Aikaterini Sfiridaki

Summary

Affiliation: University of Crete
Country: Greece

Publications

  1. ncbi request reprint Evaluation of bone disease in multiple myeloma: a correlation between biochemical markers of bone metabolism and other clinical parameters in untreated multiple myeloma patients
    Michael G Alexandrakis
    Department of Haematology, University Hospital of Crete, Heraklion, Greece
    Clin Chim Acta 325:51-7. 2002
  2. pmc Circulating osteopontin: a dual marker of bone destruction and angiogenesis in patients with multiple myeloma
    Aikaterini Sfiridaki
    Department of Hematology, University Hospital of Heraklion, Crete, Greece
    J Hematol Oncol 4:22. 2011
  3. doi request reprint Histological expression of angiogenic factors: VEGF, PDGFRalpha, and HIF-1alpha in Hodgkin lymphoma
    Freda H Passam
    3rd Department of Internal Medicine, Medical School of Athens, Sotiria Hospital, Athens, Greece
    Pathol Res Pract 205:11-20. 2009
  4. doi request reprint Angiogenesis-related growth factors and cytokines in the serum of patients with B non-Hodgkin lymphoma; relation to clinical features and response to treatment
    F H Passam
    III Department of Internal Medicine, Sotiria Hospital, Medical School of Athens, University of Athens, Athens, Greece
    Int J Lab Hematol 30:17-25. 2008
  5. ncbi request reprint Relationship between serum levels of vascular endothelial growth factor, hepatocyte growth factor and matrix metalloproteinase-9 with biochemical markers of bone disease in multiple myeloma
    Michael G Alexandrakis
    Department of Haematology, University Hospital of Heraklion, Heraklion, Crete, Greece
    Clin Chim Acta 379:31-5. 2007
  6. ncbi request reprint Angiogenic molecules in Hodgkin's disease: results from sequential serum analysis
    F H Passam
    3rd Department of Internal Medicine, Sotiria Hospital, Medical School of Athens, University of Athens, Mesogeion 152, 11527 Athens, Greece
    Int J Immunopathol Pharmacol 19:161-70. 2006
  7. ncbi request reprint Serum evaluation of angiogenic cytokine basic fibroblast growth factor, hepatocyte growth factor and TNF-alpha in patients with myelodysplastic syndromes: correlation with bone marrow microvascular density
    M G Alexandrakis
    Department of Hematology, University Hospital of Heraklion, Crete, Greece
    Int J Immunopathol Pharmacol 18:287-95. 2005
  8. ncbi request reprint The assessment of proliferating cell nuclear antigen immunostaining in myelodysplastic syndromes and its prognostic significance
    M G Alexandrakis
    Department of Hematology, University Hospital of Heraklion, P O BOX 1352 Heraklion, Crete, Greece
    Eur J Histochem 49:27-32. 2005
  9. ncbi request reprint Bone marrow microvascular density and angiogenic growth factors in multiple myeloma
    Michael G Alexandrakis
    Department of Hematology, University Hospital of Heraklion, Crete, Greece
    Clin Chem Lab Med 42:1122-6. 2004
  10. ncbi request reprint Relation between bone marrow angiogenesis and serum levels of angiogenin in patients with myelodysplastic syndromes
    Michael G Alexandrakis
    Department of Haematology, University Hospital of Heraklion, Medical School of Crete, P O Box 1352, Heraklion, Crete, Greece
    Leuk Res 29:41-6. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Evaluation of bone disease in multiple myeloma: a correlation between biochemical markers of bone metabolism and other clinical parameters in untreated multiple myeloma patients
    Michael G Alexandrakis
    Department of Haematology, University Hospital of Crete, Heraklion, Greece
    Clin Chim Acta 325:51-7. 2002
    ..In this study, these markers were studied in relation to bone disease severity and other clinical parameters of MM activity...
  2. pmc Circulating osteopontin: a dual marker of bone destruction and angiogenesis in patients with multiple myeloma
    Aikaterini Sfiridaki
    Department of Hematology, University Hospital of Heraklion, Crete, Greece
    J Hematol Oncol 4:22. 2011
    ..47 and 0.30 respectively, p < 0.05). These results support osteopontin as a dual marker of bone destruction and angiogenic activity in myeloma patients. Osteopontin represents a useful biomarker for monitoring myeloma disease activity...
