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Genomes and GenesSpecies | Gerassimos A PangalisSummaryAffiliation: University of Athens Country: Greece Publications
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Publications
Massive intravascular hemolysis: a fatal complication of clostridium perfringens septicemia in a patient with acute myeloid leukemiaGeorge Vaiopoulos
First Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Laikon General Hospital, Greece
Leuk Lymphoma 45:2157-9. 2004..We describe a fatal case of a 74-year old man with acute myeloid leukemia complicated by massive intravascular hemolysis due to Clostridium perfringens sepsis...- Differential diagnosis of Waldenstrom's macroglobulinemia and other B-cell disordersGerassimos A Pangalis
First Department of Internal Medicine and Department of Hematology, National and Kapodistrian University of Athens, Laikon General Hospital, 16 Sevastoupoleos Street, Athens 11526, Greece
Clin Lymphoma 5:235-40. 2005..Research in this field should continue to further clarify the disease entities that overlap with WM. New technology such as gene-expression profile techniques may contribute to this purpose... - Serum syndecan-1, basic fibroblast growth factor and osteoprotegerin in myeloma patients at diagnosis and during the course of the diseaseMaria-Christina Kyrtsonis
Hematology Section and Research Laboratory, First Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens, Greece
Eur J Haematol 72:252-8. 2004..CONCLUSIONS: Pretreatment syndecan-1, bFGF and OPG levels were found to be increased at diagnosis. Syndecan-1 and OPG fluctuated according to MM activity. Elevated serum syndecan-1 and bFGF levels predicted short survival... - Combination chemotherapy plus low-dose involved-field radiotherapy for early clinical stage Hodgkin's lymphomaTheodoros P Vassilakopoulos
Haematology Section, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece
Int J Radiat Oncol Biol Phys 59:765-81. 2004..The long-term toxicity with respect to secondary malignancies appears to be acceptable... - Topoisomerase IIalpha expression as an independent prognostic factor in Hodgkin's lymphomaIpatia A Doussis-Anagnostopoulou
Laboratory of Histology and Embryology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
Clin Cancer Res 14:1759-66. 2008.... - Early-stage gastric MALT lymphoma: is it a truly localized disease?Marina P Siakantaris
Department of Haematology, National and Kapodistrian University of Athens, Medical School, Laikon General Hospital, Athens, Greece
Oncologist 14:148-54. 2009..The clinical significance of occult blood disease and the potential appropriate intervention need to be further investigated... - Serum levels of soluble syndecan-1 in Hodgkin's lymphomaTheodoros P Vassilakopoulos
First Department of Internal Medicine and Department of Haematology, National and Kapodistrian University of Athens, Laikon University Hospital, Athens, Greece
Anticancer Res 25:4743-6. 2005..CONCLUSION: The serum levels of syndecan-1 were elevated in patients with HL, but were not strongly correlated with other potential prognostic factors. Their effect on prognosis deserves further evaluation... - Development and validation of a clinical prediction rule for bone marrow involvement in patients with Hodgkin lymphomaTheodoros P Vassilakopoulos
Haematology Section, First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Blood 105:1875-80. 2005..Patients with standard risk should be staged with unilateral biopsy, but patients with high risk may benefit from bilateral biopsy... - Differential diagnosis of Waldenstrom's macroglobulinemia from other low-grade B-cell lymphoproliferative disordersGerassimos A Pangalis
Haematology Section, First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Semin Oncol 30:201-5. 2003..Based on the former, diagnosis is usually easy. It may be harder in LPL cases not secreting IgM. We consider that WM should be, for the time being, handled as a separate entity. Further studies are necessary... - Non-gastric extra-nodal marginal zone lymphomas--a single centre experience on 76 patientsChristina Kalpadakis
Department of Haematology, University of Crete, Medical School, University Hospital of Heraklion, Heraklion Crete, Greece
Leuk Lymphoma 49:2308-15. 2008..The 5- and 10-year progression free survival was 56% and 41%, respectively. The only feature associated with inferior outcome was disease localisation to the lung... - Favorable outcome of primary cutaneous marginal zone lymphoma treated with intralesional rituximabMaria-Christina Kyrtsonis
First Department of Internal Medicine and Department of Haematology, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens, Greece
