Gerasimos Siasos

Summary

Affiliation: University of Athens Medical School
Location: Athens, Greece
Publications:
1: Tousoulis D, Siasos G, Maniatis K, Oikonomou E, Vlasis K, Papavassiliou AG,
Stefanadis C. Novel Biomarkers Assessing the Calcium Deposition in Coronary
Artery Disease. Curr Med Chem. 2012 Jan 10. [Epub ahead of print] PubMed PMID:
.


2: Siasos G, Tousoulis D, Oikonomou E, Zaromitidou M, Stefanadis C, Papavassiliou
AG. Inflammatory markers in hyperlipidemia: from experimental models to clinical
practice. Curr Pharm Des. 2011 Dec;17(37):4132-46. PubMed PMID: .


3: Androulakis E, Tousoulis D, Papageorgiou N, Latsios G, Siasos G, Tsioufis C,
Giolis A, Stefanadis C. Inflammation in hypertension: current therapeutic
approaches. Curr Pharm Des. 2011 Dec;17(37):4121-31. PubMed PMID: .


4: Papageorgiou N, Tousoulis D, Androulakis E, Giotakis A, Siasos G, Latsios G,
Stefanadis C. Lifestyle Factors and Endothelial Function. Curr Vasc Pharmacol.
2011 Nov 21. [Epub ahead of print] PubMed PMID: .


5: Siasos G, Tousoulis D, Oikonomou E, Zaromitidou M, Verveniotis A, Plastiras A,
Kioufis S, Maniatis K, Miliou A, Siasou Z, Stefanadis C, Papavassiliou AG.
Effects of omega-3 fatty acids on endothelial function, arterial wall properties,
inflammatory and fibrinolytic status in smokers: A cross over study. Int J
Cardiol. 2011 Nov 17. [Epub ahead of print] PubMed PMID: .


6: Tousoulis D, Siasos G, Oikonomou E, Stougianos P, Papageorgiou N,
Papavassiliou AG, Stefanadis C. Asymmetric dimethylarginine (ADMA): is really a
biomarker for cardiovascular prognosis? Int J Cardiol. 2011 Dec 1;153(2):123-5.
Epub 2011 Sep 19. PubMed PMID: .


7: Tousoulis D, Papageorgiou N, Latsios G, Siasos G, Antoniades C, Stefanadis C.
C-reactive protein and endothelial dysfunction: gazing at the coronaries. Int J
Cardiol. 2011 Oct 6;152(1):1-3. Epub 2011 Aug 20. PubMed PMID: .


8: Avgerinou G, Tousoulis D, Siasos G, Oikonomou E, Maniatis K, Papageorgiou N,
Paraskevopoulos T, Miliou A, Koumaki D, Latsios G, Therianiou A, Trikas A,
Kampoli AM, Stefanadis C. Anti-tumor necrosis factor alpha treatment with
adalimumab improves significantly endothelial function and decreases inflammatory
process in patients with chronic psoriasis. Int J Cardiol. 2011 Sep
15;151(3):382-3. Epub 2011 Jul 18. PubMed PMID: .


9: Tousoulis D, Androulakis E, Papageorgiou N, Briasoulis A, Siasos G, Antoniades
C, Stefanadis C. From atherosclerosis to acute coronary syndromes: the role of
soluble CD40 ligand. Trends Cardiovasc Med. 2010 Jul;20(5):153-64. Review. PubMed
PMID: .


10: Papaoikonomou S, Tousoulis D, Tentolouris N, Papadogiannis D, Miliou A,
Hatzis G, Papageorgiou N, Siasos G, Tsioufis C, Latsios G, Stefanadis C.
Assessment of the effects of the A3872G polymorphism on the C-reactive protein
gene in patients with diabetes mellitus type 2. Int J Cardiol. 2011 Sep
1;151(2):243-5. Epub 2011 Jul 7. PubMed PMID: .


11: Chrysohoou C, Skoumas J, Pitsavos C, Masoura C, Siasos G, Galiatsatos N,
Psaltopoulou T, Mylonakis C, Margazas A, Kyvelou S, Mamatas S, Panagiotakos D,
Stefanadis C. Long-term adherence to the Mediterranean diet reduces the
prevalence of hyperuricaemia in elderly individuals, without known cardiovascular
disease: the Ikaria study. Maturitas. 2011 Sep;70(1):58-64. Epub 2011 Jul 2.
PubMed PMID: .


12: Panagiotakos DB, Chrysohoou C, Siasos G, Zisimos K, Skoumas J, Pitsavos C,
Stefanadis C. Sociodemographic and lifestyle statistics of oldest old people (>80
years) living in ikaria island: the ikaria study. Cardiol Res Pract. 2011 Feb
24;2011:679187. PubMed PMID: ; PubMed Central PMCID: PMC3051199.


13: Siasos G, Tousoulis D, Gialafos E, Oikonomou E, Zaromitidou M, Aggeli C,
Korompelis P, Kallianos A, Rapti A, Zisimos K, Marinos G, Stefanadis C,
Papavassiliou AG. Association of sarcoidosis with endothelial function, arterial
wall properties, and biomarkers of inflammation. Am J Hypertens. 2011
Jun;24(6):647-53. doi: 10.1038/ajh.2011.30. Epub 2011 Mar 3. PubMed PMID:
.


