P P Sfikakis

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Regression of sight-threatening macular edema in type 2 diabetes following treatment with the anti-tumor necrosis factor monoclonal antibody infliximab
    Petros P Sfikakis
    First Department of Propedeutic Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Diabetes Care 28:445-7. 2005
  2. ncbi Age-related thymic activity in adults following chemotherapy-induced lymphopenia
    P P Sfikakis
    Athens University Medical School, Athens, Greece
    Eur J Clin Invest 35:380-7. 2005
  3. ncbi Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis
    P P Sfikakis
    First Department of Propedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Arthritis Rheum 56:1985-93. 2007
  4. doi Clonal expansion of B-cells in human systemic lupus erythematosus: evidence from studies before and after therapeutic B-cell depletion
    Petros P Sfikakis
    First Department of Propedeutic and Internal Medicine, Athens University Medical School, Laikon Hospital, Greece
    Clin Immunol 132:19-31. 2009
  5. doi The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions
    Petros P Sfikakis
    First Department of Propedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Curr Dir Autoimmun 11:180-210. 2010
  6. pmc Detection of subclinical synovial inflammation by microwave radiometry
    Evangelia Zampeli
    First Department of Propedeutic and Internal Medicine, Athens University Medical School, Athens, Greece
    PLoS ONE 8:e64606. 2013
  7. ncbi Increased levels of soluble TNF-like cytokine 1A in ankylosing spondylitis
    Maria Konsta
    First Department of Propaedeutic and Internal Medicine, Medical School, University of Athens, Athens, Greece
    Rheumatology (Oxford) 52:448-51. 2013
  8. pmc Predictors of new atherosclerotic carotid plaque development in patients with rheumatoid arthritis: a longitudinal study
    Evangelia Zampeli
    First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Ag Thoma, 17, GR 11527 Athens, Greece
    Arthritis Res Ther 14:R44. 2012
  9. doi Subclinical femoral atheromatosis in rheumatoid arthritis: comparable prevalence to diabetes mellitus in a case-control study
    Athanase Protogerou
    First Department of Propaedeutic and Internal Medicine, Medical School, University of Athens, Laikon Hospital, Ag Thoma, 17, 11527 Athens, Greece
    Ann Rheum Dis 71:1534-6. 2012
  10. pmc The diagnostic value of ultrasonography-derived edema of the temporal artery wall in giant cell arteritis: a second meta-analysis
    Aikaterini Arida
    First Department of Propedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    BMC Musculoskelet Disord 11:44. 2010

Detail Information

Publications82

  1. ncbi Regression of sight-threatening macular edema in type 2 diabetes following treatment with the anti-tumor necrosis factor monoclonal antibody infliximab
    Petros P Sfikakis
    First Department of Propedeutic Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Diabetes Care 28:445-7. 2005
  2. ncbi Age-related thymic activity in adults following chemotherapy-induced lymphopenia
    P P Sfikakis
    Athens University Medical School, Athens, Greece
    Eur J Clin Invest 35:380-7. 2005
    ..We examined whether thymic activity contributes to reconstitution of the peripheral T-cell pool, a critical process for patients recovering from antineoplastic therapy...
  3. ncbi Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis
    P P Sfikakis
    First Department of Propedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Arthritis Rheum 56:1985-93. 2007
    ..Our goal was to test the hypothesis that treatment with the oral endothelin receptor antagonist bosentan might improve vascular endothelial function in SSc patients...
  4. doi Clonal expansion of B-cells in human systemic lupus erythematosus: evidence from studies before and after therapeutic B-cell depletion
    Petros P Sfikakis
    First Department of Propedeutic and Internal Medicine, Athens University Medical School, Laikon Hospital, Greece
    Clin Immunol 132:19-31. 2009
    ..Since clonal expansion may lead to preferential survival/growth of potentially autoreactive B-cells further studies are warranted, especially as therapies aiming to reduce B-cell survival emerge...
  5. doi The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions
    Petros P Sfikakis
    First Department of Propedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Curr Dir Autoimmun 11:180-210. 2010
    ..It is hoped that more efficacious drugs that will ideally target the deleterious proinflammatory properties of TNF without compromising its protective role in host defense and (auto)immunity will be available in the near future...
