N Papanas

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi request reprint Ankle-brachial index: a surrogate marker of microvascular complications in type 2 diabetes mellitus?
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Int Angiol 26:253-7. 2007
  2. ncbi request reprint Gevokizumab in type 1 diabetes mellitus: extreme remedies for extreme diseases?
    Kalliopi Pafili
    Diabetes Clinic, Democritus University of Thrace, University Hospital of Alexandroupolis, Second Department of Internal Medicine, G Kondyli 22c, Alexandroupolis 68100, Greece 30 2551074713 30 25510 74723
    Expert Opin Investig Drugs 23:1277-84. 2014
  3. ncbi request reprint Tofogliflozin: the road goes ever on
    Kalliopi Pafili
    Democritus University of Thrace, University Hospital of Alexandroupolis, Diabetes Clinic, Second Department of Internal Medicine, G Kondyli 22c, Alexandroupolis 68100, Greece
    Expert Opin Pharmacother 15:1197-201. 2014
  4. ncbi request reprint The importance of patient compliance with insulin pens: how can a new user-friendly pen help?
    Kalliopi Pafili
    Democritus University of Thrace, University Hospital of Alexandroupolis, Second Department of Internal Medicine, Diabetes Clinic, G Kondyli 22c, Alexandroupolis 68100, Greece
    Expert Opin Drug Deliv 11:629-32. 2014
  5. doi request reprint A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy
    N Papanas
    Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece University of Manchester and Manchester Diabetes Centre, Manchester, UK
    Diabet Med 30:525-34. 2013
  6. doi request reprint Increased cardiovascular and renal disease but not reduced life expectancy among diabetic participants in the general Northern Greek population
    N Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Angiology 63:443-7. 2012
  7. doi request reprint Prediabetic neuropathy: does it exist?
    Nikolaos Papanas
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Curr Diab Rep 12:376-83. 2012
  8. ncbi request reprint Advances in the topical treatment of diabetic foot ulcers
    N Papanas
    Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Curr Diabetes Rev 8:209-18. 2012
  9. ncbi request reprint Writing a research abstract: eloquence in miniature
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Int Angiol 31:297-302. 2012
  10. pmc Long-term respiratory follow-up of H1N1 infection
    Paul Zarogoulidis
    Unit of Infectious Diseases, Democritus University Thrace, Dragana, 68100 Alexandroupolis, Greece
    Virol J 8:319. 2011

Collaborators

Detail Information

Publications99

  1. ncbi request reprint Ankle-brachial index: a surrogate marker of microvascular complications in type 2 diabetes mellitus?
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Int Angiol 26:253-7. 2007
    ..The aim of this study was to investigate the potential role of ankle-brachial index (ABI) as a marker of microvascular disease in patients with type 2 diabetes mellitus...
  2. ncbi request reprint Gevokizumab in type 1 diabetes mellitus: extreme remedies for extreme diseases?
    Kalliopi Pafili
    Diabetes Clinic, Democritus University of Thrace, University Hospital of Alexandroupolis, Second Department of Internal Medicine, G Kondyli 22c, Alexandroupolis 68100, Greece 30 2551074713 30 25510 74723
    Expert Opin Investig Drugs 23:1277-84. 2014
    ..Insulin is the cornerstone of type 1 diabetes mellitus (T1DM) therapy. However, it cannot achieve a delay in the onset or evolution of this condition, while cardiovascular morbidity remains an unquestionable threat...
  3. ncbi request reprint Tofogliflozin: the road goes ever on
    Kalliopi Pafili
    Democritus University of Thrace, University Hospital of Alexandroupolis, Diabetes Clinic, Second Department of Internal Medicine, G Kondyli 22c, Alexandroupolis 68100, Greece
    Expert Opin Pharmacother 15:1197-201. 2014
    ..Moreover, it would be welcome to examine the utility of its therapeutic use in combination with insulin and metformin...
  4. ncbi request reprint The importance of patient compliance with insulin pens: how can a new user-friendly pen help?
    Kalliopi Pafili
    Democritus University of Thrace, University Hospital of Alexandroupolis, Second Department of Internal Medicine, Diabetes Clinic, G Kondyli 22c, Alexandroupolis 68100, Greece
    Expert Opin Drug Deliv 11:629-32. 2014
    ..Moreover, an analysis of patients' perception on injecting higher doses with FT in comparison to other insulin injectors would be useful...
  5. doi request reprint A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy
    N Papanas
    Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece University of Manchester and Manchester Diabetes Centre, Manchester, UK
    Diabet Med 30:525-34. 2013
    ..It remains to be established whether this test can predict foot ulceration and amputation, thereby contributing to the identification of high-risk patients...
  6. doi request reprint Increased cardiovascular and renal disease but not reduced life expectancy among diabetic participants in the general Northern Greek population
    N Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Angiology 63:443-7. 2012
    ..001), old age (P < .001), and car accidents (P = .004). In conclusion, the cardiovascular and renal disease burden among diabetic participants did not reduce life expectancy, especially in men...
