L Probert

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Glial expression of tumor necrosis factor in transgenic animals: how do these models reflect the "normal situation"?
    L Probert
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Glia 36:212-9. 2001
  2. ncbi A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice
    G Kassiotis
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 29:912-7. 1999
  3. ncbi TNF-alpha transgenic and knockout models of CNS inflammation and degeneration
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Neuroimmunol 72:137-41. 1997
  4. ncbi TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis
    G Kassiotis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 29:774-80. 1999
  5. pmc Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Am J Pathol 153:801-13. 1998
  6. doi Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function
    A Voulgari-Kokota
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, 127 Vasilissis Sophias Ave, 11521 Athens, Greece
    Exp Neurol 236:161-70. 2012
  7. ncbi Positive and negative implications of tumor necrosis factor neutralization for the pathogenesis of multiple sclerosis
    E Taoufik
    Hellenic Pasteur Institute, Athens, Greece
    Neurodegener Dis 5:32-7. 2008
  8. ncbi TNF and related molecules: trends in neuroscience and clinical applications
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Neuroimmunol 72:113-7. 1997
  9. ncbi Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Immunol 158:438-45. 1997
  10. ncbi The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 25:1794-7. 1995

Collaborators

Detail Information

Publications10

  1. ncbi Glial expression of tumor necrosis factor in transgenic animals: how do these models reflect the "normal situation"?
    L Probert
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Glia 36:212-9. 2001
    ....
  2. ncbi A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice
    G Kassiotis
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 29:912-7. 1999
    ..We conclude that TNF is sufficient to induce primary inflammatory demyelination and neurological deficits even in the absence of adaptive immunity...
  3. ncbi TNF-alpha transgenic and knockout models of CNS inflammation and degeneration
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Neuroimmunol 72:137-41. 1997
    ....
  4. ncbi TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis
    G Kassiotis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 29:774-80. 1999
    ..Taken together, these results indicate that although TNF is not required for the progression of MBP-induced EAE, it contributes positively by advancing the onset of disease...
  5. pmc Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Am J Pathol 153:801-13. 1998
    ....
  6. doi Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function
    A Voulgari-Kokota
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, 127 Vasilissis Sophias Ave, 11521 Athens, Greece
    Exp Neurol 236:161-70. 2012
    ....
  7. ncbi Positive and negative implications of tumor necrosis factor neutralization for the pathogenesis of multiple sclerosis
    E Taoufik
    Hellenic Pasteur Institute, Athens, Greece
    Neurodegener Dis 5:32-7. 2008
    ..The inflammatory mediators are generally secreted by myelin-specific, CD4+ T cells, CD8+ T cells, macrophages and activated glial cells and include a large number of cytokines, chemokines and other proinflammatory proteins...
  8. ncbi TNF and related molecules: trends in neuroscience and clinical applications
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Neuroimmunol 72:113-7. 1997
    ....
  9. ncbi Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Immunol 158:438-45. 1997
    ..These results demonstrate that target cells mediating the neuroinflammatory activities of TNF localize in the vicinity of astrocytes rather than neurons...
  10. ncbi The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 25:1794-7. 1995
    ..Our results show that in TNF-transgenic mice the IL-1 receptor accepts the whole pathogenic load of TNF, thereby acting as a potent downstream mediator in the pathogenesis of chronic arthritis...