Research Topics
Species | S TsagarakisSummaryAffiliation: University of Athens Country: Greece Publications
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Publications
A reappraisal of the utility of somatostatin receptor scintigraphy in patients with ectopic adrenocorticotropin Cushing's syndromeS Tsagarakis
Department of Endocrinology, Diabetes, and Metabolism, Evangelismos Hospital, 10676 Athens, Greece
J Clin Endocrinol Metab 88:4754-8. 2003..In summary, in this study a substantial number of patients had positive tumor localization by SRS. Therefore, SRS is a useful tool in the evaluation of patients with EAS...- The desmopressin and combined CRH-desmopressin tests in the differential diagnosis of ACTH-dependent Cushing's syndrome: constraints imposed by the expression of V2 vasopressin receptors in tumors with ectopic ACTH secretionS Tsagarakis
Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece
J Clin Endocrinol Metab 87:1646-53. 2002..Moreover, following the combined CRH-desmopressin test only the ACTH but not the F responses were diagnostically useful, but still far from completely discriminating patients with CD and EAS... - Lymphocytic hypophysitis: late recurrence following successful transsphenoidal surgeryStylianos Tsagarakis
Department of Endocrinology, Diabetes and Metabolism Evangelismos Hospital, and 2nd Department of Radiology, University of Athens, Athens, Greece
Endocrine 25:85-90. 2004.... - The application of the combined corticotropin-releasing hormone plus desmopressin stimulation during petrosal sinus sampling is both sensitive and specific in differentiating patients with Cushing's disease from patients with the occult ectopic adrenocortS Tsagarakis
Department of Endocrinology, Athens Polyclinic Hospital, Athens, Greece
J Clin Endocrinol Metab 92:2080-6. 2007..A crucial issue, however, is whether such an amplified stimulation may affect the specificity of the procedure, and this was the main aim of the present study... - Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implicationsS Tsagarakis
Department of Endocrinology, Athens Polyclinic, Athens, Greece
Pituitary 8:251-4. 2005..Therefore, assessment of the integrity of ADH secretion, hypothalamic-pituitary adrenal (HPA) axis and thyroid axis is crucial to ensure survival and optimal rehabilitation of TBI patients... - Endogenous subclinical hypercortisolism: Diagnostic uncertainties and clinical implicationsS Tsagarakis
Department of Endocrinology, Athens Polyclinic, Athens, Greece
J Endocrinol Invest 29:471-82. 2006..In summary, SH does exist and is associated with a negative impact in patients' health; however, hormonal cut-off criteria for decision-making remain to be defined... - Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studiesS Tsagarakis
Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece
J Clin Endocrinol Metab 86:583-9. 2001..Thus, aberrant expression of the GIP receptor does not exclusively involve cells of a zona fasciculata phenotype, as previously reported, but may also occur in other types of differentiated adrenocortical cells... - Pituitary-adrenal responses to human corticotropin-releasing hormone in critically ill patientsIoanna Dimopoulou
Pesmazoglou 2 Street, 14561, Kifissia, Athens, Greece
Intensive Care Med 33:454-9. 2007..To investigate the pattern of pituitary-adrenal responses to human corticotropin-releasing hormone (hCRH) in critically ill patients and to examine the relation between responses and clinical outcome... - Endocrine alterations in critically ill patients with stroke during the early recovery periodIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece
Neurocrit Care 3:224-9. 2005..Endocrine abnormalities in critically ill patients with stroke during the early recovery period have not been well characterized... - A prospective study on adrenal cortex responses and outcome prediction in acute critical illness: results from a large cohort of 203 mixed ICU patientsIoanna Dimopoulou
Attikon Hospital, Medical School, Second Department of Critical Care Medicine, University of Athens, 2 Pesmazoglou Street, 14561 Athens, Greece