14: Papageorgiou N, Tousoulis D, Psaltopoulou T, Giolis A, Antoniades C, Tsiamis
E, Miliou A, Toutouzas K, Siasos G, Stefanadis C. Divergent anti-inflammatory
effects of different oil acute consumption on healthy individuals. Eur J Clin
Nutr. 2011 Apr;65(4):514-9. Epub 2011 Feb 16. PubMed PMID: .


15: Oikonomou E, Tousoulis D, Siasos G, Zaromitidou M, Papavassiliou AG,
Stefanadis C. The role of inflammation in heart failure: new therapeutic
approaches. Hellenic J Cardiol. 2011 Jan-Feb;52(1):30-40. Review. PubMed PMID:
.


16: Siasos G, Tousoulis D, Stefanadis C. CYP2C19 genotype and outcomes of
clopidogrel treatment. N Engl J Med. 2011 Feb 3;364(5):481-2. PubMed PMID:
.


17: Boutsikou M, Konstadoulakis M, Tousoulis D, Aggeli C, Bistola V, Doumba P,
Siasos G, Latsios G, Papageorgiou N, Tentolouris C, Stefanadis C. Lymphocyte
activation and apoptotic process in acute coronary syndromes. Int J Cardiol. 2011
Mar 17;147(3):449-50. Epub 2011 Jan 11. PubMed PMID: .


18: Gialafos E, Rapti A, Kouranos V, Aggeli K, Papaioannou TG, Kallianos A,
Siasos G, Kostopoulos C, Stefanadis C. Detection of right ventricular dysfunction
by tissue Doppler imaging in asymptomatic patients with pulmonary sarcoidosis.
Eur Respir J. 2011 Jan;37(1):212-5. PubMed PMID: .


19: Tousoulis D, Siasos G, Zaromytidou M, Papageorgiou N, Stefanadi E, Oikonomou
E, Stefanadis C. The role of the cytochrome P450 polymorphisms in clopidogrel
efficacy and clinical utility. Curr Med Chem. 2011;18(3):427-38. Review. PubMed
PMID: .


20: Tousoulis D, Andreou I, Tsiatas M, Miliou A, Tentolouris C, Siasos G,
Papageorgiou N, Papadimitriou CA, Dimopoulos MA, Stefanadis C. Effects of
rosuvastatin and allopurinol on circulating endothelial progenitor cells in
patients with congestive heart failure: the impact of inflammatory process and
oxidative stress. Atherosclerosis. 2011 Jan;214(1):151-7. Epub 2010 Nov 11.
PubMed PMID: .


21: Tousoulis D, Andreou I, Antoniades C, Siasos G, Stougiannos P, Trikas A,
Stefanadis C. Do endothelial progenitor cells modify our strategy to treat risk
factors? Int J Cardiol. 2011 Oct 6;152(1):95-7. Epub 2010 Nov 26. PubMed PMID:
.


22: Siasos G, Tousoulis D, Siasou G, Moschos MM, Oikonomou E, Zaromitidou M,
Marinos G, Korompelis P, Papavassiliou AG, Stefanadis C. The association between
glaucoma, vascular function and inflammatory process. Int J Cardiol. 2011 Jan
7;146(1):113-5. Epub 2010 Oct 29. PubMed PMID: .


23: Tousoulis D, Koutsogiannis M, Papageorgiou N, Siasos G, Antoniades C, Tsiamis
E, Stefanadis C. Endothelial dysfunction: potential clinical implications.
Minerva Med. 2010 Aug;101(4):271-84. Review. PubMed PMID: .


24: Tousoulis D, Antoniades C, Tsiamis E, Charakida M, Siasos G, Tsioufis C,
Stefanadis C. Gene therapy for dysfunctional endothelium: is dimethylarginine
dimethylaminohydrolase-2 a therapeutic target? Int J Cardiol. 2010 Oct
8;144(2):173-4. Epub 2010 Jun 9. PubMed PMID: .


25: Panas M, Gialafos E, Spengos K, Papaioannou TG, Aggeli K, Kladi A, Siasos G,
Gialafos J, Vassilopoulos D, Stefanadis C. Prevalence of interatrial block in
patients with Friedreichs ataxia. Int J Cardiol. 2010 Nov 19;145(2):386-7. Epub
2010 Mar 7. PubMed PMID: .


26: Papageorgiou N, Tousoulis D, Siasos G, Stefanadis C. Is fibrinogen a marker
of inflammation in coronary artery disease? Hellenic J Cardiol. 2010
Jan-Feb;51(1):1-9. PubMed PMID: .


27: Tousoulis D, Koniari K, Antoniades C, Papageorgiou N, Miliou A, Noutsou M,
Nikolopoulou A, Marinou K, Stefanadi E, Siasos G, Charakida M, Kamboli AM,
Stefanadis C. Combined effects of atorvastatin and metformin on glucose-induced
variations of inflammatory process in patients with diabetes mellitus. Int J
Cardiol. 2011 May 19;149(1):46-9. Epub 2009 Dec 24. PubMed PMID: .


