Research Topics
Species | Nikolaos G PapadopoulosSummaryAffiliation: University of Athens Country: Greece Publications
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Detail Information
Publications
Association of rhinovirus infection with increased disease severity in acute bronchiolitisNikolaos G Papadopoulos
Research Laboratories, Second Department of Pediatrics, University of Athens School of Medicine, Athens, Greece
Am J Respir Crit Care Med 165:1285-9. 2002..In conclusion, rhinovirus is second only to RSV as a causative agent of bronchiolitis and is associated with more severe disease. The presence of more than one pathogen may influence the natural history of acute bronchiolitis...- Antimicrobial strategies: an option to treat allergy?Nikolaos G Papadopoulos
Allergy Research Centre, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Biomed Pharmacother 61:21-8. 2007..In addition, it provides a synopsis of potential therapeutic strategies either directly against the microorganisms or in respect to the associated inflammation... - Respiratory viruses in childhood asthmaNikolaos G Papadopoulos
Allergy Department, Second Pediatric Clinic, University of Athens, Greece
Curr Opin Allergy Clin Immunol 7:91-5. 2007.... - Mechanisms of rhinovirus-induced asthmaNikolaos G Papadopoulos
Allergy Department, Second Paediatric Clinic, University of Athens, Greece
Paediatr Respir Rev 5:255-60. 2004.... 
Research needs in allergy: an EAACI position paper, in collaboration with EFANikolaos G Papadopoulos
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Clin Transl Allergy 2:21. 2012..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...- IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmaticsLuminita A Stanciu
Department of Respiratory Medicine, National Heart and Lung Institute, Wright Fleming Institute for Infection and Immunity, Imperial College London, Norfolk Place, London, UK
Respir Res 6:67. 2005..In this study, we investigated whether excess IL-4 during repeated TCR/CD3 stimulation of CD8+ T cells from atopic asthmatic subjects alters the balance of type 1/type 2 cytokine production in favour of the latter... - Atypical bacteria and macrolides in asthmaParaskevi Xepapadaki
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Allergy Asthma Clin Immunol 4:111-6. 2008..In the present report, evidence of the involvement of Chlamydophila and Mycoplasma infection in the development and the progression of asthma are reviewed... - Does respiratory syncytial virus subtype influences the severity of acute bronchiolitis in hospitalized infants?Nikolaos G Papadopoulos
Research Laboratories, 2nd Department of Pediatrics, University of Athens School of Medicine, 13 Levadias Str, Goudi 11527, Greece
Respir Med 98:879-82. 2004..These results support the notion that RSV-A-induced bronchiolitis is more severe than RSV-B-induced one, in agreement with the majority of previously published studies... 
New visions in respiratory allergy (asthma and allergic rhinitis): an iPAC summary and future trendsNikolaos G Papadopoulos
Department of Allergy, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Pediatr Allergy Immunol 19:51-9. 2008....- The efficacy of montelukast during the allergy season in pediatric patients with persistent asthma and seasonal aeroallergen sensitivityNikolaos G Papadopoulos
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
J Asthma 46:413-20. 2009..To determine the effect of montelukast on asthma during the allergy season in children with persistent asthma and seasonal aeroallergen sensitivity... - Do rhinoviruses cause pneumonia in children?Nikolaos G Papadopoulos
Allergy Unit, 2nd Dpt of Pediatrics, University of Athens, Greece
Paediatr Respir Rev 5:S191-5. 2004..Current mechanistic data suggest that rhinoviruses could be the cause of pneumonia in immunocompetent subjects. This notion is supported by epidemiological evidence, however, more clinical studies are needed to assess the actual burden... - Rhinoviruses in the pathogenesis of asthmaNikolaos G Papadopoulos
Allergy Unit, Second Pediatric Clinic, University of Athens, 13 Levadias Street, 115 27 Goudi, Athens, Greece
Curr Allergy Asthma Rep 3:137-45. 2003..Furthermore, in an atopic environment, responses to the virus are skewed by and toward an "atopic," Th2-like balance, which may further enhance inflammation and exacerbate asthma... - Viruses and bacteria in acute asthma exacerbations--a GA² LEN-DARE systematic reviewN G Papadopoulos
Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University, Athens, Greece
Allergy 66:458-68. 2011.... - The role of respiratory viruses in the origin and exacerbations of asthmaNikolaos G Papadopoulos
Allergy Unit, 2nd Pediatric Clinic, University of Athens, Greece
