Research Topics
| C RoussosSummaryAffiliation: University of Athens Country: Greece Publications
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Detail Information
Publications
Clinical review: idiopathic pulmonary fibrosis acute exacerbations--unravelling Ariadne's threadSpyros A Papiris
2nd Pulmonary Department, Attikon University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462, Haidari, Greece
Crit Care 14:246. 2010..Admission to an intensive care unit (ICU) is a particular clinical and ethical challenge because of the extremely poor outcome. Transplantation in the ICU setting often presents insurmountable difficulties...- Bench-to-bedside review: weaning failure--should we rest the respiratory muscles with controlled mechanical ventilation?Theodoros Vassilakopoulos
Department of Critical Care and Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, Athens, Greece
Crit Care 10:204. 2006..When CMV is used, concurrent administration of antioxidants (which decrease oxidative stress and thus attenuate VIDD) seems justified, since antioxidants may be beneficial (and are certainly not harmful) in critical care patients... - Bench-to-bedside review: pulmonary-renal syndromes--an update for the intensivistSpyros A Papiris
2nd Pulmonary Department, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece
Crit Care 11:213. 2007..Renal transplantation is the only alternative in end-stage renal disease. Newer immunomodulatory agents such as those causing TNF blockade, B-cell depletion and mycophenolate mofetil could be used in patients with refractory disease... - MRC chronic Dyspnea Scale: Relationships with cardiopulmonary exercise testing and 6-minute walk test in idiopathic pulmonary fibrosis patients: a prospective studyEffrosyni D Manali
Second Pulmonary Department, Attikon University Hospital, National and Kapodistrian University of Athens, Greece
BMC Pulm Med 10:32. 2010.... 
Respiratory failureC Roussos
Dept of Critical Care, University of Athens Medical School, Evangelismos Hospital, Athens, Greece
Eur Respir J Suppl 47:3s-14s. 2003..Modulation of the pattern of breathing, however, ultimately results in alveolar hypoventilation and carbon dioxide retention...- Non-invasive assessment of the microcirculation in critically ill patientsS Nanas
First Critical Care Department, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece
Anaesth Intensive Care 37:733-9. 2009..Near-infrared spectroscopy can detect tissue oxygenation deficits and impaired microvascular reactivity in critically ill patients, as well as discriminate among groups with different disease severity... 
Carbapenem-resistant versus carbapenem-susceptible Acinetobacter baumannii bacteremia in a Greek intensive care unit: risk factors, clinical features and outcomesC Routsi
1st Department of Intensive Care, Evangelismos Hospital, University of Athens Medical School, 45 47 Ipsilantou Str, 106 76, Athens, Greece
Infection 38:173-80. 2010..The objective of this study was to determine specific risk factors for and outcome of bacteremia due to CRAB isolates among our ICU patients with A. baumannii bacteremia...- Oxygen kinetics and debt during recovery from expiratory flow-limited exercise in healthy humansI Vogiatzis
Department of Critical Care Medicine and Pulmonary Services, G P Livanos and M Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece
Eur J Appl Physiol 99:265-74. 2007..EFL O(2) debt was 52 +/- 22% greater than control (2.19 +/- 0.58 vs. 1.49 +/- 0.38 l). We conclude that EFL exercise increases the O(2) debt and leads to hypoxemia in part due to hypercapnia... - Static pressure-volume curves and body posture in severe chronic bronchitisS D Mentzelopoulos
Dept of Intensive Care Medicine, University of Athens Medical School, Evaggelismos Hospital, 45-47 Ipsilandou Str, GR 106 75, Athens, Greece
Eur Respir J 28:165-74. 2006..Pronation effects on ventilation homogeneity and carbon dioxide arterial tension are maximised, implying that pronation can be useful during early controlled ventilation... - Effect of pulmonary rehabilitation on muscle remodelling in cachectic patients with COPDI Vogiatzis
Evangelismos Hospital, National and Kapodistrian University of Athens, Dept of Critical Care Medicine and Pulmonary Services, Pulmonary Rehabilitation Centre, Athens, Greece
Eur Respir J 36:301-10. 2010.... - Chest wall volume regulation during exercise in COPD patients with GOLD stages II to IVI Vogiatzis