28: Andreou I, Tousoulis D, Miliou A, Tentolouris C, Zisimos K, Gounari P, Siasos
G, Papageorgiou N, Papadimitriou CA, Dimopoulos MA, Stefanadis C. Effects of
rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a
randomized placebo-controlled study. Atherosclerosis. 2010 May;210(1):194-8. Epub
2009 Nov 10. PubMed PMID: .


29: Marinos G, Vasileiou I, Katsargyris A, Klonaris CP, Korombelis P, Michail O,
Valatsou A, Griniatsos J, Vlasis K, Siasos G, Souliotis K, Konstantopoulos K.
Management of minor medical problems and trauma: the role of general practice.
Rural Remote Health. 2009 Oct-Dec;9(4):1019. Epub 2009 Oct 19. PubMed PMID:
.


30: Tousoulis D, Kampoli AM, Siasos G, Stefanadi E, Antoniades C, Papavassiliou
AG, Stefanadis C. Circulating biomarkers for the diagnosis and prognosis of heart
failure. Curr Med Chem. 2009;16(29):3828-40. PubMed PMID: .


31: Kampoli AM, Tousoulis D, Antoniades C, Siasos G, Stefanadis C. Biomarkers of
premature atherosclerosis. Trends Mol Med. 2009 Jul;15(7):323-32. Epub 2009 Jul
3. Review. PubMed PMID: .


32: Stefanadi E, Tousoulis D, Androulakis ES, Papageorgiou N, Charakida M, Siasos
G, Tsioufis C, Stefanadis C. Inflammatory markers in essential hypertension:
potential clinical implications. Curr Vasc Pharmacol. 2010 Jul;8(4):509-16.
Review. PubMed PMID: .


33: Tousoulis D, Antonopoulos AS, Antoniades C, Saldari C, Stefanadi E, Siasos G,
Stougianos P, Plastiras A, Korompelis P, Stefanadis C. Role of depression in
heart failure--choosing the right antidepressive treatment. Int J Cardiol. 2010
Apr 1;140(1):12-8. Epub 2009 Jun 6. Review. PubMed PMID: .


34: Siasos G, Tousoulis D, Vlachopoulos C, Antoniades C, Stefanadi E, Ioakeimidis
N, Zisimos K, Siasou Z, Papavassiliou AG, Stefanadis C. The impact of oral
L-arginine supplementation on acute smoking-induced endothelial injury and
arterial performance. Am J Hypertens. 2009 Jun;22(6):586-92. Epub 2009 Mar 19.
PubMed PMID: .


35: Siasos G, Tousoulis D, Stefanadis C. Multiple mechanisms affect the
clopidogrel response. J Am Coll Cardiol. 2009 Mar 10;53(10):900-1; author reply
901. PubMed PMID: .


36: Gounari P, Tousoulis D, Antoniades C, Kampoli AM, Stougiannos P, Papageorgiou
N, Roulia G, Stefanadi E, Siasos G, Tsioufis C, Stefanadis C. Rosuvastatin but
not ezetimibe improves endothelial function in patients with heart failure, by
mechanisms independent of lipid lowering. Int J Cardiol. 2010 Jun
25;142(1):87-91. Epub 2009 Feb 6. PubMed PMID: .


37: Tousoulis D, Siasos G, Stefanadis C. Aspirin resistance: what the
cardiologist needs to know? Int J Cardiol. 2009 Feb 20;132(2):153-6. Epub 2009
Jan 22. PubMed PMID: .


38: Vasileiou I, Marinos G, Katsargyris A, Georgiou C, Vlasis K, Siasos G,
Gialafos E, Klonaris C, Konstantopoulos K, Giannopoulos A. Avian flu: how
informed are children in Greece? South Med J. 2008 Nov;101(11):1121-5. PubMed
PMID: .


39: Charakida M, Tousoulis D, Skoumas I, Pitsavos C, Vasiliadou C, Stefanadi E,
Antoniades C, Latsios G, Siasos G, Stefanadis C. Inflammatory and thrombotic
processes are associated with vascular dysfunction in children with familial
hypercholesterolemia. Atherosclerosis. 2009 Jun;204(2):532-7. Epub 2008 Oct 5.
PubMed PMID: .


40: Tousoulis D, Antoniades C, Marinou K, Vasiliadou C, Bouras G, Stefanadi E,
Latsios G, Siasos G, Toutouzas K, Stefanadis C. Methionine-loading rapidly
impairs endothelial function, by mechanisms independent of endothelin-1: evidence
for an association of fasting total homocysteine with plasma endothelin-1 levels.
J Am Coll Nutr. 2008 Jun;27(3):379-86. PubMed PMID: .


41: Tousoulis D, Zisimos K, Antoniades C, Stefanadi E, Siasos G, Tsioufis C,
Papageorgiou N, Vavouranakis E, Vlachopoulos C, Stefanadis C. Oxidative stress
and inflammatory process in patients with atrial fibrillation: the role of left
atrium distension. Int J Cardiol. 2009 Aug 21;136(3):258-62. Epub 2008 Jul 25.
PubMed PMID: .


