Georgia Salanti

Summary

Affiliation: University of Ioannina
Country: Greece

Publications

  1. doi request reprint Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial
    Georgia Salanti
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Clin Epidemiol 64:163-71. 2011
  2. ncbi request reprint A nonparametric changepoint model for stratifying continuous variables under order restrictions and binary outcome
    Georgia Salanti
    Institute for Medical Statistics and Epidemiology, Klinikum rechts der Isar, Munich, Germany
    Stat Methods Med Res 12:351-67. 2003
  3. ncbi request reprint Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene-gene-environment interaction
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, U K
    Stat Med 25:4147-63. 2006
  4. pmc Meta-analysis and The Cochrane Collaboration: 20 years of the Cochrane Statistical Methods Group
    Joanne E McKenzie
    School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
    Syst Rev 2:80. 2013
  5. doi request reprint Characteristics of a loop of evidence that affect detection and estimation of inconsistency: a simulation study
    Areti Angeliki Veroniki
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina 45110, Greece
    BMC Med Res Methodol 14:106. 2014
  6. doi request reprint Evaluating novel agent effects in multiple-treatments meta-regression
    Georgia Salanti
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Med 29:2369-83. 2010
  7. doi request reprint A case study of multiple-treatments meta-analysis demonstrates that covariates should be considered
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    J Clin Epidemiol 62:857-64. 2009
  8. ncbi request reprint Meta-analysis of genetic association studies under different inheritance models using data reported as merged genotypes
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Med 27:764-77. 2008
  9. ncbi request reprint Bayesian meta-analysis and meta-regression for gene-disease associations and deviations from Hardy-Weinberg equilibrium
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    Stat Med 26:553-67. 2007
  10. doi request reprint Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer
    Davide Mauri
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Natl Cancer Inst 100:1780-91. 2008