  3. doi request reprint Histological expression of angiogenic factors: VEGF, PDGFRalpha, and HIF-1alpha in Hodgkin lymphoma
    Freda H Passam
    3rd Department of Internal Medicine, Medical School of Athens, Sotiria Hospital, Athens, Greece
    Pathol Res Pract 205:11-20. 2009
    ..As microvessel formation is not increased in Hodgkin, additional functions of these angiogenic molecules should be investigated...
  4. doi request reprint Angiogenesis-related growth factors and cytokines in the serum of patients with B non-Hodgkin lymphoma; relation to clinical features and response to treatment
    F H Passam
    III Department of Internal Medicine, Sotiria Hospital, Medical School of Athens, University of Athens, Athens, Greece
    Int J Lab Hematol 30:17-25. 2008
    ..Both indolent and aggressive B cell lymphomas have increased production of angiogenic mediators and cytokines with IL-8 and IL-16 potentially reflecting the response to treatment...
  5. ncbi request reprint Relationship between serum levels of vascular endothelial growth factor, hepatocyte growth factor and matrix metalloproteinase-9 with biochemical markers of bone disease in multiple myeloma
    Michael G Alexandrakis
    Department of Haematology, University Hospital of Heraklion, Heraklion, Crete, Greece
    Clin Chim Acta 379:31-5. 2007
    ..We studied molecules involved in angiogenesis (MMP-9, HGF, VEGF) in relation to disease stage, extent of bone destruction, and markers of bone turnover (Ntx and PICP)...
  6. ncbi request reprint Angiogenic molecules in Hodgkin's disease: results from sequential serum analysis
    F H Passam
    3rd Department of Internal Medicine, Sotiria Hospital, Medical School of Athens, University of Athens, Mesogeion 152, 11527 Athens, Greece
    Int J Immunopathol Pharmacol 19:161-70. 2006
    ..HGF seems to be the prominent molecule in Hodgkin's disease, which may be used to monitor the disease status and the response to treatment...
  7. ncbi request reprint Serum evaluation of angiogenic cytokine basic fibroblast growth factor, hepatocyte growth factor and TNF-alpha in patients with myelodysplastic syndromes: correlation with bone marrow microvascular density
    M G Alexandrakis
    Department of Hematology, University Hospital of Heraklion, Crete, Greece
    Int J Immunopathol Pharmacol 18:287-95. 2005
    ....
  8. ncbi request reprint The assessment of proliferating cell nuclear antigen immunostaining in myelodysplastic syndromes and its prognostic significance
    M G Alexandrakis
    Department of Hematology, University Hospital of Heraklion, P O BOX 1352 Heraklion, Crete, Greece
    Eur J Histochem 49:27-32. 2005
    ..001). We conclude that elevated PCNA PI and TNF-a serum levels are increased in high risk myelodysplastic disease and that a high PCNA PI is predictive of a shorter survival in this group of patients...
  9. ncbi request reprint Bone marrow microvascular density and angiogenic growth factors in multiple myeloma
    Michael G Alexandrakis
    Department of Hematology, University Hospital of Heraklion, Crete, Greece
    Clin Chem Lab Med 42:1122-6. 2004
    ..We conclude that angiogenesis in MM, as expressed by the bone marrow MVD and the serum levels of angiogenic molecules such as HGF and TNF-alpha, increases with advancing clinical stage and decreases after effective chemotherapy...
  10. ncbi request reprint Relation between bone marrow angiogenesis and serum levels of angiogenin in patients with myelodysplastic syndromes
    Michael G Alexandrakis
    Department of Haematology, University Hospital of Heraklion, Medical School of Crete, P O Box 1352, Heraklion, Crete, Greece
    Leuk Res 29:41-6. 2005
    ..001) and also between MVD and IL-6 (P < 0.05). Using multivariate analysis, only IL-6 displayed independent prognostic value and was inversely related to MDS survival...