  7. doi request reprint Prediabetic neuropathy: does it exist?
    Nikolaos Papanas
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Curr Diab Rep 12:376-83. 2012
    ..In practice, therapy of prediabetic neuropathy should be addressed towards normoglycemia and correction of cardiovascular risk factors. However, additional work is needed to establish the long-term results of this approach...
  8. ncbi request reprint Advances in the topical treatment of diabetic foot ulcers
    N Papanas
    Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Curr Diabetes Rev 8:209-18. 2012
    ..Moreover, we should not be oblivious to the fact that established and emerging treatments need to be practised in the setting of multidisciplinary foot clinics to reduce the number of amputations...
  9. ncbi request reprint Writing a research abstract: eloquence in miniature
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Int Angiol 31:297-302. 2012
    ..Moreover, they must comply with provided instructions. Finally, they should be pleasant to read and encourage study of the corresponding full work...
  10. pmc Long-term respiratory follow-up of H1N1 infection
    Paul Zarogoulidis
    Unit of Infectious Diseases, Democritus University Thrace, Dragana, 68100 Alexandroupolis, Greece
    Virol J 8:319. 2011
    ..The first case of 2009 pandemic influenza A (H1N1) virus infection was documented in our Hospital on 10th August 2009...
  11. pmc A giant adrenal lipoma presenting in a woman with chronic mild postprandial abdominal pain: a case report
    Stylianos Kapetanakis
    Surgical Department, Navy Hospital of Crete, Chania, Greece
    J Med Case Reports 5:136. 2011
    ..abstract:..
  12. pmc A diabetic patient presenting with stiff hand following fasciectomy for Dupuytren's contracture: A case report
    Katia Fournier
    Hand Therapy Department, King s College Hospital, London, SE5 9RS, UK
    Cases J 1:277. 2008
    ..Given the patient's diabetes mellitus and the striking similarity with the typical diabetic stiff hand, it is suggested that diabetes may have contributed to the development of the complication...
  13. pmc Characteristics of patients presenting to the vascular emergency department of a tertiary care hospital: a 2-year study
    Ioannis Kotsikoris
    Department of Vascular Surgery, Red Cross Hospital, Athens, Greece
    BMC Res Notes 4:481. 2011
    ..abstract:..
  14. pmc HbA1c is associated with severity of obstructive sleep apnea hypopnea syndrome in nondiabetic men
    Nikolaos Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism at the 2nd Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Vasc Health Risk Manag 5:751-6. 2009
    ..Thus, severity of OSAS may be an additional marker of cardiovascular risk, as well as of future diabetes, in these subjects. However, further work is needed to confirm the clinical significance of these observations...
  15. ncbi request reprint Oral antidiabetic agents: anti-atherosclerotic properties beyond glucose lowering?
    N Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism at the Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Curr Pharm Des 15:3179-92. 2009
    ..Thus, oral antidiabetic agents are now emerging as useful tools for the attenuation of the atherosclerotic activity and for the protection of the vasculature in patients with type 2 diabetes...
  16. ncbi request reprint Metformin and lactic acidosis in patients with type 2 diabetes--from pride and prejudice to sense and sensibility
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Acta Clin Belg 64:42-8. 2009
    ..To present the cases of lactic acidosis encountered in our department among metformin-treated type 2 diabetic patients and to investigate the role of contraindications to metformin use...
  17. doi request reprint Achilles tendon volume in type 2 diabetic patients with or without peripheral neuropathy: MRI study
    N Papanas
    Outpatient Clinic of Diabetic Foot at Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Exp Clin Endocrinol Diabetes 117:645-8. 2009
    ..There is no difference in AT volume between patients with and without neuropathy. However, in neuropathic patients increased AT volume is associated with severity of neuropathy...
  18. doi request reprint The diabetic hand: a forgotten complication?
    Nikolaos Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism at the Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    J Diabetes Complications 24:154-62. 2010
    ..Recently, reduced hand strength is beginning to be recognized as a further complication of diabetes. Thus, the hand may reveal substantial pathology in diabetes, and ideally, clinical examination should not ignore it...
  19. ncbi request reprint Glycaemic control is correlated with well-being index (WHO-5) in subjects with type 2 diabetes
    N Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism in the Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Exp Clin Endocrinol Diabetes 118:364-7. 2010
    ..69+/-5.47 vs. mean+/-SD: 17.11+/-6.38, p=0.011). Finally, WHO-5 score was significantly (p=0.013) lower in subjects with neuropathic pain than in those without neuropathic pain...