Curr Opin Allergy Clin Immunol 3:39-44. 2003..The present review focuses and comments on the increasing body of evidence correlating respiratory viral infections with asthma onset and exacerbations... - Duration of postviral airway hyperresponsiveness in children with asthma: effect of atopyParaskevi Xepapadaki
Allergy Unit, 2nd Pediatric Clinic, University of Athens
J Allergy Clin Immunol 116:299-304. 2005..However, an increased rate of symptomatic cold and asthma episodes in atopic children is associated with considerable cumulative prolongation of AHR, which might help explain the role of atopy as a risk factor for asthma persistence... - Rhinovirus viremia in children with respiratory infectionsMaria Xatzipsalti
Allergy Department, Second Pediatric Clinic, University of Athens, Athens, Greece
Am J Respir Crit Care Med 172:1037-40. 2005..CONCLUSIONS: Viremia may occur during RV respiratory infections in normal children and is rather common in the early course of acute asthma exacerbations, suggesting that rhinoviremia may be involved in asthma exacerbation pathogenesis... - Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinovirusesStelios Psarras
Allergy Department, 2nd Pediatric Clinic, University of Athens, Greece
J Allergy Clin Immunol 117:291-7. 2006..The possibility that viral infection may mediate angiogenesis, thus contributing to airway remodeling, has not been evaluated... - Effect of clarithromycin on acute asthma exacerbations in children: an open randomized studyIoanna Koutsoubari
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Pediatr Allergy Immunol 23:385-90. 2012..The aim of the study was to evaluate the efficacy of clarithromycin on medium-term asthma activity when given as an add-on therapy in children with acute asthma... - Optimized techniques for the extraction of grape allergens appropriate for in vivo and in vitro testing and diagnosisEmilia V Vassilopoulou
Allergy Research Centre of 2nd Paediatric Clinic, University of Athens, Athens, Greece
Mol Nutr Food Res 51:360-6. 2007.... - Human Metapneumovirus as a causative agent of acute bronchiolitis in infantsParaskevi Xepapadaki
Research Laboratories, Second Department of Pediatrics, University of Athens, 13 Levadias Street, 11527 Goudi, Athens, Greece
J Clin Virol 30:267-70. 2004..These findings suggest that hMPV is a common and important causative agent in infants with bronchiolitis, with clinical characteristics similar to that of RSV... - Pathogenesis of respiratory syncytial virus bronchiolitis-related wheezingStelios Psarras
Allergy Unit, 2nd Pediatric Clinic, University of Athens, Greece
Paediatr Respir Rev 5:S179-84. 2004..In that sense, RSV bronchiolitis may serve as a marker, reflecting predisposition of the individual for virus induced wheezing early in life and/or asthma later in life... - Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal childrenDimitrios Gourgiotis
Research Laboratories, 2nd Department of Paediatrics, University of Athens, School of Medicine, P and A Kyriakou Children's Hospital, Athens, Greece
J Asthma 41:285-7. 2004..Because CD30 has been associated with Th-2 cells, this observation supports the possibility of pidotimod being able to affect the Th-1/Th-2 balance in atopic asthma... - Rhinovirus infection induces cytotoxicity and delays wound healing in bronchial epithelial cellsApostolos Bossios
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Respir Res 6:114. 2005..Recent observations, however, have questioned this knowledge. The aim of this study was to evaluate the ability of RV to induce epithelial cytotoxicity and affect epithelial repair in-vitro... - Reintroduction of cow's milk in milk-allergic children: safety and risk factorsEmilia Vassilopoulou
Allergy Unit, 2nd Department of Pediatrics, University of Athens, Athens, Greece
Int Arch Allergy Immunol 146:156-61. 2008..Less 'invasive' procedures able to predict tolerance would be useful as clinical tools. The purpose of this study was to identify potential risk factors for clinical reactivity in CM-allergic children assessed for CM reintroduction... - Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling featuresChrysanthi L Skevaki
UPC Research Laboratories, Allergy Department, 2nd Pediatric Clinic, University of Athens, 41 Fidipidou str, Athens, 115 27, Greece
Clin Transl Allergy 2:14. 2012..abstract:.. - The longest wheal diameter is the optimal measurement for the evaluation of skin prick testsGeorge N Konstantinou
Department of Allergy and Allergy Research Center, Pediatric Hospital P and A Kiriakou, National and Kapodistrian University of Athens, Athens, Greece
