S Tsakiris

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi request reprint Alterations in antioxidant status, protein concentration, acetylcholinesterase, Na+, K+-ATPase, and Mg2+-ATPase activities in rat brain after forced swimming
    T Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Int J Sports Med 27:19-24. 2006
  2. ncbi request reprint Effect of L-carnitine administration on the modulated rat brain protein concentration, acetylcholinesterase, Na+K+-ATPase and Mg2+-ATPase activities induced by forced swimming
    T Tsakiris
    Department of Experimental Physiology, Medical School, Athens University, PO Box 65257, GR 15401 Athens, Greece
    Br J Sports Med 42:367-72. 2008
  3. ncbi request reprint Alpha-tocopherol supplementation prevents the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals
    S Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Eur J Clin Nutr 63:215-21. 2009
  4. ncbi request reprint Medical physiology and experimentation: reconsidering the undergraduate examination structure
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, PO Box 65257, Athens GR 15401, Greece
    Adv Physiol Educ 30:94-5. 2006
  5. ncbi request reprint The protective effect of L-cysteine and glutathione on the adult and aged rat brain (Na+,K+)-ATPase and Mg2+-ATPase activities in galactosemia in vitro
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Metab Brain Dis 20:87-95. 2005
  6. ncbi request reprint The effect of galactose metabolic disorders on rat brain Na+,K+-ATPase activity
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Greece
    Z Naturforsch C 57:939-43. 2002
  7. ncbi request reprint Reduced acetylcholinesterase activity in erythrocyte membranes from patients with phenylketonuria
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, PO Box 65257, GR 154 01 Athens, Greece
    Clin Biochem 35:615-9. 2002
  8. ncbi request reprint The in vitro effects of galactose and its derivatives on rat brain Mg2+-ATPase activity
    Stylianos Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Athens, Greece
    Pharmacol Toxicol 91:254-7. 2002
  9. ncbi request reprint alpha-tocopherol supplementation reduces the elevated 8-hydroxy-2-deoxyguanosine blood levels induced by training in basketball players
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Clin Chem Lab Med 44:1004-8. 2006
  10. ncbi request reprint Protective effect of L-cysteine and glutathione on the modulated suckling rat brain Na+, K+, -ATPase and Mg2+ -ATPase activities induced by the in vitro galactosaemia
    Stylianos Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Athens, Greece
    Pharmacol Res 49:475-9. 2004

Collaborators

  • George A Karikas
  • Joanne Traeger-Synodinos
  • C Pantos
  • Alexandra Margeli
  • Iordanis Mourouzis
  • Helen Michelakakis
  • Charalambos Antoniades
  • Kleopatra H Schulpis
  • Charis Liapi
  • Apostolos Zarros
  • K H Schulpis
  • Haris Carageorgiou
  • Theodore Parthimos
  • Irene Simintzi
  • Panagoula Angelogianni
  • Ioannis Papassotiriou
  • Dimitrios G Vlachos
  • Theodore Tsakiris
  • Nikolina Skandali
  • Kyriakoula Marinou
  • Nickolaos Parthimos
  • Foteini Anifantaki
  • Elena Gkrouzman
  • Hussam Al-Humadi
  • Panagiota Galanopoulou
  • Aris Antsaklis
  • George D Vlachos
  • Evangelos D Papakonstantinou
  • T Tsakiris
  • Christi Tsopanakis
  • Zois Mellios
  • Vasileios Stolakis
  • Stamatios Theocharis
  • P Angelogianni
  • I Papassotiriou
  • T Parthimos
  • Dennis Cokkinos
  • Panagiotis Behrakis
  • Spyros Mesogitis
  • N Parthimos
  • Irini Feskou
  • C Tesseromatis
  • C Tsopanakis
  • Vassilios Tzotzes
  • George P Chrousos
  • Maria Vounatsou
  • Christos Plataras
  • Joanna Tjamouranis
  • Artemis Doulgeraki
  • K Schulpis
  • Marios Margaritis
  • Argyro Kyriakaki
  • Alexios Fotios A Mentis
  • Christine Tesseromatis
  • Eleftheria Roma
  • M Tsironi
  • C Lazaropoulou
  • G Reclos
  • George A Partsinevelos
  • E Goussetis
  • K Skenderi
  • Marcos Moukas
  • Maria Kalogerakou
  • A Gounaris
  • A Bartzeliotou
  • Anastasia Bartzeliotou
  • Christina Lazaropoulou
  • Spyros Regoutas
  • Aglaia Giannoulia-Karantana
  • Constantinos Bakogiannis
  • Ioanna Tjamouranis
  • Konstantinos Kalimeris
  • Andreas Gavriilidis
  • Evangelos D Papaconstantinou
  • George J Reclos
  • Dennis Varonos
  • Antonios Sideris
  • Constantinos Mourouzis
  • M Moukas
  • P Behrakis
  • Zetta Papadopoulou-Daifoti
  • S Georgala
  • T Michas
  • S Regoutas
  • J Tjamouranis
  • A Doulgeraki

Detail Information

Publications80

  1. ncbi request reprint Alterations in antioxidant status, protein concentration, acetylcholinesterase, Na+, K+-ATPase, and Mg2+-ATPase activities in rat brain after forced swimming
    T Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Int J Sports Med 27:19-24. 2006
    ..This stress condition may modulate brain intracellular Mg 2+ concentration, neural excitability, metabolic energy production, and neurotransmission...
