D Tousoulis

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. doi request reprint The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals
    Dimitris Tousoulis
    S Karagiorga 69, Glifada 166 75, Athens, Greece
    J Hypertens 28:925-30. 2010
  2. ncbi request reprint The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 109:48-52. 2006
  3. doi request reprint Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta
    S Brili
    Athens University Medical School, S Karagiorga 69, Glifada, Athens 16675, Greece
    Heart 98:325-9. 2012
  4. ncbi request reprint Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease
    Dimitris Tousoulis
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Diabetes Care 26:2749-53. 2003
  5. ncbi request reprint Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Glifada, Athens, Greece
    Atherosclerosis 170:261-7. 2003
  6. doi request reprint Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 149:46-9. 2011
  7. doi request reprint Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Am J Hypertens 23:237-42. 2010
  8. ncbi request reprint Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, A Cardiology Department, Greece
    Eur J Heart Fail 7:1126-32. 2005
  9. ncbi request reprint Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Athens, Greece
    Atherosclerosis 178:359-63. 2005
  10. pmc Evaluating endothelial function in humans: a guide to invasive and non-invasive techniques
    D Tousoulis
    Athens University Medical School, S Karagiorga Street 69, 166 75, Glifada, Athens, Greece
    Heart 91:553-8. 2005

Collaborators

Detail Information

Publications127 found, 100 shown here

  1. doi request reprint The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals
    Dimitris Tousoulis
    S Karagiorga 69, Glifada 166 75, Athens, Greece
    J Hypertens 28:925-30. 2010
    ..We examined the impact of acute homocysteinemia on endothelial function in hypertensive patients and healthy individuals, and the potential role of ET-1...
  2. ncbi request reprint The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 109:48-52. 2006
    ..In this study we assessed the effects of low-dose atorvastatin treatment, on inflammatory process in patients admitted for unstable angina with low cholesterol level...
  3. doi request reprint Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta
    S Brili
    Athens University Medical School, S Karagiorga 69, Glifada, Athens 16675, Greece
    Heart 98:325-9. 2012
    ..To investigate the effects of atorvastatin on endothelial function and low-grade systemic inflammation in subjects with successful surgery for aortic coarctation repair (SCR)...
  4. ncbi request reprint Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease
    Dimitris Tousoulis
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Diabetes Care 26:2749-53. 2003
    ....
  5. ncbi request reprint Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Glifada, Athens, Greece
    Atherosclerosis 170:261-7. 2003
    ....
  6. doi request reprint Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 149:46-9. 2011
    ..We examined the effect of combined therapy with atorvastatin and metformin on glucose-induced variations of inflammatory molecules in patients with newly diagnosed diabetes mellitus type 2 (DM)...
  7. doi request reprint Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Am J Hypertens 23:237-42. 2010
    ..We examined the impact of A1675G on the risk and the severity of coronary artery disease (CAD), and the expression of proatherogenic inflammatory molecules in hypertensive patients...
  8. ncbi request reprint Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, A Cardiology Department, Greece
    Eur J Heart Fail 7:1126-32. 2005
    ..Both statins and vitamin E separately improve endothelial function in patients with hypercholesterolemia and/or advanced atherosclerosis...
  9. ncbi request reprint Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Athens, Greece
    Atherosclerosis 178:359-63. 2005
    ..These findings indicate that atorvastatin may improve forearm vasodilatory response to reactive hyperemia and depress inflammatory process in patients with heart failure and normal baseline cholesterol levels...
  10. pmc Evaluating endothelial function in humans: a guide to invasive and non-invasive techniques
    D Tousoulis
    Athens University Medical School, S Karagiorga Street 69, 166 75, Glifada, Athens, Greece
    Heart 91:553-8. 2005
  11. ncbi request reprint Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Nutr 27:379-86. 2008
    ..We also examined the role of endothelin-1 (ET-1) in the development of endothelial dysfunction in these two conditions...