  6. pmc Detection of subclinical synovial inflammation by microwave radiometry
    Evangelia Zampeli
    First Department of Propedeutic and Internal Medicine, Athens University Medical School, Athens, Greece
    PLoS ONE 8:e64606. 2013
    ....
  7. ncbi Increased levels of soluble TNF-like cytokine 1A in ankylosing spondylitis
    Maria Konsta
    First Department of Propaedeutic and Internal Medicine, Medical School, University of Athens, Athens, Greece
    Rheumatology (Oxford) 52:448-51. 2013
    ..To determine the expression of soluble TNF-like cytokine 1A (sTL1A), a new member of the TNF superfamily, in patients with AS...
  8. pmc Predictors of new atherosclerotic carotid plaque development in patients with rheumatoid arthritis: a longitudinal study
    Evangelia Zampeli
    First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Ag Thoma, 17, GR 11527 Athens, Greece
    Arthritis Res Ther 14:R44. 2012
    ..We assessed longitudinally the factors associated with new carotid plaques in nondiabetic RA patients and apparently healthy individuals...
  9. doi Subclinical femoral atheromatosis in rheumatoid arthritis: comparable prevalence to diabetes mellitus in a case-control study
    Athanase Protogerou
    First Department of Propaedeutic and Internal Medicine, Medical School, University of Athens, Laikon Hospital, Ag Thoma, 17, 11527 Athens, Greece
    Ann Rheum Dis 71:1534-6. 2012
    ..The presence of atheromatic plaques in femoral arteries of RA patients without DM was compared with with DM patients...
  10. pmc The diagnostic value of ultrasonography-derived edema of the temporal artery wall in giant cell arteritis: a second meta-analysis
    Aikaterini Arida
    First Department of Propedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    BMC Musculoskelet Disord 11:44. 2010
    ..We specifically re-examined the diagnostic value of the ultrasonography-derived halo sign, a dark hypoechoic circumferential thickening around the artery lumen, indicating vasculitic wall edema, in GCA...
  11. pmc Interrelated modulation of endothelial function in Behcet's disease by clinical activity and corticosteroid treatment
    Athanase D Protogerou
    Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Medical School, University of Athens, V, Sofias, 115 28, Athens, Greece
    Arthritis Res Ther 9:R90. 2007
    ....
  12. pmc Colour duplex sonography of temporal arteries before decision for biopsy: a prospective study in 55 patients with suspected giant cell arteritis
    Maria Karahaliou
    Radiology Department, Laikon Hospital, 17 Agiou Thoma Street, Athens, 11527, Greece
    Arthritis Res Ther 8:R116. 2006
    ..Biopsy is not necessary in a substantial proportion of patients in whom bilateral halo signs can be found by CDS...
  13. doi Sleep disturbances and interleukin 6 receptor inhibition in rheumatoid arthritis
    Kalliopi Fragiadaki
    Athens University Medical School, 17 Ag Thoma str, 11527, Athens, Greece
    J Rheumatol 39:60-2. 2012
    ..In this pilot study we examined whether administration of the IL-6 receptor antagonist tocilizumab in patients with rheumatoid arthritis (RA) affects sleep disturbances...
  14. pmc Infliximab for diabetic macular edema refractory to laser photocoagulation: a randomized, double-blind, placebo-controlled, crossover, 32-week study
    Petros P Sfikakis
    First Department of Propaedeutic and Internal Medicine, Laiko General Hospital, Athens, Greece
    Diabetes Care 33:1523-8. 2010
    ..Based on encouraging preliminary findings, we aimed to assess efficacy and safety of the anti-tumor necrosis factor (TNF) monoclonal antibody infliximab in this condition...
  15. ncbi Rituximab anti-B-cell therapy in systemic lupus erythematosus: pointing to the future
    Petros P Sfikakis
    First Department of Propedeutic and Internal Medicine, Athens University Medical School, Greece
    Curr Opin Rheumatol 17:550-7. 2005
    ..To discuss the clinical effects and the immunologic consequences of transient B-cell depletion using the anti-CD20 monoclonal antibody rituximab in systemic lupus erythematosus...