Detail Information

Publications49

  1. doi request reprint Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial
    Georgia Salanti
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Clin Epidemiol 64:163-71. 2011
    ..To present some simple graphical and quantitative ways to assist interpretation and improve presentation of results from multiple-treatment meta-analysis (MTM)...
  2. ncbi request reprint A nonparametric changepoint model for stratifying continuous variables under order restrictions and binary outcome
    Georgia Salanti
    Institute for Medical Statistics and Epidemiology, Klinikum rechts der Isar, Munich, Germany
    Stat Methods Med Res 12:351-67. 2003
    ..An application will outline the benefit of using bivariate step functions in modelling...
  3. ncbi request reprint Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene-gene-environment interaction
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, U K
    Stat Med 25:4147-63. 2006
    ..The methodology is implemented in an original meta-analysis of studies relating the risk of bladder cancer to two N-acetyltransferase genes, NAT1 and NAT2, and smoking status...
  4. pmc Meta-analysis and The Cochrane Collaboration: 20 years of the Cochrane Statistical Methods Group
    Joanne E McKenzie
    School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
    Syst Rev 2:80. 2013
    ..Finally, we consider the importance of robust statistical methodology for Cochrane systematic reviews, note research gaps, and reflect on the challenges that the Statistical Methods Group faces in its future direction...
  5. doi request reprint Characteristics of a loop of evidence that affect detection and estimation of inconsistency: a simulation study
    Areti Angeliki Veroniki
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina 45110, Greece
    BMC Med Res Methodol 14:106. 2014
    ..However, the test is believed to be underpowered. We aim to evaluate its properties when applied to a loop typically found in published networks...
  6. doi request reprint Evaluating novel agent effects in multiple-treatments meta-regression
    Georgia Salanti
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Med 29:2369-83. 2010
    ....
  7. doi request reprint A case study of multiple-treatments meta-analysis demonstrates that covariates should be considered
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    J Clin Epidemiol 62:857-64. 2009
    ....
  8. ncbi request reprint Meta-analysis of genetic association studies under different inheritance models using data reported as merged genotypes
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Med 27:764-77. 2008
    ....
  9. ncbi request reprint Bayesian meta-analysis and meta-regression for gene-disease associations and deviations from Hardy-Weinberg equilibrium
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    Stat Med 26:553-67. 2007
    ..The proposed hierarchical models allow the synthesis of data across gene-disease association studies with appropriate consideration of HWE issues...
  10. doi request reprint Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer
    Davide Mauri
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Natl Cancer Inst 100:1780-91. 2008
    ..Many systemic nonhormonal regimens have been evaluated across several hundreds of randomized trials in advanced breast cancer. We aimed to quantify the relative merits of these regimens in prolonging survival...
  11. pmc Graphical tools for network meta-analysis in STATA
    Anna Chaimani
    Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    PLoS ONE 8:e76654. 2013
    ..To this end, we provide a set of STATA routines that can be easily employed to present the evidence base, evaluate the assumptions, fit the network meta-analysis model and interpret its results. ..
  12. ncbi request reprint A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
    ..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
  13. pmc Family-based versus unrelated case-control designs for genetic associations
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS Genet 2:e123. 2006
    ..Conclusions were largely similar in diverse subgroup analyses. Unrelated case-control and family-based designs give overall similar estimates of association. We cannot rule out rare large biases or common small biases...
  14. doi request reprint Effects of study precision and risk of bias in networks of interventions: a network meta-epidemiological study
    Anna Chaimani
    Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece, Department of Orthopaedics, School of Medicine, University of Ioannina, Ioannina, Greece, Molecular Cell Biology and Regenerative Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Department of Orthodontics and Dentofacial Orthopedics, Dental School, Medical Faculty, University of Bern, Bern, Switzerland, Private Practice, Corfu, Greece, Center for Evidence Based Medicine and Department of Biostatistics, Program in Public Health, Brown University, Providence, RI, USA and School of Social and Community Medicine, University of Bristol, Bristol, UK
    Int J Epidemiol 42:1120-31. 2013
    ..Small studies give generally imprecisely estimated treatment effects, and study variance can serve as a surrogate for study size...
  15. doi request reprint Evaluation of inconsistency in networks of interventions
    Areti Angeliki Veroniki
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Int J Epidemiol 42:332-45. 2013
    ..No evidence exists so far regarding the extent of inconsistency in full networks of interventions or the factors that control its statistical detection...
  16. doi request reprint Evaluating the impact of imputations for missing participant outcome data in a network meta-analysis
    Loukia M Spineli
    Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, University Campus, Ioannina, Greece
    Clin Trials 10:378-88. 2013
    ..IMORs also account for the increased uncertainty due to missingness in the meta-analysis results...
  17. ncbi request reprint Evaluation of networks of randomized trials
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    Stat Methods Med Res 17:279-301. 2008
    ..Finally, we discuss the implications of inconsistency, network geometry and asymmetry in informing the planning of future trials...