  2. ncbi request reprint Effect of L-carnitine administration on the modulated rat brain protein concentration, acetylcholinesterase, Na+K+-ATPase and Mg2+-ATPase activities induced by forced swimming
    T Tsakiris
    Department of Experimental Physiology, Medical School, Athens University, PO Box 65257, GR 15401 Athens, Greece
    Br J Sports Med 42:367-72. 2008
    ..Forced exercise produces free radicals and L-carnitine (L-C) administration reduces oxidative stress...
  3. ncbi request reprint Alpha-tocopherol supplementation prevents the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals
    S Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Eur J Clin Nutr 63:215-21. 2009
    ..Vitamin E (alpha-tocopherol, alpha-T) reduces lipid peroxidation. Paraoxonase 1/arylesterase (PON 1/Aryl) activities are closely related to oxidation and atherogenesis...
  4. ncbi request reprint Medical physiology and experimentation: reconsidering the undergraduate examination structure
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, PO Box 65257, Athens GR 15401, Greece
    Adv Physiol Educ 30:94-5. 2006
  5. ncbi request reprint The protective effect of L-cysteine and glutathione on the adult and aged rat brain (Na+,K+)-ATPase and Mg2+-ATPase activities in galactosemia in vitro
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Metab Brain Dis 20:87-95. 2005
    ..Cys and GSH increased TAS resulting in a reversion of the inhibited (Na+,K+)-ATPase in both models of the in vitro galactosemia and the stimulated Mg2+-ATPase in galactokinase deficiency galactosemia only...
  6. ncbi request reprint The effect of galactose metabolic disorders on rat brain Na+,K+-ATPase activity
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Greece
    Z Naturforsch C 57:939-43. 2002
    ..b) The observed brain Na+,K+-ATPase inhibitions in the presence of toxic concentrations of Gal-1-P and/or galtol could modulate the neural excitability, the metabolic energy production and the catecholaminergic and serotoninergic system...
  7. ncbi request reprint Reduced acetylcholinesterase activity in erythrocyte membranes from patients with phenylketonuria
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, PO Box 65257, GR 154 01 Athens, Greece
    Clin Biochem 35:615-9. 2002
    ..b) To determine the in vitro effects of Phe, Ala and Phe plus Ala on their AChE activities...
  8. ncbi request reprint The in vitro effects of galactose and its derivatives on rat brain Mg2+-ATPase activity
    Stylianos Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Athens, Greece
    Pharmacol Toxicol 91:254-7. 2002
    ....
  9. ncbi request reprint alpha-tocopherol supplementation reduces the elevated 8-hydroxy-2-deoxyguanosine blood levels induced by training in basketball players
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Clin Chem Lab Med 44:1004-8. 2006
    ..The aim of the present study was to investigate the effect of alpha-tocopherol (alpha-Te) supplementation on DNA oxidative damage induced by heavy training in basketball players...
  10. ncbi request reprint Protective effect of L-cysteine and glutathione on the modulated suckling rat brain Na+, K+, -ATPase and Mg2+ -ATPase activities induced by the in vitro galactosaemia
    Stylianos Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Athens, Greece
    Pharmacol Res 49:475-9. 2004
    ....
  11. ncbi request reprint alpha-Tocopherol supplementation restores the reduction of erythrocyte glucose-6-phosphate dehydrogenase activity induced by forced training
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, P O Box 65257, GR 15401 Athens, Greece
    Pharmacol Res 54:373-9. 2006
    ..Erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity is closely related to free radical production. alpha-Tocopherol (alpha-T) is implicated with the reduction of lipid peroxidation...
  12. ncbi request reprint The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Greece
    Pharmacol Res 53:1-5. 2006
    ..Additionally, neurological symptoms, including learning and memory processes, may be related to the high or toxic concentrations of the sweetener metabolites...
  13. ncbi request reprint The beneficial effect of L-cysteine supplementation on DNA oxidation induced by forced training
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, P O Box 65257, GR 15401 Athens, Greece
    Pharmacol Res 53:386-90. 2006
    ..Forced training is closely implicated with free radicals production and indication of tissue damage as well as DNA oxidation...