  16. ncbi Psoriasis induced by anti-tumor necrosis factor therapy: a paradoxical adverse reaction
    P P Sfikakis
    Athens University Medical School, Greece
    Arthritis Rheum 52:2513-8. 2005
    ..The interpretation of this paradoxical side effect of anti-TNF therapy remains unclear but may relate to altered immunity induced by the inhibition of TNF activity in predisposed individuals...
  17. ncbi Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial
    P P Sfikakis
    Athens University Medical School, Athens, Greece
    Arthritis Rheum 52:501-13. 2005
    ..This open-label study was undertaken to evaluate the efficacy of the anti-CD20 monoclonal antibody rituximab in the treatment of lupus nephritis...
  18. pmc Behçet's disease: a new target for anti-tumour necrosis factor treatment
    P P Sfikakis
    First Department of Propaedeutic Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Ann Rheum Dis 61:ii51-3. 2002
    ..At least three open, long term studies, including larger numbers of patients are currently being conducted...
  19. ncbi Tumor necrosis factor biology in experimental and clinical arthritis
    Petros P Sfikakis
    First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Curr Opin Rheumatol 15:380-6. 2003
    ....
  20. ncbi Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis
    P P Sfikakis
    First Department of Propedeutic and Internal Medicine, Athens University Medical School, 3, Amaryllidos Str, 15452, Athens, Greece
    Clin Immunol 123:66-73. 2007
    ..Further studies should examine whether modulation of Tregs by therapeutic B cell depletion contributes and/or predicts lupus disease remission...
  21. ncbi Anti-TNF therapy in the management of Behcet's disease--review and basis for recommendations
    P P Sfikakis
    Athens University, Greece
    Rheumatology (Oxford) 46:736-41. 2007
  22. ncbi Circulating P- and L-selectin and T-lymphocyte activation and patients with autoimmune rheumatic diseases
    P P Sfikakis
    First Department of Propedeutic Medicine, Laikon Hospital, Athens University Medical School, Greece
    Clin Rheumatol 18:28-32. 1999
    ..The possible clinical value of quantitation of circulating P-selectin in patients with RA and SSc on the one hand, and L-selectin in patients with SLE on the other, should be investigated by prospective studies...
  23. ncbi Effects of 2-chlorodeoxyadenosine and gold sodium thiomalate on human bcl-2 gene expression
    P P Sfikakis
    First Dept. of Propedeutic Medicine-Laikon Hospital, Athens, Greece
    Immunopharmacol Immunotoxicol 20:63-77. 1998
    ....
  24. ncbi B-cell kinase lyn deficiency in patients with systemic lupus erythematosus
    S N Liossis
    First Department of Propedeutic Medicine, Athens University Medical School, Laikon Hospital, Greece
    J Investig Med 49:157-65. 2001
    ....
  25. ncbi Gene-specific formation and repair of DNA monoadducts and interstrand cross-links after therapeutic exposure to nitrogen mustards
    Vassilis L Souliotis
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, Athens, Greece
    Clin Cancer Res 9:4465-74. 2003
    ..To investigate the possibility of measuring the gene-specific DNA damage after therapeutic exposure to nitrogen mustards and to examine its relationship with the clinical response...
  26. doi Myocardial performance and aortic elasticity are impaired in patients with ankylosing spondylitis
    I Moyssakis
    Cardiology Department, Laiko General Hospital, Athens, Greece
    Scand J Rheumatol 38:216-21. 2009
    ..To measure aortic stiffness and global left ventricular (LV) function in patients with ankylosing spondylitis (AS) and no clinical evidence of heart disease...
  27. ncbi Abnormal spatial QRS-T angle, a marker of ventricular repolarisation, predicts serious ventricular arrhythmia in systemic sclerosis
    E Gialafos
    First Department of Propaedeutic and Internal Medicine, Athens University Medical School, Greece
    Clin Exp Rheumatol 30:327-31. 2012
    ..We examined whether spQRS-Ta is abnormal in asymptomatic SSc patients and assessed its predictive value for possibly concurrent, serious ventricular arrhythmia...
  28. doi A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis
    A D Protogerou
    First Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laikon Hospital, Ag Thoma 17, 11527 Athens, Greece
    Atherosclerosis 219:734-6. 2011
    ..7 ± 1.3 to 7.0 ± 1.0m/s (p < 0.001). Whether these beneficial arterial changes are direct effects of the IL-6/IL-6 receptor pathway inhibition, maintained over time and translate into better clinical outcome warrants further studies...