  12. doi request reprint Antidepressive treatment as a modulator of inflammatory process in patients with heart failure: effects on proinflammatory cytokines and acute phase protein levels
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 134:238-43. 2009
    ..In the present study we evaluated the impact of antidepressive medication on the expression of proinflammatory cytokines and acute phase response proteins, in patients with HF and major depression...
  13. ncbi request reprint Effects of early administration of atorvastatin treatment on thrombotic process in normocholesterolemic patients with unstable angina
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 106:333-7. 2006
    ..We assessed the effects of short-term atorvastatin treatment on thrombotic/fibrinolysis markers in normocholesterolemic in patients with unstable angina...
  14. ncbi request reprint Pro-inflammatory cytokines in acute coronary syndromes: from bench to bedside
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Athens, Greece
    Cytokine Growth Factor Rev 17:225-33. 2006
    ..At a clinical level, circulating cytokines have a prognostic role since they are useful markers predicting future coronary events in patients with advanced atherosclerosis and in patients after ACS...
  15. ncbi request reprint Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C
    C Antoniades
    Cardiology Department, Athens University Medical School, Greece
    Diabet Med 21:552-8. 2004
    ....
  16. pmc Effects of atorvastatin on reactive hyperaemia and the thrombosis-fibrinolysis system in patients with heart failure
    D Tousoulis
    Cardiology Unit, Athens University Medical School, 69 S Karagiorga, 16675, Athens, Greece
    Heart 91:27-31. 2005
    ....
  17. doi request reprint Soluble receptor for advanced glycation end-product levels are related to albuminuria and arterial stiffness in essential hypertension
    K Dimitriadis
    First Cardiology Clinic, University of Athens, Hippokration Hospital, 3 Kolokotroni Street, 15236 P Panteli, Athens, Greece
    Nutr Metab Cardiovasc Dis 23:382-8. 2013
    ..We investigated the interrelationships of sRAGE with albumin to creatinine ratio (ACR) and arterial stiffness in essential hypertension...
  18. doi request reprint Impact of type 2 diabetes mellitus on diffuse inflammatory activation of de novo atheromatous lesions: implications for systemic inflammation
    K Toutouzas
    First Department of Cardiology, Athens Medical School, Hippokration Hospital, Holargos, Greece
    Diabetes Metab 35:299-304. 2009
    ..We investigated whether or not, in patients with DM, thermal heterogeneity of culprit lesions (CLs) correlates with that of non-culprit lesions (NCLs) and with systemic inflammation...
  19. pmc Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina
    D Tousoulis
    Athens University Medical School, Athens, Greece
    Heart 91:1319-23. 2005
    ..To assess the effects of intravenous vitamin C administration on the vasomotor responses to intracoronary L-arginine infusion in epicardial coronary arteries...
  20. ncbi request reprint Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis
    Charalambos Antoniades
    A Cardiology Department, Athens University Medical School, Athens, Greece
    Clin Cardiol 30:295-300. 2007
    ..Type 2 diabetes mellitus (T2DM) is characterized by endothelial dysfunction, increased thrombogenicity and abnormal inflammatory response...
  21. pmc Vasomotor effects of L- and D-arginine in stenotic atheromatous coronary plaque
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Heart 86:296-301. 2001
    ..This finding is consistent with partial deficiency of the substrate for nitric oxide synthesis, L-arginine, at the site of complex stenoses...
  22. doi request reprint Prognostic clinical and angiographic characteristics for the development of a new significant lesion in remote segments after successful percutaneous coronary intervention
    E Tsiamis
    First Department of Cardiology, Hippokration Hospital, University of Athens, Athens, Greece
    Int J Cardiol 143:29-34. 2010
    ..The purpose of the study was to investigate the clinical and angiographic factors related to the progression of non-culprit lesions (NCL) of patients undergoing percutaneous coronary interventions (PCI)...