Intensive Care Med 33:2116-21. 2007..To assess whether adrenal cortex hormones predict ICU mortality in acute, mixed, critically ill patients... - High incidence of neuroendocrine dysfunction in long-term survivors of aneurysmal subarachnoid hemorrhageIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece
Stroke 35:2884-9. 2004..To investigate the incidence, pattern, and magnitude of neuroendocrine changes in long-term survivors of aneurysmal subarachnoid hemorrhage (SAH)... - Acromegaly caused by ectopic growth hormone-releasing hormone secretion by a carcinoid bronchial tumor: a rare entityKalliopi Athanassiadi
Department of Thoracic Surgery, Evangelismos General Hospital, Athens, Greece
J Thorac Cardiovasc Surg 128:631-2. 2004 - The low-dose corticotropin stimulation test in acute traumatic and non-traumatic brain injury: incidence of hypo-responsiveness and relationship to outcomeIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, 10675 Athens, Greece
Intensive Care Med 30:1216-9. 2004..To investigate adrenal responses to the low-dose corticotropin (ACTH) stimulation test in acute traumatic or non-traumatic brain injury (BI) and to assess its value in predicting outcome... - Relationship of thyroid function to post-traumatic S-100b serum levels in survivors of severe head injury: preliminary resultsIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, 45 47 Ipsilandou Street, 106 75 Athens, Greece
Intensive Care Med 30:298-301. 2004..To assess thyroid function abnormalities in survivors of severe head trauma and to examine their relationship with indices of brain injury severity... - Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levelsIoanna Dimopoulou
Department of Clinical Care Medicine, Evangelismos Hospital, Athens, Greece
Crit Care Med 32:404-8. 2004..This disorder is associated with prior vasopressor dependency and higher interleukin-6 levels... - High prevalence of decreased cortisol reserve in brain-dead potential organ donorsIoanna Dimopoulou
Departments of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
Crit Care Med 31:1113-7. 2003..To investigate the adrenocortical function in brain-dead patients, potential organ donors... - Endocrine abnormalities in critical care patients with moderate-to-severe head trauma: incidence, pattern and predisposing factorsIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece
Intensive Care Med 30:1051-7. 2004..To investigate the incidence and type of endocrine abnormalities in critical care patients with traumatic brain injury (TBI) and to examine their relationships to possible predisposing factors... - Evaluation of GH reserve in patients with adrenal incidentalomas and biochemical evidence of subclinical autonomous glucocorticoid hypersecretionM Tzanela
Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece
Clin Endocrinol (Oxf) 62:597-602. 2005..46, P = 0.002). CONCLUSIONS: In conclusion, our results provide evidence that, contrary to patients with overt CS, SAGH does not affect the GH secretory response to provocative stimulation... - Thyroid function changes and cytokine alterations following major surgeryIoannis Ilias
Department of Endocrinology, Elena Venizelou Hospital, Athens, Greece
Neuroimmunomodulation 14:243-7. 2007..Significant negative correlations were noted among TNF-alpha, IL-6 and IL-8 against T(3) and FT(4). Cytokines are responsible, at least in part, for NTI following major operations... - Pituitary-adrenal responses following major abdominal surgeryIoanna Dimopoulou
2nd Department of Critical Care Medicine, Attikon Hospital, Athens University School of Medicine, Athens, Greece
Hormones (Athens) 7:237-42. 2008..Perioperative pituitary-adrenal responses after major abdominal surgery have not been well characterized. The aim of the present study was to further clarify perioperative pituitary-adrenal responses... - Contribution of endocrine parameters in predicting outcome of multiple trauma patients in an intensive care unitIoannis Ilias
Department of Endocrinology, Elena Venizelou Hospital, and Athens University School of Medicine, Greece
Hormones (Athens) 6:218-26. 2007..To evaluate whether tentative prognostic models for intensive care unit survival of multiple trauma patients could be improved by including endocrine parameters... 
