Research Topics
Genomes and GenesSpecies | Panos RoussosSummaryAffiliation: University of Crete Country: Greece Publications
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Detail Information
Publications
Planning, decision-making and the COMT rs4818 polymorphism in healthy malesPanos Roussos
Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Crete, Greece
Neuropsychologia 46:757-63. 2008..While high prefrontal dopamine levels may be advantageous for non-emotional problem solving, they lead to disadvantageous choices when decision-making depends on processing of emotional feedback...
The association of schizophrenia risk D-amino acid oxidase polymorphisms with sensorimotor gating, working memory and personality in healthy malesPanos Roussos
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
Neuropsychopharmacology 36:1677-88. 2011....
The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy malesPanos Roussos
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
Biol Psychiatry 69:479-86. 2011....- Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818c/g polymorphismPanos Roussos
Department of Psychiatry and Behavioral Sciences, University of Crete, Greece
Biol Psychiatry 66:997-1004. 2009..Here, we explored the effects of the synonymous COMT rs4818 C/G polymorphism and tolcapone on PPI and working memory... - A risk PRODH haplotype affects sensorimotor gating, memory, schizotypy, and anxiety in healthy male subjectsPanos Roussos
Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
Biol Psychiatry 65:1063-70. 2009..We assessed the relationship between these high-risk PRODH polymorphisms and schizophrenia-related endophenotypes in a large and highly homogeneous cohort of healthy males... - Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphismStella G Giakoumaki
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece
Neuropsychopharmacology 33:3058-68. 2008..These results suggest that early information processing and working memory may both depend on PFC DA signaling, and that they may both relate to PFC DA levels according to an inverted U-shaped curve function... - The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy malesPanos Roussos
Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
Bipolar Disord 13:250-9. 2011..The aim of this study was to examine the phenotypic consequences of the risk CACNA1C and ANK3 alleles in a large homogeneous cohort of healthy young males... - Cognitive and emotional processing associated with the Season of Birth and dopamine D4 receptor genePanos Roussos
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
Neuropsychologia 48:3926-33. 2010..SOB should be included in future studies of risky behaviors and behavioral genetic studies of the dopamine system... - Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteersVassilis Koudas
Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, P O Box 2208, Heraklion, 71003, Crete, Greece
Psychopharmacology (Berl) 205:1-9. 2009..The human pupil may be a suitable physiological test system for the assessment of excessive daytime sleepiness (EDS), but pupillometric assessment could be confounded by medication for comorbid hypertension and mood disorders... - Low baseline startle and deficient affective startle modulation in remitted bipolar disorder patients and their unaffected siblingsStella G Giakoumaki
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion 71003, Greece
Psychophysiology 47:659-68. 2010..Low startle and blunted startle reactivity may represent trait deficits in remitted BD patients and their relatives, possibly associated with attentional deficits and adaptive down-regulation of emotion... - The dopamine D(3) receptor Ser9Gly polymorphism modulates prepulse inhibition of the acoustic startle reflexPanos Roussos
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece
Biol Psychiatry 64:235-40. 2008..The Ser9Gly polymorphism is a common variant of the DRD(3) gene and determines the gain of function of the D(3) receptor. This is the first study to examine the influence of the DRD(3) Ser9Gly polymorphism on human PPI... - Cognitive and emotional processing in high novelty seeking associated with the L-DRD4 genotypePanos Roussos
Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
Neuropsychologia 47:1654-9. 2009..The proposed role of the NS phenotype in human evolution and in disorders of impulsivity is discussed under the light of the present findings... - Sustained attention and working memory deficits follow a familial pattern in schizophreniaStella G Giakoumaki
Department of Psychology, University of Crete, Rethymno, Greece
Arch Clin Neuropsychol 26:687-95. 2011..Reaction time and false alarm rates are suggested as additional useful endophenotypic measures that could potentially account for differences in performance in tasks that are not purported to examine the specific measures per se... - Disruption of prepulse inhibition of the startle reflex by the preferential D(3) agonist ropinirole in healthy malesStella G Giakoumaki
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, P O Box 2208, Heraklion, 71003, Crete, Greece
Psychopharmacology (Berl) 194:289-95. 2007..Emerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects... - Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophreniaPanos Bitsios
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, PO Box 2208, University of Crete, Heraklion 71003, Crete, Greece
Pharmacogenomics 12:559-66. 2011..It will soon be understood if tolcapone represents one of the first hypothesis-driven, biology-based, genotype-specific, targeted treatments of cognitive and negative symptoms of schizophrenia... - The 5-min pupillary alertness test is sensitive to modafinil: a placebo controlled study in patients with sleep apneaAlexandra Nikolaou
Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, P O Box 2208, Heraklion 71003, Crete, Greece
Psychopharmacology (Berl) 196:167-75. 2008..The extent of pupillary miosis during 5 min in darkness is a simple, recently introduced alertness test which may become useful in the clinical assessment of normal and pathological sleepiness... - Evidence of disrupted prepulse inhibition in unaffected siblings of bipolar disorder patientsStella G Giakoumaki
Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, Crete, Greece
Biol Psychiatry 62:1418-22. 2007..To address this issue, the present study examined whether disrupted PPI is present in individuals at high risk for BD...