  23. ncbi request reprint Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response
    Charalambos Antoniades
    Department of Cardiology, Athens University Medical School, Athens, Greece
    Am J Cardiol 94:1181-4. 2004
    ..01 for all). This phenomenon was associated with a respective increase in the inflammatory process and changes in the thrombosis/fibrinolysis system...
  24. doi request reprint Impact of metabolic syndrome on clinical outcomes after new generation drug-eluting stent implantation: the 'obesity paradox' phenomenon is still apparent
    C Patsa
    First Department of Cardiology, Athens Medical School, Hippokration Hospital, 114 Vas Sophias Str, 11527 Athens, Greece
    Nutr Metab Cardiovasc Dis 23:307-13. 2013
    ..Therefore, we evaluated the impact of the new generation DES on patients with an isolated lesion in the proximal segment of the left anterior descending artery (pLAD) suffering from MS...
  25. ncbi request reprint Circulating endothelial progenitor cells as biomarkers for prediction of cardiovascular outcomes
    C Bakogiannis
    1st Cardiology Unit, Athens University Medical School, Greece
    Curr Med Chem 19:2597-604. 2012
    ....
  26. ncbi request reprint Assessment of acute coronary syndromes: focus on novel biomarkers
    D Tousoulis
    1st Cardiology Unit, Athens University Medical School, Greece
    Curr Med Chem 19:2572-87. 2012
    ..In the current review, we summarize recent evidence of the most promising biomarkers and discuss their potential role in clinical practice in patients suffering from ACSs...
  27. ncbi request reprint Biomarkers determining cardiovascular risk in patients with kidney disease
    G Siasos
    Department of Biological Chemistry, University of Athens Medical School, Athens, Greece
    Curr Med Chem 19:2555-71. 2012
    ....
  28. ncbi request reprint Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Am J Clin Nutr 84:781-8. 2006
    ..Homocystinemia is a metabolic abnormality associated with endothelial dysfunction and increased cardiovascular disease risk. The underlying mechanisms of these effects, however, are obscure...
  29. ncbi request reprint The role of microRNAs in cardiovascular disease
    N Papageorgiou
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Med Chem 19:2605-10. 2012
    ..Understanding the underlying mechanisms, in which these major regulatory gene families are implicated, will provide novel opportunities for diagnosis and therapy of cardiovascular diseases...
  30. doi request reprint Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia
    Marietta Charakida
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 204:532-7. 2009
    ..However, it is unknown whether these abnormalities present in FH children and contribute to their vascular dysfunction...
  31. ncbi request reprint Predictive value of biomarkers in patients with heart failure
    D Tousoulis
    1st Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece
    Curr Med Chem 19:2534-47. 2012
    ..In the present review, we will discuss the usefulness and significance of potentials or established biomarkers in HF patients focusing on their ability to predict adverse events, morbidity and mortality...
  32. ncbi request reprint Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes
    D Tousoulis
    Athens University Medical School, Athens, Greece
    Eur J Clin Invest 37:623-8. 2007
    ..Although sCD40L is part of immune response, the mechanisms regulating its release in different disease states remain unknown...
  33. ncbi request reprint Chemokines in patients with ischaemic heart disease and the effect of coronary angioplasty
    E Economou
    Cardiology Unit, Athens University Medical School, Hippokration Hospital, 114 Vasillisis Sofias, 11528, Athens, Greece
    Int J Cardiol 80:55-60. 2001
    ..MCP-1 levels remain significantly elevated for at least 6 months following elective PTCA, suggesting an inflammatory stimulation...
  34. ncbi request reprint Endothelial dysfunction: potential clinical implications
    D Tousoulis
    Hippokration Hospital, Athens University Medical School, Greece
    Minerva Med 101:271-84. 2010
    ..Despite of the fact that there are several strategies aiming to improve endothelial dysfunction by enhancing nitric oxide bioavailability, it is still unclear whether they could be beneficial at a clinical level...
