G Touloumi

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Rates and determinants of virologic and immunological response to HAART resumption after treatment interruption in HIV-1 clinical practice
    Giota Touloumi
    Department of Hygiene, Epidemiology, and Medical Statistics, Athens University Medical School, Athens, Greece
    J Acquir Immune Defic Syndr 49:492-8. 2008
  2. ncbi A comparison of two methods for the estimation of precision with incomplete longitudinal data, jointly modelled with a time-to-event outcome
    G Touloumi
    Department of Hygiene and Epidemiology, University of Athens Medical School, M Asias 75, 115 27 Athens, Greece
    Stat Med 22:3161-75. 2003
  3. ncbi Short-term effects of air pollution on total and cardiovascular mortality: the confounding effect of influenza epidemics
    Giota Touloumi
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    Epidemiology 16:49-57. 2005
  4. ncbi Seasonal confounding in air pollution and health time-series studies: effect on air pollution effect estimates
    G Touloumi
    Department of Hygiene and Epidemiology, Athens Medical School, Athens, Greece
    Stat Med 25:4164-78. 2006
  5. ncbi Future trends of HCV-related cirrhosis and hepatocellular carcinoma under the currently available treatments
    V Sypsa
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Viral Hepat 12:543-50. 2005
  6. ncbi Investigating regional differences in short-term effects of air pollution on daily mortality in the APHEA project: a sensitivity analysis for controlling long-term trends and seasonality
    E Samoli
    Department of Hygiene and Epidemiology, University of Athens, Medical School, Athens, Greece
    Environ Health Perspect 109:349-53. 2001
  7. ncbi Impact of missing data due to drop-outs on estimators for rates of change in longitudinal studies: a simulation study
    G Touloumi
    Department of Hygiene and Epidemiology, University of Athens Medical School, M Asias 75, 115 27 Athens, Greece
    Stat Med 20:3715-28. 2001
  8. ncbi Comparison of smoothing techniques for CD4 data in a Markov model with states defined by CD4: an example on the estimation of the HIV incubation time distribution
    V Sypsa
    Department of Hygiene and Epidemiology, Athens University Medical School, M Asias 75, 11527 Athens, Greece
    Stat Med 20:3667-76. 2001
  9. ncbi Short-term effects of nitrogen dioxide on mortality: an analysis within the APHEA project
    E Samoli
    Dept of Hygiene and Epidemiology, University of Athens Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece
    Eur Respir J 27:1129-38. 2006
  10. ncbi The temporal pattern of mortality responses to ambient ozone in the APHEA project
    E Samoli
    Department of Hygiene and Epidemiology, University of Athens Medical School, 115 27 Athens, Greece
    J Epidemiol Community Health 63:960-6. 2009

Detail Information

Publications48

  1. ncbi Rates and determinants of virologic and immunological response to HAART resumption after treatment interruption in HIV-1 clinical practice
    Giota Touloumi
    Department of Hygiene, Epidemiology, and Medical Statistics, Athens University Medical School, Athens, Greece
    J Acquir Immune Defic Syndr 49:492-8. 2008
    ..To describe CD4 and HIV RNA changes during treatment resumption (TR) after treatment interruption (TI) compared with response to first highly active antiretroviral therapy (HAART) and to investigate predictors...
  2. ncbi A comparison of two methods for the estimation of precision with incomplete longitudinal data, jointly modelled with a time-to-event outcome
    G Touloumi
    Department of Hygiene and Epidemiology, University of Athens Medical School, M Asias 75, 115 27 Athens, Greece
    Stat Med 22:3161-75. 2003
    ..This bias was largely corrected by Louis and modified MI methods, which gave broadly similar estimates. Given the relative simplicity of the modified MI method, it may be preferable...
  3. ncbi Short-term effects of air pollution on total and cardiovascular mortality: the confounding effect of influenza epidemics
    Giota Touloumi
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    Epidemiology 16:49-57. 2005
    ..Air pollution is associated with total mortality. This association may be confounded by uncontrolled time-varying risk factors such as influenza epidemics...