Dept of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, Pulmonary Rehabilitation Centre, M Simou and G P Livanos Laboratories, Athens, Greece
Eur Respir J 32:42-52. 2008.... - Exercise-induced skeletal muscle deoxygenation in O-supplemented COPD patientsI Vogiatzis
G P Livanos and M Simou Laboratories, Evangelismos Hospital, Department of Critical Care Medicine and Pulmonary Services, National and Kapodistrian University of Athens, Athens, Greece
Scand J Med Sci Sports 19:364-72. 2009..In O2-supplemented COPD patients, peripheral muscle oxygenation for a given work load is similar to that in healthy subjects, thus suggesting that skeletal muscle O2 consumption becomes normal for a given O2 delivery in COPD patients.. - Nasal inflammation in sleep apnoea patients using CPAP and effect of heated humidificationI Koutsourelakis
Medical School of Athens University, Center of Sleep Disorders, Evangelismos Hospital, 45 47 Ipsilandou Str, GR 106 75, Athens, Greece
Eur Respir J 37:587-94. 2011..In conclusion, nasal obstruction of OSA patients on CPAP treatment is inflammatory in origin and the addition of heated humidification decreases nasal resistance and mucosal inflammation... - Randomised trial of nasal surgery for fixed nasal obstruction in obstructive sleep apnoeaI Koutsourelakis
Dept of Critical Care and Pulmonary Services, Centre of Sleep Disorders, Medical School of Athens University, Athens, Greece
Eur Respir J 31:110-7. 2008..6% specificity) responders/nonresponders. In conclusion, nasal surgery rarely treats obstructive sleep apnoea effectively. Baseline nasal breathing epochs can predict the surgery outcome... - Effects of severity of chronic obstructive pulmonary disease on thyroid functionI Dimopoulou
Department of Pulmonary and Critical Care Medicine, Evangelismos General Hospital, Athens, Greece
Metabolism 50:1397-401. 2001..It is concluded that in stable COPD, severity of disease through hypoxemia is important in determining the peripheral metabolism of thyroid hormones. Whether this constitutes an adaptation is not known... - Thoracoabdominal motion in ankylosing spondylitis: association with standardised clinical measures and response to therapyG E Tzelepis
Department of Pathophysiology, University of Athens Medical School, Greece
Ann Rheum Dis 68:966-71. 2009.... - Combined expression of p53, Bcl-2, and p21WAF-1 proteins in lung cancer and premalignant lesions: association with clinical characteristicsI Kalomenidis
Department of Pulmonary and Critical Care Medicine, Medical School of Athens University, Evangelismos Hospital, Athens, Greece
Lung 179:265-78. 2001..We conclude that p53 and Bcl-2 alterations may happen early in bronchial carcinogenesis and that absence of these alterations in combination with p21WAF-1, overexpression may be associated with a less aggressive tumor behavior... - Prone position reduces lung stress and strain in severe acute respiratory distress syndromeS D Mentzelopoulos
University of Athens Medical School, Dept of Intensive Care Medicine, Attikon University Hospital, Athens, Greece
Eur Respir J 25:534-44. 2005..In early/severe acute respiratory distress syndrome, pronation under positive end-expiratory pressure optimisation may reduce ventilator-induced lung injury risk. Pronation benefits may be maintained in post-prone semirecumbent position... - Pulmonary capillary endothelium-bound angiotensin-converting enzyme activity in acute lung injuryS E Orfanos
Critical Care Department, Evangelismos Hospital, University of Athens Medical School, Greece
Circulation 102:2011-8. 2000.... - Predictors of residual sleepiness in adequately treated obstructive sleep apnoea patientsI Koutsourelakis
Center of Sleep Disorders, Medical School of Athens University, Dept of Critical Care and Pulmonary Services, Evangelismos Hospital, Greece
Eur Respir J 34:687-93. 2009..In conclusion, predictors of residual excessive sleepiness in adequately CPAP-treated OSAS were a history of depression, diabetes and heart disease, and a higher ESS score and lower RDI on initial assessment... - Risk factors for and influence of bloodstream infections on mortality: a 1-year prospective study in a Greek intensive-care unitM Pratikaki
Department of Intensive Care, Medical School, University of Athens, Evangelismos Hospital, Athens, Greece
Epidemiol Infect 137:727-35. 2009..44, 95% CI 1.22-1.7, P<0.001 and OR 0.47, 95% CI 0.23-0.97, P=0.04 respectively)... - Aspergillus bronchitis causing atelectasis and acute respiratory failure in an immunocompromised patientC Routsi