42: Tousoulis D, Drolias A, Antoniades C, Vasiliadou C, Marinou K, Latsios G,
Stefanadi E, Gounari P, Siasos G, Papageorgiou N, Trikas A, Stefanadis C.
Antidepressive treatment as a modulator of inflammatory process in patients with
heart failure: effects on proinflammatory cytokines and acute phase protein
levels. Int J Cardiol. 2009 May 15;134(2):238-43. Epub 2008 Jun 24. PubMed PMID:
.


43: Tousoulis D, Kampoli AM, Stefanadi E, Antoniades C, Siasos G, Papavassiliou
AG, Stefanadis C. New biochemical markers in acute coronary syndromes. Curr Med
Chem. 2008;15(13):1288-96. Review. PubMed PMID: .


44: Nikolopoulou A, Tousoulis D, Antoniades C, Petroheilou K, Vasiliadou C,
Papageorgiou N, Koniari K, Stefanadi E, Latsios G, Siasos G, Stefanadis C. Common
community infections and the risk for coronary artery disease and acute
myocardial infarction: evidence for chronic over-expression of tumor necrosis
factor alpha and vascular cells adhesion molecule-1. Int J Cardiol. 2008 Nov
12;130(2):246-50. Epub 2007 Dec 11. PubMed PMID: .


45: Tousoulis D, Antoniades C, Nikolopoulou A, Koniari K, Vasiliadou C, Marinou
K, Koumallos N, Papageorgiou N, Stefanadi E, Siasos G, Stefanadis C. Interaction
between cytokines and sCD40L in patients with stable and unstable coronary
syndromes. Eur J Clin Invest. 2007 Aug;37(8):623-8. PubMed PMID: .


46: Siasos G, Tousoulis D, Vlachopoulos C, Antoniades C, Stefanadi E, Ioakeimidis
N, Andreou I, Zisimos K, Papavassiliou AG, Stefanadis C. Short-term treatment
with L-arginine prevents the smoking-induced impairment of endothelial function
and vascular elastic properties in young individuals. Int J Cardiol. 2008 Jun
6;126(3):394-9. Epub 2007 Jun 22. PubMed PMID: .


47: Siasos G, Tousoulis D, Siasou Z, Stefanadis C, Papavassiliou AG. Shear
stress, protein kinases and atherosclerosis. Curr Med Chem. 2007;14(14):1567-72.
Review. PubMed PMID: .


48: Antoniades C, Tousoulis D, Marinou K, Papageorgiou N, Bosinakou E, Tsioufis
C, Stefanadi E, Latsios G, Tentolouris C, Siasos G, Stefanadis C. Effects of
insulin dependence on inflammatory process, thrombotic mechanisms and endothelial
function, in patients with type 2 diabetes mellitus and coronary atherosclerosis.
Clin Cardiol. 2007 Jun;30(6):295-300. PubMed PMID: .


49: Tousoulis D, Böger RH, Antoniades C, Siasos G, Stefanadi E, Stefanadis C.
Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical
perspective. Nat Clin Pract Cardiovasc Med. 2007 May;4(5):274-83. Review. PubMed
PMID: .


50: Tousoulis D, Kourtellaris P, Antoniades C, Vasiliadou C, Papageorgiou N,
Tentolouris C, Siasos G, Stefanadi E, Stefanadis C. Effects of irbesartan and
perindopril on forearm reactive hyperemia and inflammatory process, in
normotensive patients with coronary artery disease. Int J Cardiol. 2008 Feb
20;124(1):127-9. Epub 2007 Mar 6. PubMed PMID: .


51: Tousoulis D, Charakida M, Stefanadi E, Siasos G, Latsios G, Stefanadis C.
Statins in heart failure. Beyond the lipid lowering effect. Int J Cardiol. 2007
Feb 7;115(2):144-50. Epub 2006 Dec 15. Review. Erratum in: Int J Cardiol. 2008
Jan 11;123(2):218. PubMed PMID: .


52: Tousoulis D, Antoniades C, Vasiliadou C, Kourtellaris P, Koniari K, Marinou
K, Charakida M, Ntarladimas I, Siasos G, Stefanadis C. Effects of atorvastatin
and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine
levels and the inflammatory process in patients with type 2 diabetes mellitus.
Heart. 2007 Feb;93(2):244-6. Epub 2006 Aug 16. PubMed PMID: ; PubMed
Central PMCID: PMC1861391.


53: Antoniades C, Tousoulis D, Marinou K, Stefanadi E, Ntarladimas I, Latsios G,
Konniari K, Papageorgiou N, Siasos G, Stefanadis C. Effects of lipid profile on
forearm hyperemic response in young subjects. Hellenic J Cardiol. 2006
May-Jun;47(3):152-7. PubMed PMID: .


54: Siasos G, Tousoulis D, Antoniades C, Stefanadi E, Stefanadis C. L-Arginine,
the substrate for NO synthesis: an alternative treatment for premature
atherosclerosis? Int J Cardiol. 2007 Apr 4;116(3):300-8. Epub 2006 Jul 24.
Review. PubMed PMID: .


