Ioannis P Trougakos

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. pmc Apolipoprotein J/Clusterin is a novel structural component of human erythrocytes and a biomarker of cellular stress and senescence
    Marianna H Antonelou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    PLoS ONE 6:e26032. 2011
  2. pmc Molecular chaperones and proteostasis regulation during redox imbalance
    Katerina Niforou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece
    Redox Biol 2:323-32. 2014
  3. pmc Apolipoprotein J/clusterin in human erythrocytes is involved in the molecular process of defected material disposal during vesiculation
    Marianna H Antonelou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    PLoS ONE 6:e26033. 2011
  4. doi request reprint Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis
    Ioannis P Trougakos
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece Electronic address
    J Proteomics 92:274-98. 2013
  5. doi request reprint Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines
    Ioannis P Trougakos
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis Zografou, Athens 15784, Greece
    Cancer Genet Cytogenet 196:109-18. 2010
  6. pmc Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
    Eleni N Tsakiri
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece
    Aging Cell 12:802-13. 2013
  7. pmc Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Clin Cancer Res 15:48-59. 2009
  8. ncbi request reprint Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways
    Eirini Balantinou
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vas Constantinou Avenue, Athens, Greece
    Free Radic Biol Med 46:1267-74. 2009
  9. doi request reprint Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster
    Eleni N Tsakiri
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens 15784, Greece
    Free Radic Biol Med 65:1155-63. 2013
  10. ncbi request reprint Increased expression levels of apolipoprotein J/clusterin during primary osteoarthritis
    Emmanouil Fandridis
    Hand Surgery Upper Limb Microsurgery Department, KAT Hospital, Kifissia, Greece
    In Vivo 25:745-9. 2011