  18. doi request reprint Synthesis of observational studies should consider credibility ceilings
    Georgia Salanti
    The Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina, School of Medicine, Ioannina, Greece
    J Clin Epidemiol 62:115-22. 2009
    ..Meta-analyses of observational studies often get spuriously precise results. We aimed to factor this skepticism in meta-analysis calculations...
  19. doi request reprint Allowing for uncertainty due to missing continuous outcome data in pairwise and network meta-analysis
    Dimitris Mavridis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece Department of Primary Education, University of Ioannina, Ioannina, Greece
    Stat Med 34:721-41. 2014
    ..We apply the methodology to examples of both pairwise and network meta-analysis with multi-arm trials. © 2014 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd. ..
  20. pmc Characteristics of networks of interventions: a description of a database of 186 published networks
    Adriani Nikolakopoulou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS ONE 9:e86754. 2014
    ..Reviewers and editors need to be aware of these assumptions and insist on their reporting and accuracy. ..
  21. doi request reprint The impact of trial characteristics on premature discontinuation of antipsychotics in schizophrenia
    Loukia M Spineli
    Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, University Campus, Ioannina, Greece
    Eur Neuropsychopharmacol 23:1010-6. 2013
    ..This research sought to identify trial characteristics that have an impact on premature discontinuation in antipsychotic trials for schizophrenia...
  22. ncbi request reprint Survival and disease-progression benefits with treatment regimens for advanced colorectal cancer: a meta-analysis
    Vassilis Golfinopoulos
    Division of Medical Oncology, University of Ioannina School of Medicine, Ioannina, Greece
    Lancet Oncol 8:898-911. 2007
    ..The aim of our study was to estimate the magnitude of survival and disease progression benefits with the use of different regimens in patients with advanced colorectal cancer...
  23. ncbi request reprint Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations
    Thomas A Trikalinos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45100, Greece
    Am J Epidemiol 163:300-9. 2006
    ..Postulated genetic associations with modest-sized odds ratios and borderline statistical significance may not be robust in such sensitivity analyses...
  24. doi request reprint Joint synthesis of multiple correlated outcomes in networks of interventions
    Orestis Efthimiou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, 1186 Ioannina 45110, Greece
    Biostatistics 16:84-97. 2015
    ..Both multiple-outcomes NMA models produce narrower confidence intervals compared with independent, univariate network meta-analyses for each outcome and have an impact on the relative ranking of the treatments. ..
  25. doi request reprint A selection model for accounting for publication bias in a full network meta-analysis
    Dimitris Mavridis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece Department of Primary Education, University of Ioannina, Ioannina, Greece
    Stat Med 33:5399-412. 2014
    ..We illustrate the methodology using a published triangular network for the failure of vascular graft or arterial patency...
  26. doi request reprint A fully Bayesian application of the Copas selection model for publication bias extended to network meta-analysis
    Dimitris Mavridis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Med 32:51-66. 2013
    ..To derive prior distributions, we use both external data and an elicitation process of expert opinion...
  27. doi request reprint Addressing missing outcome data in meta-analysis
    Dimitris Mavridis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece Department of Primary Education, University of Ioannina, Ioannina, Greece
    Evid Based Ment Health 17:85-9. 2014
    ..Most statistical analyses assume missing data to be missing at random, which is an unverifiable assumption. The aim of this paper is to present methods used to account for missing outcome data in a systematic review and meta-analysis...
  28. doi request reprint Initial orthodontic alignment effectiveness with self-ligating and conventional appliances: a network meta-analysis in practice
    Nikolaos Pandis
    Private Practice, Corfu, Greece Assistant Professor, Department of Orthodontics and Dentofacial Orthopedics, Dental School, Medical Faculty, University of Bern, Bern, Switzerland PhD candidate, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    Am J Orthod Dentofacial Orthop 145:S152-63. 2014
    ..In this article, the network meta-analysis approach is introduced in a nontechnical manner using a worked example on the treatment effectiveness of conventional and self-ligating appliances. ..
  29. pmc Evaluating the quality of evidence from a network meta-analysis
    Georgia Salanti
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS ONE 9:e99682. 2014
    ..The proposed framework can be used to determine confidence in the results from a network meta-analysis. Judgements about evidence from a network meta-analysis can be different from those made about evidence from pairwise meta-analyses. ..
  30. doi request reprint A practical introduction to multivariate meta-analysis
    Dimitris Mavridis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Methods Med Res 22:133-58. 2013
    ..The various model-fitting options are illustrated in two examples and specific guidance is provided on how to run a multivariate meta-analysis using various software packages...
  31. doi request reprint Network meta-analysis models to account for variability in treatment definitions: application to dose effects
    Cinzia Del Giovane
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Med 32:25-39. 2013
    ..The proposed approach can be a useful exploratory tool to explain sources of heterogeneity and inconsistency when there is doubt whether similar interventions should be grouped under the same node...
  32. ncbi request reprint Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge University, Cambridge, UK