  11. ncbi request reprint Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma
    M G Alexandrakis
    Department of Hematology, University Hospital of Heraklion, P O BOX 1352 Heraklion, Crete, Greece
    Ann Hematol 82:19-23. 2003
    ..These molecules correlate with biochemical markers of disease activity and may play a role in the progression of multiple myeloma...
  12. ncbi request reprint Elevated serum concentration of hepatocyte growth factor in patients with multiple myeloma: correlation with markers of disease activity
    M G Alexandrakis
    Division of Medicine, University Hospital of Heraklion, Crete, Greece
    Am J Hematol 72:229-33. 2003
    ..However, an independent association of HGF with bone turnover markers was not shown in this study, thus its role in MM bone disease needs to be further clarified...
  13. ncbi request reprint Effect of different levels of pressure support and proportional assist ventilation on breathing pattern, work of breathing and gas exchange in mechanically ventilated hypercapnic COPD patients with acute respiratory failure
    F Passam
    Pulmonary Department, University Hospital of Heraklion, Heraklion, Crete, Greece
    Respiration 70:355-61. 2003
    ....
  14. ncbi request reprint Interleukin-18 in multiple myeloma patients: serum levels in relation to response to treatment and survival
    M G Alexandrakis
    Division of Medicine, University Hospital of Heraklion, Medical School of Crete, PO Box 1352, Crete, Greece
    Leuk Res 28:259-66. 2004
    ..We conclude that increased serum IL-18 in myeloma patients correlates with advanced disease, increased levels of angiogenic cytokines and worse survival...
  15. ncbi request reprint Serum level of interleukin-16 in multiple myeloma patients and its relationship to disease activity
    Michael G Alexandrakis
    Department of Haematology, University Hospital of Heraklion, Crete, Greece
    Am J Hematol 75:101-6. 2004
    ..In the pre-treatment group, IL-16 correlated with alpha1AT and IL-6 (r=0.374, P<0.01 and r=0.454, P<0.002, respectively). IL-16 may play a role in multiple myeloma; however, further functional studies are required...
  16. pmc The relation between bone marrow angiogenesis and the proliferation index Ki-67 in multiple myeloma
    M G Alexandrakis
    Department of Haematology, University Hospital of Heraklion, PO Box 1352, 71110, Heraklion, Crete, Greece
    J Clin Pathol 57:856-60. 2004
    ..This study investigated the association between microvascular density (MVD) and the Ki-67 proliferation index (Ki-67 PI), bone marrow infiltration, and C reactive protein (CRP) in patients with multiple myeloma...
  17. ncbi request reprint Clinical significance of circulating endothelial adhesion molecules (sE-selectin and sICAM) in untreated multiple myeloma patients
    Michael G Alexandrakis
    Department of Haematology, Division of Medicine, Medical School of Crete, P O Box 1352, Heraklion, Crete, Greece
    Clin Chim Acta 349:39-43. 2004
    ..In the current study, serum soluble adhesion molecules (sICAM-1 and sE-selectin) were measured in untreated multiple myeloma (MM) patients in relation with other markers of disease activity. MATERIALS and..
  18. ncbi request reprint Systemic levels of interleukin-6 and matrix metalloproteinase-9 in patients with multiple myeloma may be useful as prognostic indexes of bone disease
    Aikaterini Sfiridaki
    Blood Bank Center, Venizelion General Hospital Heraklion, Crete, Greece
    Clin Chem Lab Med 43:934-8. 2005
    ..03, p<0.003, p<0.002, p<0.003 and p<0.001, respectively). Levels of MMP-9 and of IL-6 in multiple myeloma correlate well with bone turnover rate and may be useful in disease evaluation...
  19. doi request reprint The significance of non correlation between interleukin-8 serum levels with bone marrow microvascular density in patients with myeloma multiple
    Constantina A Pappa
    Hematology Department, Venizelion Hospital of Heraklion, Knossou Avenue, zip code 71409, Heraklion, Greece
    Pathol Oncol Res 19:539-43. 2013
    ..The lack of correlation between IL-8 with MVD suggests that its levels represent the inflammatory element of MM disease and the participation in angiogenesis process is rather complex with multifactorial mechanisms. ..