  29. ncbi Tuberculosis and granuloma formation in patients receiving anti-TNF therapy
    A Iliopoulos
    Department of Rheumatology, Army General Hospital of Athens, Athens, Greece
    Int J Tuberc Lung Dis 10:588-90. 2006
    ..The notion of granuloma-free TB in patients receiving anti-TNF therapy could shift a clinician's path away from performing a biopsy, thus delaying the establishment of a correct diagnosis...
  30. ncbi Glucocorticoid effects on myocardial performance in patients with systemic sclerosis
    L Antoniades
    Department of Therapeutics, Athens University Medical School, Alexandra Hospital, Greece
    Clin Exp Rheumatol 19:431-7. 2001
    ....
  31. doi Association between transcriptional activity, local chromatin structure, and the efficiencies of both subpathways of nucleotide excision repair of melphalan adducts
    Hara Episkopou
    Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Cancer Res 69:4424-33. 2009
    ..In conclusion, a continuous, parallel variation of the state of transcription and local chromatin condensation, on one hand, and the rates of both GGR and TCR, on the other hand, have been shown...
  32. ncbi Adhesion and lymphocyte costimulatory molecules in systemic rheumatic diseases
    P P Sfikakis
    First Department of Propedeutic Medicine, Athens University Medical School, Greece
    Clin Rheumatol 18:317-27. 1999
    ....
  33. ncbi Infliximab treatment-induced formation of autoantibodies is common in Behçet's disease
    A Elezoglou
    Department of Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Clin Exp Rheumatol 25:S65-9. 2007
    ..To study autoantibody formation in patients with Behçet's disease (BD) who received long-term treatment with the anti-TNF monoclonal antibody infliximab...
  34. ncbi The incidence of irreversible retinal toxicity in patients treated with hydroxychloroquine: a reappraisal
    Ioannis Mavrikakis
    Department of Ophthalmology, Athens Eye Hospital, Athens, Greece
    Ophthalmology 110:1321-6. 2003
    ..To define the risk of hydroxychloroquine (HCQ)-related retinal toxicity in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) who are receiving recommended dosages of the drug (< or =6.5 mg/kg/day)...
  35. doi Absence of radiographic progression of hip arthritis during infliximab treatment for ankylosing spondylitis
    M Konsta
    First Department of Propaedeutic and Internal Medicine, Athens University Medical School, Athens, Greece
    Clin Rheumatol 32:1229-32. 2013
    ..59 ± 0.79 mm) was not reduced. These results suggest that radiographic progression of hip arthritis in ankylosing spondylitis may be arrested during infliximab treatment...
  36. ncbi Adjunctive anakinra in patients with active rheumatoid arthritis despite methotrexate, or leflunomide, or cyclosporin-A monotherapy: a 48-week, comparative, prospective study
    G Karanikolas
    First Department of Propedeutic and Internal Medicine, Laiko Hospital, Athens, Greece
    Rheumatology (Oxford) 47:1384-8. 2008
    ..To assess the efficacy and safety of anakinra (ANK) as an add-on therapy in RA patients with inadequate response to monotherapy with non-biological DMARDs...
  37. doi Thoracoabdominal motion in ankylosing spondylitis: association with standardised clinical measures and response to therapy
    G E Tzelepis
    Department of Pathophysiology, University of Athens Medical School, Greece
    Ann Rheum Dis 68:966-71. 2009
    ....
  38. ncbi Melphalan-induced DNA damage in vitro as a predictor for clinical outcome in multiple myeloma
    Meletios A Dimopoulos
    Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens, Greece
    Haematologica 92:1505-12. 2007
    ....
  39. ncbi Extent of damage and repair in the p53 tumor-suppressor gene after treatment of myeloma patients with high-dose melphalan and autologous blood stem-cell transplantation is individualized and may predict clinical outcome
    Meletios A Dimopoulos
    Department of Clinical Therapeutics, University of Athens School of Medicine, Greece
    J Clin Oncol 23:4381-9. 2005
    ..To quantitate the individual levels of melphalan-induced DNA damage formation and repair in vivo and to search for possible correlations with clinical outcome in patients with multiple myeloma (MM)...