Eur J Haematol 77:300-3. 2006..Apart from mild local pain during the injection, no other adverse effects were observed. In conclusion, rituximab can be safely administered intralesionally in patients with PCMZL and can produce disease remission... - Hodgkin's lymphoma in first relapse following chemotherapy or combined modality therapy: analysis of outcome and prognostic factors after conventional salvage therapyTheodoros P Vassilakopoulos
Hematology Section, First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, 16 Sevastoupoleos Street, Athens, Greece
Eur J Haematol 68:289-98. 2002..The combination of these prognostic factors defines a sizeable subgroup of patients with favorable outcome following conventional salvage therapy... - Mutation analysis of IgVH genes in splenic marginal zone lymphomas: correlation with clinical characteristics and outcomeChristina Kalpadakis
Department of Haematology, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece
Anticancer Res 29:1811-6. 2009..To determine the immunoglobulin variable heavy chain (IgVH) gene usage and somatic mutation patterns in a series of SMZL patients and to correlate these findings with the clinical features and outcome... - Hepatic and renal plasma cell lesions in a patient with multiple myeloma in hematological remissionZacharoula Galani
First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Anticancer Res 27:571-4. 2007..This case is an interesting model of refractory MM extraosseous involvement, that a clinician should be aware of when carrying out differential diagnosis... - Prognostic value of serum free light chain ratio at diagnosis in multiple myelomaMarie Christine Kyrtsonis
Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Br J Haematol 137:240-3. 2007..The 5-year disease-specific survival was 82% and 30% in patients with sFLCR lower than and equal or greater than the median, respectively (P = 0.0001). sFLCR was an independent prognostic factor... - Pure infradiaphragmatic Hodgkin's lymphoma. Clinical features, prognostic factor and comparison with supradiaphragmatic diseaseTheodoros P Vassilakopoulos
First Dept. of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Haematologica 91:32-9. 2006..Patients with stage IIB disease should probably be classified as having advanced HL because of the unacceptable rate of primary refractory disease... - Combination of rituximab with chlorambucil as first line treatment in patients with mantle cell lymphoma: a highly effective regimenSotirios Sachanas
Department of Hematology, Athens Medical Center Psychikon Branch, Laikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece
Leuk Lymphoma 52:387-93. 2011..There were no serious side effects. These results show that the R-Chl combination could be an effective therapeutic option as first line treatment in MCL, especially for patients with indolent disease characteristics... - CD138 expression helps distinguishing Waldenström's macroglobulinemia (WM) from splenic marginal zone lymphoma (SMZL)Marie Christine Kyrtsonis
Hematology Section of the First Department of Propedeutic Internal Medicine, National and Kapodistrian University of Athens, Laikon University Hospital, Athens, Greece
Clin Lymphoma Myeloma Leuk 11:99-102. 2011..0008 and, .00021 respectively). Moreover, CD138 expression was related to serum IgM levels in WM patients (P=.0006). In conclusion, CD138 expression may constitute an additional aid in the distinction between WM and SMZL... - A randomized trial comparing intensified CNOP vs. CHOP in patients with aggressive non-Hodgkin's lymphomaGerassimos A Pangalis
Hematology Section, First Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, 16 Sevastoupoleos Str, P O Box 14044, Athens 11510, Greece
Leuk Lymphoma 44:635-44. 2003..14). In conclusion, iCNOP was equally effective to CHOP in patients with ANHL, producing more leukopenia and febrile episodes, but less alopecia. The development of two cases of secondary AML in th e iCNOP arm is of concern... - Adult T-cell leukemia/lymphoma (ATLL): report of two fully documented Hellenic patientsStyliani I Kokoris
Haematology Section, 1st Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laikon General Hospital of Athens, Greece
Leuk Lymphoma 45:715-21. 2004..In conclusion, the two aforementioned patients are the first fully documented ATLL patients described in Greece. Investigation for HTLV-I antibodies should be mandatory in all patients with T-cell lymphoproliferative disorders... - Kikuchi's lymphadenopathy: a relatively rare but important cause of lymphadenopathy in Greece, potentially associated with the antiphospholipid syndromeTheodoros P Vassilakopoulos
First Department of Internal Medicine and Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, 17 Ag Thoma Street, Goudi, Athens, 11527, Greece
Rheumatol Int 30:925-32. 2010..In this setting, autoimmune disorders, mainly lupus and APLS, should be considered and excluded by the appropriate laboratory work-up... - Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone with or without radiotherapy in primary mediastinal large B-cell lymphoma: the emerging standard of careTheodoros P Vassilakopoulos