  35. ncbi request reprint Increased coronary sinus blood temperature: correlation with systemic inflammation
    K Toutouzas
    First Department of Cardiology, Athens Medical School, Hippokration Hospital, Greece
    Eur J Clin Invest 36:218-23. 2006
    ..Coronary sinus and RA blood temperature measurements were performed by a 7F thermography catheter. DeltaTau was calculated by subtracting the RA from the CS blood temperature...
  36. ncbi request reprint Monitoring calcific aortic valve disease: the role of biomarkers
    G Latsios
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Med Chem 19:2548-54. 2012
    ..Also, several studies have investigated the role of biomarkers regarding their utility in the screening of calcific aortic valve disease and their putative clinical value, though their role still remains undetermined...
  37. doi request reprint Adherence to the Mediterranean diet and albuminuria levels in Greek adolescents: data from the Leontio Lyceum ALbuminuria (3L study)
    A Mazaraki
    First Cardiology Clinic, University of Athens, Hippokration Hospital, 43 Agias Marinas Street, Melissia, Athens, Greece
    Eur J Clin Nutr 65:219-25. 2011
    ..The aim of the study was to assess the relationships of adherence rates to the Mediterranean diet with albumin to creatinine ratio (ACR), in a cohort of Greek adolescents who participated in the Leontio Lyceum ALbuminuria (3L) study...
  38. pmc Endothelial function and inflammation in coronary artery disease
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Heart 92:441-4. 2006
    ..However, randomised controlled trials are required to explore further whether drugs targeting the inflammatory process and endothelial function will constitute a reasonable adjunctive treatment for patients with coronary artery disease...
  39. doi request reprint Independent association of circulating resistin with glomerular filtration rate in the early stages of essential hypertension
    K Dimitriadis
    First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, Greece
    J Hum Hypertens 23:668-73. 2009
    ..Moreover, the independent association of resistin with eGFR suggests involvement of resistin in the progression of kidney damage in the early stages of hypertension...
  40. doi request reprint Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga Street 69, 166 75 Glifada, Athens, Greece
    Clin Nutr 27:594-600. 2008
    ..We compared the acute effects of several alcoholic beverages on endothelial function, inflammatory process and thrombosis/fibrinolysis system in young adults...
  41. ncbi request reprint Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Herz 28:628-38. 2003
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  42. ncbi request reprint Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Thromb Haemost 89:990-5. 2003
    ..In conclusion, combined administration of vitamin C and vitamin E at high dosages, improved endothelial function and decreased plasma levels of PAI-1, vWF and PAI-1/tPA ratio in chronic smokers...
  43. ncbi request reprint Clinical utility of biomarkers in premature atherosclerosis
    A M Kampoli
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Med Chem 19:2521-33. 2012
    ....
  44. doi request reprint Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals
    N Papageorgiou
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Eur J Clin Nutr 65:514-9. 2011
    ..In this parallel study, we assessed the acute effects of extra virgin olive oil, soy oil, corn oil and cod liver oil on circulating soluble(s) forms of adhesion molecules and TNF-α...
  45. ncbi request reprint Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis
    P P Sfikakis
    First Department of Propedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Arthritis Rheum 56:1985-93. 2007
    ..Our goal was to test the hypothesis that treatment with the oral endothelin receptor antagonist bosentan might improve vascular endothelial function in SSc patients...
  46. ncbi request reprint Circulating biomarkers for the diagnosis and prognosis of heart failure
    D Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Greece
    Curr Med Chem 16:3828-40. 2009
    ....
  47. doi request reprint Endothelial function and inflammation in coronary artery disease
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Postgrad Med J 84:368-71. 2008
    ..However, randomised controlled trials are required to explore further whether drugs targeting the inflammatory process and endothelial function will constitute a reasonable adjunctive treatment for patients with coronary artery disease...
  48. pmc Endogenous endothelin maintains coronary artery tone by endothelin type A receptor stimulation in patients undergoing coronary arteriography
    Z S Kyriakides
    2nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
    Heart 84:176-82. 2000
    ..To examine the contribution of endothelin type A (ET(A)) receptor stimulation by endogenously generated endothelin-1 (ET-1) to the maintenance of coronary vascular tone in humans...