  40. doi Intravitreal administration of the anti-tumor necrosis factor agent infliximab for neovascular age-related macular degeneration
    Panagiotis G Theodossiadis
    Attikon University Hospital, 2nd Department of Ophthalmology, University of Athens, Athens, Greece
    Am J Ophthalmol 147:825-30, 830.e1. 2009
    ..To present our preliminary experience on intravitreal administration of an anti-tumor necrosis factor (TNF) monoclonal antibody for neovascular age-related macular degeneration (AMD)...
  41. pmc Expanding role of circulating adhesion molecules in assessing prognosis and treatment response in human immunodeficiency virus infection
    Nikolaos V Sipsas
    Department of Pathophysiology, Athens University Medical School, Mikras Asias 75, Athens, GR 115 27, Greece
    Clin Diagn Lab Immunol 11:996-1001. 2004
  42. doi Intravitreal administration of the anti-TNF monoclonal antibody infliximab in the rabbit
    Panagiotis G Theodossiadis
    2nd Department of Ophthalmology, Attikon University Hospital, University of Athens, Athens, Greece
    Graefes Arch Clin Exp Ophthalmol 247:273-81. 2009
    ..Since intravitreal injection (when available) is a substitute for systemic administration of various drugs targeting the eye, we aimed to evaluate the safety of intravitreal injection of infliximab in the rabbit eye...
  43. ncbi Regression of neovascular age-related macular degeneration following infliximab therapy
    Nikos N Markomichelakis
    Ocular Inflammation and Immunology Service, Gennimatas Hospital, Athens University Medical School, Athens, Greece
    Am J Ophthalmol 139:537-40. 2005
    ..To describe the effects of the antitumor necrosis factor (TNF) monoclonal antibody Infliximab systemic therapy on choroidal neovacularisation (CNV) secondary to age-related macular degeneration (AMD)...
  44. ncbi Progressive changes in chromatin structure and DNA damage response signals in bone marrow and peripheral blood during myelomagenesis
    M Gkotzamanidou
    1 Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA 2 Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
    Leukemia 28:1113-21. 2014
    ..0003). We conclude that progressive changes in chromatin structure, transcriptional activity and DDR pathways during myelomagenesis occur in malignant plasma cells and that these changes are also reflected in PBMCs. ..
  45. doi Circulating levels of TNF-like cytokine 1A correlate with the progression of atheromatous lesions in patients with rheumatoid arthritis
    G Bamias
    First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Medical School, Ethnikon and Kapodistriakon Univesity, Athens, Greece
    Clin Immunol 147:144-50. 2013
    ..026), or carotid and/or femoral arteries (P = 0.022). Dysregulated TL1A-induced signaling may be associated with risk for accelerated atherosclerosis in RA...
  46. ncbi Are clusters of patients with distinct clinical expression present in Behçet's disease?
    A Arida
    First Department of Propedeutic and Internal Medicine, Athens University Medical School, Athens, Greece
    Clin Exp Rheumatol 27:S48-51. 2009
    ..Herein, we searched for specific associations between each disease manifestation to all other manifestations in Greek patients with BD...
  47. ncbi Lung scintigraphy with nonspecific human immunoglobulin G ((99m)Tc-HIG) in the evaluation of pulmonary involvement in connective tissue diseases: correlation with pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT)
    Ch Kostopoulos
    Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
    Eur J Nucl Med Mol Imaging 35:343-51. 2008
    ..Our aim was the evaluation of technetium-labeled human polyclonal immunoglobulin G (HIG) lung scintigraphy in the early detection and assessment of the severity of the pulmonary involvement in CTD patients...
  48. ncbi Tamoxifen exerts testosterone-dependent and independent effects on thymic involution
    P P Sfikakis
    First Department of Propaedeutic Medicine, Athens University Medical School, Greece
    Int J Immunopharmacol 20:305-12. 1998
    ....
  49. ncbi Infliximab for chronic cystoid macular edema associated with uveitis
    Nikos N Markomichelakis
    Ocular Inflammation and Immunology Service, Department of Ophthalmology, Laikon Hospital, Athens University Medical School, Athens, Greece
    Am J Ophthalmol 138:648-50. 2004
    ..To assess the efficacy of the anti-TNF monoclonal antibody infliximab in uveitis patients without clinically evident ocular inflammation and impaired visual acuity because of chronic cystoid macular edema (CME)...