  14. ncbi request reprint Erythrocyte membrane acetylcholinesterase activity in subjects with MTHFR 677C-->T genotype
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Greece
    Clin Chem Lab Med 44:23-7. 2006
    ..Increased homocysteine (Hcy) blood levels are correlated with vascular and neurological problems...
  15. ncbi request reprint Protective effect of L-phenylalanine on rat brain acetylcholinesterase inhibition induced by free radicals
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, P O Box 65257, GR 154 01, Athens, Greece
    Clin Biochem 33:103-6. 2000
    ....
  16. ncbi request reprint Protective effect of L-cysteine and glutathione on rat brain Na+,K+-ATPase inhibition induced by free radicals
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Greece
    Z Naturforsch C 55:271-7. 2000
    ..Moreover, Cys and GSH could regulate towards normal values the neural excitability and metabolic energy production, which may be disturbed by free radical action on Na+,K+-ATPase...
  17. ncbi request reprint The effect of galactose metabolic disorders on rat brain acetylcholinesterase activity
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Greece
    Z Naturforsch C 55:852-5. 2000
    ..Consequently the direct action of these substances on the enzyme might explain the brain cholinergic dysfunction in untreated galactosemia patients...
  18. ncbi request reprint Erythrocyte membrane acetylcholinesterase, Na+, K+-ATPase and Mg2+-ATPase activities in patients with classical galactosaemia
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, and Institute of Child Health, Aghia Sophia Children s Hospital, Athens, Greece
    Acta Paediatr 94:1223-6. 2005
    ..Classical galactosaemia is commonly presented by high blood galactose (Gal) and galactose-1-phosphate (Gal-1-P) levels followed by mental retardation, seizures, etc. dependent on the mutation of the patients...
  19. ncbi request reprint Effects of L-phenylalanine on acetylcholinesterase and Na(+), K(+)-ATPase activities in adult and aged rat brain
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, P O Box 65257, GR 154 01 Athens, Greece
    Mech Ageing Dev 122:491-501. 2001
    ....
  20. ncbi request reprint Effects of L-phenylalanine on acetylcholinesterase, (Na+,K+)-ATPase and Mg2+-ATPase activities in adult rat whole brain and frontal cortex
    S Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Greece
    Z Naturforsch C 56:132-7. 2001
    ....
  21. ncbi request reprint Reduced Mg2+-ATPase activity in the hypoglycemic adult rat brain
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Greece
    Z Naturforsch C 56:912-4. 2001
    ..b) The inhibited brain Mg2+-ATPase in hypoglycemia produces low intracellular Mg2+, which could modulate the activity of Mg2+-dependent enzymes and the rates of protein synthesis and growth of the cell...
  22. ncbi request reprint Suckling rat brain regional distribution of Na+,K+-atpase activity in the in vitro galactosaemia: the effect of L-cysteine and glutathione
    Kyriakoula Marinou
    Department of Experimental Physiology, Medical School, University of Athens, P O Box 65257, GR 15401, Athens, Greece
    Metab Brain Dis 20:45-54. 2005
    ..This phenomenon is reversed by antioxidants Cys and GSH, implying that free radicals may be implicated in the observed enzyme inactivation...
  23. ncbi request reprint The effect of basketball training on the players' erythrocyte membrane acetylcholinesterase, (Na+,K+)-ATPase and Mg2+-ATPase activities
    T Parthimos
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Int J Sports Med 28:650-4. 2007
    ..This stress condition may modulate cholinergic and catecholaminergic/serotoninergic functions in players...
  24. ncbi request reprint Mg2+-ATPase activity in suckling rat brain regions in galactosaemia in vitro. L-Cysteine and glutathione effects
    Kyriakoula Marinou
    Department of Experimental Physiology, Medical School, University of Athens, P O Box 65257, GR 15401 Athens, Greece
    Toxicol In Vitro 19:167-72. 2005
    ....
  25. ncbi request reprint The effect of L-cysteine and glutathione on inhibition of Na+, K+-ATPase activity by aspartame metabolites in human erythrocyte membrane
    K H Schulpis
    Institute of Child Health, Research Center, Aghia Sophia Children s Hospital, Athens, Greece
    Eur J Clin Nutr 60:593-7. 2006
    ..Reports have implicated Aspartame (N-L-a-aspartyl-L-phenylalanine methyl ester, ASP) in neurological problems...
  26. ncbi request reprint Serum paraoxonase/arylesterase activities in phenylketonuric patients on diet
    K H Schulpis
    Institute of Child Health, Aghia Sophia Children s Hospital, Athens, Greece
    Eur J Clin Nutr 61:803-8. 2007
    ..To compare serum paraoxonase/arylesterase (PON-aryl) activities in phenylketonuric (PKU) patients with high and low phenylalanine (Phe) blood concentration...
