Georgia Sotiropoulou

Summary

Affiliation: University of Patras
Country: Greece

Publications

  1. pmc Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell
    Georgia Sotiropoulou
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion Patras 26500, Greece
    RNA 15:1443-61. 2009
  2. pmc Development and immunochemical evaluation of a novel chicken IgY antibody specific for KLK6
    Georgia Sotiropoulou
    Department of Pharmacy, University of Patras, 265 00, Rion Patras, Greece
    Chem Cent J 6:148. 2012
  3. doi request reprint Targeting the kallikrein-related peptidases for drug development
    Georgia Sotiropoulou
    Department of Pharmacy, School of Health Sciences, University of Patras, 265 00 Rion Patras, Greece Electronic address
    Trends Pharmacol Sci 33:623-34. 2012
  4. pmc What's new on circulating tumor cells? A meeting report
    Evi S Lianidou
    Department of Chemistry, University of Athens, 15771 Athens, Greece
    Breast Cancer Res 12:307. 2010
  5. doi request reprint Kallikrein-related peptidases: bridges between immune functions and extracellular matrix degradation
    Georgia Sotiropoulou
    Department of Pharmacy, University of Patras, Greece
    Biol Chem 391:321-31. 2010
  6. pmc Functional roles of human kallikrein-related peptidases
    Georgia Sotiropoulou
    Department of Pharmacy, University of Patras, Rion, 26500 Rion Patras, Greece
    J Biol Chem 284:32989-94. 2009
  7. doi request reprint A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition
    Georgios Pampalakis
    Department of Pharmacy, University of Patras, Rion Patras, Greece
    Cancer Res 69:3779-87. 2009
  8. ncbi request reprint The epigenetic basis for the aberrant expression of kallikreins in human cancers
    Georgios Pampalakis
    Department of Pharmacy, School of Health Sciences, University of Patras, GR 26500 Rion Patras, Greece, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Biol Chem 387:795-9. 2006
  9. doi request reprint Down-regulation of dicer expression in ovarian cancer tissues
    Georgios Pampalakis
    Department of Pharmacy, University of Patras, Rion Patras, 26500, Greece
    Clin Biochem 43:324-7. 2010
  10. doi request reprint Novel splice variants of prostate-specific antigen and applications in diagnosis of prostate cancer
    Georgios Pampalakis
    Department of Pharmacy, University of Patras, Rion Patras 26500, Greece
    Clin Biochem 41:591-7. 2008