  20. doi request reprint Foot temperature in type 2 diabetic patients with or without peripheral neuropathy
    N Papanas
    Outpatient Clinic of the Diabetic Foot at the Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Exp Clin Endocrinol Diabetes 117:44-7. 2009
    ..913, p<0.001; group B: r (s)=0.956, p<0.001). Finally, in group A, DNI score showed a significant positive correlation with dorsal temperature (r (s)=0.856, p<0.001), as well as plantar temperature (r (s)=0.859, p<0.001)...
  21. pmc Becaplermin gel in the treatment of diabetic neuropathic foot ulcers
    Nikolaos Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism at the Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Interv Aging 3:233-40. 2008
    ..Future research also needs to assess the potential room for improvement with becaplermin, for instance by combination with other growth factors or by exploring alternative modes of drug delivery...
  22. ncbi request reprint Writing a case report: polishing a gem?
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Int Angiol 27:344-9. 2008
    ..If properly prepared, case reports can still communicate new observations in an interesting and pleasant way, thereby enriching our knowledge, even in the era of evidence-based medicine...
  23. doi request reprint Evaluation of a new foam to increase skin hydration of the foot in type 2 diabetes: a pilot study
    Nikolaos Papanas
    Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Int Wound J 8:297-300. 2011
    ..In conclusion, results with the new foam appear encouraging in ameliorating skin dryness in the diabetic foot and further investigation is warranted...
  24. ncbi request reprint Education for dietary freedom in type 1 diabetes? Yes, it's possible
    Nikolaos Papanas
    Democritus University of Thrace, Alexandroupolis, Greece
    Diabetes Educ 34:54-8. 2008
  25. doi request reprint New diagnostic tests for diabetic distal symmetric polyneuropathy
    Nikolaos Papanas
    Outpatient Clinic of the Diabetic Foot in the Second Department of Internal Medicine at Democritus University of Thrace, Greece
    J Diabetes Complications 25:44-51. 2011
    ..Moreover, their cost-effectiveness needs more careful appraisal. The clinician should, therefore, still rely on established modalities to diagnose neuropathy, but wider use of the new tests is expected in the near future...
  26. ncbi request reprint Letters to the editor: definitely not children of a lesser god
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Thrace, Greece
    Int Angiol 28:418-20. 2009
    ..Clarity and brevity should be their principal values. It is also important to comply with the journals' instructions for correspondence. Thus, eloquent letters to the editor may promote knowledge and enable fruitful exchange of ideas...
  27. ncbi request reprint Metformin and heart failure: never say never again
    Nikolaos Papanas
    Democritus University of Thrace, University Hospital of Alexandroupolis, Outpatient Clinic of Obesity, Diabetes and Metabolism, 68100 Alexandroupolis, Greece 30 25310 39000 30 25510 74723
    Expert Opin Pharmacother 13:1-8. 2012
    ....
  28. pmc Increased serum levels of uric acid are associated with sudomotor dysfunction in subjects with type 2 diabetes mellitus
    N Papanas
    Outpatient Clinic of Obesity, Diabetes, and Metabolism, Second Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece
    Exp Diabetes Res 2011:346051. 2011
    ..001; group B: r(s) = 0.848, P < 0.001). In conclusion, SUA levels were higher in T2DM patients with sudomotor dysfunction than those without this complication. The potential role of SUA in sudomotor dysfunction merits further study...
  29. ncbi request reprint Pioglitazone: a valuable component of combination therapy for type 2 diabetes mellitus
    Nikolaos Papanas
    Democritus University of Thrace, University Hospital of Alexandroupolis, Second Department of Internal Medicine, Outpatient Clinic of Obesity, Diabetes and Metabolism, 68100 Alexandroupolis, Greece 30 2551 084972 30 2551 074723
    Expert Opin Pharmacother 12:1457-61. 2011
    ..Importantly, however, patients should be appropriately selected, especially to avoid those with heart failure, in order to minimize adverse events attributable to water retention...
  30. doi request reprint Cilostazol in diabetic neuropathy: premature farewell or new beginning?
    N Papanas
    Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Angiology 62:605-8. 2011
    ..Hence, more data is needed to confirm or refute the poor clinical efficacy of cilostazol. Importantly, future studies should include larger patient series, provide longer follow-up data, and employ more accurate diagnostic tools...
  31. ncbi request reprint Delivering a powerful oral presentation: all the world's a stage
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Int Angiol 30:185-91. 2011
    ..Ideally, the successful oral presentation is a performance. Thus, the speaker may make the most of appearance, voice, eye contact and movement, in order to increase eloquence...
  32. doi request reprint Peripheral neuropathy is associated with increased serum levels of uric acid in type 2 diabetes mellitus
    N Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Greece
    Angiology 62:291-5. 2011
    ..001; group B: r(s) = .87, P < .001). Serum uric acid is increased in patients with T2DM with neuropathy versus those without. Whether SUA is involved in the pathogenesis of T2DM peripheral neuropathy remains to be established...