  27. ncbi request reprint Effect of aging on the activities of acetylcholinesterase, Na+,K(+)-ATPase and Mg(2+)-ATPase in rat pituitary and hypothalamus
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Greece
    Z Naturforsch C 53:168-72. 1998
    ..The age-related alterations of AChE, Na+,K(+)-ATPase and Mg(2+)-ATPase activities may reflect changes in secretion and responses of some hormones of pituitary and hypothalamus...
  28. ncbi request reprint L-cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities
    Theodore Parthimos
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Clin Chem Lab Med 45:67-72. 2007
    ....
  29. ncbi request reprint The effect of aspartame on acetylcholinesterase activity in hippocampal homogenates of suckling rats
    Irene Simintzi
    Department of Experimental Physiology, Medical School, University of Athens, P O Box 65257, GR 15401 Athens, Greece
    Pharmacol Res 56:155-9. 2007
    ..Neurological disturbances have been implicated with aspartame (ASP) consumption and the cholinergic system with acetylcholinesterase (AChE) seems actively involved...
  30. doi request reprint l-Cysteine and glutathione restore the modulation of rat frontal cortex Na+, K+ -ATPase activity induced by aspartame metabolites
    Irene Simintzi
    Department of Physiology, Medical School, Athens University, P O Box 65257, GR 15401 Athens, Greece
    Food Chem Toxicol 46:2074-9. 2008
    ..Studies have suggested that aspartame (ASP) ingestion is implicated in neurological problems...
  31. ncbi request reprint An in vivo and in vitro study of erythrocyte membrane acetylcholinesterase, (Na+, K+)-ATPase and Mg2+-ATPase activities in basketball players on alpha-tocopherol supplementation. The role of L-carnitine
    Kleopatra H Schulpis
    Institute of Child Health, Research Center, Aghia Sophia Children s Hospital, GR 11527 Athens, Greece
    Clin Nutr 26:63-9. 2007
    ..In vitro, we aimed to find out any additional effect of L-carnitine (L-C) on the modulated enzyme activities...
  32. ncbi request reprint L-Cysteine and glutathione restore the reduction of rat hippocampal Na+, K+-ATPase activity induced by aspartame metabolites
    Irene Simintzi
    Department of Experimental Physiology, Medical School, Athens University, P O Box 65257, GR 15401 Athens, Greece
    Toxicology 237:177-83. 2007
    ..Cys or GSH completely or partially restored both enzyme activities...
  33. ncbi request reprint Dramatic reduction of erythrocyte glucose-6-phosphate dehydrogenase activity in athletes participating in the ultradistance foot race "Spartathlon"
    K H Schulpis
    Institute of Child Health Research Center, Athens, Greece
    Scand J Clin Lab Invest 68:228-32. 2008
    ..To investigate the effect of a long-distance endurance exercise "Spartathlon" on erythrocyte glucose-6-phosphate dehydrogenase (G(6)PD) activity...
  34. ncbi request reprint L-phenylalanine effect on rat diaphragm acetylcholinesterase and Na+,K(+)-ATPase
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Cholargos, Greece
    Z Naturforsch C 53:1055-60. 1998
    ..c) The combination of high Phe concentrations effects on AChE and Na+,K(+)-ATPase could influence the levels of the diaphragm synaptic ACh...
  35. ncbi request reprint L-phenylalanine effect on rat brain acetylcholinesterase and Na+,K(+)-ATPase
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Greece
    Z Naturforsch C 53:163-7. 1998
    ..The above results suggest: a) A direct effect of Phe on AChE, b) A direct effect of low Phe concentrations and an indirect effect of high ones on Na+,K(+)-ATPase...
  36. doi request reprint The in vivo and in vitro effects of L-carnitine supplementation on the erythrocyte membrane acetylcholinesterase, Na+, K+-ATPase and Mg2+-ATPase activities in basketball players
    Theodore Parthimos
    Department of Experimental Physiology, Medical School, University of Athens, and Institute of Child Health, Research Center, Aghia Sophia Children s Hospital, Athens, Greece
    Clin Chem Lab Med 46:137-42. 2008
    ..We investigated whether the activities of erythrocyte membrane acetylcholinesterase (AChE), Na+, K+-ATPase and Mg2+-ATPase are modulated in basketball players pre- vs. post-forced training with or without L-carnitine (L-C) supplementation...