Dept of Pulmonary and Critical Care, Evangelismos Hospital, Athens, Greece
Infection 29:243-4. 2001.... - Intermittent recruitment with high-frequency oscillation/tracheal gas insufflation in acute respiratory distress syndromeS D Mentzelopoulos
First Dept of Intensive Care Medicine, University of Athens Medical School, Athens, Greece
Eur Respir J 39:635-47. 2012..3%) out of 61 versus 23 (35.9%) out of 64 subjects; p = 0.004). Intermittent recruitment with HFO-TGI and RMs may improve survival in early/severe ARDS... - Breath markers of oxidative stress and airway inflammation in Seasonal Allergic RhinitisC Gratziou
Asthma and Allergy Center, Pulmonary and Critical Care Department, G P Livanos and M Simos Laboratories, Athens University Medical School, Athens, Greece
Int J Immunopathol Pharmacol 21:949-57. 2008..Besides, intranasal steroid treatment may have a regulatory role in the OS... - Effects of rehabilitation on chest wall volume regulation during exercise in COPD patientsO Georgiadou
M Simou and G P Livanos Laboratoris, Pulmonary Rehabilitation Centre, Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, Athens, Greece
Eur Respir J 29:284-91. 2007..The improvement in exercise capacity following rehabilitation is independent of the pattern of exercise-induced dynamic hyperinflation... - Strenuous resistive breathing induces proinflammatory cytokines and stimulates the HPA axis in humansT Vassilakopoulos
Department of Critical Care, University of Athens Medical School, Evangelismos Hospital, GR 10675 Athens, Greece
Am J Physiol 277:R1013-9. 1999..92, respectively; P < 0.01). Moderate IRB did not produce any change. We conclude that severe IRB produces proinflammatory cytokines and stimulates the HPA axis in humans secondary to the production of cytokines (especially IL-6)... - cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell linesG Haramis
G P Livanos and M Simou Laboratories, Department of Critical Care and Pulmonary Services, Evangelismos Hospital, University of Athens School of Medicine, Athens, Greece
Br J Pharmacol 155:804-13. 2008..Soluble guanylyl cyclase (sGC) is a receptor for nitric oxide that generates cGMP. This second messenger molecule has established roles in cellular physiology; however, less is known about its effects in tumour cells... - Dry cough and dyspnoea rapidly increasing to respiratory failure in a male smokerI Sigala
Dept. of Critical Care and Pulmonary Services, 45-47 Ipsilantou Street, Evangelismos Hospital, GR 10675, Athens, Greece
Eur Respir J 25:1122-5. 2005 - Contribution of pain to inspiratory muscle dysfunction after upper abdominal surgery: A randomized controlled trialT Vassilakopoulos
Department of Critical Care and Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, Greece
Am J Respir Crit Care Med 161:1372-5. 2000..MEP showed the same tendency as Psniff, but the observed changes did not reach statistical significance. We conclude that pain contributes to inspiratory muscle dysfunction after upper abdominal surgery... - Cough and fever in a female with Crohn's disease receiving infliximabG Stratakos
Department of Critical Care and Pulmonary Services, Evangelismos Hospital, Athens, Greece
Eur Respir J 26:354-7. 2005 - Exhaled nitric oxide in seasonal allergic rhinitis: influence of pollen season and therapyC Gratziou
Asthma and Allergy Center, Pulmonary and Critical Care Department, University of Athens Medical School, Evgenidio Hospital, 20 Papadiamantopoulou, 115 28 Ilisia, Athens, Greece
Clin Exp Allergy 31:409-16. 2001..Thus, exhaled NO may be used as a non-invasive index for early detection of lower airway inflammation and for monitoring the optional treatment in patients with seasonal allergic rhinitis... - The effect of hypoxemic reperfusion on cerebral protection after a severe global ischemic brain insultE E Douzinas
Evangelismos Hospital, Department of Critical Care, University of Athens Medical School, Greece
Intensive Care Med 27:269-75. 2001..We tested whether hypoxemic reperfusion (HR) after global cerebral ischemia would improve neurological recovery... - Pulmonary hypertension, interstitial lung fibrosis, and lung iron deposition in thalassaemia majorE Zakynthinos
Department of Critical Care and Pulmonary Services, University of Athens Medical School, Evangelismos' Hospital, Athens, Greece
Thorax 56:737-9. 2001..This presentation suggests that interstitial fibrosis may complicate lung involvement in TM and can significantly contribute to the development of PH... - Predisposing factors for critical illness polyneuromyopathy in a multidisciplinary intensive care unitS Nanas