55: Tousoulis D, Antoniades C, Charakida M, Toutouzas K, Trikas A, Stefanadi E,
Siasos G, Latsios G, Stefanadis C. Cold pressor test as a marker for the
detection of early stage coronary atherosclerosis. Int J Cardiol. 2007 Jan
31;115(1):120-2. Epub 2006 Jun 19. PubMed PMID: .


56: Vlachopoulos C, Kosmopoulou F, Alexopoulos N, Ioakeimidis N, Siasos G,
Stefanadis C. Acute mental stress has a prolonged unfavorable effect on arterial
stiffness and wave reflections. Psychosom Med. 2006 Mar-Apr;68(2):231-7. PubMed
PMID: .


57: Toutouzas K, Drakopoulou M, Stefanadi E, Siasos G, Stefanadis C.
Intracoronary thermography: does it help us in clinical decision making? J Interv
Cardiol. 2005 Dec;18(6):485-9. Review. PubMed PMID: .

Publications

  1. Tousoulis D, Boger R, Antoniades C, Siasos G, Stefanadi E, Stefanadis C. Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective. Nat Clin Pract Cardiovasc Med. 2007;4:274-83 pubmed
    ..Here, we present a critique of the existing literature about the role of L-arginine in the prevention of atherosclerosis. ..
  2. Vlachopoulos C, Kosmopoulou F, Alexopoulos N, Ioakeimidis N, Siasos G, Stefanadis C. Acute mental stress has a prolonged unfavorable effect on arterial stiffness and wave reflections. Psychosom Med. 2006;68:231-7 pubmed
    ..Given the important pathophysiologic and prognostic role of these parameters, our results provide important mechanistic links between acute mental stress and increased cardiovascular risk. ..
  3. Tousoulis D, Antoniades C, Tsiamis E, Charakida M, Siasos G, Tsioufis C, et al. Gene therapy for dysfunctional endothelium: is dimethylarginine dimethylaminohydrolase-2 a therapeutic target?. Int J Cardiol. 2010;144:173-4 pubmed publisher
  4. Panas M, Gialafos E, Spengos K, Papaioannou T, Aggeli K, Kladi A, et al. Prevalence of interatrial block in patients with Friedreich's ataxia. Int J Cardiol. 2010;145:386-387 pubmed publisher
    ..Early recognition of IAB could allow the identification of asymptomatic FA patients who are prone to develop potentially life-threatening arrhythmias. ..
  5. Papageorgiou N, Tousoulis D, Siasos G, Stefanadis C. Is fibrinogen a marker of inflammation in coronary artery disease?. Hellenic J Cardiol. 2010;51:1-9 pubmed
  6. Boutsikou M, Konstadoulakis M, Tousoulis D, Aggeli C, Bistola V, Doumba P, et al. Lymphocyte activation and apoptotic process in acute coronary syndromes. Int J Cardiol. 2011;147:449-50 pubmed publisher
  7. Papageorgiou N, Tousoulis D, Psaltopoulou T, Giolis A, Antoniades C, Tsiamis E, et al. Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals. Eur J Clin Nutr. 2011;65:514-9 pubmed publisher
    ..These findings indicate that acute consumption of specific types of oil is associated with specific significant anti-inflammatory effects. ..
  8. Tousoulis D, Siasos G, Stefanadis C. Aspirin resistance: what the cardiologist needs to know?. Int J Cardiol. 2009;132:153-6 pubmed publisher
    ..Further studies needed to elucidate the appropriate management of aspirin resistance. ..
  9. Tousoulis D, Zisimos K, Antoniades C, Stefanadi E, Siasos G, Tsioufis C, et al. Oxidative stress and inflammatory process in patients with atrial fibrillation: the role of left atrium distension. Int J Cardiol. 2009;136:258-62 pubmed publisher
    ..The maximum diameter of left atrium is the only independent predictor of oxidized LDL, suggesting that left atrium distension may predict oxidative stress status in these patients. ..