Department of Haematology, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, Greece
Oncologist 17:239-49. 2012..Rituximab-CHOP (R-CHOP) is the standard of care for diffuse large B-cell lymphoma, whereas efficacy in PMLBCL has not been adequately confirmed... - Immunotherapeutic and immunoregulatory drugs in haematologic malignanciesGerassimos A Pangalis
First Department of Internal Medicine, First Department of Propedeutic Internal Medicine and Department of Hematology, National and Kapodistrian University of Athens Medical School, Laikon General Hospital, Athens, Greece
Curr Top Med Chem 6:1657-86. 2006..The addition of these agents in therapeutic regimens has improved considerably the treatment of hematological malignancies... - Immunohistochemical expression and prognostic significance of CCND3, MCM2 and MCM7 in Hodgkin lymhomaAndreas Marnerides
Department of Pathology, Laikon General Hospital, National and Kapodistrian University of Athens, Greece
Anticancer Res 31:3585-94. 2011..Increased proliferation rate may be associated with inferior outcome in patients with Hodgkin lymphoma (HL). Minichromosome maintenance proteins (MCMs) and D-type cyclins are essential for DNA replication... - The prognostic significance of beta(2)-microglobulin in patients with Hodgkin's lymphomaTheodoros P Vassilakopoulos
Hematology Section, First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Haematologica 87:701-8; discussion 708. 2002..001). INTERPRETATION AND CONCLUSIONS: s beta(2)m is not a potent prognostic factor for FFS in optimally treated patients with HL. However s beta(2)m may be predictive of OS, probably due to its effect on the timing of treatment failure... - Treatment strategies for pediatric nodular lymphocyte predominant Hodgkin's lymphomaTheodoros P Vassilakopoulos
First Department of Internal Medicine and Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Leuk Lymphoma 47:1450-1. 2006 - A morphometric study of bone marrow angiogenesis in hairy cell leukaemia with clinicopathological correlationsPenelope Korkolopoulou
Department of Pathology, First Department of Internal Medicine, School of Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece
Br J Haematol 122:900-10. 2003..Furthermore, the prognostic significance of angiogenesis requires the concomitant assessment of MVD and the complexity of the microvascular network... - B-chronic lymphocytic leukemia: practical aspectsGerassimos A Pangalis
Hematology Section, 1st Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Hematol Oncol 20:103-46. 2002..Supportive care is an important part of patient management and it involves restoring hypogammaglobulinemia and disease-related anemia by polyvalent immunoglobulin administration and erythropoietin respectively... - Ida-FLAG plus imatinib mesylate-induced molecular remission in a patient with chemoresistant Ph1+ acute myeloid leukemiaNora Athina Viniou
First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Eur J Haematol 72:58-60. 2004..The addition of imatinib mesylate led to a molecular remission, which is sustained for 10 months so far... - Downstaging Rai stage III B-chronic lymphocytic leukemia patients with the administration of recombinant human erythropoietinGerassimos A Pangalis
National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, 16 Sevastoupoleos St, P O Box 14044, Athens 11510, Greece
Haematologica 87:500-6. 2002.... - Thrombotic microangiopathy in a patient with Sezary syndrome treated with interferon-alphaMarianna Politou
First Department of Internal Medicine, University of Athens Medical School, Greece
Nephrol Dial Transplant 19:733-5. 2004 - Treatment of relapsed or refractory Waldenström's macroglobulinemia with bortezomibMeletios A Dimopoulos
Department of Clinical Therapeutics, Euroclinic Hospital, Athens, Greece
Haematologica 90:1655-8. 2005..Thus, this agent is worth studying in patients with Waldenström's macroglobulinemia (WM)... - Treatment of Waldenstrom's macroglobulinemia with rituximab: prognostic factors for response and progressionMeletios A Dimopoulos
Department of Clinical Therapeutics, University of Athens School of Medicine, Greece
Leuk Lymphoma 45:2057-61. 2004..We conclude that rituximab is an effective treatment modality for patients with WM. Patients with both low levels of monoclonal protein and normal albumin are the best candidates for treatment with standard dose rituximab... - Primary adult-onset macrophage activation syndrome with multisystemic tissue phagocytosisAnastasios Andreopoulos
1st Department of Internal Medicine and Department of Haematology, Laikon General Hospital, National Kapodistrian University of Athens, 17 Ag Thoma st, Athens, Greece