  33. ncbi request reprint The role of nuclear medicine in the diagnosis of common and specific diabetic infections
    Nikolaos Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece
    Hell J Nucl Med 13:150-7. 2010
    ..The main indications of nuclear medicine tests are diabetic foot osteomyelitis, malignant external otitis, rhinocerebral mucormycosis and renal infections...
  34. doi request reprint A prospective study on the use of the indicator test Neuropad® for the early diagnosis of peripheral neuropathy in type 2 diabetes
    N Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism in the Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Exp Clin Endocrinol Diabetes 119:122-5. 2011
    ..001). Neuropad® had 83.33% sensitivity and 68.04% specificity for neuropathy. There was a modest but significant agreement (kappa = 0.259, p < 0.001) between Neuropad® and NDS for neuropathy...
  35. pmc Association between foot temperature and sudomotor dysfunction in type 2 diabetes
    Nikolaos Papanas
    Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Greece, Alexandroupolis, Greece
    J Diabetes Sci Technol 4:803-7. 2010
    ..Increased foot skin temperature has been described as a feature of diabetic neuropathy. The aim of this present study was to investigate the association between foot temperature and sudomotor dysfunction in type 2 diabetes mellitus...
  36. ncbi request reprint Benefit-risk assessment of becaplermin in the treatment of diabetic foot ulcers
    Nikolaos Papanas
    Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Drug Saf 33:455-61. 2010
    ..Finally, longer follow-up data are necessary to shed more light on the potential risk of malignancy in connection with becaplermin use...
  37. ncbi request reprint Lanarkshire Oximetry Index as a diagnostic tool for peripheral arterial disease in type 2 diabetes: a pilot study
    Nikolaos Papanas
    Outpatient Clinic of the Diabetic Foot in the Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Angiology 61:388-91. 2010
    ..377, P < .001). Lanarkshire Oximetry Index is a potentially useful alternative diagnostic test for PAD in type 2 diabetes. A cut-off value of 0.9 has high sensitivity and modest specificity. Agreement between LOI and ABI is moderate...
  38. ncbi request reprint Advances in treating the ischaemic diabetic foot
    Nikolaos Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism at the Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Curr Vasc Pharmacol 6:23-8. 2008
    ..From a practical point of view, until novel modalities are available, increased vigilance and prompt aggressive revascularisation are indispensable to reduce the rate of amputations...
  39. doi request reprint Post-thyroidectomy thyroxine replacement dose in patients with or without compensated heart failure: the role of cytokines
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Ethnikis Antistasis 44, Alexandroupolis 68100, Greece
    Cytokine 41:121-6. 2008
    ..To investigate the potential association between serum inflammatory cytokine levels and post-thyroidectomy thyroxine replacement dose in patients with or without compensated heart failure...
  40. ncbi request reprint Peripheral arterial occlusive disease as a predictor of the extent of coronary atherosclerosis in patients with coronary artery disease with and without diabetes mellitus
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    J Int Med Res 32:422-8. 2004
    ..0%), but a very low sensitivity (16.4%). We conclude that a diagnosis of PAOD among patients with CAD had a low sensitivity but a high specificity for detecting those with severe CAD, particularly in patients without diabetes...
  41. ncbi request reprint An unusual case of hypoglycemia or who's afraid of the big bad wolf?
    Nikolaos Papanas
    Diabetes Educ 32:355-6. 2006
  42. ncbi request reprint Growth factors in the treatment of diabetic foot ulcers: new technologies, any promises?
    N Papanas
    Outpatient Department of Diabetes, Obesity and Metabolism at the Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Int J Low Extrem Wounds 6:37-53. 2007
    ..The former has been approved by the FDA for the treatment of neuropathic ulcers when there is adequate blood supply. The latter is less demonstrably useful. Advances include methods of delivering growth factors...
  43. ncbi request reprint The diabetic foot: a plea for the elementary?
    N Papanas
    Diabetic Foot Clinic, King s College Hospital, London, UK
    Acta Diabetol 43:152-3. 2006
    ..Indeed, more forceful implementation of elementary knowledge is needed, coupled with continuous education and research, to reduce the number of amputations...
  44. ncbi request reprint Revisiting the frequency of peripheral arterial disease in patients with coronary artery disease: is there a difference between diabetic and non-diabetic patients?
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Vasa 35:227-31. 2006
    ....
  45. ncbi request reprint Gliclazide treatment lowers serum ICAM-1 levels in poorly controlled type 2 diabetic patients
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Diabetes Metab 32:344-9. 2006
    ..To investigate the potential effect of gliclazide on serum ICAM-1 (intercellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) levels in poorly controlled type 2 diabetic patients...
  46. ncbi request reprint Severity of liver echogenicity is correlated to serum c-peptide levels in type 2 diabetic patients
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Acta Clin Belg 61:5-9. 2006
    ..To investigate the correlation between liver echogenicity and serum C-peptide levels in type 2 diabetic patients treated with oral hypoglycaemic agents...