Detail Information

Publications57

  1. Avgerinou G, Tousoulis D, Siasos G, Oikonomou E, Maniatis K, Papageorgiou N, et al. Anti-tumor necrosis factor ? treatment with adalimumab improves significantly endothelial function and decreases inflammatory process in patients with chronic psoriasis. Int J Cardiol. 2011;151:382-3 pubmed publisher
  2. Nikolopoulou A, Tousoulis D, Antoniades C, Petroheilou K, Vasiliadou C, Papageorgiou N, et al. Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1. Int J Cardiol. 2008;130:246-50 pubmed
    ..These findings are important since they demonstrate that past HAV, HSV and HP infections may affect cardiovascular risk, while recent CP infection may be implicated in the triggering of AMI among CAD patients. ..
  3. Tousoulis D, Antoniades C, Nikolopoulou A, Koniari K, Vasiliadou C, Marinou K, et al. Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes. Eur J Clin Invest. 2007;37:623-8 pubmed
    ..Diabetes mellitus and smoking (but not IL-6 or adhesion molecules) were the only factors independently associated with sCD40L levels in CAD and AMI patients. ..
  4. Tousoulis D, Kourtellaris P, Antoniades C, Vasiliadou C, Papageorgiou N, Tentolouris C, et al. Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease. Int J Cardiol. 2008;124:127-9 pubmed
  5. Tousoulis D, Papageorgiou N, Latsios G, Siasos G, Antoniades C, Stefanadis C. C-reactive protein and endothelial dysfunction: gazing at the coronaries. Int J Cardiol. 2011;152:1-3 pubmed publisher
  6. Siasos G, Tousoulis D, Antoniades C, Stefanadi E, Stefanadis C. L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis?. Int J Cardiol. 2007;116:300-8 pubmed
    ..In conclusion, L-arginine administration may be useful in patients with premature atherosclerosis. ..
  7. Androulakis E, Tousoulis D, Papageorgiou N, Latsios G, Siasos G, Tsioufis C, et al. Inflammation in hypertension: current therapeutic approaches. Curr Pharm Des. 2011;17:4121-31 pubmed
    ..Although the available data are encouraging, further large scale studies are required to evaluate the reported anti-inflammatory effects in management and treatment of arterial hypertension. ..
  8. Toutouzas K, Drakopoulou M, Stefanadi E, Siasos G, Stefanadis C. Intracoronary thermography: does it help us in clinical decision making?. J Interv Cardiol. 2005;18:485-9 pubmed
  9. Tousoulis D, Kampoli A, Siasos G, Stefanadi E, Antoniades C, Papavassiliou A, et al. Circulating biomarkers for the diagnosis and prognosis of heart failure. Curr Med Chem. 2009;16:3828-40 pubmed
  10. Siasos G, Tousoulis D, Siasou G, Moschos M, Oikonomou E, Zaromitidou M, et al. The association between glaucoma, vascular function and inflammatory process. Int J Cardiol. 2011;146:113-5 pubmed publisher
  11. Tousoulis D, Koutsogiannis M, Papageorgiou N, Siasos G, Antoniades C, Tsiamis E, et al. Endothelial dysfunction: potential clinical implications. Minerva Med. 2010;101:271-84 pubmed
    ..Despite of the fact that there are several strategies aiming to improve endothelial dysfunction by enhancing nitric oxide bioavailability, it is still unclear whether they could be beneficial at a clinical level. ..
  12. Tousoulis D, Siasos G, Zaromytidou M, Papageorgiou N, Stefanadi E, Oikonomou E, et al. The role of the cytochrome P450 polymorphisms in clopidogrel efficacy and clinical utility. Curr Med Chem. 2011;18:427-38 pubmed
  13. Tousoulis D, Koniari K, Antoniades C, Papageorgiou N, Miliou A, Noutsou M, et al. Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus. Int J Cardiol. 2011;149:46-9 pubmed publisher
    ..In addition, combined treatment with atorvastatin and metformin reduces the post-glucose loading levels of TNF-? compared to metformin monotherapy. ..
  14. Gounari P, Tousoulis D, Antoniades C, Kampoli A, Stougiannos P, Papageorgiou N, et al. Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering. Int J Cardiol. 2010;142:87-91 pubmed publisher
    ..These findings indicate a direct beneficial effect of statins in patients with congestive heart failure, further to lipid-lowering. ..
  15. Vasileiou I, Marinos G, Katsargyris A, Georgiou C, Vlasis K, Siasos G, et al. Avian flu: how informed are children in Greece?. South Med J. 2008;101:1121-5 pubmed publisher
    ..This study highlights the need for adaptation of health programs in Greek schools, which should include the provision of accurate information. ..
  16. Tousoulis D, Antoniades C, Charakida M, Toutouzas K, Trikas A, Stefanadi E, et al. Cold pressor test as a marker for the detection of early stage coronary atherosclerosis. Int J Cardiol. 2007;115:120-2 pubmed
  17. Antoniades C, Tousoulis D, Marinou K, Papageorgiou N, Bosinakou E, Tsioufis C, et al. Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis. Clin Cardiol. 2007;30:295-300 pubmed
  18. Tousoulis D, Kampoli A, Stefanadi E, Antoniades C, Siasos G, Papavassiliou A, et al. New biochemical markers in acute coronary syndromes. Curr Med Chem. 2008;15:1288-96 pubmed
    ..In the future further, studies are necessary to elucidate the exact role of the new biochemical markers in ACS. ..
  19. Siasos G, Tousoulis D, Siasou Z, Stefanadis C, Papavassiliou A. Shear stress, protein kinases and atherosclerosis. Curr Med Chem. 2007;14:1567-72 pubmed