  37. ncbi request reprint Erythrocyte membrane Na+,K+-ATPase and Mg2+-ATPase activities in subjects with methylenetetrahydrofolate reductase (MTHFR) 677 C-->T genotype and moderate hyperhomocysteinaemia. The role of L-phenylalanine and L-alanine
    Kleopatra H Schulpis
    1 Institute of Child Health, Research Centre, Aghia Sophia Children s Hospital, Athens, Greece
    Clin Chem Lab Med 44:423-7. 2006
    ..The aim of our study was to investigate erythrocyte membrane Na(+),K(+)-ATPase and Mg(2+)-ATPase activities in patients with methylenetetrahydrofolate reductase (MTHFR) 677 C-->T genotype...
  38. ncbi request reprint The effect of in vitro homocystinuria on the suckling rat hippocampal acetylcholinesterase
    Kleopatra H Schulpis
    Inborn Errors of Metabolism Department, Institute of Child Health Research Center, Aghia Sophia Children s Hospital, Athens, Greece
    Metab Brain Dis 21:21-8. 2006
    ..001). Mix A, Mix B1, or Mix B2 activated hippocampal AChE by 40, 30, (p < 0.001), and 12% (p < 0.01), respectively. In contrast, the S-containing amino acids, Mix A, Mix B1, Mix B2 failed to affect the pure AChE activity...
  39. ncbi request reprint L-cysteine's effect on modulated rat brain enzymes with forced swimming
    Theodore Tsakiris
    Department of Physiology, Medical School, Athens University, GR 15401 Athens, Greece
    Int J Sport Nutr Exerc Metab 19:285-97. 2009
    ....
  40. ncbi request reprint Effect of diet on plasma total antioxidant status in phenylketonuric patients
    K H Schulpis
    Institute of Child Health, Aghia Sophia Children s Hospital, Athens, Greece
    Eur J Clin Nutr 57:383-7. 2003
    ..Phenylketonuria (PKU), an inborn error of phenylalanine (Phe) metabolism, is treated with a low Phe lifelong diet, which is a vegetarian and contains many antioxidants...
  41. doi request reprint Equilibrated diet restores the effects of early age choline-deficient feeding on rat brain antioxidant status and enzyme activities: the role of homocysteine, L-phenylalanine and L-alanine
    Charis Liapi
    Department of Pharmacology, Medical School, University of Athens, Athens, Greece
    Metab Brain Dis 23:289-301. 2008
    ....
  42. ncbi request reprint The effect of alpha-Tocopherol supplementation on training-induced elevation of S100B protein in sera of basketball players
    Kleopatra H Schulpis
    Institute of Child Health, Research Center, Aghia Sophia Children s Hospital, GR 11527, Athens, Greece
    Clin Biochem 40:900-6. 2007
    ..To investigate the effect of alpha-Tocopherol (alpha-T) supplementation on S100B elevated serum levels in basketball players' training...
  43. ncbi request reprint Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne
    K H Schulpis
    Institute of Child Health, and Pharmacokinetics and Parenteral Nutrition Unit, Aghia Sophia Children's Hospital, Athens, Greece
    Int J Dermatol 40:33-6. 2001
    ..Daily vitamin supplementation along with frequent evaluations of Hcy blood levels are recommended for the prevention of a premature occlusive vascular disease...
  44. ncbi request reprint Effects of L-phenylalanine on acetylcholinesterase and Na+,K+-ATPase activities in suckling rat frontal cortex, hippocampus and hypothalamus
    Artemis Doulgeraki
    Department of Experimental Physiology, Medical School, University of Athens, Greece
    Z Naturforsch C 57:182-8. 2002
    ..c) In the hypothalamus, the behavioral problems in PKU "off diet" may be related to noradrenaline (NA) levels, which are probably correlated with the modulated Na+,K+-ATPase by Phe...
  45. ncbi request reprint Alanine reverses the inhibitory effect of phenylalanine on acetylcholinesterase activity
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Greece
    Z Naturforsch C 57:506-11. 2002
    ....
  46. ncbi request reprint Selegiline long-term effects on brain acetylcholinesterase, (Na+,K+)-ATPase activities, antioxidant status and learning performance of aged rats
    Haris Carageorgiou
    Department of Experimental Pharmacology, Medical School, University of Athens, Athens, Greece
    Pharmacol Res 48:245-51. 2003
    ....
  47. doi request reprint Effects of adult-onset streptozotocin-induced diabetes on the rat brain antioxidant status and the activities of acetylcholinesterase, (Na(+),K (+))- and Mg(2+)-ATPase: modulation by L-cysteine
    Apostolos Zarros
    Department of Pharmacology, Medical School, University of Athens, Athens, Greece
    Metab Brain Dis 24:337-48. 2009
    ..As concerns the use of Cys as a neuroprotective agent against diabetes, our in vitro findings could be indicative of a possible protective role of Cys under different in vivo experimental conditions...
  48. doi request reprint Evidence for the participation of the stimulated sympathetic nervous system in the regulation of carnitine blood levels of soccer players during a game
    Kleopatra H Schulpis
    Institute of Child Health, Research Center, Aghia Sophia Children s Hospital, GR 11527 Athens, Greece
    Metabolism 58:1080-6. 2009
    ....