  4. ncbi Seasonal confounding in air pollution and health time-series studies: effect on air pollution effect estimates
    G Touloumi
    Department of Hygiene and Epidemiology, Athens Medical School, Athens, Greece
    Stat Med 25:4164-78. 2006
    ..g. 8-12 per year) could be used as the basic, relatively conservative, analysis whereas the PS and natural splines in combination with PACF could be applied to provide a reasonable range of the effect estimate...
  5. ncbi Future trends of HCV-related cirrhosis and hepatocellular carcinoma under the currently available treatments
    V Sypsa
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Viral Hepat 12:543-50. 2005
    ..Intensive primary prevention efforts coupled with increased access to the currently available treatments are necessary to control the chronic consequences of HCV epidemic...
  6. ncbi Investigating regional differences in short-term effects of air pollution on daily mortality in the APHEA project: a sensitivity analysis for controlling long-term trends and seasonality
    E Samoli
    Department of Hygiene and Epidemiology, University of Athens, Medical School, Athens, Greece
    Environ Health Perspect 109:349-53. 2001
    ..However, these results must be investigated further...
  7. ncbi Impact of missing data due to drop-outs on estimators for rates of change in longitudinal studies: a simulation study
    G Touloumi
    Department of Hygiene and Epidemiology, University of Athens Medical School, M Asias 75, 115 27 Athens, Greece
    Stat Med 20:3715-28. 2001
    ..The potential biases due to incomplete data require greater recognition in reports of longitudinal studies. Sensitivity analyses to assess the effect of drop-outs on inferences about the target parameters are important...
  8. ncbi Comparison of smoothing techniques for CD4 data in a Markov model with states defined by CD4: an example on the estimation of the HIV incubation time distribution
    V Sypsa
    Department of Hygiene and Epidemiology, Athens University Medical School, M Asias 75, 11527 Athens, Greece
    Stat Med 20:3667-76. 2001
    ..Ad hoc was the method that performed better, in terms of bias, than the other smoothing approaches...
  9. ncbi Short-term effects of nitrogen dioxide on mortality: an analysis within the APHEA project
    E Samoli
    Dept of Hygiene and Epidemiology, University of Athens Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece
    Eur Respir J 27:1129-38. 2006
    ..The results of this large study are consistent with an independent effect of nitrogen dioxide on mortality, but the role of nitrogen dioxide as a surrogate of other unmeasured pollutants cannot be completely ruled out...
  10. ncbi The temporal pattern of mortality responses to ambient ozone in the APHEA project
    E Samoli
    Department of Hygiene and Epidemiology, University of Athens Medical School, 115 27 Athens, Greece
    J Epidemiol Community Health 63:960-6. 2009
    ....
  11. ncbi Progression of HIV infection in the post-HAART era among a cohort of HIV+ Greek haemophilia patients
    O Katsarou
    Second Blood Transfusion Center and Haemophilia Center, Laikon General Hospital, Athens, Greece
    Haemophilia 11:360-5. 2005
    ..Among haemophilia subjects, due to the high rates of HCV/HIV coinfection, ESLD, the predominant cause of non-AIDS mortality, will become an increasingly important clinical problem...
  12. ncbi Confounding and effect modification in the short-term effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 project
    K Katsouyanni
    Department of Hygiene and Epidemiology, University of Athens Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece
    Epidemiology 12:521-31. 2001
    ..Furthermore, they show that the heterogeneity found in the effect parameters among cities reflects real effect modification, which is explained by specific city characteristics...
  13. ncbi Investigating the dose-response relation between air pollution and total mortality in the APHEA-2 multicity project
    E Samoli
    Department of Hygiene and Epidemiology, University of Athens, Medical School, Athens 115 27, Greece
    Occup Environ Med 60:977-82. 2003
    ..However, investigation of the city specific dose-response curves should precede the application of linear models...