  47. ncbi request reprint The steel ball-bearing test: a new test for evaluating protective sensation in the diabetic foot
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, 68100, Alexandroupolis, Greece
    Diabetologia 49:739-43. 2006
    ..The aim of the study was to assess a new steel ball-bearing test as a means of evaluating protective sensation in the diabetic foot...
  48. ncbi request reprint Reproducibility of the new indicator test for sudomotor function (Neuropad) in patients with type 2 diabetes mellitus: short communication
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Dragana, Alexandroupolis 68100, Greece
    Exp Clin Endocrinol Diabetes 113:577-81. 2005
    ..Inter-observer reproducibility was excellent (p = 0.001), both in patients with sudomotor dysfunction and in those without sudomotor dysfunction. Intra- and interobserver Coefficient of Variance ranged between 4.1 % and 5.1 %...
  49. ncbi request reprint Pseudoclaudication as a manifestation of diabetic neuropathy
    N Papanas
    Diabetic Foot Clinic, King s College Hospital, London, UK
    Diabet Med 22:1608-10. 2005
    ..The case suggests that, in the absence of other identifiable causes and in the presence of peripheral diabetic neuropathy, "intermittent claudication" may be due to the neuropathy itself...
  50. ncbi request reprint Impact of diabetes mellitus on severity of concomitant peripheral arterial occlusive disease in patients with coronary artery disease
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Acta Clin Belg 60:129-34. 2005
    ..The aim of the study was to evaluate the impact of Diabetes Mellitus (DM) on severity of concomitant Peripheral Arterial Occlusive Disease (PAOD) in patients with Coronary Artery Disease (CAD)...
  51. ncbi request reprint Risk factors for concomitant peripheral arterial occlusive disease in patients with coronary artery disease: is there a difference between diabetic and non-diabetic patients?
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Acta Clin Belg 60:122-8. 2005
    ..The aim of the present study was investigation of cardiovascular risk factors for concomitant Peripheral Arterial Occlusive Disease (PAOD) in diabetic vs. non-diabetic patients with coronary artery disease (CAD)...
  52. ncbi request reprint Evaluation of aortic arch calcification in type 2 diabetic patients
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Vasa 34:113-7. 2005
    ....
  53. ncbi request reprint Evaluation of a new indicator test for sudomotor function (Neuropad) in the diagnosis of peripheral neuropathy in type 2 diabetic patients
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, Greece
    Exp Clin Endocrinol Diabetes 113:195-8. 2005
    ..2+/-1.9 min in those with a DNI value between 2.5 and 4.5, while it was 32.8+/-2.6 min in those with a DNI value between 5 and 8 (p=0.003)...
  54. ncbi request reprint Mean platelet volume in patients with type 2 diabetes mellitus
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Platelets 15:475-8. 2004
    ..To evaluate mean platelet volume (MPV) in type 2 diabetic versus non-diabetic patients, as well as to investigate the associations between MPV and diabetic complications...
  55. ncbi request reprint The new indicator test (Neuropad): a valuable diagnostic tool for small-fiber impairment in patients with type 2 diabetes
    Nikolaos Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Diabetes Educ 33:257-8, 260, 262 passim. 2007
    ..The purpose of this study was to evaluate the new indicator test for sudomotor function (Neuropad) in the diagnosis of small-fiber impairment in patients with type 2 diabetes...
  56. ncbi request reprint Aortic arch calcification predicts the extent of coronary atherosclerosis in patients with or without type 2 diabetes: short communication
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Acta Clin Belg 62:52-5. 2007
    ..The aim of this study was to evaluate the sensitivity and specificity of aortic arch calcification for detection of severe coronary atherosclerosis in patients suffering from coronary artery disease (CAD), with or without type 2 diabetes...
  57. ncbi request reprint A comparison of the new indicator test for sudomotor function (Neuropad) with the vibration perception threshold and the clinical examination in the diagnosis of peripheral neuropathy in subjects with type 2 diabetes
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, Greece
    Exp Clin Endocrinol Diabetes 116:135-8. 2008
    ..8% and specificity was 67.2%. Sensitivity and specificity of VPT for neuropathy were 78.9% and 85.9% respectively. A significant correlation was shown between time to colour change of the indicator test and VPT (rs=0.889, p<0.001)...
  58. ncbi request reprint Sensitivity and specificity of a new indicator test (Neuropad) for the diagnosis of peripheral neuropathy in type 2 diabetes patients: a comparison with clinical examination and nerve conduction study
    Nikolaos Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    J Diabetes Complications 21:353-8. 2007
    ....
  59. ncbi request reprint The diabetic foot: established and emerging treatments
    N Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Acta Clin Belg 62:230-8. 2007
    ..The endeavour should be coupled with widespread education on the elementary rules to achieve both primary and secondary prevention...