  49. doi request reprint The effect of the mode of delivery on maternal-neonatal interleukin-6, biogenic amine and their precursor amino acid concentrations
    Kleopatra H Schulpis
    Institute of Child Health, Research Center, Aghia Sophia Children s Hospital, Athens, Greece
    Clin Chem Lab Med 46:1624-30. 2008
    ..The aim of our study was to investigate the effect of the mode of delivery on maternal-neonatal IL-6, biogenic amine and their precursor amino acid levels...
  50. ncbi request reprint 8-hydroxy-2-desoxyguanosine serum concentrations as a marker of DNA damage in patients with classical galactosaemia
    Kleopatra H Schulpis
    Institute of Child Health, Aghia Sophia Children s Hospital, Athens, Greece
    Acta Paediatr 95:164-9. 2006
    ..Galactose/lactose restriction intake is the only treatment. 8-hydroxy-2-desoxyguanosine (8-OHdG) is a marker of oxidized DNA damage...
  51. doi request reprint The effect of the mode of delivery on the maternal-neonatal erythrocyte membrane acetylcholinesterase activity
    Dimitrios G Vlachos
    Department of Physiology, Medical School, Athens University, P O Box 65257, Athens 15401, Greece
    Clin Biochem 41:818-23. 2008
    ..Free radical production and high catecholamine levels are implicated with the modulation of acetylcholinesterase (AChE) activity...
  52. ncbi request reprint Cadmium effects on brain acetylcholinesterase activity and antioxidant status of adult rats: modulation by zinc, calcium and L-cysteine co-administration
    Haris Carageorgiou
    Department of Experimental Pharmacology, Medical School, University of Athens, Athens, Greece
    Basic Clin Pharmacol Toxicol 97:320-4. 2005
    ..Zinc, Ca and Cys, given just before Cd administration, modified the Cd-induced effects and restored rat brain total antioxidant status to the control levels...
  53. doi request reprint Combined thirty-day exposure to thioacetamide and choline-deprivation alters serum antioxidant status and crucial brain enzyme activities in adult rats
    Charis Liapi
    Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Metab Brain Dis 24:441-51. 2009
    ....
  54. doi request reprint Effects of short-term exposure to manganese on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na,K)-ATPase and Mg-ATPase: modulation by L-cysteine
    Charis Liapi
    Department of Pharmacology, Medical School, University of Athens, Greece
    Basic Clin Pharmacol Toxicol 103:171-5. 2008
    ..The activity of Na+,K+-ATPase is not affected by Mn, while Mg2+-ATPase activity is slightly (but significantly) inhibited by Mn, possibly due to Mg replacement...
  55. ncbi request reprint The effect of diet on Paraoxonase 1/Arylesterase activities in patients with disorders of galactose metabolism
    Kleopatra H Schulpis
    Institute of Child Health, Research Centre, Aghia Sophia Children s Hospital, Athens, Greece
    Clin Endocrinol (Oxf) 67:687-92. 2007
    ..To investigate the effects of diet on the antiatherogenic enzyme Paraoxonase 1/Arylesterase (PON1/Aryl) activities in patients with disorders of galactose metabolism...
  56. ncbi request reprint The effect of aspartame metabolites on the suckling rat frontal cortex acetylcholinesterase. An in vitro study
    Irene Simintzi
    Department of Experimental Physiology, Medical School, University of Athens, P O Box 65257, GR 15401 Athens, Greece
    Food Chem Toxicol 45:2397-401. 2007
    ..High or toxic doses of the sweetener remarkably decreased the enzyme activity. If this in vitro finding comes into human reality, it may be suggested that cholinergic symptoms are related to the consumption of the above ASP doses...
  57. ncbi request reprint Suckling rat brain regional distribution of acetylcholinesterase activity in galactosaemia in vitro
    Kyriakoula Marinou
    Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
    Metab Brain Dis 20:227-36. 2005
    ..Frontal cortex and hippocampus AChE was significantly inhibited by Gal derivatives, whereas hypothalamus AChE activity remained unaltered possibly due to the histologically different innervation of this area...
  58. ncbi request reprint Effects of gestational and lactational choline deprivation on brain antioxidant status, acetylcholinesterase, (Na(+),K(+))- and Mg(2+)-ATPase activities in offspring rats
    Charis Liapi
    Department of Experimental Pharmacology, Medical School, University of Athens, Athens, Greece
    Clin Chem Lab Med 45:651-6. 2007
    ....