  50. ncbi Nocebo in fibromyalgia: meta-analysis of placebo-controlled clinical trials and implications for practice
    D D Mitsikostas
    Department of Neurology, Naval Hospital, Athens, Greece
    Eur J Neurol 19:672-80. 2012
    ..We examined AEs following placebo administration in RCTs for fibromyalgia (FM), a condition characterized by patients' poor medication adherence, which may affect outcome and/or increase healthcare costs...
  51. ncbi CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition
    C G Katsiari
    First Department of Propedeutic Medicine, Athens University Medical School, Laikon Hospital, Greece
    Lupus 11:370-8. 2002
    ..These findings indicate that, besides Ca2+/calcineurin-dependent mechanisms, other pathways are involved in the dysregulation of CD40L in SLE immune cells, dissection of which may have important therapeutic implications...
  52. ncbi Glutamate levels and activity of the T cell voltage-gated potassium Kv1.3 channel in patients with systemic lupus erythematosus
    C Poulopoulou
    Athens University Medical School, Athens, Greece
    Arthritis Rheum 58:1445-50. 2008
    ..3 channel activity in patients with systemic lupus erythematosus (SLE)...
  53. doi Orbital lobular panniculitis in Weber-Christian disease: sustained response to anti-TNF treatment and review of the literature
    Ioannis Mavrikakis
    Department of Ophthalmology, Metropolitan Hospital, Athens, Greece
    Surv Ophthalmol 55:584-9. 2010
    ..Depending on the stage of inflammation, Weber-Christian disease should be included in the differential diagnosis of both proptosis and enophthalmos. Anti-TNF antibodies can successfully treat patients at the early inflammatory stage...
  54. ncbi Tumor necrosis factor antagonists: preliminary evidence for an emerging approach in the treatment of ocular inflammation
    Panagiotis G Theodossiadis
    Second Department of Ophthalmology, Laikon Hospital, Athens University Medical School, Greece
    Retina 27:399-413. 2007
    ..Until such results are available, knowledge regarding the use of anti-TNF regimens in ophthalmology is incomplete. However, the preliminary evidence points to a growing optimism for targeting TNF in patients with ocular inflammation...
  55. ncbi Baseline osteocalcin levels and incident diabetes in a 3-year prospective study of high-risk individuals
    S Liatis
    First Department of Propaedeutic Medicine and Diabetes Center, Athens University Medical School, Laiko General Hospital, 17 Ag Thoma str, 11527 Athens, Greece Electronic address
    Diabetes Metab 40:198-203. 2014
    ..For this reason, the hypothesis that lower baseline osteocalcin plasma levels are associated with diabetes was prospectively tested...
  56. doi Effect of supine versus sitting position on noninvasive assessment of aortic pressure waveform: a randomized cross-over study
    D Vrachatis
    1 Hypertension Center and Cardiovascular Research Laboratory, 1st Department of Propaedeutic Medicine, Laiko Hospital Medical School, National and Kapodistrian University of Athens, Athens, Greece 2 Biomedical Engineering Unit, 1st Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    J Hum Hypertens 28:236-41. 2014
    ..Reduced PP amplification and SEVR were further observed in the supine position, due to increased pressure wave reflections (AIx). ..
  57. ncbi Hypersensitivity reactions to carboplatin administration are common but not always severe: a 10-year experience
    A Polyzos
    First Department of Propedeutic Medicine, Athens University Medical School, Laikon Hospital, Athens, Greece
    Oncology 61:129-33. 2001
    ..This is not the case when the intraperitoneal route of carboplatin administration is used when indicated...
  58. ncbi Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study
    P K Tsantoulis
    Department of Histology and Embryology, Molecular Carcinogenesis Group, School of Medicine, University of Athens, Athens, Greece
    Oncogene 27:3256-64. 2008
    ..CFSs were on average less flexible than nonfragile regions, contained more guanine-cytosine (GC) and Alu sequences. Importantly, regions with loss-of-heterozygosity were also less flexible and had a higher Alu percentage...