    ..Targeted inhibition of many kinase types and subtypes is an immense research field as this may lead to novel therapeutic approaches to prevent atherogenesis. ..
  20. Marinos G, Vasileiou I, Katsargyris A, Klonaris C, Korombelis P, Michail O, et al. Management of minor medical problems and trauma: the role of general practice. Rural Remote Health. 2009;9:1019 pubmed
    ..Many emergency patients visiting hospitals can be managed at the primary care level. The development of a 'practice-based curriculum' for GPs would be an excellent method to obtain higher professional standards. ..
  21. Tousoulis D, Andreou I, Tsiatas M, Miliou A, Tentolouris C, Siasos G, et al. Effects of rosuvastatin and allopurinol on circulating endothelial progenitor cells in patients with congestive heart failure: the impact of inflammatory process and oxidative stress. Atherosclerosis. 2011;214:151-7 pubmed publisher
    ..The impact of rosuvastatin on EPCs is not mediated by changes in inflammatory and oxidative status. ..
  22. Siasos G, Tousoulis D, Oikonomou E, Zaromitidou M, Stefanadis C, Papavassiliou A. Inflammatory markers in hyperlipidemia: from experimental models to clinical practice. Curr Pharm Des. 2011;17:4132-46 pubmed
    ..Although, cholesterol lowering treatment has several important beneficial effects, there is still little clinical experience or data from clinical trials, in order to treat patients with hyperlipidemia and impaired inflammatory status. ..
  23. Tousoulis D, Siasos G, Oikonomou E, Stougianos P, Papageorgiou N, Papavassiliou A, et al. Asymmetric dimethylarginine (ADMA): is really a biomarker for cardiovascular prognosis?. Int J Cardiol. 2011;153:123-5 pubmed publisher
  24. Panagiotakos D, Chrysohoou C, Siasos G, Zisimos K, Skoumas J, Pitsavos C, et al. Sociodemographic and lifestyle statistics of oldest old people (>80 years) living in ikaria island: the ikaria study. Cardiol Res Pract. 2011;2011:679187 pubmed publisher
    ..This concept must be further explored in order to understand how these factors relate and which are the most important in shaping prolonged life. ..
  25. Papaoikonomou S, Tousoulis D, Tentolouris N, Papadogiannis D, Miliou A, Hatzis G, et al. Assessment of the effects of the A3872G polymorphism on the C-reactive protein gene in patients with diabetes mellitus type 2. Int J Cardiol. 2011;151:243-5 pubmed publisher
  26. Andreou I, Tousoulis D, Miliou A, Tentolouris C, Zisimos K, Gounari P, et al. Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a randomized placebo-controlled study. Atherosclerosis. 2010;210:194-8 pubmed publisher
    ..This finding reveals a novel pleiotropic effect of statins in patients with heart failure, and provides further insights into the pathophysiological mechanisms of MPO in heart failure. ..
  27. Stefanadi E, Tousoulis D, Androulakis E, Papageorgiou N, Charakida M, Siasos G, et al. Inflammatory markers in essential hypertension: potential clinical implications. Curr Vasc Pharmacol. 2010;8:509-16 pubmed
    ..However, further randomized studies are required to determine the potential favorable effects of suppression of inflammation in the management of arterial hypertension. ..
  28. Tousoulis D, Antonopoulos A, Antoniades C, Saldari C, Stefanadi E, Siasos G, et al. Role of depression in heart failure--choosing the right antidepressive treatment. Int J Cardiol. 2010;140:12-8 pubmed publisher
    ..Even though certain conclusions cannot be drawn yet, evidence suggests that the use of selective serotonin reuptake inhibitors may have a beneficial effect on clinical outcome of heart failure patients. ..
  29. Charakida M, Tousoulis D, Skoumas I, Pitsavos C, Vasiliadou C, Stefanadi E, et al. Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia. Atherosclerosis. 2009;204:532-7 pubmed publisher
    ..05) and FH status (beta=-25.2(10.6), p<0.05) (R(2) for the model: 0.63, p=0.001). Inflammatory and haemostatic abnormalities are present in FH children and contribute to the endothelial dysfunction observed in these children. ..
  30. Tousoulis D, Antoniades C, Marinou K, Vasiliadou C, Bouras G, Stefanadi E, et al. Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels. J Am Coll Nutr. 2008;27:379-86 pubmed
    ..These findings suggest that despite its potential role in chronic homocysteinemia, ET-1 has a limited contribution to the development of endothelial dysfunction in acute, methionine-induced homocysteinemia in humans. ..
  31. Tousoulis D, Charakida M, Stefanadi E, Siasos G, Latsios G, Stefanadis C. Statins in heart failure. Beyond the lipid lowering effect. Int J Cardiol. 2007;115:144-50 pubmed
    ..Finally the statin dose and the interaction with co-administered drugs need to be studied. ..
  32. Tousoulis D, Drolias A, Antoniades C, Vasiliadou C, Marinou K, Latsios G, et al. Antidepressive treatment as a modulator of inflammatory process in patients with heart failure: effects on proinflammatory cytokines and acute phase protein levels. Int J Cardiol. 2009;134:238-43 pubmed publisher
  33. Kampoli A, Tousoulis D, Antoniades C, Siasos G, Stefanadis C. Biomarkers of premature atherosclerosis. Trends Mol Med. 2009;15:323-32 pubmed publisher