  59. ncbi request reprint Effect of CDP-choline on hippocampal acetylcholinesterase and Na+,K(+)-ATPase in adult and aged rats
    Christos Plataras
    Department of Experimental Physiology, Medical School, University of Athens, PO Box 65257, GR 154 01 Athens, Greece
    Z Naturforsch C 58:277-81. 2003
    ..It is suggested that: CDP-choline can restore hippocampal AChE and Na+,K(+)-ATPase activities in the aged rat and thus it may play a role in improving memory performance which is impaired by aging and some neuronal disturbances...
  60. ncbi request reprint In vivo and in vitro effects of cadmium on adult rat brain total antioxidant status, acetylcholinesterase, (Na+, K+)-ATPase and Mg2+-ATPase activities: protection by L-cysteine
    Haris Carageorgiou
    Department of Experimental Pharmacology, Medical School, University of Athens, Athens, Greece
    Basic Clin Pharmacol Toxicol 94:112-8. 2004
    ....
  61. ncbi request reprint Effects of hyper- and hypothyroidism on acetylcholinesterase, (Na(+), K (+))- and Mg ( 2+ )-ATPase activities of adult rat hypothalamus and cerebellum
    Haris Carageorgiou
    Department of Experimental Pharmacology, Medical School, University of Athens, Athens, Greece
    Metab Brain Dis 22:31-8. 2007
    ..Moreover, the above TH-induced changes may affect the monoamine neurotransmitter systems...
  62. doi request reprint The neuroprotective role of L-cysteine towards the effects of short-term exposure to lanthanum on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase
    Charis Liapi
    Department of Pharmacology, Medical School, University of Athens, Athens, Greece
    Biometals 22:329-35. 2009
    ..A role for the already reported concentration-dependent interaction of La with Ca-binding sites (such as Ca(2+)-ATPase) might be considered for certain of the above phenomena...
  63. ncbi request reprint Low serum biotinidase activity in children with valproic acid monotherapy
    K H Schulpis
    Institute of Child Health, Aghia Sophia Children's Hospital, Athens, Greece
    Epilepsia 42:1359-62. 2001
    ..CONCLUSIONS: It is suggested that VPA impairs the liver mitochondrial function, resulting in a low biotinidase activity and or biotin deficiency. Biotin supplementation could restore some of the side effects of the drug...
  64. doi request reprint Maternal-neonatal erythrocyte membrane Na(+), K (+)-ATPase and Mg (2+)-ATPase activities in relation to the mode of delivery
    Dimitrios G Vlachos
    Department of Physiology, Medical School, Athens University, Athens, Greece
    Eur J Appl Physiol 103:501-8. 2008
    ....
  65. doi request reprint Effects of adult-onset choline deprivation on the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase in crucial rat brain regions
    Charis Liapi
    Department of Pharmacology, Medical School, University of Athens, Athens, Greece
    Food Chem Toxicol 47:82-5. 2009
    ....
  66. ncbi request reprint Morning preprandial plasma ghrelin and catecholamine concentrations in patients with phenylketonuria and normal controls: evidence for catecholamine-mediated ghrelin regulation
    Kleopatra H Schulpis
    Institute of Child Health, Athens, Greece
    J Clin Endocrinol Metab 89:3983-7. 2004
    ....
  67. ncbi request reprint In vivo effects of high phenylalanine blood levels on Na+,K+-ATPase, Mg2+-ATPase activities and biogenic amine concentrations in phenylketonuria
    Kleopatra H Schulpis
    Institute of Child Health, Aghia Sophia Children s Hospital, Athens, Greece
    Clin Biochem 35:281-5. 2002
    ....
  68. ncbi request reprint Changes in antioxidant status, protein concentration, acetylcholinesterase, (Na+,K+)-, and Mg2+ -ATPase activities in the brain of hyper- and hypothyroid adult rats
    Haris Carageorgiou
    Department of Experimental Pharmacology, Medical School, University of Athens, Athens, Greece
    Metab Brain Dis 20:129-39. 2005
    ..Such changes of the enzyme activities may differentially modulate the brain intracellular Mg2+, neural excitability, as well as the uptake and release of biogenic amines...
  69. ncbi request reprint Valproic acid monotherapy induces DNA oxidative damage
    Kleopatra H Schulpis
    Institute of Child Health, Research Center Athens, Athens, Greece
    Toxicology 217:228-32. 2006
    ..8-OHdG evaluation may be a useful biomarker to follow up the increased risk of degeneration process in VPA patients...
  70. ncbi request reprint Changes of the brain synapses during aging. New aspects
    K Schulpis
    Institute of Child Health, Agia Sophia Children s Hospital, Athens, Greece
    Z Naturforsch C 56:921-9. 2001
    ..These numerous multifactorial approaches are essential to understand the process of aging. The more we learn about it, the more we realize how to achieve "successful" aging...