  49. ncbi request reprint Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major
    Constadina Aggeli
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, Greece
    Int J Cardiol 105:80-4. 2005
    ..We examined endothelial function and serum levels of inflammatory mediators in transfusion-dependent patients with beta-thalassemia major...
  50. ncbi request reprint Novel biomarkers assessing the calcium deposition in coronary artery disease
    D Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Curr Med Chem 19:901-20. 2012
    ..Within this context, the present review sets out to discuss the role of new biomarkers assessing calcium deposition in coronary arteries and their role in the prognosis, progression, and treatment of cardiovascular disease...
  51. doi request reprint Gender variation of exercise-induced anti-arrhythmic protection: the Ikaria Study
    E Oikonomou
    First Cardiology Clinic, Hippokration Hospital, University of Athens Medical School, Athens, Greece
    QJM 104:1035-43. 2011
    ....
  52. ncbi request reprint Inflammatory biomarkers predicting events in atherosclerosis
    E Stefanadi
    Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Curr Med Chem 17:1690-707. 2010
    ..Thus, further studies are required to evaluate the predictive role of such molecules, as well as others under investigation in states of atherosclerosis...
  53. ncbi request reprint Statin treatment is associated with reduced thermal heterogeneity in human atherosclerotic plaques
    C Stefanadis
    Department of Cardiology, Athens Medical School, Athens, Greece
    Eur Heart J 23:1664-9. 2002
    ..Statins seem to have an antiinflammatory effect which results in plaque stabilization. The aim of this study was to investigate the effect of statins on plaque temperature...
  54. ncbi request reprint Effects of insulin resistance on endothelial function: possible mechanisms and clinical implications
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Diabetes Obes Metab 10:834-42. 2008
    ..Finally, improved endothelial function by such treatments is not in itself proof of reduced risk for atherosclerosis; this remains to be directly tested in clinical trials...
  55. pmc Effects of L-arginine on flow mediated dilatation induced by atrial pacing in diseased epicardial coronary arteries
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Heart 89:531-4. 2003
    ..To examine the effects of L-arginine on basal coronary tone and flow mediated dilatation induced by atrial pacing in patients with coronary artery disease and stable angina...
  56. ncbi request reprint Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction
    Charalambos Antoniades
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 46:1101-9. 2005
    ....
  57. ncbi request reprint Flavonoids in atherosclerosis: an overview of their mechanisms of action
    G Siasos
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Curr Med Chem 20:2641-60. 2013
    ..In the context of this evidence in this review article we summarize the so far acquired knowledge of the most important mechanisms of action of flavonoids in atherosclerosis progression...
  58. ncbi request reprint Adiponectin and cardiovascular disease: mechanisms and new therapeutic approaches
    G Siasos
    Department of Biological Chemistry, University of Athens Medical School, Athens, Greece
    Curr Med Chem 19:1193-209. 2012
    ..Current knowledge on the main actions of adiponectin and therapeutic approaches for cardiovascular disease is summarized in this review...
  59. ncbi request reprint The role of the cytochrome P450 polymorphisms in clopidogrel efficacy and clinical utility
    D Tousoulis
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Curr Med Chem 18:427-38. 2011
    ....
  60. ncbi request reprint Effects of lipid profile on forearm hyperemic response in young subjects
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Hellenic J Cardiol 47:152-7. 2006
    ..In the present study we examined the effect of lipid profile on forearm vasodilatory response to reactive hyperemia, an index of endothelial function, in a cohort of young, low-risk adults...
  61. ncbi request reprint Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals
    Gerasimos Siasos
    Athens University Medical School, 1st Cardiology Department, Greece
    Int J Cardiol 126:394-9. 2008
    ..Aim of the present study was to investigate in healthy smokers the effect of a short-term daily L-arginine administration on vascular function...