Collaborators

Detail Information

Publications18

  1. pmc Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell
    Georgia Sotiropoulou
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion Patras 26500, Greece
    RNA 15:1443-61. 2009
    ..Furthermore, these exciting insights into aberrant microRNA control in cancer-associated circuits may be exploited for cancer therapies that will target deregulated miRNA switches...
  2. pmc Development and immunochemical evaluation of a novel chicken IgY antibody specific for KLK6
    Georgia Sotiropoulou
    Department of Pharmacy, University of Patras, 265 00, Rion Patras, Greece
    Chem Cent J 6:148. 2012
    ..abstract:..
  3. doi request reprint Targeting the kallikrein-related peptidases for drug development
    Georgia Sotiropoulou
    Department of Pharmacy, School of Health Sciences, University of Patras, 265 00 Rion Patras, Greece Electronic address
    Trends Pharmacol Sci 33:623-34. 2012
    ..Here, we review current approaches for the design and testing of KLK-based therapeutics...
  4. pmc What's new on circulating tumor cells? A meeting report
    Evi S Lianidou
    Department of Chemistry, University of Athens, 15771 Athens, Greece
    Breast Cancer Res 12:307. 2010
    ..A liquid biopsy approach that can be used for prognostic and predictive purposes was proposed for the analysis of CTCs...
  5. doi request reprint Kallikrein-related peptidases: bridges between immune functions and extracellular matrix degradation
    Georgia Sotiropoulou
    Department of Pharmacy, University of Patras, Greece
    Biol Chem 391:321-31. 2010
    ..Finally, we present evidence of KLK participation in autoimmune diseases and allergies...
  6. pmc Functional roles of human kallikrein-related peptidases
    Georgia Sotiropoulou
    Department of Pharmacy, University of Patras, Rion, 26500 Rion Patras, Greece
    J Biol Chem 284:32989-94. 2009
    ..In addition, KLKs have emerged as versatile signaling molecules. In summary, KLKs represent attractive biomarkers for clinical applications and potential therapeutic targets for common human pathologies...
  7. doi request reprint A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition
    Georgios Pampalakis
    Department of Pharmacy, University of Patras, Rion Patras, Greece
    Cancer Res 69:3779-87. 2009
    ..We suggest that KLK6 is an epigenetically regulated tumor suppressor in human breast cancer and provide ways of pharmacologic modulation...
  8. ncbi request reprint The epigenetic basis for the aberrant expression of kallikreins in human cancers
    Georgios Pampalakis
    Department of Pharmacy, School of Health Sciences, University of Patras, GR 26500 Rion Patras, Greece, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Biol Chem 387:795-9. 2006
    ..Epigenetic regulation provides a new mechanism for the pharmacological modulation of kallikreins in human cancers with putative therapeutic implications...
  9. doi request reprint Down-regulation of dicer expression in ovarian cancer tissues
    Georgios Pampalakis
    Department of Pharmacy, University of Patras, Rion Patras, 26500, Greece
    Clin Biochem 43:324-7. 2010
    ..The purpose of this study was to investigate whether Dicer mRNA expression is altered during progression of ovarian cancer...
  10. doi request reprint Novel splice variants of prostate-specific antigen and applications in diagnosis of prostate cancer
    Georgios Pampalakis
    Department of Pharmacy, University of Patras, Rion Patras 26500, Greece
    Clin Biochem 41:591-7. 2008
    ..We aimed to identify novel splice variants of prostate-specific antigen/or human kallikrein 3 (PSA/KLK3), the most widely used serum biomarker for case-finding, screening and monitoring of prostate cancer...
  11. ncbi request reprint Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer
    Georgios Pampalakis
    Department of Pharmacy, School of Health Sciences, University of Patras, GR 26500 Rion Patras, Greece
    Biol Chem 387:773-82. 2006
    ..This allows for the pharmacological modulation of KLK6 with potential therapeutic implications...
  12. doi request reprint Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates
    Georgios Pampalakis
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion Patras 26500, Greece
    Comput Biol Chem 32:111-21. 2008
    ....
  13. pmc Netrin-1 overexpression is predictive of ovarian malignancies
    Anastasios D Papanastasiou
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion Patras, 26500, Greece
    Oncotarget 2:363-7. 2011
    ..The fact that increased NTN1 is specifically observed in cancerous tissues indicates that NTN1 may represent a novel candidate biomarker for ovarian cancer...
  14. ncbi request reprint Cloning and characterization of novel isoforms of the human kallikrein 6 gene
    Georgios Pampalakis
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion, Greece
    Biochem Biophys Res Commun 320:54-61. 2004
    ..We show that in normal mammary epithelial cells and mammary tumor cell lines that overexpress the KLK6 gene, splice variants account for approximately 10-20% of all mRNA species...
  15. pmc Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer
    Georgia Sotiropoulou
    Department of Pharmacy, School of Health Sciences, University of Patras, Greece
    Mol Med 8:42-55. 2002
    ..Altered glycosylation patterns of the MUC1 mucin, in particular, is a target antigen for immunotherapy of breast and other cancers...
  16. ncbi request reprint Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer
    Georgios Pampalakis
    Department of Pharmacy, University of Patras, Rion Patras, Greece
    Biochim Biophys Acta 1776:22-31. 2007
    ..These findings may have clinical implications for the underlying molecular mechanism and management of cancer and other disorders in which KLK activity is elevated...
  17. pmc Evolutionary history of tissue kallikreins
    Athanasia Pavlopoulou
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion Patras, Greece
    PLoS ONE 5:e13781. 2010
    ..The study of this unique family will further assist in selecting new model organisms for functional studies of proteolytic pathways involving KLKs...
  18. ncbi request reprint Emerging interest in the kallikrein gene family for understanding and diagnosing cancer
    Georgia Sotiropoulou
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion, 26500 Patras, Greece
    Oncol Res 13:381-91. 2003
    ..An understanding of the physiology of human kallikreins is emerging with potential clinical applications...