National and Kapodistrian University, Medical School, First Critical Care Department, Evangelismos Hospital, Athens, Greece
Acta Neurol Scand 118:175-81. 2008..To investigate risk factors of critical illness polyneuromyopathy (CIPM) in a general multidisciplinary intensive care unit (ICU)... - Prone position improves expiratory airway mechanics in severe chronic bronchitisS D Mentzelopoulos
University of Athens Medical School, Dept of Intensive Care Medicine, Attikon University Hospital, Athens, Greece
Eur Respir J 25:259-68. 2005..9+/-4.2 versus 47.9+/-4.0 mL x s(-1)), and shunt fraction (0.16+/-0.03 versus 0.21+/-0.03); benefits were reversed in SRPP. In severe chronic bronchitis, prone positioning reduces airway resistance and dynamic hyperinflation... - Early recovery of oxygen kinetics after submaximal exercise test predicts functional capacity in patients with chronic heart failureS Nanas
Pulmonary and Critical Care Medicine Department, National and Kapodestrian University, Papadiamantopoulou 20, Athens 115 28, Greece
Eur J Heart Fail 3:685-92. 2001..The significance of recovery O2 kinetics parameters in predicting exercise capacity, and the parameters of submaximal exercise testing have not been thoroughly examined... - Propofol-induced hyperamylasaemia in a general intensive care unitS Nanas
First Critical Care Department, Medical School, National and Kapodistrian University, Evangelismos Hospital, Athens, Greece
Anaesth Intensive Care 35:920-3. 2007..021). Propofol infusion is associated with biochemical evidence of pancreatic injury. Amylase levels monitoring of propofol-sedated patients is warranted... - Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insultE E Douzinas
Department of Critical Care, Evangelismos Hospital, Athens, Greece
Intensive Care Med 27:905-10. 2001..In the present study, we investigated the effect of hypoxaemic reperfusion on brain histopathological changes... - Prolonged oxygen kinetics during early recovery from maximal exercise in adult patients with cystic fibrosisE Pouliou
Adult Cystic Fibrosis Outpatient Clinic, Athens Chest Hospital, Greece
Chest 119:1073-8. 2001.... - Reactive oxygen species stimulate VEGF production from C(2)C(12) skeletal myotubes through a PI3K/Akt pathwayI Kosmidou
George P. Livanos Laboratory, Critical Care Department and Pulmonary Services, Evangelismos Hospital, University of Athens, Athens 10675, Greece
Am J Physiol Lung Cell Mol Physiol 280:L585-92. 2001..We conclude that ROS induce VEGF release from myotubes via a PI3K/Akt-dependent pathway... - A role for transoesophageal echocardiography in the early diagnosis of catastrophic antiphospholipid syndromeE G Zakynthinos
Department of Critical Care and Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, Athens, Greece
J Intern Med 248:519-24. 2000..Cerebral and coronary angiograms were negative, suggesting possible microthrombotic occlusive disease in the setting of CAPS... - Respiratory muscle performance with stretch-shortening cycle manoeuvres: maximal inspiratory pressure-flow curvesG E Tzelepis
Department of Pathophysiology and Laiko General Hospital, University of Athens Medical School, Athens, Greece
Acta Physiol Scand 185:251-6. 2005..To test the hypothesis that the maximal inspiratory muscle (IM) performance, as assessed by the maximal IM pressure-flow relationship, is enhanced with the stretch-shortening cycle (SSC)... - Rohrer's constant, K2, as a factor of determining inspiratory resistance of common adult endotracheal tubesA G Flevari
2nd Department of Critical Care Medicine, Attikon Hospital, Medical School, University of Athens, Athens, Greece
Anaesth Intensive Care 39:410-7. 2011..00012). Therefore, knowing the performing size of an ETT may help the clinicians identify ETT obstruction and deal with weaning problems... - Obstructive sleep apnoea and oral breathing in patients free of nasal obstructionI Koutsourelakis
Centre of Sleep Disorders, Medical School of Athens University, Dept of Critical Care and Pulmonary Services, Evangelismos Hospital, Athens, Greece
Eur Respir J 28:1222-8. 2006..736) and BMI (r2 = 0.036). In conclusion, apnoeics spent more time breathing orally and oro-nasally than simple snorers, and the apnoea/hypopnoea index is a major determinant of the time spent breathing orally and oro-nasally... - Regulation of the expression of soluble guanylyl cyclase by reactive oxygen speciesC Gerassimou