  59. doi Acute transverse myelitis and antiphospholipid antibodies in lupus. No evidence for anticoagulation
    C G Katsiari
    First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Eur J Neurol 18:556-63. 2011
    ..Registry creation of ATM in patients with SLE is needed to obtain more definite answers on the role of aPL in this condition...
  60. ncbi Aortic stiffness in systemic sclerosis is increased independently of the extent of skin involvement
    I Moyssakis
    Laikon Hospital, Department of Cardiology, 17 Agiou Thomas Street, GR 15727 Goudi, Athens, Greece
    Rheumatology (Oxford) 44:251-4. 2005
    ..To study the stiffness of large arteries in relation to the extent of skin and lung fibrosis, aortic distensibility was examined in patients with diffuse and limited systemic sclerosis (SSc)...
  61. ncbi The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: a reappraisal
    Christina G Katsiari
    1 st Department of Propedeutic and Internal Medicine, University of Athens Medical School, Athens, Greece
    Semin Arthritis Rheum 39:491-503. 2010
    ..To review current developments, regarding the pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus (SLE)...
  62. ncbi Cutaneous side effects of anti-tumor necrosis factor biologic therapy: a clinical review
    Aikaterini Evaggelia Moustou
    1st Department of Dermatology, Andreas Sygros Hospital, University of Athens Medical School, Athens, Greece
    J Am Acad Dermatol 61:486-504. 2009
    ..Anti-tumor necrosis factor (anti-TNF) biologic agents have been associated with a number of adverse events...
  63. doi Prolactin and preclinical atherosclerosis in menopausal women with cardiovascular risk factors
    George A Georgiopoulos
    Department of Therapeutics, Alexandra Hospital, Athens University Medical School, Greece
    Hypertension 54:98-105. 2009
    ..In contrast, no correlation was observed with other risk factors or surrogate markers of atherosclerosis. Prospective studies to assess whether prolactin is an additional hormone increasing cardiovascular risk are warranted...
  64. ncbi Successful treatment of refractory adult-onset Still's disease with infliximab. A prospective, non-comparative series of four patients
    Alexander Kokkinos
    First Propaedeutic Department of Internal Medicine, Laikon General Hospital, Athens University Medical School, 17 Ag Thoma st, 11527 Athens, Greece
    Clin Rheumatol 23:45-9. 2004
    ....
  65. ncbi Subclinical peripheral arterial disease in rheumatoid arthritis
    Kimon S Stamatelopoulos
    Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, 80, Vassilissis Sofias Ave, PO Box 11528, Athens, Greece
    Atherosclerosis 212:305-9. 2010
    ..Therefore in the present structural study we examined femoral versus carotid subclinical atherosclerosis in RA and controls...
  66. doi Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: a long-term prospective study
    John N Boletis
    Nephrology Department, Laikon Hospital, Athens, Greece
    Nephrol Dial Transplant 24:2157-60. 2009
    ..Subsequent to cyclophosphamide-based induction therapy of lupus nephritis, and despite maintenance chronic immunosuppressive treatment, many patients experience relapses...
  67. doi A single infliximab infusion vs corticosteroids for acute panuveitis attacks in Behçet's disease: a comparative 4-week study
    Nikos Markomichelakis
    Ophthalmology Department, Ocular Inflammation Immunology Service, General Hospital, Athens, Greece
    Rheumatology (Oxford) 50:593-7. 2011
    ..To compare a single infusion of the anti-TNF antibody infliximab vs CSs for acute panuveitis attacks in Behçet's disease (BD)...
  68. ncbi Expansion of CD8+ T cells that express low levels of the B cell-specific molecule CD20 in patients with multiple myeloma
    Ourania Katopodis
    Department of Therapeutics, Alexandra Hospital, Athens, Greece
    Br J Haematol 120:478-81. 2003
    ..Because expansion of these T cells may be related to disease status, further studies should investigate their potentially unique function in plasma cell dyscrasias...
  69. ncbi A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth
    Dimos D Mitsikostas
    Athens Naval Hospital, Department of Neurology, Headache Clinic, Athens, Greece
    Brain 127:1200-9. 2004
    ..These recommendations should be verified by a properly controlled and prospective study in both adult and paediatric populations...