Int Arch Allergy Immunol 151:343-5. 2010..Mean diameter or longest diameter are the 2 most frequently used parameters for wheal response assessment after skin prick testing (SPT). We aimed to compare these 2 parameters taking as gold standard the surface of the wheal skin response... - A 5-year venom immunotherapy protocol with 50 μg maintenance dose: safety and efficacy in school childrenGeorge N Konstantinou
Department of Allergy and Clinical Immunology, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece
Pediatr Allergy Immunol 22:393-7. 2011..A remaining problem is the relative effectiveness and safety of different immunotherapy protocols used with respect to maintenance dose, injection interval, and duration... - Assessment of airflow limitation, airway inflammation, and symptoms during virus-induced wheezing episodes in 4- to 6-year-old childrenGeorge N Konstantinou
Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, Thessaloniki, Greece
J Allergy Clin Immunol 131:87-93.e1-5. 2013..It is disputed whether recurrent episodes of wheeze in preschool-aged children comprise a distinct asthma phenotype... - Viral infections and allergiesParaskevi Xepapadaki
Allergy Department, 2nd Pediatric Clinic, University of Athens, Greece
Immunobiology 212:453-9. 2007..In the present report, recent data on the role of viral infections in the development and progression of allergy and asthma are reviewed... - Association of passive exposure of pregnant women to environmental tobacco smoke with asthma symptoms in childrenParaskevi Xepapadaki
Allergy Department, 2nd Pediatric Clinic, University of Athens, 13 Levadias Str, Goudi 11527, Greece
Pediatr Allergy Immunol 20:423-9. 2009..Public health policies should be oriented not only towards smoking cessation, but also reinforce elimination of ETS exposure of pregnant women... - The role of respiratory viruses in the pathogenesis of pediatric asthmaIoanna M Velissariou
Second Department of Pediatrics, P and A Kyriakou Children s Hospital, University of Athens, Greece
Pediatr Ann 35:637-42. 2006..In addition, repetitive infections play an important role in perpetuating inflammation and airway hyperresponsiveness, especially in the presence of atopy, leading from childhood asthma to a more persistent asthma phenotype... - Rhinovirus infections and adenoidal hypertrophy: do they interact with atopy in children?Artem Javadyan
University of Athens, P and A Kiriakou Children s Hospital, 13 Livadias St, GR 11527 Athens, Greece
Expert Rev Anti Infect Ther 1:223-9. 2003..This review focuses on the interactions between rhinoviral infection, the host's immune status and adenoidal disease... - Cellular and animals models for rhinovirus infection in asthmaMaria Xatzipsalti
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Contrib Microbiol 14:33-41. 2007..Cellular models are invaluable investigational tools for understanding mechanisms of RV-induced asthma and evaluating new targets for therapy... - Risk of allergic reactions to wine, in milk, egg and fish-allergic patientsEmilia Vassilopoulou
Allergy Research Centre, 2nd Department of Pediatrics, University of Athens, Greece
Clin Transl Allergy 1:10. 2011..abstract:.. - Effect of Greek raisins (Vitis vinifera L.) from different origins on gastric cancer cell growthAndriana C Kaliora
Department of Science of Dietetics and Nutrition, Harokopion University of Athens, Athens, Greece
Nutr Cancer 60:792-9. 2008..These results indicate that the methanol extracts from currants, rich in phenolic compounds, exhibit cancer preventive efficacy by limiting cell proliferation, inducing cell death, and suppressing ICAM-1 levels in AGS cells... - Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg+/HBeAg- mothersLemonica Koumbi
Second Department of Pediatrics, Allergy Research Center, University of Athens, Athens, Greece
Cell Mol Immunol 7:454-8. 2010..This encounter, however, did not impair their T-cell responses to vaccination... - Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndromeEmilia Vassilopoulou
Allergy Research Centre, Second Pediatric Clinic, University of Athens, Athens, Greece
Int Arch Allergy Immunol 143:92-102. 2007..A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were detected... - The genomic signature of human rhinoviruses A, B and CSpyridon Megremis
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
PLoS ONE 7:e44557. 2012..Since viral recognition is dependent on RNA motifs rich in CpG and UpA, it is possible that the overall described genome evolution mechanism acts in order to protect the virus from host recognition... - Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitisConstantinos Pitsios
Department of Allergology and Clinical Immunology, Laikon General Hospital, Athens, Greece
Ann Allergy Asthma Immunol 96:673-8. 2006..CONCLUSIONS: Prophylactic administration of mometasone furoate before the pollen season is safe and may lead to improved control of SAR compared with the use of nedocromil sodium... - Dendritic cells in viral bronchiolitisParaskevi Maggina