    ..Here, we review the roles of specific biomarkers that have been implicated in premature atherosclerosis. ..
  34. Antoniades C, Tousoulis D, Marinou K, Stefanadi E, Ntarladimas I, Latsios G, et al. Effects of lipid profile on forearm hyperemic response in young subjects. Hellenic J Cardiol. 2006;47:152-7 pubmed
  35. Tousoulis D, Antoniades C, Vasiliadou C, Kourtellaris P, Koniari K, Marinou K, et al. Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus. Heart. 2007;93:244-6 pubmed
  36. Papageorgiou N, Tousoulis D, Androulakis E, Giotakis A, Siasos G, Latsios G, et al. Lifestyle factors and endothelial function. Curr Vasc Pharmacol. 2012;10:94-106 pubmed
    ..However, little is known about how individual's genetic background interacts with environmental influences on vascular health, thereby making the interpretation of the relative importance of lifestyle interventions more complicated. ..
  37. Siasos G, Tousoulis D, Oikonomou E, Zaromitidou M, Verveniotis A, Plastiras A, et al. Effects of ?-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: a cross over study. Int J Cardiol. 2013;166:340-6 pubmed publisher
    ..05) and IL-6 (p=0.01) and increased levels of PAI-1 (p=0.05). ?-3 PUFAs improved endothelial function and the elastic properties of the arterial tree in healthy smokers, with a parallel anti-inflammatory effect. ..
  38. Siasos G, Tousoulis D, Vlachopoulos C, Antoniades C, Stefanadi E, Ioakeimidis N, et al. Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals. Int J Cardiol. 2008;126:394-9 pubmed
    ..1). Short-term daily administration of L-arginine improves arterial performance in healthy smokers and abrogates the smoking-induced increase in arterial stiffness and wave reflections in these individuals. ..
  39. Tousoulis D, Androulakis E, Papageorgiou N, Briasoulis A, Siasos G, Antoniades C, et al. From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand. Trends Cardiovasc Med. 2010;20:153-64 pubmed publisher
    ..Whether specific agents target the CD40/CD40L system as well as its pathogenic role in ACS remains to be elucidated by large-scale studies in the future. ..
  40. Chrysohoou C, Skoumas J, Pitsavos C, Masoura C, Siasos G, Galiatsatos N, et al. Long-term adherence to the Mediterranean diet reduces the prevalence of hyperuricaemia in elderly individuals, without known cardiovascular disease: the Ikaria study. Maturitas. 2011;70:58-64 pubmed publisher
    ..The potential different effect size as regards the relationship between diet and UA levels between genders, deserves further investigation. ..
  41. Siasos G, Tousoulis D, Stefanadis C. Multiple mechanisms affect the clopidogrel response. J Am Coll Cardiol. 2009;53:900-1; author reply 901 pubmed publisher
  42. Siasos G, Tousoulis D, Vlachopoulos C, Antoniades C, Stefanadi E, Ioakeimidis N, et al. The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance. Am J Hypertens. 2009;22:586-92 pubmed publisher
    ..05 for both vs. baseline). Oral L-arginine improves endothelial function and vascular elastic properties of the arterial tree during the acute phase of smoking, an effect accompanied by reduced sICAM-1 levels in these subjects. ..
  43. Gialafos E, Rapti A, Kouranos V, Aggeli K, Papaioannou T, Kallianos A, et al. Detection of right ventricular dysfunction by tissue Doppler imaging in asymptomatic patients with pulmonary sarcoidosis. Eur Respir J. 2011;37:212-5 pubmed publisher
  44. Kalampogias A, Siasos G, Oikonomou E, Tsalamandris S, Mourouzis K, Tsigkou V, et al. Basic Mechanisms in Atherosclerosis: The Role of Calcium. Med Chem. 2016;12:103-13 pubmed
    ..5H2O] to the form of Hydroxylapatite [Ca10(PO4)6(OH)2]. This review is devoted to broaden the understanding regarding atherosclerosis and the central role of calcium in the development of the condition. ..
  45. Kokkou E, Siasos G, Georgiopoulos G, Oikonomou E, Verveniotis A, Vavuranakis M, et al. The impact of dietary flavonoid supplementation on smoking-induced inflammatory process and fibrinolytic impairment. Atherosclerosis. 2016;251:266-272 pubmed publisher
    ..These findings shed further light on the favorable effects of flavonoids in cardiovascular health. ..
  46. Tsigkou V, Siasos G, Rovos K, Tripyla N, Tousoulis D. Peripheral artery disease and antiplatelet treatment. Curr Opin Pharmacol. 2018;39:43-52 pubmed publisher
    ..Furthermore, vorapaxar, a protease-activated receptor inhibitor, exhibits antiplatelet properties and has been studied in PAD. ..
  47. Siasos G, Gouliopoulos N, Moschos M, Oikonomou E, Kollia C, Konsola T, et al. Role of endothelial dysfunction and arterial stiffness in the development of diabetic retinopathy. Diabetes Care. 2015;38:e9-e10 pubmed publisher
  48. Siasos G, Athanasiou D, Terzis G, Stasinaki A, Oikonomou E, Tsitkanou S, et al. Acute effects of different types of aerobic exercise on endothelial function and arterial stiffness. Eur J Prev Cardiol. 2016;23:1565-72 pubmed publisher
    ..Both CAE and hIAE can favourably affect endothelial function, suggesting another cardioprotective effect of acute exercise. These types of aerobic exercise have a different impact on the central and peripheral arterial stiffness. ..