  62. ncbi request reprint Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga Street 69, 166 75 Glifada Athens, Greece
    Int J Cardiol 100:347-53. 2005
    ..Treatments with beneficial effects on endothelial dysfunction may also improve prognosis in patients with heart failure...
  63. doi request reprint Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study
    Stella Brili
    First Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 51:742-9. 2008
    ..The purpose of this study was to evaluate the effect of ramipril on endothelial function and inflammatory process in a group of normotensive subjects with successfully repaired coarctation of the aorta (SCR)...
  64. ncbi request reprint Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 115:203-7. 2007
    ..However, the underlying mechanisms of the acute coronary syndromes are still obscure. We evaluated the differences of inflammatory and thrombotic markers, at the acute phase of unstable angina (UA) and acute myocardial infarction (AMI)...
  65. doi request reprint Oxidative stress and inflammatory process in patients with atrial fibrillation: the role of left atrium distension
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens, Medical School, Athens, Greece
    Int J Cardiol 136:258-62. 2009
    ..We searched for clinical determinants of oxidative stress status, endothelial function and inflammatory process in patients with chronic atrial fibrillation...
  66. pmc Inflammatory and thrombotic mechanisms in coronary atherosclerosis
    D Tousoulis
    Cardiology Unit, Athens University Medical School, Athens, Greece
    Heart 89:993-7. 2003
    ..There may thus be therapeutic potential in modifying the atherosclerotic, vasomotor, and thrombotic components of ischaemic heart disease...
  67. ncbi request reprint The oxidative stress menace to coronary vasculature: any place for antioxidants?
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 16675, Glifada, Athens, Greece
    Curr Pharm Des 15:3078-90. 2009
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  68. ncbi request reprint Alpha-1 microglobulin as a new inflammatory marker in newly diagnosed hypertensive patients
    Gregory P Vyssoulis
    Hypertension Unit, 1st Cardiology Department, Athens University, Hippokration General Hospital, Athens, Greece
    Am J Hypertens 20:1016-21. 2007
    ..In the present study we examined the ability of urinary A1M excretion to reflect the overall inflammatory status in patients with newly diagnosed essential hypertension and normal renal function...
  69. ncbi request reprint Ultrasound contrast agents: updated data on safety profile
    C Aggeli
    Department of Cardiology, University of Athens Medical School, Hippokration Hospital, Greece
    Curr Pharm Des 18:2253-8. 2012
    ..So the question is: should we fear contrast utilization or should we consider them as an adjunctive and indispensable clinical tool for daily bedside practice?..
  70. doi request reprint Adiponectin: from obesity to cardiovascular disease
    C Antoniades
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Obes Rev 10:269-79. 2009
    ..Circulating adiponectin levels should be interpreted with caution, as they may have completely different prognostic value, depending on the underlying disease state...
  71. doi request reprint Essential hypertension: is there a role for inflammatory mechanisms?
    Emmanuel S Androulakis
    First Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Cardiol Rev 17:216-21. 2009
    ..These data may have great impact on future therapeutic strategies...
  72. doi request reprint Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers
    Dimitris Tousoulis
    Hippokration Hospital, Athens University Medical School, Athens, Greece
    Br J Nutr 103:43-9. 2010
    ..However, all types of oils did not affect inflammatory process and systemic oxidative stress, suggesting that their effect on endothelial function may not be mediated by free radicals bioavailability...
  73. doi request reprint Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a randomized placebo-controlled study
    Ioannis Andreou
    A Cardiology Department, Hippokration Hospital, Athens University Medical School, 11528 Athens, Greece
    Atherosclerosis 210:194-8. 2010
    ..Therefore in the present study we examined the effects of rosuvastatin and allopurinol on MPO levels in patients HF...
  74. ncbi request reprint Homocysteine: a risk factor for coronary artery disease?