  14. ncbi Comparative evaluation of the QUANTIPLEX HIV-1 RNA 2.0 and 3.0 (bDNA) assays and the AMPLICOR HIV-1 MONITOR v1.5 test for the quantitation of human immunodeficiency virus type 1 RNA in plasma
    C G Anastassopoulou
    Department of Hygiene and Epidemiology, National Retrovirus Reference Center, Athens University Medical School, 75 Mikras Asias Street, GR-11527 (Goudi, Athens, Greece
    J Virol Methods 91:67-74. 2001
    ..5) were found at frequencies of 80% for bDNA 2.0 and bDNA 3.0 and only at 58.5% for bDNA 2.0 and Monitor v1.5. In contrast, bDNA 3.0 and Monitor v1.5 measurements were highly correlated (r=0.96) and in good agreement (92.7%)...
  15. ncbi Natural course of treated and untreated chronic HCV infection: results of the nationwide Hepnet.Greece cohort study
    E K Manesis
    Liver Unit, Euroclinic, Athens, Greece
    Aliment Pharmacol Ther 29:1121-30. 2009
    ..The effect of such treatments on the natural course of CHC has been evaluated in small clinical trials with conflicting results...
  16. ncbi Incidence and risk factors of chronic renal disease in a cohort of Greek HIV-1-infected adults
    V Sakka
    Red Cross General Hospital of Athens, Infectious Diseases Unit, Athens, Greece
    J Int AIDS Soc 15:18310. 2012
    ..3%) experienced some degree of renal dysfunction during HIV infection. Older age and female gender were major predictors of CKD, whereas high current CD4+count and baseline eGFR were protective...
  17. ncbi Changes in T cell receptor excision DNA circle (TREC) levels in HIV type 1-infected subjects pre- and post-highly active antiretroviral therapy
    Giota Touloumi
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    AIDS Res Hum Retroviruses 20:47-54. 2004
    ..TREC values, which likely represent a simple indicator of naive T-lymphocyte reserve, may be a clinically useful marker for long-term prognosis of HIV-1 infection and for immune reconstitution after successful HAART...
  18. ncbi Differences in HIV RNA levels before the initiation of antiretroviral therapy among 1864 individuals with known HIV-1 seroconversion dates
    Giota Touloumi
    Department of Hygiene and Epidemiology, Athens Univerity Medical School, Greece
    AIDS 18:1697-705. 2004
    ....
  19. ncbi Virological and immunological response to HAART therapy in a community-based cohort of HIV-1-positive individuals
    G Touloumi
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    HIV Clin Trials 2:6-16. 2001
    ....
  20. ncbi Acute effects of ozone on mortality from the "air pollution and health: a European approach" project
    Alexandros Gryparis
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    Am J Respir Crit Care Med 170:1080-7. 2004
    ..The dose-response curve of ozone effects on total mortality during the summer did not deviate significantly from linearity...
  21. ncbi Highly active antiretroviral therapy interruption: predictors and virological and immunologic consequences
    Giota Touloumi
    Athens University Medical School, Athens, Greece
    J Acquir Immune Defic Syndr 42:554-61. 2006
    ..Further research is needed to investigate the reasons why TI is higher in women. We have identified characteristics of subjects with the greatest risk for CD4 loss in whom TI may have greater risks...
  22. ncbi Reconstructing and predicting the hepatitis C virus epidemic in Greece: increasing trends of cirrhosis and hepatocellular carcinoma despite the decline in incidence of HCV infection
    V Sypsa
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Viral Hepat 11:366-74. 2004
    ..Despite the progress in the reduction of HCV transmission, primary prevention does not seem adequate to reverse the rise in the incidence of cirrhosis and HCC...
  23. ncbi Short-term effects of ambient particles on mortality in the elderly: results from 28 cities in the APHEA2 project
    E Aga
    Dept Hygiene-Epidemiology, University of Athens, Athens, Greece
    Eur Respir J Suppl 40:28s-33s. 2003
    ..The effects among the older persons are of particular importance, since the attributable number of events will be much larger, compared to the number of deaths among the younger population...
  24. ncbi Short-term effects of carbon monoxide on mortality: an analysis within the APHEA project
    Evangelia Samoli
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    Environ Health Perspect 115:1578-83. 2007
    ..We investigated the short-term effects of carbon monoxide on total and cardiovascular mortality in 19 European cities participating in the APHEA-2 (Air Pollution and Health: A European Approach) project...