Allergy Research Centre, 2nd Paediatric Clinic, Medical School, University of Athens, 41 Fidippidou Street, Goudi, 11527, Athens, Greece
Expert Rev Clin Immunol 5:271-82. 2009..This review focuses on current data, both from in vivo and in vitro studies, that highlight the interplay between DCs and the viral causes of bronchiolitis... - Effect of simulated gastro-duodenal digestion on the allergenic reactivity of beta-lactoglobulinApostolos Bossios
Athens University, P, and A, Kyriakou Children s Hospital, Athens, Greece
Clin Transl Allergy 1:6. 2011..abstract:.. - Otitis media with effusion: an effort to understand and clarify the uncertaintiesFotini-Maria Chantzi
University of Athens, Second Department of Pediatrics, and the ENT department, P and A Kyriakou Children's Hospital, Athens 115 27, Greece
Expert Rev Anti Infect Ther 3:117-29. 2005..An effort will be made to clarify those aspects sufficiently supported by evidence-based studies, and to underline those that remain unfounded... - Whole blood interferon-γ release assay is a useful tool for the diagnosis of tuberculosis infection particularly among Bacille Calmette Guèrin-vaccinated childrenMaria N Tsolia
Second Department of Pediatrics, P and A Kyriakou Children s Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece
Pediatr Infect Dis J 29:1137-40. 2010..It is concluded that QuantiFERON-TB Gold-In-Tube compares with the tuberculin skin test in the diagnosis of TB disease and latent tuberculosis infection in TB contacts among children and has enhanced specificity... - Antiatherogenic effect of Pistacia lentiscus via GSH restoration and downregulation of CD36 mRNA expressionGeorge V Z Dedoussis
Department of Science of Dietetics Nutrition, Harokopio University, 70 El Venizelou Str, 17 671 Kallithea, Athens, Greece
Atherosclerosis 174:293-303. 2004..lentiscus triterpenes exert antioxidant/antiatherogenic effect. Additionally, our results provide strong evidence of the resin's antiatherogenic effect; therefore it is credited with beneficial health aspects... - Comparison of four nasal sampling methods for the detection of viral pathogens by RT-PCR-A GA(2)LEN projectIrini S Spyridaki
Allergy Research Center, 2nd Pediatric Clinic, University of Athens, 41 Fidippidou str, 11527 Athens, Greece
J Virol Methods 156:102-6. 2009..61 for brushings. Nasal washes yielded the highest rate of viral detection without excessive patient discomfort. In contrast, nasal brushes produced the lowest detection rates and demonstrated the highest level of discomfort... - A recombinant hypoallergenic parvalbumin mutant for immunotherapy of IgE-mediated fish allergyInes Swoboda
Institute of Medical and Chemical Laboratory Diagnostics, Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria
J Immunol 178:6290-6. 2007..Using the hypoallergenic carp parvalbumin mutant Mut-CD/EF, it may be possible to treat fish allergy by immunotherapy... - Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineeringKuan Wei Chen
Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
Mol Immunol 45:2486-98. 2008..Thus the rDer p 2 derivatives exhibited less in vivo allergenic activity and allergenicity than the Der p 2 allergen but preserved immunogenicity and may hence represent candidates for specific immunotherapy of house-dust mite allergy... - Consumption of heat-treated egg by children allergic or sensitized to egg can affect the natural course of egg allergy: hypothesis-generating observationsGeorge N Konstantinou
J Allergy Clin Immunol 122:414-5. 2008 - Epidemiology of psoriatic arthritis in northwest Greece, 1982-2001Yannis Alamanos
Department of Hygiene and Epidemiology, University of Ioannina Medical School, 451 10 Ioannina, Greece
J Rheumatol 30:2641-4. 2003..CONCLUSION: The incidence and prevalence of PsA in Northwest Greece was roughly half that reported in studies from the US and Northern Europe. This frequency tended to increase in the last decade... - Mouse respiratory epithelial cells support efficient replication of human rhinovirusTobias J Tuthill
Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
J Gen Virol 84:2829-36. 2003..These observations suggest that the development of mouse models of respiratory tract infection by major as well as minor group HRV should be pursued... - Reducing agents inhibit rhinovirus-induced up-regulation of the rhinovirus receptor intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cellsAlberto Papi
University Medicine, University of Southampton, Southampton, UK
FASEB J 16:1934-6. 2002..This oxidant generation was completely inhibited by GSH. We conclude that redox-mediated intracellular pathways represent an important target for the therapeutic control of rhinovirus-induced diseases...