    Kyriakoula Marinou
    University Cardiology Department, Hippokration Hospital, Athens, Greece
    Hellenic J Cardiol 46:59-67. 2005
  75. doi request reprint Association of inflammatory markers with angiographic severity and extent of coronary artery disease
    Maria Drakopoulou
    1st Department of Cardiology, Medical School of Athens University, Hippokration Hospital, Athens, Greece
    Atherosclerosis 206:335-9. 2009
    ....
  76. ncbi request reprint Inflammatory markers in essential hypertension: potential clinical implications
    Elli Stefanadi
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 8:509-16. 2010
    ..However, further randomized studies are required to determine the potential favorable effects of suppression of inflammation in the management of arterial hypertension...
  77. ncbi request reprint Evidence of vascular dysfunction in young patients with successfully repaired coarctation of aorta
    Stella Brili
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Vasilissis Sofias 114, 11528 Athens, Greece
    Atherosclerosis 182:97-103. 2005
    ..These results may partly explain the high incidence of coronary artery disease in patients with repaired coarctation of the aorta...
  78. ncbi request reprint Novel therapeutic strategies targeting vascular redox in human atherosclerosis
    Alexis S Antonopoulos
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Recent Pat Cardiovasc Drug Discov 4:76-87. 2009
    ....
  79. doi request reprint The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance
    Gerasimos Siasos
    Department of Biological Chemistry, Athens University Medical School, Athens, Greece
    Am J Hypertens 22:586-92. 2009
    ..We investigated the effect of L-arginine on vascular function and inflammatory process in healthy smokers at rest and after acute smoking...
  80. ncbi request reprint Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure
    Athanasios Trikas
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Eur J Heart Fail 8:804-9. 2006
    ..The calcium sensitizer levosimendan improves myocardial contractility in patients with heart failure, although its effects on inflammation and apoptosis are unknown...
  81. ncbi request reprint Relationship of fibrinogen with arterial stiffness and wave reflections
    Charalambos Vlachopoulos
    Hypertension Unit, 1st Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
    J Hypertens 25:2110-6. 2007
    ..This study investigated whether the fibrinogen level is associated with arterial stiffness and wave reflections...
  82. ncbi request reprint Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy
    Costas Tentolouris
    Cardiology Units, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Athens, Greece
    Int J Cardiol 94:301-5. 2004
    ..We compared endothelial function and levels of IL-6 and TNF-alpha between patients with ischemic heart failure, dilated cardiomyopathy, CAD and healthy controls...
  83. ncbi request reprint Genetic polymorphisms G894T on the eNOS gene is associated with endothelial function and vWF levels in premature myocardial infarction survivors
    Charalambos Antoniades
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, S Karagiorga Street 69, 166 75, Glifada, Athens, Greece
    Int J Cardiol 107:95-100. 2006
    ....
  84. ncbi request reprint Significance of exercise-induced ST changes in leads aVR, V5, and V1. Discrimination of patients with single- or multivessel coronary artery disease
    Andreas P Michaelides
    Department of Cardiology, Medical School of Athens University, Hippokration Hospital, Athens, Greece
    Clin Cardiol 26:226-30. 2003
    ..It was also postulated that ST elevation in aVR and simultaneous ST depression in V5 (aVR-E + V5-D) is a marker of ischemia due to significant stenosis of the LAD in patients with single-vessel disease...
  85. ncbi request reprint The failure of immunomodulation therapy in heart failure: does the statins "paradigm" prove the rule?
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 8:114-21. 2010
    ..Thus, more large scale clinical trials are required to evaluate the impact of statins on immune imbalance and its restoration in patients with CHF...
  86. ncbi request reprint Microalbuminuria is associated with unfavourable cardiac geometric adaptations in essential hypertensive subjects
    C Tsioufis
    Department of Cardiology, University of Athens, Hippokration Hospital, Greece
    J Hum Hypertens 16:249-54. 2002
    ....
  87. ncbi request reprint Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective
    Dimitris Tousoulis
    Athens University Medical School, S Karagiorga 69, Glifada, 16675 Athens, Greece
    Nat Clin Pract Cardiovasc Med 4:274-83. 2007
    ..Here, we present a critique of the existing literature about the role of L-arginine in the prevention of atherosclerosis...