Collaborators

Detail Information

Publications24

  1. pmc Apolipoprotein J/Clusterin is a novel structural component of human erythrocytes and a biomarker of cellular stress and senescence
    Marianna H Antonelou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    PLoS ONE 6:e26032. 2011
    ..Moreover, we studied the erythrocytic membrane sCLU content during organismal aging, in conditions of increased organismal stress and accelerated RBCs senescence, as well as during physiological in vivo cellular senescence...
  2. pmc Molecular chaperones and proteostasis regulation during redox imbalance
    Katerina Niforou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece
    Redox Biol 2:323-32. 2014
    ..In the current review we present a synopsis of the various classes of intra- and extracellular chaperones, the effects of oxidants on cellular homeodynamics and diseases and the redox regulation of chaperones. ..
  3. pmc Apolipoprotein J/clusterin in human erythrocytes is involved in the molecular process of defected material disposal during vesiculation
    Marianna H Antonelou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    PLoS ONE 6:e26033. 2011
    ..It was hypothesized that sCLU loss relates to RBCs vesiculation, a mechanism that removes erythrocyte membrane patches containing defective or potentially harmful components...
  4. doi request reprint Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis
    Ioannis P Trougakos
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece Electronic address
    J Proteomics 92:274-98. 2013
    ..This article is part of a Special Issue entitled: Posttranslational Protein modifications in biology and Medicine. ..
  5. doi request reprint Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines
    Ioannis P Trougakos
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis Zografou, Athens 15784, Greece
    Cancer Genet Cytogenet 196:109-18. 2010
    ..The transcriptome profiles reported here provide novel information about the considerable molecular differences between these two widely used human osteosarcoma cell lines...
  6. pmc Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
    Eleni N Tsakiri
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece
    Aging Cell 12:802-13. 2013
    ..Prolonged deregulation of this proteostasis circuit accelerates aging. ..
  7. pmc Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Clin Cancer Res 15:48-59. 2009
    ..However, the molecular mechanisms underlying its function remained largely unknown...
  8. ncbi request reprint Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways
    Eirini Balantinou
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vas Constantinou Avenue, Athens, Greece
    Free Radic Biol Med 46:1267-74. 2009
    ....
  9. doi request reprint Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster
    Eleni N Tsakiri
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens 15784, Greece
    Free Radic Biol Med 65:1155-63. 2013
    ..Our in vivo studies demonstrate that chronic ingestion of AGEs or lipofuscin disrupts proteostasis and accelerates the functional decline that occurs with normal aging. ..
  10. ncbi request reprint Increased expression levels of apolipoprotein J/clusterin during primary osteoarthritis
    Emmanouil Fandridis
    Hand Surgery Upper Limb Microsurgery Department, KAT Hospital, Kifissia, Greece
    In Vivo 25:745-9. 2011
    ..Taken together, these observations indicate that the sCLU protein or mRNA expression level may be of a significant diagnostic and/or prognostic value during OA progression...
  11. doi request reprint The molecular chaperone apolipoprotein J/clusterin as a sensor of oxidative stress: implications in therapeutic approaches - a mini-review
    Ioannis P Trougakos
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens, Greece
    Gerontology 59:514-23. 2013
    ....
  12. ncbi request reprint Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Cancer Res 64:1834-42. 2004
    ..The described CLU-specific siRNA oligonucleotides that can potently silence CLU gene expression may thus prove valuable agents during antitumor therapy or at other pathological conditions where CLU has been implicated...
  13. doi request reprint Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status
    Niki Chondrogianni
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, Athens, Greece
    Aging Cell 7:717-32. 2008
    ..These data reveal the continuous interplay between the integrity of proteasome function, senescence and cell survival...
  14. ncbi request reprint Clusterin/Apolipoprotein J up-regulation after zinc exposure, replicative senescence or differentiation of human haematopoietic cells
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Ageing, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Ave, Athens, 11635, Greece
    Biogerontology 7:375-82. 2006
    ..Overall, our results suggest that CLU is actively involved in both replicative senescence and terminal differentiation in different types of human haematopoietic cells...
  15. ncbi request reprint Oxidative stress-mediated biomolecular damage and inflammation in tumorigenesis
    Fabiola Sesti
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece
    In Vivo 26:395-402. 2012
    ..In the present manuscript, we will focus on the role of free radical-mediated biomolecular damage and inflammation in tumorigenesis...
  16. pmc Prothymosin α and a prothymosin α-derived peptide enhance T(H)1-type immune responses against defined HER-2/neu epitopes
    Kyriaki Ioannou
    Department of Animal and Human Physiology, Faculty of Biology, University of Athens, Athens 15784, Greece
    BMC Immunol 14:43. 2013
    ..The aim of this study was to investigate whether proTα- or proTα(100-109)-matured DCs are functionally competent and to provide preliminary evidence for the mode of action of these agents...
  17. ncbi request reprint Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Ageing, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Free Radic Res 40:1324-34. 2006
    ..This review emphasizes on CLU gene regulation by oxidative stress that is the common link between all pathological conditions where CLU has been implicated...
  18. doi request reprint Chapter 9: Oxidative stress in malignant progression: The role of Clusterin, a sensitive cellular biosensor of free radicals
    Ioannis P Trougakos
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis Zografou, Athens 15784, Greece
    Adv Cancer Res 104:171-210. 2009
    ..This review focuses on CLU regulation by oxidative injury that is the common molecular link of most, if not all, pathological conditions where CLU has been functionally implicated...
  19. ncbi request reprint Reduced expression levels of the senescence biomarker clusterin/apolipoprotein j in lymphocytes from healthy centenarians
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Ageing, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Ann N Y Acad Sci 1067:294-300. 2006
    ....
  20. doi request reprint Natural compounds with anti-ageing activity
    Aikaterini Argyropoulou
    Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece
    Nat Prod Rep 30:1412-37. 2013
    ....
  21. doi request reprint The amazing ubiquitin-proteasome system: structural components and implication in aging
    Eleni N Tsakiri
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    Int Rev Cell Mol Biol 314:171-237. 2015
    ..We propose that mild UPS activation in the young organism will, likely, promote antiaging effects and/or suppress age-related diseases. ..
  22. pmc Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress
    Eleni N Tsakiri
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    FASEB J 27:2407-20. 2013
    ..The higher investment in proteostasis maintenance in the gonads plausibly facilitates proteome stability across generations; it also provides evidence in support of the trade-off theories of aging...
  23. ncbi request reprint Crystalline yolk spheroids in Drosophila melanogaster oocyte: freeze fracture and two-dimensional reconstruction analysis
    Issidora S Papassideri
    Department of Cell Biology and Biophysics, Athens University, Panepistimiopolis, Zografou, Athens 15784, Greece
    J Insect Physiol 53:370-6. 2007
    ....
  24. doi request reprint Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles
    Antonios Christodoulou
    Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
    Bioorg Med Chem Lett 21:3110-2. 2011
    ..The majority of the derivatives possessed noticeable cytotoxicity in a low μM range indicating an interesting structure-activity relationship...