7. 2004..Furthermore, affected individuals displayed hypouricemia with increased fractional excretion of uric acid, suggesting possible involvement of PTH in the renal handling of this metabolite... - Active Paget's disease of bone with normal biomarkers of bone metabolism: a case report and review of the literatureLamprini Gkouva
Department of Endocrinology, University Hospital of Ioannina, Dim Hatzi 68, Ioannina, 45445, Greece
Clin Rheumatol 30:139-44. 2011.... - Predictors of endothelial dysfunction in young women with polycystic ovary syndromeMaria Kravariti
F.R.C.P, Department of Endocrinology, University of Ioannina, Panepistimiou Avenue, 45 110 Ioannina, Greece
J Clin Endocrinol Metab 90:5088-95. 2005..e. early 20s), and largely independent of obesity. This suggests that women with PCOS are at increased risk for early onset cardiovascular disease and may gain particular benefit from measures to improve endothelial function... - Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel diseaseK H Katsanos
Hepato Gastroenterology Unit, School of Medicine, University of Ioannina, Ioannina, 451 10, Greece
Growth Horm IGF Res 11:364-7. 2001..11 pg/ml, P<0.0001). The reduced IGF-1 and IGFBP-3 levels in patients with active IBD suggest that this systemic inflammatory condition is associated with a degree of acquired GH resistance, possibly induced by inflammatory cytokines... - Possible reasons for different pattern disappearance of thyroglobulin and thyroid peroxidase autoantibodies in patients with differentiated thyroid carcinoma following total thyroidectomy and iodine-131 ablationD Thomas
Department of Endocrinology, Diabetes and Metabolism, Metaxa Memorial Anticancer Research Hospital, Piraeus, Greece
J Endocrinol Invest 30:173-80. 2007..Although tumor size and age may influence the pattern of thyroid autoantibody reduction, the exact reasons for the different rhythm of autoantibodies decrease must further be evaluated... - Detection of herpes virus DNA in post-operative thyroid tissue specimens of patients with autoimmune thyroid diseaseD Thomas
Department of Endocrinology, Diabetes and Metabolism, Metaxa Memorial Anticancer Research Hospital, Piraeus, Greece
Exp Clin Endocrinol Diabetes 116:35-9. 2008.... - The role of fine-needle aspiration biopsy in the management of patients with thyroid nodulesP Zagorianakou
Department of Pathology-Cytology, Medical School, University of Ioannina, Greece
In Vivo 19:605-9. 2005..We conclude that FNA is an effective screening test in the evaluation of the necessity for surgical treatment in patients with thyroid nodules... - Association of SHBG gene polymorphism with menarcheN Xita
Department of Endocrinology and Laboratory of Reproductive Genetics, University of Ioannina, Ioannina, Greece
Mol Hum Reprod 11:459-62. 2005..24+/-1.15 years) than those with shorter allele genotypes (12.67+/-1.15, P=0.018). These findings provide evidence for a genetic contribution of SHBG gene to the age of menarche... - The role of Fas-mediated apoptosis in thyroid diseaseM Andrikoula
Division of Endocrinology, Department of Medicine, University of Ioannina Medical School, Ioannina 45110, Greece
Eur J Endocrinol 144:561-8. 2001..However, the exact mechanisms involved in the regulation of apoptosis in thyroid disease remain unclear. Further investigation is needed... - The Sp1 COLIA1 gene polymorphism, and not vitamin D receptor or estrogen receptor gene polymorphisms, determines bone mineral density in postmenopausal Greek womenZ Efstathiadou
Division of Endocrinology, Department of Internal Medicine, University of Ioannina School of Medicine, Ioannina, Greece
Osteoporos Int 12:326-31. 2001..When all five polymorphisms are considered simultaneously, the Sp1 COLIA1 polymorphism seems to have the most unequivocal effect on BMD, at least in postmenopausal women... - Combined estrogen receptor alpha and estrogen receptor beta genotypes influence the age of menarcheI Stavrou
Department of Endocrinology and Laboratory of Reproductive Genetics, University of Ioannina, 45110 Ioannina, Greece
Hum Reprod 21:554-7. 2006..In the present study, we examined whether ERbeta genotypes alone, or in combination with ERalpha genotypes, may also influence onset of menarche... - Correlation of estrogen receptor beta gene polymorphisms with spinal bone mineral density in peri- and post-menopausal Greek womenZ Efstathiadou
Division of Endocrinology, Department of Internal Medicine, University of Ioannina School of Medicine, 45110 Ioannina, Greece
Maturitas 53:380-5. 2006..05]. Furthermore, no interaction between the two polymorphisms on BMD was found. In conclusion, in a Greek female post-menopausal population, the two ERbeta gene polymorphisms were not associated with BMD, or metabolic bone markers... - Apolipoprotein E polymorphism is not associated with spinal bone mineral density in peri- and postmenopausal Greek womenZ Efstathiadou
Division of Endocrinology, Department of Internal Medicine, University of Ioannina School of Medicine, Ioannina, Greece
Maturitas 48:259-64. 2004..The aim of the present study was to determine the possible effect of ApoE gene polymorphism on spinal bone mineral density and metabolic bone markers in Greek women... - Isolated ACTH deficiency associated with Crohn's diseaseG Kalambokis
Department of Internal Medicine, Medical School of Ioannina, Ioannina, Greece
J Endocrinol Invest 27:961-4. 2004..However more evidence is needed before isolated ACTH deficiency is added to the list of extraintestinal manifestations of CD... - Transcription factor-mediated proliferation and apoptosis in benign and malignant thyroid lesionsKonstantinos P Letsas
Second Department of Cardiology, Evangelismos General Hospital of Athens, Greece
Pathol Int 55:694-702. 2005..Furthermore, prothymosin alpha may promote cell survival through the Bcl2 anti-apoptotic pathway, while E2F-1-induced apoptosis via p53-independent pathways may be associated with transcriptional activation of bax pro-apoptotic gene... - Fine-needle aspiration biopsy-RT-PCR expression analysis of prothymosin alpha and parathymosin in thyroid: novel proliferation markers?Konstantinos P Letsas
Medical School of Ioannina, Greece
Neoplasma 54:57-62. 2007....