  88. ncbi request reprint Statins in heart failure. Beyond the lipid lowering effect
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Int J Cardiol 115:144-50. 2007
    ..Finally the statin dose and the interaction with co-administered drugs need to be studied...
  89. ncbi request reprint Basic fibroblast growth factor changes in response to coronary angioplasty in patients with stable angina
    Anastasia A Katinioti
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga 69, 16675, Athens, Greece
    Int J Cardiol 84:195-9. 2002
    ..Following PTCA, bFGF levels decreased significantly and remained stable for 6 months after the procedure. Thus, bFGF level may change in response to PTCA in patients with coronary artery disease and stable angina...
  90. ncbi request reprint Novel therapies targeting vascular endothelium
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Endothelium 13:411-21. 2006
    ..Although there are a variety of strategies to improve NO bioavailability in human endothelium, it is still unclear whether they have any direct benefit at a clinical level...
  91. doi request reprint Biomarkers of premature atherosclerosis
    Anna Maria Kampoli
    Athens University Medical School, 1 st Cardiology Department, Hippokration Hospital, Athens, Greece
    Trends Mol Med 15:323-32. 2009
    ..Here, we review the roles of specific biomarkers that have been implicated in premature atherosclerosis...
  92. ncbi request reprint Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 47:1959-66. 2006
    ....
  93. pmc Assessing inflammatory status in cardiovascular disease
    Dimitris Tousoulis
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Heart 93:1001-7. 2007
  94. ncbi request reprint Left atrial function, cytokines and soluble apoptotic markers in mitral stenosis: effects of valvular replacement
    Athanasios Trikas
    Cardiology Department, University of Athens, Hippokration Hospital, Greece
    Int J Cardiol 99:111-5. 2005
    ..The purpose of the present study was the evaluation of the effect of mitral valve replacement on the LA function, on inflammatory process and apoptotic markers in patients with MS and HF...
  95. ncbi request reprint Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1
    Aggeliki Nikolopoulou
    Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Int J Cardiol 130:246-50. 2008
    ....
  96. doi request reprint Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases
    Dimitris Tousoulis
    A Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 201:236-47. 2008
    ....
  97. ncbi request reprint Effects of smoking on nitric oxide synthesis in epicardial normal and atheromatous coronary arteries
    Costas Tentolouris
    Hippokration Hospital, Athens University Medical School, Greece
    Int J Cardiol 95:69-73. 2004
    ..05). Therefore, the difference in vasomotor response to LNMMA in relation to smoking is localised to the proximal coronary segments...
  98. ncbi request reprint Impact of lifestyle habits on the prevalence of the metabolic syndrome among Greek adults from the ATTICA study
    Demosthenes B Panagiotakos
    Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
    Am Heart J 147:106-12. 2004
    ..In this study, we evaluated the effect of leisure time physical activity (PA) and the Mediterranean diet (MD) on the prevalence of the MS...
  99. doi request reprint Recent therapeutic approaches to platelet activation in coronary artery disease
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Pharmacol Ther 127:108-20. 2010
    ..Presently, antiplatelet intervention remains an important therapeutic modality, with novel antiplatelet therapies, such as prasugrel and ticagrelor under clinical investigation...
  100. doi request reprint The CD40/CD40 ligand system: linking inflammation with atherothrombosis
    Charalambos Antoniades
    1st Department of Cardiology, University of Athens Medical School, Athens, Greece
    J Am Coll Cardiol 54:669-77. 2009
    ....
  101. ncbi request reprint Potential role of endothelial progenitor cells in the pathophysiology of heart failure: clinical implications and perspectives
    Ioannis Andreou
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, S Karagiorga 69, Glifada 16 675, Athens, Greece
    Atherosclerosis 189:247-54. 2006
    ..However, the exact role of EPCs in heart failure and their potential therapeutic implications still remain to be elucidated...