  25. ncbi Modelling competing risks data with missing cause of failure
    Giorgos Bakoyannis
    Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece
    Stat Med 29:3172-85. 2010
    ..All three methods were also applied on real data modelling time to AIDS or non-AIDS cause of death in HIV-1 infected individuals...
  26. ncbi Acute effects of ambient particulate matter on mortality in Europe and North America: results from the APHENA study
    Evangelia Samoli
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    Environ Health Perspect 116:1480-6. 2008
    ..S. NMMAPS (National Morbidity, Mortality and Air Pollution Study) projects, along with Canadian data...
  27. ncbi Robustness of a parametric model for informatively censored bivariate longitudinal data under misspecification of its distributional assumptions: A simulation study
    Nikos Pantazis
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    Stat Med 26:5473-85. 2007
    ..The proposed model seems robust enough, but its performance on smaller data sets or under more extreme departures of its assumptions needs further investigation...
  28. ncbi Quantitation of human immunodeficiency virus type 1 DNA forms with the second template switch in peripheral blood cells predicts disease progression independently of plasma RNA load
    Leondios G Kostrikis
    Department of Hygiene and Epidemiology, Athens University Medical School, 75 Mikras Asias, 11527 Athens, Greece
    J Virol 76:10099-108. 2002
    ..This parameter may have important implications for understanding the virological response to combination antiretroviral therapy...
  29. ncbi Cellular HIV-1 DNA load predicts HIV-RNA rebound and the outcome of highly active antiretroviral therapy
    Angelos E Hatzakis
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    AIDS 18:2261-7. 2004
    ..To assess whether cellular HIV-1 DNA prior to highly active antiretroviral therapy (HAART) initiation predicts its outcome...
  30. ncbi The effect of antiretroviral treatment of different durations in primary HIV infection
    Nikos Pantazis
    Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece
    AIDS 22:2441-50. 2008
    ....
  31. ncbi Estimating the exposure-response relationships between particulate matter and mortality within the APHEA multicity project
    Evangelia Samoli
    Department of Hygiene and Epidemiology, University of Athens, Athens, Greece
    Environ Health Perspect 113:88-95. 2005
    ..The heterogeneity found in the different city-specific relations reflects real effect modification, which can be explained partly by factors characterizing the air pollution mix, climate, and the health of the population...
  32. ncbi Elevated serum levels of soluble immune activation markers are associated with increased risk for death in HAART-naive HIV-1-infected patients
    Nikolaos V Sipsas
    Department of Pathophysiology, Laikon General Hospital and School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    AIDS Patient Care STDS 17:147-53. 2003
    ..Further studies are needed to assess the effect of HAART on the levels of immune activation markers and their prognostic value...
  33. ncbi Short-term effects of ambient particles on cardiovascular and respiratory mortality
    Antonis Analitis
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    Epidemiology 17:230-3. 2006
    ..62% (0.35 to 0.90%) and 0.84% (0.11 to 1.57%), respectively. CONCLUSIONS: These effect estimates are appropriate for health impact assessment and standard-setting procedures...
  34. ncbi Effects of first antiretroviral regimen on lipid levels in HIV (+) individuals
    A Papadopoulos
    Fourth Department of Internal Medicine, Athens Medical School, Attikon University General Hospital, Greece
    J Chemother 24:38-47. 2012
    ....
  35. ncbi Lamivudine monotherapy in HBeAg-negative chronic hepatitis B: prediction of response-breakthrough and long-term clinical outcome
    S Manolakopoulos
    Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece
    Aliment Pharmacol Ther 23:787-95. 2006
    ..Factors that predict response and breakthrough phenomenon to lamivudine monotherapy in patients with HBeAg-negative chronic hepatitis B have not been well defined...
  36. ncbi Significance of immune status, genotype and viral load in the severity of chronic hepatitis C in HIV infected haemophilia patients
    J Delladetsima
    Department of Pathology, Laikon General Hospital, Athens, Greece
    Haemophilia 8:668-73. 2002
    ..Our results suggest that HCV/HIV coinfection may aggravate the course of hepatitis in the phase of immunocompetence, most probably through an immune mediated process. Genotype 1 seems to be associated with advanced liver disease...