    Eur J Hum Genet 13:840-8. 2005
    ..Moreover, power is limited for HWE testing in most current genetic association studies...
  33. doi request reprint A hands-on practical tutorial on performing meta-analysis with Stata
    Anna Chaimani
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Evid Based Ment Health 17:111-6. 2014
    ..We address the three topics covered in the previous issues of the journal, focusing on their implementation in Stata using a working example from mental health research. ..
  34. doi request reprint Using conditional power of network meta-analysis (NMA) to inform the design of future clinical trials
    Adriani Nikolakopoulou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina, 45110, Greece
    Biom J 56:973-90. 2014
    ..Our methodology can help investigators calculate the required sample size under different assumptions about heterogeneity and make decisions about the number and design of future studies (set of treatments compared). ..
  35. doi request reprint Accounting for uncertainty due to 'last observation carried forward' outcome imputation in a meta-analysis model
    Vasiliki Dimitrakopoulou
    Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    Stat Med 34:742-52. 2014
    ..Our method can be regarded as a useful sensitivity analysis that can be used in the presence of concerns about the LOCF process. Copyright © 2014 JohnWiley & Sons, Ltd. ..
  36. doi request reprint Demystifying fixed and random effects meta-analysis
    Adriani Nikolakopoulou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Evid Based Ment Health 17:53-7. 2014
    ..The aim of this paper was to explain the assumptions underlying each model and their implications in the interpretation of summary results...
  37. doi request reprint How to interpret meta-analysis models: fixed effect and random effects meta-analyses
    Adriani Nikolakopoulou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Evid Based Ment Health 17:64. 2014
    ..The observed effect sizes are synthesised to obtain a summary treatment effect via meta-analysis. ..
  38. pmc Underlying genetic models of inheritance in established type 2 diabetes associations
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    Am J Epidemiol 170:537-45. 2009
    ..Information on the genetic model of robustly replicated association signals derived from genome-wide association studies may be useful for predictive modeling and for designing biologic and functional experiments...
  39. doi request reprint Autologous chondrocyte implantation for the treatment of cartilage lesions of the knee: a systematic review of randomized studies
    Haris S Vasiliadis
    Department of Orthopaedics, School of Medicine, University of Ioannina, Orthopaedic Sports Medicine Center, Ioannina, Greece
    Knee Surg Sports Traumatol Arthrosc 18:1645-55. 2010
    ..However, there is insufficient data to say whether ACI is superior to other treatment strategies. More high quality studies and harmonization in the reported outcomes are needed before specific suggestions for practice can be made...
  40. doi request reprint Exploring and accounting for publication bias in mental health: a brief overview of methods
    Dimitris Mavridis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Evid Based Ment Health 17:11-5. 2014
    ..Selection models, although underused, could be useful resource when publication bias and heterogeneity are suspected because they address directly the problem of publication bias and not that of small-study effects...
  41. doi request reprint Endoscopic release for carpal tunnel syndrome
    Haris S Vasiliadis
    Department of Orthopaedics, University of Ioannina, Ioannina, Greece
    Cochrane Database Syst Rev 1:CD008265. 2014
    ..Surgical treatment consists of the release of the nerve by cutting the transverse carpal ligament. This can be done either with an open approach or endoscopically...
  42. ncbi request reprint Obstacles and opportunities in meta-analysis of genetic association studies
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    Genet Med 7:13-20. 2005
    ..We believe that systematic review and meta-analysis has an important role to play in understanding genetic association studies and should help us to separate the wheat from the chaff...
  43. ncbi request reprint A network of investigator networks in human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 162:302-4. 2005
    ....
  44. pmc A non-parametric framework for estimating threshold limit values
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    BMC Med Res Methodol 5:36. 2005
    ..To estimate a threshold limit value for a compound known to have harmful health effects, an 'elbow' threshold model is usually applied. We are interested on non-parametric flexible alternatives...
  45. doi request reprint Homophily and co-occurrence patterns shape randomized trials agendas: illustration in antifungal agents
    Evangelos C Rizos
    Department of Internal Medicine, University Hospital of Ioannina, Ioannina, Greece
    J Clin Epidemiol 64:830-42. 2011
    ..To assess whether there are preferences and avoidances for specific comparisons in a clinical trials agenda...
  46. ncbi request reprint Exploring the geometry of treatment networks
    Georgia Salanti
    University of Ioannina School of Medicine, Ioannina, Greece
    Ann Intern Med 148:544-53. 2008
    ..Several treatment options exist for many conditions. Randomized trial evidence on the relative merits of various options may be missing or biased...
  47. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  48. ncbi request reprint Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis
    Simon Sanderson
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Am J Epidemiol 166:741-51. 2007
    ..73 (95% CI: 1.70, 4.31). The importance of considering joint effects between genetic and environmental factors in the etiology of common complex diseases is underlined...
  49. ncbi request reprint The emergence of networks in human genome epidemiology: challenges and opportunities
    Daniela Seminara
    Epidemiology and Genetics Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, EPN Bldg, Rm 5142, MSC 7393, 6130 Executive Blvd, Bethesda, MD 20892, USA
    Epidemiology 18:1-8. 2007