  60. ncbi request reprint An insertion/deletion polymorphism in the alpha2B adrenoceptor gene is associated with peripheral neuropathy in patients with type 2 diabetes mellitus
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, Greece
    Exp Clin Endocrinol Diabetes 115:327-30. 2007
    ..It was significantly higher (p=0.04) in patients with I/D (3.7+/-1) than in those with I/I (2.5+/-0.9) and significantly higher (p=0.001) in patients with D/D (5.6+/-1.3) than in those with I/D (3.7+/-1)...
  61. ncbi request reprint Use of the new indicator test (Neuropad) for the assessment of the staged severity of neuropathy in type 2 diabetic patients
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece
    Exp Clin Endocrinol Diabetes 115:58-61. 2007
    ..A highly significant (Kendall's tau-b=0.848, p=0.001) correlation was shown between time until complete colour change of the test and Michigan class of neuropathy...
  62. doi request reprint The ε4 allele of the APOE gene is associated with more severe peripheral neuropathy in type 2 diabetic patients
    C Monastiriotis
    Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Angiology 64:451-5. 2013
    ..036), diabetes duration (aOR: 1.05, 95% CI: 1.00-1.09, P = .039), and hemoglobin A1c (aOR: 1.32, 95% CI: 1.05-1.66, P = .020). In conclusion, the ε4 carrier status appears to be associated with severe peripheral neuropathy in T2DM...
  63. ncbi request reprint An insertion/deletion polymorphism in the alpha2B adrenoceptor gene is associated with age at onset of type 2 diabetes mellitus
    D Papazoglou
    Second Department of Internal Medicine, Medical School of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece
    Exp Clin Endocrinol Diabetes 114:424-7. 2006
    ..3% of its variance. This result indicates that the D allele may be implicated in impaired glucose metabolism leading to earlier manifestation of diabetes in predisposed subjects...
  64. ncbi request reprint Gravity of aortic arch calcification as evaluated in adult Greek patients
    G Symeonidis
    Second Department of Internal Medicine, O Agios Dimitrios Hospital, Thessaloniki, Greece
    Int Angiol 21:233-6. 2002
    ..The aim of the present study was to evaluate the gravity of aortic arch calcification in adult Greek patients...
  65. doi request reprint The fatty acid amide hydrolase (FAAH) Pro129Thr polymorphism is not associated with severe obesity in Greek subjects
    D Papazoglou
    Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Horm Metab Res 40:907-10. 2008
    ..We were unable to find robust evidence of an association of the Pro129Thr variant with severe obesity, and any related quantitative traits among the obese Greek subjects examined...
  66. ncbi request reprint Could sustained monomorphic ventricular tachycardia in the early phase of a prime acute myocardial infarction affect patient outcome?
    E Hatzinikolaou-Kotsakou
    Academic Cardiology Department, Academic General Hospital Alexandroupolis, Demokritus University of Thrace, Alexandroupolis, Greece
    J Electrocardiol 40:72-7. 2007
    ..The aim of the study was to estimate the prognostic implications of the occurrence of sustained monomorphic ventricular tachycardia in the early phase (<72 h) of a prime acute myocardial infarction...
  67. doi request reprint Mean platelet volume and platelet distribution width in patients with chronic obstructive pulmonary disease: the role of comorbidities
    P Steiropoulos
    Department of Pneumonology, Democritus University of Thrace, Alexandroupolis, Greece
    Angiology 64:535-9. 2013
    ..In patients with COPD, MPV and WBC levels are higher than those of smokers with normal pulmonary function and are significantly correlated. Whether these effects relate to vascular risk in patients with COPD remain to be established...
  68. ncbi request reprint Mean Platelet Volume and Platelet Distribution Width in non-diabetic subjects with obstructive sleep apnoea syndrome: new indices of severity?
    E Nena
    Sleep Laboratory, Department of Pneumonology, Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Greece
    Platelets 23:447-54. 2012
    ....
  69. doi request reprint Fibrates: therapeutic potential for diabetic nephropathy?
    I Kouroumichakis
    Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Eur J Intern Med 23:309-16. 2012
    ..This review examines the role of PPAR-α activation in diabetic nephropathy and summarises data from experimental and clinical studies on the emerging therapeutic potential of fibrates in diabetic nephropathy...
  70. ncbi request reprint Matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 levels in severely obese patients: what is the effect of weight loss?
    D Papazoglou
    Medical School of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece
    Exp Clin Endocrinol Diabetes 118:730-4. 2010
    ....
  71. doi request reprint Monocyte chemoattractant protein 1 is correlated with glycemic control and peripheral arterial disease in type 2 diabetic patients with metabolic syndrome
    K Papatheodorou
    Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis Greece
    Angiology 64:223-9. 2013
    ..The latter is associated with worse glycemic control and PAD. These results suggest a potential contributory role for MCP-1 in the pathogenesis of PAD in the presence of hyperglycemia and MetS in T2DM...