Int J Hematol 86:394-6. 2007..Similar cases necessitate further study for classification and management... - The splenic form of mantle cell lymphomaMaria K Angelopoulou
Hematology Section, First Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, 16 Sevastoupoleos Street, 11510 Athens, Greece
Eur J Haematol 68:12-21. 2002..CONCLUSIONS: We conclude that this presentation represents a separate form of MCL which requires splenectomy. It remains to be seen whether it carries a better prognosis than classical MCL... - Pegylated liposomal doxorubicin in the CHOP regimen for older patients with aggressive (stages III/IV) non-Hodgkin's lymphomaNikolas Tsavaris
Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, Greece
Anticancer Res 22:1845-8. 2002.... - Reversible dilated cardiomyopathy associated with amphotericin B treatmentIoannis Moyssakis
Department of Cardiology, Laikon General Hospital, Athens, Greece
Int J Antimicrob Agents 25:444-7. 2005..The clinical data from our cases and two similar cases reported in the literature suggest that the presence of other factors predisposing to cardiac dysfunction may facilitate the occurrence of this rare side effect... - Primary effusion lymphoma in two HIV-negative patients successfully treated with pleurodesis as first-line therapyX Yiakoumis
Department of Haematology, Iatriko Athinon, Psychicon Branch, 1st Kyriakidou Str, P Psychikon, 15452 Athens, Greece
Anticancer Res 30:271-6. 2010..We also perform a review of the relevant literature regarding the clinical data, treatment, and survival of PEL in HIV-negative patients... - Elevated serum levels of IL-10 are associated with inferior progression-free survival in patients with Hodgkin's disease treated with radiotherapyCarlo Visco
Department of Lymphoma and Myeloma, University of Texas, MD Anderson Cancer Center, Houston, USA
Leuk Lymphoma 45:2085-92. 2004..0001). In conclusion, high serum IL-10 is independently associated with inferior PFS in patients with HD treated with RT... - Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's MacroglobulinemiaRoger G Owen
Leeds General Infirmary, Leeds, UK
Semin Oncol 30:110-5. 2003..Patients with clinical features attributable to IgM monoclonal gammopathy but no overt evidence of lymphoma are considered to constitute a distinct clinical group and the term "IgM-related disorders" is proposed... - Correspondence re: M. Provencio, et al. the topoisomerase IIa expression correlates with survival in patients with advanced Hodgkin's lymphoma. Clin. Cancer Res., 9: 1406-1411, 2003Theodoros P Vassilakopoulos
Clin Cancer Res 9:5430-1; author reply 5431. 2003 - Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomibKonstantinos Anargyrou
Department of Haematology, 251 General Air Force Hospital, Athens, Greece
Haematologica 93:451-4. 2008..This increase was significant in patients who responded to treatment. In conclusion, angiopoietin-1/angiopoietin-2 ratio normalization reflected response to bortezomib... - Outcome and toxicity in relapsed hairy cell leukemia patients treated with rituximabMaria K Angelopoulou
Leuk Lymphoma 49:1817-20. 2008 - BCL-2 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease predicts a poorer prognosis in patients treated with ABVD or equivalent regimensGeorge Z Rassidakis
Department of Lymphoma Myeloma, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Blood 100:3935-41. 2002..We conclude that BCL-2 is frequently expressed by HRS cells in cHD and is associated with inferior FFS in patients treated with ABVD or equivalent regimens... - CD20 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin's disease: associations with presenting features and clinical outcomeGeorge Z Rassidakis
Department of Lymphoma-Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 20:1278-87. 2002..CONCLUSION: CD20 is expressed by HRS cells in 22% of patients with classical HD but is not associated with different FFS after treatment with equivalent regimens... - Expression of Epstein-Barr virus latent membrane protein-1 in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma: associations with presenting features, serum interleukin 10 levels, and clinical outcomeMarco Herling
Department of Lymphoma and Myeloma, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:2114-20. 2003..CONCLUSIONS: LMP-1 was expressed by HRS cells in 21% of cHL and correlated with mixed cellularity type and higher serum interleukin 10 levels. The presence of LMP-1 was not associated with FFS or OS in uniformly treated patients... - BAX expression in Hodgkin and Reed-Sternberg cells of Hodgkin's disease: correlation with clinical outcomeGeorge Z Rassidakis
Department of Lymphoma Myeloma, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Clin Cancer Res 8:488-93. 2002..Therefore, we correlated BAX expression with presenting features and clinical outcome in untreated patients with HD...