  70. ncbi Aberrant expression of the costimulatory molecule CD40 ligand on monocytes from patients with systemic lupus erythematosus
    Christina G Katsiari
    First Department of Propedeutic Medicine, Athens University Medical School, Athens, Greece
    Clin Immunol 103:54-62. 2002
    ....
  71. doi Atherosclerosis in rheumatoid arthritis versus diabetes: a comparative study
    Kimon S Stamatelopoulos
    Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, 80, Vassilissis Sofias Ave, Athens, Greece
    Arterioscler Thromb Vasc Biol 29:1702-8. 2009
    ..The extent to which atherosclerosis is accelerated in chronic inflammatory diseases is not established. We compared preclinical atherosclerosis in rheumatoid arthritis with diabetes mellitus, a known coronary heart disease equivalent...
  72. pmc Levels of soluble CD40 ligand (CD154) in serum are increased in human immunodeficiency virus type 1-infected patients and correlate with CD4(+) T-cell counts
    Nikolaos V Sipsas
    Department of Pathophysiology, Laikon General Hospital and School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    Clin Diagn Lab Immunol 9:558-61. 2002
    ....
  73. ncbi Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis
    Giorgos Bamias
    First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Clin Immunol 129:249-55. 2008
    ..Treatment with an anti-TNF agent significantly decreased TL1A serum levels. We conclude that TL1A may serve as an inflammatory marker in RA. Interactions between TL1A and its receptors may be important in the pathogenesis of RA...
  74. ncbi Elevated serum levels of soluble immune activation markers are associated with increased risk for death in HAART-naive HIV-1-infected patients
    Nikolaos V Sipsas
    Department of Pathophysiology, Laikon General Hospital and School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    AIDS Patient Care STDS 17:147-53. 2003
    ..Further studies are needed to assess the effect of HAART on the levels of immune activation markers and their prognostic value...
  75. ncbi Costimulation blockade in the treatment of rheumatic diseases
    Stamatis Nick C Liossis
    Department of Medicine, Patras University Hospital, University of Patras Medical School, Patras, Greece
    BioDrugs 18:95-102. 2004
    ....
  76. ncbi Ophthalmologic monitoring for antimalarial toxicity
    Petros P Sfikakis
    J Rheumatol 31:1011-2; author reply 1012. 2004
  77. ncbi Preferential in vivo DNA repair of melphalan-induced damage in human genes is greatly affected by the local chromatin structure
    Vassilis L Souliotis
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vassileos Constantinou Ave, Athens 11635, Greece
    DNA Repair (Amst) 5:972-85. 2006
    ..To conclude, the in vivo gene-specific repair of melphalan-induced damage in humans is greatly affected by the local chromatin structure...
  78. doi Tumor necrosis factor inhibitors and uveitis: comment on the article by Lim et al
    Petros P Sfikakis
    Arthritis Rheum 58:1554-5; author reply 1556-7. 2008
  79. doi Rituximab-induced B cell depletion in autoimmune diseases: potential effects on T cells
    Stamatis Nick C Liossis
    Division of Rheumatology, Department of Internal Medicine, University of Patras Medical School, 26504 Rion, Patras, Greece
    Clin Immunol 127:280-5. 2008
    ..Further controlled studies are needed to confirm the role of B cell depletion in modifying T cell function in vivo...
  80. ncbi Intra- and intercellular variations in the repair efficiency of O6-methylguanine, and their contribution to kinetic complexity
    Vassilis L Souliotis
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vassileos Constantinou Ave, Athens 11635, Greece
    Mutat Res 568:155-70. 2004
    ..The additional cellular factors involved appear not to be related to the transcriptional state of the sequences being repaired, but may reflect different states of chromatin condensation...
  81. ncbi Treatment of small intestinal disease in systemic sclerosis with octreotide: a prospective study in seven patients
    George C Nikou
    Section of Gastroenterology, 1st Department of Propaedeutic Internal Medicine, Medical School, University of Athens, Greece
    J Clin Rheumatol 13:119-23. 2007
    ..Symptoms associated with small intestinal involvement in patients with systemic sclerosis (SSc) are usually severe and resistant to treatment...
  82. ncbi Treatment of pulmonary hypertension secondary to alveolar microlithiasis with Bosentan: a case report
    Elias J Gialafos
    Sarcoidosis Vasc Diffuse Lung Dis 22:237. 2005