  37. ncbi MELD vs Child-Pugh and creatinine-modified Child-Pugh score for predicting survival in patients with decompensated cirrhosis
    George V Papatheodoridis
    2nd Department of Internal Medicine, National University of Medical School, Hippokration General Hospital, 114 Vas Sophias Ave, 115 27 Athens, Greece
    World J Gastroenterol 11:3099-104. 2005
    ..We compared the predictive values of MELD, Child-Pugh and creatinine-modified Child-Pugh scores in decompensated cirrhosis...
  38. ncbi Association of clinical progression in classic Kaposi's sarcoma with reduction of peripheral B lymphocytes and partial increase in serum immune activation markers
    Alexander J Stratigos
    Department of Dermatology, University of Athens, Andreas Sygros Hospital, Athens, Greece
    Arch Dermatol 141:1421-6. 2005
    ..To evaluate various immunologic markers in the peripheral blood of patients with early and advanced classic Kaposi's sarcoma (CKS)...
  39. ncbi Different convergence parameters applied to the S-PLUS GAM function
    Klea Katsouyanni
    Epidemiology 13:742-3. 2002
  40. ncbi Changes over calendar time in the risk of specific first AIDS-defining events following HIV seroconversion, adjusting for competing risks
    Abdel Babiker
    Int J Epidemiol 31:951-8. 2002
    ..CONCLUSION: These findings suggest that studies reporting a stable trend for particular AIDS diseases over the period 1979-2001 may not have accounted for the competing risks among other events or lack the power to detect smaller trends...
  41. ncbi Empirical Bayes and adjusted estimates approach to estimating the relation of mortality to exposure of PM(10)
    Alain Le Tertre
    InVS, Environmental Health Unit, Saint Maurice cedex, France
    Risk Anal 25:711-8. 2005
    ..From these different estimates, attributable numbers of deaths per year were calculated. The advantages and limits of the different approaches are discussed through real data and in a simulation study...
  42. ncbi The temporal pattern of mortality responses to air pollution: a multicity assessment of mortality displacement
    Antonella Zanobetti
    Environmental Epidemiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 13:87-93. 2002
    ..The effect size estimate for airborne particles more than doubles when we consider longer-term effects, which has important implications for risk assessment...
  43. ncbi Gender differences in HIV progression to AIDS and death in industrialized countries: slower disease progression following HIV seroconversion in women
    Inmaculada Jarrin
    National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
    Am J Epidemiol 168:532-40. 2008
    ..74, 95% CI: 0.56, 0.98). Sex differences in HIV disease progression have become larger and statistically significant in the era of highly active antiretroviral therapy, supporting a stronger impact of health interventions among women...
  44. ncbi Response to combination antiretroviral therapy: variation by age
    Ian Weller
    AIDS 22:1463-73. 2008
    ..The poorer virological responses in children may increase the likelihood of emergence of resistance...
  45. ncbi Changes in the risk of death after HIV seroconversion compared with mortality in the general population
    Krishnan Bhaskaran
    MRC Clinical Trials Unit, 222 Euston Rd, London NW1 2DA, United Kingdom
    JAMA 300:51-9. 2008
    ..Mortality among human immunodeficiency virus (HIV)-infected individuals has decreased dramatically in countries with good access to treatment and may now be close to mortality in the general uninfected population...
  46. ncbi The temporal pattern of respiratory and heart disease mortality in response to air pollution
    Antonella Zanobetti
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 111:1188-93. 2003
    ..We found similar effects when stratifying by age groups. These larger effects are important for risk assessment...
  47. ncbi Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohort
    Sarah Fidler
    Imperial College, St Mary s Hospital, London, UK
    AIDS 21:1283-91. 2007
    ..To investigate the effect of a short course of HAART during primary HIV infection (PHI) on rate of CD4 cell and viral load change...
  48. ncbi Impact of missing data due to selective dropouts in cohort studies and clinical trials
    Giota Touloumi
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK
    Epidemiology 13:347-55. 2002
    ..The objective of this paper is to evaluate the impact of selective dropouts attributable to death or disease progression on the estimates of marker change among different groups...