  71. doi request reprint Effects of fulminant hepatic encephalopathy on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na(+),K (+))- and Mg (2+)-ATPase: comparison of the enzymes' response to in vitro treatment with ammonia
    Apostolos Zarros
    Department of Physiology, Medical School, University of Athens, P O Box 65257, Athens, Greece
    Metab Brain Dis 23:255-64. 2008
    ....
  72. ncbi request reprint Changes in acetylcholinesterase, Na+,K+-ATPase, and Mg2+-ATPase activities in the frontal cortex and the hippocampus of hyper- and hypothyroid adult rats
    Haris Carageorgiou
    Department of Experimental Pharmacology, Medical School, University of Athens, Goudi, GR 11527 Athens, Greece
    Metabolism 56:1104-10. 2007
    ..Moreover, the above TH-induced changes may affect the monoamine neurotransmitter systems in the examined brain regions...
  73. ncbi request reprint Effects of (-)deprenyl (selegiline) on acetylcholinesterase and Na(+),K(+)-ATPase activities in adult rat whole brain
    Charalambos Antoniades
    Department of Experimental Physiology, Medical School, University of Athens, P O Box 65257, GR 154 01 Athens, Greece
    Pharmacol Res 46:165-9. 2002
    ..We conclude that (-)deprenyl is an indirect AChE inhibitor and Na(+),K(+)-ATPase stimulator in the rat brain (in vitro)...
  74. doi request reprint Maternal-neonatal amino acid blood levels in relation to the mode of delivery
    Kleopatra H Schulpis
    Institute of Child Health, Research Centre, Aghia Sophia Children s Hospital, Athens, Greece
    Acta Obstet Gynecol Scand 88:71-6. 2009
    ..To investigate the effect of the mode of delivery on maternal-neonatal amino acid levels as high blood levels of some amino acids are implicated with endurance exercise...
  75. ncbi request reprint The effect of the mode of delivery on the maternal-neonatal carnitine blood levels and antioxidant status
    Kleopatra H Schulpis
    Institute of Child Health, Research Center, Aghia Sophia Children s Hospital, Athens, Greece
    Clin Chem Lab Med 46:680-6. 2008
    ..Carnitine blood levels are closely related to beta-oxidation and implicated with strenuous muscle contractions. Normal delivery process is characterized by the participation of the uterus and most skeletal muscles...
  76. ncbi request reprint The effect of diet on total antioxidant status, erythrocyte membrane Na+,K+-ATPase and Mg2+-ATPase activities in patients with classical galactosaemia
    Kleopatra H Schulpis
    Institute of Child Health, Aghia Sophia Children s Hospital, GR 11527 Athens, Greece
    Clin Nutr 24:151-7. 2005
    ..The aim of this study was to evaluate the erythrocyte membrane Na+,K+-ATPase and Mg2+-ATPase activities in galactosaemic patients and to correlate them to Gal-1-P, total antioxidant status (TAS) and membrane protein content (PC)...
  77. ncbi request reprint L-cysteine supplementation protects the erythrocyte glucose-6-phosphate dehydrogenase activity from reduction induced by forced training
    Kleopatra H Schulpis
    Institute of Child Health, Research Center, Aghia Sophia Children s Hospital, GR 11527 Athens, Greece
    Clin Biochem 39:1002-6. 2006
    ..L-cysteine (L-cys) is implicated in the reduction of free radical production...
  78. ncbi request reprint Low total antioxidant status is implicated with high 8-hydroxy-2-deoxyguanosine serum concentrations in phenylketonuria
    Kleopatra H Schulpis
    Institute of Child Health, Aghia Sophia Children s Hospital, 11527 Athens, Greece
    Clin Biochem 38:239-42. 2005
    ..Phenylketonuria (PKU), an inborn error of metabolism, is treated with a low phenylalanine (Phe) lifelong diet, which can be characterized as vegetarian. 8-Hydroxy-2-deoxyguanosine (8-OHdG) is highly implicated in degenerative diseases...
  79. ncbi request reprint Increased plasma adiponectin concentrations in poorly controlled patients with phenylketonuria normalize with a strict diet: evidence for catecholamine-mediated adiponectin regulation and a complex effect of phenylketonuria diet on atherogenesis risk fact
    Kleopatra H Schulpis
    Institute of Child Health, 11527 Athens, Greece
    Metabolism 54:1350-5. 2005
    ..Homocysteine production appears to be unfavorably affected by a strict PKU diet, diverging from the rest of the atherogenesis risk factors, which were improved in the well-controlled patients...
  80. ncbi request reprint Acetylcholinesterase activity and biogenic amines in phenylketonuria
    Kleopatra H Schulpis
    Institute of Child Health, Aghia Sophia Children s Hospital, 11527 Athens, Greece
    Clin Chem 48:1794-6. 2002