Clinical and biochemical impact of BCL1 polymorphic genotype of the glucocorticoid receptor gene in patients with adrenal incidentalomasM Tzanela
Department of Endocrinology, Evangelismos Hospital, 45 47 Ipsilantous St, Athens, Greece
J Endocrinol Invest 35:395-400. 2012..The genotype- phenotype associations of this polymomorphism in patients presenting with AI has not been extensively investigated...- Assessment of GH reserve before and after successful treatment of adult patients with Cushing's syndromeMarinella Tzanela
Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, 10676 Athens, Greece
Clin Endocrinol (Oxf) 60:309-14. 2004..In the majority of these patients the disruption of GH secretion is normalized within a year after successful treatment of endogenous cortisol excess... - Role of [(18)F]FDG-PET/CT in the detection of occult recurrent medullary thyroid cancerEvangelia Skoura
Department of Nuclear Medicine, Evangelismos Hospital, Athens, Greece
Nucl Med Commun 31:567-75. 2010..In this study we report our experience with 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography/computed tomography ([(18)F]FDG-PET/CT) in the evaluation of this specific group... - Ex-vivo effect of dexamethasone on cytokine production from whole blood of septic patients: correlation with disease severityEvangelos J Giamarellos-Bourboulis
4th Department of Internal Medicine, University of Athens, Medical School, Greece
Cytokine 49:89-94. 2010.... - Hypothalamic-pituitary dysfunction in critically ill patients with traumatic and nontraumatic brain injuryIoanna Dimopoulou
Second Department of Critical Care Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Greece
Intensive Care Med 31:1020-8. 2005..A significant number of studies have shown that critically ill patients with brain injury (BI) frequently exhibit abnormal pituitary hormonal responses during the immediate postinjury period... - Bilateral inferior petrosal sinuses sampling in the routine investigation of Cushing's syndrome: a comparison with MRIIoannis S Kaskarelis
Department of Radiology, Evangelismos General Hospital, 11 Amasias St, Athens, Greece 11634
AJR Am J Roentgenol 187:562-70. 2006..The routine use of a multimodality diagnostic approach including BIPSS, MRI, and biochemical tests is suggested to avoid the risk of mismanagement for patients with CS... - The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing's syndromeIrene Zervolea
Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Centre for Scientific Research 'Demokritos, 15310 Athens, Greece
Eur J Endocrinol 152:895-902. 2005.... - Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care MedicinePaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 36:1937-49. 2008..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients... - Reproducibility of the corticotropin stimulation test in septic shockIoanna Dimopoulou
Anesth Analg 103:1056-7; author reply 1057. 2006 - A newly detected mutation of the RET protooncogene in exon 8 as a cause of multiple endocrine neoplasia type 2ASotirios Bethanis
Department of Endocrinology, Athens Polyclinic, Athens, Greece
Hormones (Athens) 6:152-6. 2007..Furthermore, patients with FMTC and exon 8 mutations should also be screened for pheochromocytoma... - Immunohistochemical localization of interleukin-6 in peripheral human endocrine glandsGeorge Kontogeorgos
Department of Pathology, G Genimatas Athens General Hospital, Greece
Endocrine 17:135-40. 2002..In conclusion, IL-6 immunoreactivity is present in almost all the human endocrine glands and it expressed in a cell-specific manner. These observations provide further support for the existence of local immune-endocrine interactions... - Prior chronic in vivo glucocorticoid excess leads to an anabolic phenotype and an extension of cellular life span of skin fibroblasts in vitroDimitris Kletsas
Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Centre for Scientific Research Demokritos, 15310 Athens, Greece
Ann N Y Acad Sci 1100:449-54. 2007.... - Chronic in vivo exposure to glucocorticoids prolongs cellular lifespan: the case of Cushing's syndrome-patients' fibroblastsHarris Pratsinis
Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Centre for Scientific Research, Demokritos, 153 10 Athens, Greece
Exp Gerontol 37:1237-45. 2002..These results support the hypothesis that stress response may have beneficial consequences in cellular longevity, as well as in tissue homeostasis...