  72. ncbi request reprint Simultaneous, painless, homolateral oculomotor and trochlear nerve palsies in a patient with type 2 diabetes mellitus. Neuropathy or brainstem infarction?
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Acta Diabetol 43:19-21. 2006
    ..An MRI scan showed multiple brainstem ischaemic infarcts. The patient was treated with intensified insulin regimen and clopidogrel. Symptoms gradually improved, and at 9 months there was no further improvement...
  73. ncbi request reprint Breastfeeding and diabetes
    E Gouveri
    Outpatient Clinic of Diabetes, Obesity and Metabolism in the Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Curr Diabetes Rev 7:135-42. 2011
    ..Therefore, health care professionals should encourage both women with and without diabetes to breastfeed their children...
  74. doi request reprint Neuropad: evaluation of three cut-off points of sudomotor dysfunction for early detection of polyneuropathy in recently diagnosed diabetes
    D Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabet Med 28:1412-5. 2011
    ..To examine the sensitivity and specificity of three cut-off points of Neuropad for the diagnosis of distal symmetric polyneuropathy and small-fibre dysfunction in patients within the first year after diagnosis of diabetes...
  75. ncbi request reprint Lower extremity compartment sindrome following coronary artery bypass
    T T Papas
    Department of Vascular Surgery, Democritus University of Thrace, Alexandroupolis, Greece
    J Cardiovasc Surg (Torino) 48:249-52. 2007
    ..Triplex ultrasonography excluded deep vein thrombosis. Compartment syndrome was diagnosed and successfully managed by fasciotomy. This case illustrates that compartment syndrome may, although rarely, be a complication of CABG...
  76. ncbi request reprint Apolipoprotein E and first-ever ischaemic stroke in Greek hospitalized patients
    G Giassakis
    Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece
    J Int Med Res 35:127-33. 2007
    ..Although the sample size was small, these results do not support a role for ApoE polymorphism in the pathogenesis of ischaemic stroke...
  77. pmc Predictors of obstructive sleep apnea in males with metabolic syndrome
    Nikolaos Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Vasc Health Risk Manag 6:281-6. 2010
    ..030). In conclusion, these results provide further evidence for the association between OSA and MS. Between subjects with MS, elevated serum glucose levels indicate a higher probability for the presence of OSA...
  78. ncbi request reprint Popliteal artery pseudoaneurysm after total knee replacement
    T T Papas
    Department of Vascular Surgery, Democritus University of Thrace, Greece
    Vasa 36:145-8. 2007
    ..5 cm long segment of the popliteal artery and reconstruction with synthetic graft (PTFE 6 mm). Her condition soon improved and the patient is capable of walking approximately 1 km per day at 18-month follow-up...
  79. ncbi request reprint Thyroxine replacement dose in patients with Hashimoto disease: a potential role for interleukin-6
    Nikolaos Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Cytokine 35:166-70. 2006
    ..To investigate the potential association between serum inflammatory cytokine levels and thyroxine replacement dose in patients with Hashimoto disease...
  80. ncbi request reprint Markers of glycemic control and insulin resistance in non-diabetic patients with Obstructive Sleep Apnea Hypopnea Syndrome: does adherence to CPAP treatment improve glycemic control?
    Paschalis Steiropoulos
    Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Sleep Med 10:887-91. 2009
    ....
  81. pmc Inflammatory markers in middle-aged obese subjects: does obstructive sleep apnea syndrome play a role?
    Paschalis Steiropoulos
    Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Mediators Inflamm 2010:675320. 2010
    ..Thus, the aim of this study was to explore differences in serum levels of inflammation markers between obese individuals with or without OSAS...
  82. ncbi request reprint The diabetic foot in end stage renal disease
    N Papanas
    Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Ren Fail 29:519-28. 2007
    ..Certainly, technical innovations have made considerable progress possible, but there is a need for further improvement to reduce the number of amputations...
  83. ncbi request reprint Endometrial carcinoma and diabetes revisited
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Eur J Gynaecol Oncol 27:505-8. 2006
    ..To investigate whether endometrial adenocarcinomas are intrinsically different in diabetic as compared to non-diabetic patients...
  84. doi request reprint Statins in prevention and treatment of severe sepsis and septic shock
    I Kouroumichakis
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Eur J Intern Med 22:125-33. 2011
    ..This review outlines current evidence on the use of statins for preventing and treating sepsis...
  85. ncbi request reprint Double gall-bladder--two pathologies: a case report
    M Pitiakoudis
    Second Department of Surgery, Democritus University of Thrace, Alexandroupolis, Greece
    Acta Chir Belg 108:261-3. 2008
    ..Predisposing factors for the development of gall-stones in one gall-bladder only, as well as surgical options, are briefly discussed...