Department of Critical Care and Pulmonary Services, G P Livanos M Simou Laboratories, University of Athens, Evangelismos Hospital, Athens, Greece
Br J Pharmacol 150:1084-91. 2007..The aim of the present study was to investigate whether reactive oxygen species (ROS) have a direct effect on soluble guanylyl cyclase (sGC) subunit levels and function and to ascertain the mechanism(s) involved... - Acute mediastinitis: spectrum of computed tomography findingsD N Exarhos
CT-MRI, Evangelismos General Hospital, Athens, Greece
Eur Radiol 15:1569-74. 2005..For the postoperative patients there is clear time dependence for CT interpretation and accuracy. In patients with suspected ADNM, and traumatic esophageal perforation CT is highly specific early after clinical presentation... - Expiratory flow limitation in morbidly obese postoperative mechanically ventilated patientsA Koutsoukou
Critical Care Department and Pulmonary Services, Evangelismos General Hospital, University of Athens Medical School, Athens, Greece
Acta Anaesthesiol Scand 48:1080-8. 2004.... - The immune response to resistive breathingT Vassilakopoulos
Critical Care Dept, Evangelismos Hospital, 45 47 Ipsilandou Str, GR 10675 Athens, Greece
Eur Respir J 24:1033-43. 2004.... - Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancerT Vassilakopoulos
Department of Critical Care and Pulmonary Services, Evangelismos Hospital, University of Athens Medical School, Athens, Greece
Lung Cancer 32:137-44. 2001..In conclusion, the SCC-Ag serum level has moderate diagnostic role in NSCLC. Both the preoperative SCC-Ag level and its postoperative decrease have prognostic significance, yet inferior to the disease stage and the patient's age... - Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock?C Routsi
1st Department of Critical Care, University of Athens Medical School, Greece
Clin Exp Immunol 142:62-7. 2005..Its sustained increase is an indication of poor outcome. The underlined pathophysiological role of sTREM-1 for the transition from sepsis or severe sepsis to septic shock might constitute a novel target for immunomodulatory therapy... - Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndromeE Vagiakis
Critical Care and Pulmonary Services, Medical School, Sleep Disorders Center, Evangelismos Hospital, University of Athens, Athens, Greece
Sleep Med 7:424-30. 2006..OSAS was diagnosed in men five times more often than in women. AHI was greater in men than in women, but women are more likely than men to have a higher AHI in REM than NREM. Sleep quality is worse in female than in male patients... - Pulmonary endothelium in acute lung injury: from basic science to the critically illS E Orfanos
Department of Critical Care and Pulmonary Medicine, M Simou Laboratory, Medical School, University of Athens, Evangelismos Hospital, 45 47 Ipsilandou St, 10675, Athens, Greece
Intensive Care Med 30:1702-14. 2004..OBJECTIVE: We highlight pathogenic mechanisms of pulmonary endothelial injury and their clinical implications in ALI/ARDS patients... - Protein S-100b serum levels in trauma-induced brain deathI Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, Medical and Nursing School, National and Kapodistrian University of Athens, Greece
Neurology 60:947-51. 2003.... - A painful and swollen right breast in a young maleG E Kapotsis
Dept of Critical Care and Pulmonary Services, 45-47 Ipsilantou Street, Evangelismos Hospital, Athens, GR 10675, Greece
Eur Respir J 24:1066-8. 2004 - Mediastinal mass with Dysphagia in an elderly patientA Kotanidou
Department of Critical Care and Pulmonary Services, Evangelismos Hospital, University of Athens, Ipsilantou 45 47, GR 10675 Athens, Greece
Infection 31:178-80. 2003..This report describes a patient with dysphagia who appeared to have esophageal tuberculosis without HIV and in the absence of other signs of tuberculosis. The patient responded promptly to treatment with tuberculostatics... - Treatment of respiratory failure: introductionM Decramer
Eur Respir J Suppl 47:1s-2s. 2003 - A 35-year-old male with chronic coughC Moschos
Dept of Pulmonary and Critical Care Services, General Hospital Evangelismos, School of Medicine, National and Kapodistrian University of Athens, 3 Ploutarhou Str, 10675 Athens, Greece
Eur Respir J 29:608-11. 2007 - Interval training as an alternative modality to continuous exercise in patients with COPDI Vogiatzis
National and Kapodistrian University of Athens, Medical School, Dept of Pulmonary and Critical Care Medicine, Eugenidion Hospital, Greece
Eur Respir J 20:12-9. 2002....