  86. ncbi request reprint Angiogenic growth factors in the treatment of peripheral arterial disease
    Dimitrios Mikroulis
    Department of Cardiothoracic Surgery, Democritus University of Thrace, Greece
    Curr Vasc Pharmacol 5:195-209. 2007
    ..VEGF is important in the pathogenesis of diabetic microvascular disease. Further studies are required before implementation of AGF therapy in clinical practice...
  87. ncbi request reprint Plasma visfatin levels in severe obstructive sleep apnea-hypopnea syndrome
    Georgia Trakada
    Department of Pneumonology, Democritus University of Thrace, Alexandroupolis, Greece
    Sleep Breath 13:349-55. 2009
    ..Aim of this study was to evaluate levels of plasma visfatin in patients with severe OSAS and examine their potential correlation with sleep characteristics and several biochemical parameters...
  88. pmc The Diabetic foot: A global threat and a huge challenge for Greece
    N Papanas
    Outpatient Clinic of the Diabetic Foot, 2nd Department of Internal Medicine, Democritus University, Thrace, Greece
    Hippokratia 13:199-204. 2009
    ..Finally, additional research should investigate feasible ways of implementing current knowledge in everyday clinical practice...
  89. ncbi request reprint Relation of C-reactive protein to the first onset and the recurrence rate in lone atrial fibrillation
    Eleni Hatzinikolaou-Kotsakou
    Academic Department of Cardiology, Academic General Hospital Alexandroupolis Demokritus University of Thrace, Thrace, Greece
    Am J Cardiol 97:659-61. 2006
    ..The elevated hs-CRP levels could also predict the recurrence rate of lone AF in patients without antiarrhythmic drugs...
  90. ncbi request reprint Acute paraplegia after the initiation of anti-tumour necrosis factor-alpha therapy for Crohn's disease
    Konstantinos Vadikolias
    Department of Neurology, University Hospital, Democritus University of Thrace, Alexandroupolis, Greece
    Eur J Gastroenterol Hepatol 19:159-62. 2007
    ..This case highlights that patients developing new neurological symptoms while on anti-tumour necrosis factor medication should be monitored closely...
  91. ncbi request reprint Common carotid intima media thickness as a marker of clinical severity in patients with symptomatic extracranial carotid artery stenosis
    Ioannis Heliopoulos
    Department of Neurology, Democritus University of Thrace, Alexandroupoli, Greece
    Clin Neurol Neurosurg 111:246-50. 2009
    ..We sought to investigate the association between CCA-IMT and clinical severity of ischemic stroke in patients with symptomatic extracranial carotid artery stenosis (SCAS)...
  92. ncbi request reprint Circulating levels of collagen type I degradation marker depend on the type of atrial fibrillation
    Dimitrios N Tziakas
    University Cardiology Department, Democritus University of Thrace, Voulgaroktonou 23, 68100 Alexandroupolis, Evros, Greece
    Europace 9:589-96. 2007
    ..To investigate the hypothesis that circulating levels of collagen type I degradation or synthesis markers are associated with the presence and pattern of atrial fibrillation (AF)...
  93. ncbi request reprint High-sensitivity CRP is correlated with neurologic symptoms and plaque instability in patients with severe stenosis of the carotid bifurcation
    Theophanis T Papas
    Department of Vascular Surgery, General Hospital Georgios Gennimatas, Athens
    Vasc Endovascular Surg 42:249-55. 2008
    ..In conclusion, serum high-sensitivity C-reactive protein levels are associated with presence of neurological symptoms and plaque instability in patients with high-grade stenosis of the carotid bifurcation...
  94. ncbi request reprint Levosimendan use reduces matrix metalloproteinase-2 in patients with decompensated heart failure
    Dimitrios N Tziakas
    Cardiology Department, Democritus University of Thrace, Alexandroupolis, Greece
    Cardiovasc Drugs Ther 19:399-402. 2005
    ..Matrix metalloproteinases (MMPs) are involved in the regulation of extracellular matrix (ECM) metabolism. We investigated the effect of levosimendan, a novel calcium sensitizer, on serum levels of MMP-2...
  95. ncbi request reprint Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss
    Dimitrios Papazoglou
    Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Patriarhou Grigoriou 97 99, Alexandroupolis 68100, Greece
    Fertil Steril 83:959-63. 2005
    ..To investigate whether four common polymorphisms (-2578C/A, -1154G/A, -634G/C, and 936C/T) of the gene encoding for vascular endothelial growth factor (VEGF) are associated with idiopathic recurrent miscarriage...
  96. ncbi request reprint Effect of angiotensin-converting enzyme insertion/deletion genotype on collagen type I synthesis and degradation in patients with atrial fibrillation and arterial hypertension
    Dimitrios N Tziakas
    Democritus University of Thrace, University Cardiology Department, Voulgaroktonou 23, Alexandroupolis 68100, Greece
    Expert Opin Pharmacother 8:2225-34. 2007
    ....